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Items: 12

1.

Antisense oligonucleotide therapies for Amyotrophic Lateral Sclerosis: Existing and emerging targets.

Klim JR, Vance C, Scotter EL.

Int J Biochem Cell Biol. 2019 May;110:149-153. doi: 10.1016/j.biocel.2019.03.009. Epub 2019 Mar 20.

PMID:
30904737
2.

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.

Klim JR, Williams LA, Limone F, Guerra San Juan I, Davis-Dusenbery BN, Mordes DA, Burberry A, Steinbaugh MJ, Gamage KK, Kirchner R, Moccia R, Cassel SH, Chen K, Wainger BJ, Woolf CJ, Eggan K.

Nat Neurosci. 2019 Feb;22(2):167-179. doi: 10.1038/s41593-018-0300-4. Epub 2019 Jan 14.

PMID:
30643292
3.

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.

Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K.

Acta Neuropathol Commun. 2018 Jul 4;6(1):55. doi: 10.1186/s40478-018-0555-8.

4.

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1.

Tripathi P, Rodriguez-Muela N, Klim JR, de Boer AS, Agrawal S, Sandoe J, Lopes CS, Ogliari KS, Williams LA, Shear M, Rubin LL, Eggan K, Zhou Q.

Stem Cell Reports. 2017 Aug 8;9(2):667-680. doi: 10.1016/j.stemcr.2017.06.008. Epub 2017 Jul 14.

5.

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection.

Wells MF, Salick MR, Wiskow O, Ho DJ, Worringer KA, Ihry RJ, Kommineni S, Bilican B, Klim JR, Hill EJ, Kane LT, Ye C, Kaykas A, Eggan K.

Cell Stem Cell. 2016 Dec 1;19(6):703-708. doi: 10.1016/j.stem.2016.11.011.

6.

Modeling ALS with motor neurons derived from human induced pluripotent stem cells.

Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN.

Nat Neurosci. 2016 Apr;19(4):542-53. doi: 10.1038/nn.4273. Review.

7.

Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.

Wrighton PJ, Klim JR, Hernandez BA, Koonce CH, Kamp TJ, Kiessling LL.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18126-31. doi: 10.1073/pnas.1409525111. Epub 2014 Nov 24.

8.

How to make spinal motor neurons.

Davis-Dusenbery BN, Williams LA, Klim JR, Eggan K.

Development. 2014 Feb;141(3):491-501. doi: 10.1242/dev.097410. Review.

9.

Small-molecule-modified surfaces engage cells through the αvβ3 integrin.

Klim JR, Fowler AJ, Courtney AH, Wrighton PJ, Sheridan RT, Wong ML, Kiessling LL.

ACS Chem Biol. 2012 Mar 16;7(3):518-25. doi: 10.1021/cb2004725. Epub 2012 Jan 26.

10.

Spatial control of cell fate using synthetic surfaces to potentiate TGF-beta signaling.

Li L, Klim JR, Derda R, Courtney AH, Kiessling LL.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11745-50. doi: 10.1073/pnas.1101454108. Epub 2011 Jun 30.

11.

A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.

Klim JR, Li L, Wrighton PJ, Piekarczyk MS, Kiessling LL.

Nat Methods. 2010 Dec;7(12):989-94. doi: 10.1038/nmeth.1532. Epub 2010 Nov 14.

12.

High-throughput discovery of synthetic surfaces that support proliferation of pluripotent cells.

Derda R, Musah S, Orner BP, Klim JR, Li L, Kiessling LL.

J Am Chem Soc. 2010 Feb 3;132(4):1289-95. doi: 10.1021/ja906089g.

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