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Items: 1 to 50 of 65

1.

TORC1 inhibition enhances immune function and reduces infections in the elderly.

Mannick JB, Morris M, Hockey HP, Roma G, Beibel M, Kulmatycki K, Watkins M, Shavlakadze T, Zhou W, Quinn D, Glass DJ, Klickstein LB.

Sci Transl Med. 2018 Jul 11;10(449). pii: eaaq1564. doi: 10.1126/scitranslmed.aaq1564.

PMID:
29997249
2.

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology.

Shavlakadze T, Zhu J, Wang S, Zhou W, Morin B, Egerman MA, Fan L, Wang Y, Iartchouk O, Meyer A, Valdez RA, Mannick JB, Klickstein LB, Glass DJ.

J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):845-852. doi: 10.1093/gerona/glx249.

3.

mTOR inhibition improves immune function in the elderly.

Mannick JB, Del Giudice G, Lattanzi M, Valiante NM, Praestgaard J, Huang B, Lonetto MA, Maecker HT, Kovarik J, Carson S, Glass DJ, Klickstein LB.

Sci Transl Med. 2014 Dec 24;6(268):268ra179. doi: 10.1126/scitranslmed.3009892.

PMID:
25540326
4.

AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women.

John MR, Harfst E, Loeffler J, Belleli R, Mason J, Bruin GJ, Seuwen K, Klickstein LB, Mindeholm L, Widler L, Kneissel M.

Bone. 2014 Jul;64:204-10. doi: 10.1016/j.bone.2014.04.015. Epub 2014 Apr 24.

PMID:
24769332
5.

Serological investigation of the collagen degradation profile of patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis.

Leeming DJ, Sand JM, Nielsen MJ, Genovese F, Martinez FJ, Hogaboam CM, Han MK, Klickstein LB, Karsdal MA.

Biomark Insights. 2012;7:119-26. Epub 2012 Sep 13.

6.

Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation.

Skjøt-Arkil H, Clausen RE, Nguyen QH, Wang Y, Zheng Q, Martinez FJ, Hogaboam CM, Han M, Klickstein LB, Larsen MR, Nawrocki A, Leeming DJ, Karsdal MA.

BMC Pulm Med. 2012 Jul 20;12:34. doi: 10.1186/1471-2466-12-34.

7.

ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans.

John MR, Widler L, Gamse R, Buhl T, Seuwen K, Breitenstein W, Bruin GJ, Belleli R, Klickstein LB, Kneissel M.

Bone. 2011 Aug;49(2):233-41. doi: 10.1016/j.bone.2011.04.007. Epub 2011 Apr 14.

PMID:
21514409
8.

Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1.

Ghiran I, Glodek AM, Weaver G, Klickstein LB, Nicholson-Weller A.

Blood. 2008 Oct 15;112(8):3465-73. doi: 10.1182/blood-2008-04-151845. Epub 2008 Aug 6.

9.

Production of a complete cDNA library.

Klickstein LB.

Curr Protoc Mol Biol. 2001 May;Chapter 5:Unit5.8A. doi: 10.1002/0471142727.mb0508as18.

PMID:
18265252
10.

Ligation of linkers or adapters to double-stranded cDNA.

Klickstein LB, Neve RL.

Curr Protoc Mol Biol. 2001 May;Chapter 5:Unit5.6. doi: 10.1002/0471142727.mb0506s13.

PMID:
18265250
11.

Conversion of mRNA into double-stranded cDNA.

Klickstein LB, Neve RL, Golemis EA, Gyuris J.

Curr Protoc Mol Biol. 2001 May;Chapter 5:Unit5.5. doi: 10.1002/0471142727.mb0505s29.

PMID:
18265249
12.

Amplification of a bacteriophage library.

Klickstein LB.

Curr Protoc Mol Biol. 2001 May;Chapter 5:Unit5.10. doi: 10.1002/0471142727.mb0510s34.

PMID:
18265244
13.

Production of a subtracted cDNA library.

Klickstein LB.

Curr Protoc Mol Biol. 2001 Aug;Chapter 25:Unit 25B.1. doi: 10.1002/0471142727.mb25b01s55.

PMID:
18265214
14.

Aggregatibacter actinomycetemcomitans leukotoxin requires beta-sheets 1 and 2 of the human CD11a beta-propeller for cytotoxicity.

Kieba IR, Fong KP, Tang HY, Hoffman KE, Speicher DW, Klickstein LB, Lally ET.

Cell Microbiol. 2007 Nov;9(11):2689-99. Epub 2007 Jun 24.

15.

Characterization of two novel LPS-binding sites in leukocyte integrin betaA domain.

Wong KF, Luk JM, Cheng RH, Klickstein LB, Fan ST.

FASEB J. 2007 Oct;21(12):3231-9. Epub 2007 May 23.

PMID:
17522381
16.

Antibody CR1-2B11 recognizes a non-polymorphic epitope of human CR1 (CD35).

Chen CH, Ghiran I, Beurskens FJ, Weaver G, Vincent JA, Nicholson-Weller A, Klickstein LB.

Clin Exp Immunol. 2007 Jun;148(3):546-54.

17.

Dissection of the temporal artery in a patient with giant cell arteritis.

Kunst CH, Weiss ET, Klickstein LB.

J Clin Rheumatol. 2001 Apr;7(2):79-82.

PMID:
17039100
18.

Rituximab for steroid-refractory chronic graft-versus-host disease.

Cutler C, Miklos D, Kim HT, Treister N, Woo SB, Bienfang D, Klickstein LB, Levin J, Miller K, Reynolds C, Macdonell R, Pasek M, Lee SJ, Ho V, Soiffer R, Antin JH, Ritz J, Alyea E.

Blood. 2006 Jul 15;108(2):756-62. Epub 2006 Mar 21.

19.

A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1).

Repik A, Pincus SE, Ghiran I, Nicholson-Weller A, Asher DR, Cerny AM, Casey LS, Jones SM, Jones SN, Mohamed N, Klickstein LB, Spitalny G, Finberg RW.

Clin Exp Immunol. 2005 May;140(2):230-40.

20.

Manifestations of inflammatory arthritis are critically dependent on LFA-1.

Watts GM, Beurskens FJ, Martin-Padura I, Ballantyne CM, Klickstein LB, Brenner MB, Lee DM.

J Immunol. 2005 Mar 15;174(6):3668-75.

21.

Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN.

Weber KS, Alon R, Klickstein LB.

Inflammation. 2004 Aug;28(4):177-88.

PMID:
15673159
22.

The integrin alpha-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation.

Xie C, Shimaoka M, Xiao T, Schwab P, Klickstein LB, Springer TA.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15422-7. Epub 2004 Oct 19.

23.

RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes.

Cherry LK, Li X, Schwab P, Lim B, Klickstein LB.

Nat Immunol. 2004 Sep;5(9):961-7. Epub 2004 Aug 8.

PMID:
15300248
24.

A role for lipid rafts in C1q-triggered O2- generation by human neutrophils.

Otabor I, Tyagi S, Beurskens FJ, Ghiran I, Schwab P, Nicholson-Weller A, Klickstein LB.

Mol Immunol. 2004 Jun;41(2-3):185-90.

PMID:
15159064
25.

Calreticulin is at the surface of circulating neutrophils and uses CD59 as an adaptor molecule.

Ghiran I, Klickstein LB, Nicholson-Weller A.

J Biol Chem. 2003 Jun 6;278(23):21024-31. Epub 2003 Mar 19.

26.

Expression and function of C1q receptors and C1q binding proteins at the cell surface.

Ghiran I, Tyagi SR, Klickstein LB, Nicholson-Weller A.

Immunobiology. 2002 Sep;205(4-5):407-20. Review.

PMID:
12396003
27.
28.
29.

Lack of age-associated LFA-1 up-regulation and impaired ICAM-1 binding in lymphocytes from patients with Down syndrome.

Lin SJ, Wang JY, Klickstein LB, Chuang KP, Chen JY, Lee JF, Shieh CC.

Clin Exp Immunol. 2001 Oct;126(1):54-63.

30.

Dual role of H-Ras in regulation of lymphocyte function antigen-1 activity by stromal cell-derived factor-1alpha: implications for leukocyte transmigration.

Weber KS, Ostermann G, Zernecke A, Schröder A, Klickstein LB, Weber C.

Mol Biol Cell. 2001 Oct;12(10):3074-86.

31.

gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.

Castells MC, Klickstein LB, Hassani K, Cumplido JA, Lacouture ME, Austen KF, Katz HR.

Nat Immunol. 2001 May;2(5):436-42.

PMID:
11323698
32.

Complement receptor 1/CD35 is a receptor for mannan-binding lectin.

Ghiran I, Barbashov SF, Klickstein LB, Tas SW, Jensenius JC, Nicholson-Weller A.

J Exp Med. 2000 Dec 18;192(12):1797-808.

33.
35.

The C3b/C4b receptor (CR1, CD35) on erythrocytes: methods for study of the polymorphisms.

Cohen JH, Atkinson JP, Klickstein LB, Oudin S, Subramanian VB, Moulds JM.

Mol Immunol. 1999 Sep-Oct;36(13-14):819-25.

PMID:
10698335
36.

C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion.

Tas SW, Klickstein LB, Barbashov SF, Nicholson-Weller A.

J Immunol. 1999 Nov 1;163(9):5056-63.

38.

C1q-binding proteins and C1q receptors.

Nicholson-Weller A, Klickstein LB.

Curr Opin Immunol. 1999 Feb;11(1):42-6. Review.

PMID:
10047536
39.

Chemokine-induced monocyte transmigration requires cdc42-mediated cytoskeletal changes.

Weber KS, Klickstein LB, Weber PC, Weber C.

Eur J Immunol. 1998 Jul;28(7):2245-51.

40.

Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

Klickstein LB, Barbashov SF, Liu T, Jack RM, Nicholson-Weller A.

Immunity. 1997 Sep;7(3):345-55.

42.

Localization of the binding site on intercellular adhesion molecule-3 (ICAM-3) for lymphocyte function-associated antigen 1 (LFA-1).

Klickstein LB, York MR, Fougerolles AR, Springer TA.

J Biol Chem. 1996 Sep 27;271(39):23920-7.

43.

Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes.

Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT.

J Exp Med. 1993 Oct 1;178(4):1407-17.

45.

Mapping of the C3b-binding site of CR1 and construction of a (CR1)2-F(ab')2 chimeric complement inhibitor.

Kalli KR, Hsu PH, Bartow TJ, Ahearn JM, Matsumoto AK, Klickstein LB, Fearon DT.

J Exp Med. 1991 Dec 1;174(6):1451-60.

46.

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2.

Lowell CA, Klickstein LB, Carter RH, Mitchell JA, Fearon DT, Ahearn JM.

J Exp Med. 1989 Dec 1;170(6):1931-46.

47.

Cloning and sequence analysis of a rat liver cDNA encoding acyl-peptide hydrolase.

Kobayashi K, Lin LW, Yeadon JE, Klickstein LB, Smith JA.

J Biol Chem. 1989 May 25;264(15):8892-9.

48.

Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

Wong WW, Cahill JM, Rosen MD, Kennedy CA, Bonaccio ET, Morris MJ, Wilson JG, Klickstein LB, Fearon DT.

J Exp Med. 1989 Mar 1;169(3):847-63.

49.

Immunoregulatory functions of complement: structural and functional studies of complement receptor type 1 (CR1; CD35) and type 2 (CR2; CD21).

Fearon DT, Klickstein LB, Wong WW, Wilson JG, Moore FD Jr, Weis JJ, Weis JH, Jack RM, Carter RH, Ahearn JA.

Prog Clin Biol Res. 1989;297:211-20. No abstract available.

PMID:
2531419
50.

Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

Klickstein LB, Bartow TJ, Miletic V, Rabson LD, Smith JA, Fearon DT.

J Exp Med. 1988 Nov 1;168(5):1699-717.

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