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Items: 33

1.

The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer.

Rampias T, Karagiannis D, Avgeris M, Polyzos A, Kokkalis A, Kanaki Z, Kousidou E, Tzetis M, Kanavakis E, Stravodimos K, Manola KN, Pantelias GE, Scorilas A, Klinakis A.

EMBO Rep. 2019 Jan 21. pii: e46821. doi: 10.15252/embr.201846821. [Epub ahead of print]

PMID:
30665945
2.

Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin.

Efentakis P, Kremastiotis G, Varela A, Nikolaou PE, Papanagnou ED, Davos CH, Tsoumani M, Agrogiannis G, Konstantinidou A, Kastritis E, Kanaki Z, Iliodromitis EK, Klinakis A, Dimopoulos MA, Trougakos IP, Andreadou I, Terpos E.

Blood. 2019 Feb 14;133(7):710-723. doi: 10.1182/blood-2018-06-858415. Epub 2018 Nov 27.

PMID:
30482794
3.

Dll1 Marks Cells of Origin of Ras-Induced Cancer in Mouse Squamous Epithelia.

Vasilaki E, Kanaki Z, Stravopodis DJ, Klinakis A.

Transl Oncol. 2018 Oct;11(5):1213-1219. doi: 10.1016/j.tranon.2018.07.011. Epub 2018 Aug 3.

4.

Magnetic nanoparticles coated with polyarabic acid demonstrate enhanced drug delivery and imaging properties for cancer theranostic applications.

Patitsa M, Karathanou K, Kanaki Z, Tzioga L, Pippa N, Demetzos C, Verganelakis DA, Cournia Z, Klinakis A.

Sci Rep. 2017 Apr 10;7(1):775. doi: 10.1038/s41598-017-00836-y.

5.

Generation of human induced pluripotent stem cells in defined, feeder-free conditions.

Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C.

Stem Cell Res. 2016 Sep;17(2):458-460. doi: 10.1016/j.scr.2016.05.006. Epub 2016 May 12.

6.

KRT14 marks bladder progenitors.

Paraskevopoulou V, Papafotiou G, Klinakis A.

Cell Cycle. 2016 Dec;15(23):3161-3162. Epub 2016 Aug 22. No abstract available.

7.

KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis.

Papafotiou G, Paraskevopoulou V, Vasilaki E, Kanaki Z, Paschalidis N, Klinakis A.

Nat Commun. 2016 Jun 20;7:11914. doi: 10.1038/ncomms11914.

8.

Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer.

Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A.

J Natl Cancer Inst. 2014 Oct 11;106(12). pii: dju320. doi: 10.1093/jnci/dju320. Print 2014 Dec.

PMID:
25306215
9.

A new tumor suppressor role for the Notch pathway in bladder cancer.

Rampias T, Vgenopoulou P, Avgeris M, Polyzos A, Stravodimos K, Valavanis C, Scorilas A, Klinakis A.

Nat Med. 2014 Oct;20(10):1199-205. doi: 10.1038/nm.3678. Epub 2014 Sep 7.

PMID:
25194568
10.

VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of metabolic sensing in the regulation of angiogenesis.

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T.

Mol Cell Oncol. 2014 Dec 23;1(3):e964024. doi: 10.4161/23723548.2014.964024. eCollection 2014 Jul-Sep.

11.

VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T.

Mol Cell. 2014 May 22;54(4):559-72. doi: 10.1016/j.molcel.2014.03.022. Epub 2014 Apr 17.

12.

ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.

Weisberg SP, Smith-Raska MR, Esquilin JM, Zhang J, Arenzana TL, Lau CM, Churchill M, Pan H, Klinakis A, Dixon JE, Mirny LA, Mukherjee S, Reizis B.

Cell Rep. 2014 Feb 13;6(3):528-40. doi: 10.1016/j.celrep.2014.01.007. Epub 2014 Jan 30.

13.

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.

Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG.

Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12.

14.

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.

Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J, Sideridou M, Dereli-Oz A, Kocylowski M, Pateras IS, Evangelou K, Kotsinas A, Orsolic I, Bursac S, Cokaric-Brdovcak M, Zoumpourlis V, Kletsas D, Papafotiou G, Klinakis A, Volarevic S, Gu W, Bartek J, Halazonetis TD, Gorgoulis VG.

Nat Cell Biol. 2013 Aug;15(8):967-77. doi: 10.1038/ncb2795. Epub 2013 Jul 14. Erratum in: Nat Cell Biol. 2013 Oct;15(10):1260.

PMID:
23851489
15.

Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.

Sesele K, Thanopoulou K, Paouri E, Tsefou E, Klinakis A, Georgopoulos S.

Aging Cell. 2013 Dec;12(6):1032-40. doi: 10.1111/acel.12131. Epub 2013 Aug 11.

16.

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.

Billiard F, Lobry C, Darrasse-Jèze G, Waite J, Liu X, Mouquet H, DaNave A, Tait M, Idoyaga J, Leboeuf M, Kyratsous CA, Burton J, Kalter J, Klinakis A, Zhang W, Thurston G, Merad M, Steinman RM, Murphy AJ, Yancopoulos GD, Aifantis I, Skokos D.

J Exp Med. 2012 May 7;209(5):1011-28. doi: 10.1084/jem.20111615. Epub 2012 Apr 30.

17.

SDF-1 activates papillary label-retaining cells during kidney repair from injury.

Oliver JA, Maarouf O, Cheema FH, Liu C, Zhang QY, Kraus C, Zeeshan Afzal M, Firdous M, Klinakis A, Efstratiadis A, Al-Awqati Q.

Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1362-73. doi: 10.1152/ajprenal.00202.2011. Epub 2012 Mar 28.

18.

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B.

Immunity. 2011 Nov 23;35(5):780-91. doi: 10.1016/j.immuni.2011.08.013. Epub 2011 Oct 20.

19.

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I.

Nature. 2011 May 12;473(7346):230-3. doi: 10.1038/nature09999.

20.

Proliferation and migration of label-retaining cells of the kidney papilla.

Oliver JA, Klinakis A, Cheema FH, Friedlander J, Sampogna RV, Martens TP, Liu C, Efstratiadis A, Al-Awqati Q.

J Am Soc Nephrol. 2009 Nov;20(11):2315-27. doi: 10.1681/ASN.2008111203. Epub 2009 Sep 17.

21.

CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.

Buonamici S, Trimarchi T, Ruocco MG, Reavie L, Cathelin S, Mar BG, Klinakis A, Lukyanov Y, Tseng JC, Sen F, Gehrie E, Li M, Newcomb E, Zavadil J, Meruelo D, Lipp M, Ibrahim S, Efstratiadis A, Zagzag D, Bromberg JS, Dustin ML, Aifantis I.

Nature. 2009 Jun 18;459(7249):1000-4. doi: 10.1038/nature08020.

22.

Igf1r as a therapeutic target in a mouse model of basal-like breast cancer.

Klinakis A, Szabolcs M, Chen G, Xuan S, Hibshoosh H, Efstratiadis A.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2359-64. doi: 10.1073/pnas.0810221106. Epub 2009 Jan 27.

23.

The hormonal action of IGF1 in postnatal mouse growth.

Stratikopoulos E, Szabolcs M, Dragatsis I, Klinakis A, Efstratiadis A.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.

24.

Notch, Myc and breast cancer.

Efstratiadis A, Szabolcs M, Klinakis A.

Cell Cycle. 2007 Feb 15;6(4):418-29. Epub 2007 Feb 9. Review.

PMID:
17329972
25.

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice.

Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A.

Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9262-7. Epub 2006 Jun 2.

26.

Germ line transformation of the olive fly Bactrocera oleae using a versatile transgenesis marker.

Koukidou M, Klinakis A, Reboulakis C, Zagoraiou L, Tavernarakis N, Livadaras I, Economopoulos A, Savakis C.

Insect Mol Biol. 2006 Feb;15(1):95-103.

PMID:
16469073
27.

PEG10 is a c-MYC target gene in cancer cells.

Li CM, Margolin AA, Salas M, Memeo L, Mansukhani M, Hibshoosh H, Szabolcs M, Klinakis A, Tycko B.

Cancer Res. 2006 Jan 15;66(2):665-72.

28.

Minos as a genetic and genomic tool in Drosophila melanogaster.

Metaxakis A, Oehler S, Klinakis A, Savakis C.

Genetics. 2005 Oct;171(2):571-81. Epub 2005 Jun 21.

29.

In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues.

Zagoraiou L, Drabek D, Alexaki S, Guy JA, Klinakis AG, Langeveld A, Skavdis G, Mamalaki C, Grosveld F, Savakis C.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11474-8. Epub 2001 Sep 18.

30.

Genome-wide insertional mutagenesis in human cells by the Drosophila mobile element Minos.

Klinakis AG, Zagoraiou L, Vassilatis DK, Savakis C.

EMBO Rep. 2000 Nov;1(5):416-21.

31.

Extrachromosomal transposition of the transposable element Minos occurs in embryos of the silkworm Bombyx mori.

Shimizu K, Kamba M, Sonobe H, Kanda T, Klinakis AG, Savakis C, Tamura T.

Insect Mol Biol. 2000 Jun;9(3):277-81.

PMID:
10886411
32.

Mobility assays confirm the broad host-range activity of the Minos transposable element and validate new transformation tools.

Klinakis AG, Loukeris TG, Pavlopoulos A, Savakis C.

Insect Mol Biol. 2000 Jun;9(3):269-75.

PMID:
10886410
33.

Retrieval of DNA sequences present at an extremely low frequency.

Zafiropoulos A, Hatzidakis G, Mavrogiannis L, Klinakis A, Kandilogiannaki M, Krambovitis E.

Biotechniques. 1997 Dec;23(6):1104-9.

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