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Items: 1 to 50 of 59

1.

Rational design of a live-attenuated eastern equine encephalitis virus vaccine through informed mutation of virulence determinants.

Trobaugh DW, Sun C, Dunn MD, Reed DS, Klimstra WB.

PLoS Pathog. 2019 Feb 11;15(2):e1007584. doi: 10.1371/journal.ppat.1007584. eCollection 2019 Feb.

2.

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.

Hasan SS, Sun C, Kim AS, Watanabe Y, Chen CL, Klose T, Buda G, Crispin M, Diamond MS, Klimstra WB, Rossmann MG.

Cell Rep. 2018 Dec 11;25(11):3136-3147.e5. doi: 10.1016/j.celrep.2018.11.067.

3.

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.

Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE Jr, Slifka MK, Fremont DH, Klimstra WB, Diamond MS.

Nat Microbiol. 2019 Jan;4(1):187-197. doi: 10.1038/s41564-018-0286-4. Epub 2018 Nov 19.

4.

Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats.

Walters AW, Kujawa MR, Albe JR, Reed DS, Klimstra WB, Hartman AL.

Virology. 2019 Jan 2;526:173-179. doi: 10.1016/j.virol.2018.10.021. Epub 2018 Nov 2.

PMID:
30396029
5.

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.

Weiss CM, Trobaugh DW, Sun C, Lucas TM, Diamond MS, Ryman KD, Klimstra WB.

mSphere. 2018 Sep 19;3(5). pii: e00209-18. doi: 10.1128/mSphere.00209-18.

6.

Mxra8 is a receptor for multiple arthritogenic alphaviruses.

Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS.

Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16.

7.

The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent.

Lane WC, Dunn MD, Gardner CL, Lam LKM, Watson AM, Hartman AL, Ryman KD, Klimstra WB.

MBio. 2018 Apr 24;9(2). pii: e00535-18. doi: 10.1128/mBio.00535-18.

8.

Gamma-interferon exerts a critical early restriction on replication and dissemination of yellow fever virus vaccine strain 17D-204.

Lam LKM, Watson AM, Ryman KD, Klimstra WB.

NPJ Vaccines. 2018 Jan 23;3:5. doi: 10.1038/s41541-017-0039-z. eCollection 2018.

9.

Ribbon scanning confocal for high-speed high-resolution volume imaging of brain.

Watson AM, Rose AH, Gibson GA, Gardner CL, Sun C, Reed DS, Lam LKM, St Croix CM, Strick PL, Klimstra WB, Watkins SC.

PLoS One. 2017 Jul 7;12(7):e0180486. doi: 10.1371/journal.pone.0180486. eCollection 2017.

10.

The expression level of C19MC miRNAs in early pregnancy and in response to viral infection.

Dumont TMF, Mouillet JF, Bayer A, Gardner CL, Klimstra WB, Wolf DG, Yagel S, Balmir F, Binstock A, Sanfilippo JS, Coyne CB, Larkin JC, Sadovsky Y.

Placenta. 2017 May;53:23-29. doi: 10.1016/j.placenta.2017.03.011. Epub 2017 Mar 16.

11.

Antibody Preparations from Human Transchromosomic Cows Exhibit Prophylactic and Therapeutic Efficacy against Venezuelan Equine Encephalitis Virus.

Gardner CL, Sun C, Luke T, Raviprakash K, Wu H, Jiao JA, Sullivan E, Reed DS, Ryman KD, Klimstra WB.

J Virol. 2017 Jun 26;91(14). pii: e00226-17. doi: 10.1128/JVI.00226-17. Print 2017 Jul 15.

12.

T Cell-Mediated Immunity towards Yellow Fever Virus and Useful Animal Models.

Watson AM, Klimstra WB.

Viruses. 2017 Apr 11;9(4). pii: E77. doi: 10.3390/v9040077. Review.

13.

Alphaviruses suppress host immunity by preventing myeloid cell replication and antagonizing innate immune responses.

Trobaugh DW, Klimstra WB.

Curr Opin Virol. 2017 Apr;23:30-34. doi: 10.1016/j.coviro.2017.02.004. Epub 2017 Mar 10. Review.

14.

MicroRNA Regulation of RNA Virus Replication and Pathogenesis.

Trobaugh DW, Klimstra WB.

Trends Mol Med. 2017 Jan;23(1):80-93. doi: 10.1016/j.molmed.2016.11.003. Epub 2016 Dec 16. Review.

15.

A Role for Human Skin Mast Cells in Dengue Virus Infection and Systemic Spread.

Troupin A, Shirley D, Londono-Renteria B, Watson AM, McHale C, Hall A, Hartstone-Rose A, Klimstra WB, Gomez G, Colpitts TM.

J Immunol. 2016 Dec 1;197(11):4382-4391. Epub 2016 Oct 31.

16.

Aedes aegypti D7 Saliva Protein Inhibits Dengue Virus Infection.

Conway MJ, Londono-Renteria B, Troupin A, Watson AM, Klimstra WB, Fikrig E, Colpitts TM.

PLoS Negl Trop Dis. 2016 Sep 15;10(9):e0004941. doi: 10.1371/journal.pntd.0004941. eCollection 2016 Sep.

17.

The 17D-204 Vaccine Strain-Induced Protection against Virulent Yellow Fever Virus Is Mediated by Humoral Immunity and CD4+ but not CD8+ T Cells.

Watson AM, Lam LK, Klimstra WB, Ryman KD.

PLoS Pathog. 2016 Jul 27;12(7):e1005786. doi: 10.1371/journal.ppat.1005786. eCollection 2016 Jul.

18.

Host translation shutoff mediated by non-structural protein 2 is a critical factor in the antiviral state resistance of Venezuelan equine encephalitis virus.

Bhalla N, Sun C, Metthew Lam LK, Gardner CL, Ryman KD, Klimstra WB.

Virology. 2016 Sep;496:147-165. doi: 10.1016/j.virol.2016.06.005. Epub 2016 Jun 15.

19.

Electroporation of Alphavirus RNA Translational Reporters into Fibroblastic and Myeloid Cells as a Tool to Study the Innate Immune System.

Gardner CL, Trobaugh DW, Ryman KD, Klimstra WB.

Methods Mol Biol. 2016;1428:127-37. doi: 10.1007/978-1-4939-3625-0_8.

PMID:
27236796
20.

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection.

Dalmia N, Klimstra WB, Mason C, Ramsay AJ.

PLoS One. 2015 Aug 28;10(8):e0136635. doi: 10.1371/journal.pone.0136635. eCollection 2015.

21.

The 5' and 3' ends of alphavirus RNAs--Non-coding is not non-functional.

Hyde JL, Chen R, Trobaugh DW, Diamond MS, Weaver SC, Klimstra WB, Wilusz J.

Virus Res. 2015 Aug 3;206:99-107. doi: 10.1016/j.virusres.2015.01.016. Epub 2015 Jan 25. Review.

22.

Human trophoblasts confer resistance to viruses implicated in perinatal infection.

Bayer A, Delorme-Axford E, Sleigher C, Frey TK, Trobaugh DW, Klimstra WB, Emert-Sedlak LA, Smithgall TE, Kinchington PR, Vadia S, Seveau S, Boyle JP, Coyne CB, Sadovsky Y.

Am J Obstet Gynecol. 2015 Jan;212(1):71.e1-71.e8. doi: 10.1016/j.ajog.2014.07.060. Epub 2014 Aug 6.

23.

Can understanding the virulence mechanisms of RNA viruses lead us to a vaccine against eastern equine encephalitis virus and other alphaviruses?

Trobaugh DW, Ryman KD, Klimstra WB.

Expert Rev Vaccines. 2014 Dec;13(12):1423-5. doi: 10.1586/14760584.2014.944168. Epub 2014 Jul 30.

24.

In vivo imaging in an ABSL-3 regional biocontainment laboratory.

Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, Cole KS.

Pathog Dis. 2014 Jul;71(2):207-12. doi: 10.1111/2049-632X.12186. Epub 2014 Jun 18. Review.

PMID:
24838691
25.

Closing the gap between viral and noninfectious arthritis.

Ryman KD, Klimstra WB.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5767-8. doi: 10.1073/pnas.1404206111. Epub 2014 Apr 14. No abstract available.

26.

Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design.

Gardner CL, Hritz J, Sun C, Vanlandingham DL, Song TY, Ghedin E, Higgs S, Klimstra WB, Ryman KD.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2719. doi: 10.1371/journal.pntd.0002719. eCollection 2014 Feb.

27.

A viral RNA structural element alters host recognition of nonself RNA.

Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS.

Science. 2014 Feb 14;343(6172):783-7. doi: 10.1126/science.1248465. Epub 2014 Jan 30.

28.

RNA viruses can hijack vertebrate microRNAs to suppress innate immunity.

Trobaugh DW, Gardner CL, Sun C, Haddow AD, Wang E, Chapnik E, Mildner A, Weaver SC, Ryman KD, Klimstra WB.

Nature. 2014 Feb 13;506(7487):245-8. doi: 10.1038/nature12869. Epub 2013 Dec 18.

29.

Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease.

Sun C, Gardner CL, Watson AM, Ryman KD, Klimstra WB.

J Virol. 2014 Feb;88(4):2035-46. doi: 10.1128/JVI.02990-13. Epub 2013 Dec 4.

30.

Mosquito saliva serine protease enhances dissemination of dengue virus into the mammalian host.

Conway MJ, Watson AM, Colpitts TM, Dragovic SM, Li Z, Wang P, Feitosa F, Shepherd DT, Ryman KD, Klimstra WB, Anderson JF, Fikrig E.

J Virol. 2014 Jan;88(1):164-75. doi: 10.1128/JVI.02235-13. Epub 2013 Oct 16.

31.

Natural variation in the heparan sulfate binding domain of the eastern equine encephalitis virus E2 glycoprotein alters interactions with cell surfaces and virulence in mice.

Gardner CL, Choi-Nurvitadhi J, Sun C, Bayer A, Hritz J, Ryman KD, Klimstra WB.

J Virol. 2013 Aug;87(15):8582-90. doi: 10.1128/JVI.00937-13. Epub 2013 May 29.

32.
33.

Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence.

Gardner CL, Ebel GD, Ryman KD, Klimstra WB.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16026-31. doi: 10.1073/pnas.1110617108. Epub 2011 Sep 6.

34.

2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.

Daffis S, Szretter KJ, Schriewer J, Li J, Youn S, Errett J, Lin TY, Schneller S, Zust R, Dong H, Thiel V, Sen GC, Fensterl V, Klimstra WB, Pierson TC, Buller RM, Gale M Jr, Shi PY, Diamond MS.

Nature. 2010 Nov 18;468(7322):452-6. doi: 10.1038/nature09489.

35.

Cell-specific targeting of lentiviral vectors mediated by fusion proteins derived from Sindbis virus, vesicular stomatitis virus, or avian sarcoma/leukosis virus.

Zhang XY, Kutner RH, Bialkowska A, Marino MP, Klimstra WB, Reiser J.

Retrovirology. 2010 Jan 25;7:3. doi: 10.1186/1742-4690-7-3.

36.

A mouse model for studying viscerotropic disease caused by yellow fever virus infection.

Meier KC, Gardner CL, Khoretonenko MV, Klimstra WB, Ryman KD.

PLoS Pathog. 2009 Oct;5(10):e1000614. doi: 10.1371/journal.ppat.1000614. Epub 2009 Oct 9.

37.

Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses.

Burke CW, Gardner CL, Steffan JJ, Ryman KD, Klimstra WB.

Virology. 2009 Dec 5;395(1):121-32. doi: 10.1016/j.virol.2009.08.039. Epub 2009 Sep 25.

38.

Similarities and differences in antagonism of neuron alpha/beta interferon responses by Venezuelan equine encephalitis and Sindbis alphaviruses.

Yin J, Gardner CL, Burke CW, Ryman KD, Klimstra WB.

J Virol. 2009 Oct;83(19):10036-47. doi: 10.1128/JVI.01209-09. Epub 2009 Jul 29.

39.

Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice.

Gardner CL, Yin J, Burke CW, Klimstra WB, Ryman KD.

Virology. 2009 Aug 1;390(2):338-47. doi: 10.1016/j.virol.2009.05.030. Epub 2009 Jun 18.

40.

Host responses to alphavirus infection.

Ryman KD, Klimstra WB.

Immunol Rev. 2008 Oct;225:27-45. doi: 10.1111/j.1600-065X.2008.00670.x. Review.

PMID:
18837774
41.

Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis.

Gardner CL, Burke CW, Tesfay MZ, Glass PJ, Klimstra WB, Ryman KD.

J Virol. 2008 Nov;82(21):10634-46. doi: 10.1128/JVI.01323-08. Epub 2008 Sep 3.

42.

Alpha/beta interferon inhibits cap-dependent translation of viral but not cellular mRNA by a PKR-independent mechanism.

Tesfay MZ, Yin J, Gardner CL, Khoretonenko MV, Korneeva NL, Rhoads RE, Ryman KD, Klimstra WB.

J Virol. 2008 Mar;82(6):2620-30. Epub 2007 Dec 26.

43.

Identification and characterization of interferon-induced proteins that inhibit alphavirus replication.

Zhang Y, Burke CW, Ryman KD, Klimstra WB.

J Virol. 2007 Oct;81(20):11246-55. Epub 2007 Aug 8.

44.

Non-pathogenic Sindbis virus causes hemorrhagic fever in the absence of alpha/beta and gamma interferons.

Ryman KD, Meier KC, Gardner CL, Adegboyega PA, Klimstra WB.

Virology. 2007 Nov 25;368(2):273-85. Epub 2007 Aug 2.

45.

Early restriction of alphavirus replication and dissemination contributes to age-dependent attenuation of systemic hyperinflammatory disease.

Ryman KD, Gardner CL, Meier KC, Biron CA, Johnston RE, Klimstra WB.

J Gen Virol. 2007 Feb;88(Pt 2):518-29.

PMID:
17251570
46.

Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses.

Ryman KD, Gardner CL, Burke CW, Meier KC, Thompson JM, Klimstra WB.

J Virol. 2007 Apr;81(7):3563-73. Epub 2007 Jan 10.

47.

Targeting Sindbis virus-based vectors to Fc receptor-positive cell types.

Klimstra WB, Williams JC, Ryman KD, Heidner HW.

Virology. 2005 Jul 20;338(1):9-21.

48.

Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells.

Ryman KD, Meier KC, Nangle EM, Ragsdale SL, Korneeva NL, Rhoads RE, MacDonald MR, Klimstra WB.

J Virol. 2005 Feb;79(3):1487-99.

50.

DC-SIGN and L-SIGN can act as attachment receptors for alphaviruses and distinguish between mosquito cell- and mammalian cell-derived viruses.

Klimstra WB, Nangle EM, Smith MS, Yurochko AD, Ryman KD.

J Virol. 2003 Nov;77(22):12022-32. Erratum in: J Virol. 2004 Jul;78(14):7862.

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