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Items: 1 to 50 of 62

1.

Immune Cell-Type Specific Ablation of Adapter Protein ADAP Differentially Modulates EAE.

Rudolph J, Meinke C, Voss M, Guttek K, Kliche S, Reinhold D, Schraven B, Reinhold A.

Front Immunol. 2019 Oct 1;10:2343. doi: 10.3389/fimmu.2019.02343. eCollection 2019.

2.

Characterization of Mice with a Platelet-Specific Deletion of the Adapter Molecule ADAP.

Rudolph JM, Guttek K, Weitz G, Meinke CA, Kliche S, Reinhold D, Schraven B, Reinhold A.

Mol Cell Biol. 2019 Apr 16;39(9). pii: e00365-18. doi: 10.1128/MCB.00365-18. Print 2019 May 1.

3.

p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation.

Düsedau HP, Kleveman J, Figueiredo CA, Biswas A, Steffen J, Kliche S, Haak S, Zagrebelsky M, Korte M, Dunay IR.

Glia. 2019 Jan;67(1):193-211. doi: 10.1002/glia.23553.

4.

Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.

Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S.

Front Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018.

5.

JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.

Edelmann B, Gupta N, Schnoeder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus R, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller AJ, Fischer T.

J Clin Invest. 2018 Oct 1;128(10):4359-4371. doi: 10.1172/JCI90312. Epub 2018 Jul 19.

6.

Ndr2 Kinase Controls Neurite Outgrowth and Dendritic Branching Through α1 Integrin Expression.

Demiray YE, Rehberg K, Kliche S, Stork O.

Front Mol Neurosci. 2018 Mar 6;11:66. doi: 10.3389/fnmol.2018.00066. eCollection 2018.

7.

TCR signalling network organization at the immunological synapses of murine regulatory T cells.

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.

Eur J Immunol. 2017 Dec;47(12):2043-2058. doi: 10.1002/eji.201747041. Epub 2017 Sep 12.

8.

The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.

Niemz J, Kliche S, Pils MC, Morrison E, Manns A, Freund C, Crittenden JR, Graybiel AM, Galla M, Jänsch L, Huehn J.

Eur J Microbiol Immunol (Bp). 2017 May 22;7(2):112-126. doi: 10.1556/1886.2017.00007. eCollection 2017 Jun.

9.

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions.

Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A.

J Exp Med. 2017 Mar 6;214(3):851-874. doi: 10.1084/jem.20160647. Epub 2017 Feb 9.

10.

JAK2-V617F activates β1-integrin-mediated adhesion of granulocytes to vascular cell adhesion molecule 1.

Gupta N, Edelmann B, Schnoeder TM, Saalfeld FC, Wolleschak D, Kliche S, Schraven B, Heidel FH, Fischer T.

Leukemia. 2017 May;31(5):1223-1226. doi: 10.1038/leu.2017.26. Epub 2017 Jan 18. No abstract available.

11.

D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.

Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00509-16. doi: 10.1128/MCB.00509-16. Print 2017 Apr 1.

12.

The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.

Schneble N, Müller J, Kliche S, Bauer R, Wetzker R, Böhmer FD, Wang ZQ, Müller JP.

Glia. 2017 Feb;65(2):416-428. doi: 10.1002/glia.23100. Epub 2016 Nov 17.

PMID:
27859601
13.

Integrin Activation Through the Hematopoietic Adapter Molecule ADAP Regulates Dendritic Development of Hippocampal Neurons.

Thiere M, Kliche S, Müller B, Teuber J, Nold I, Stork O.

Front Mol Neurosci. 2016 Sep 30;9:91. eCollection 2016.

14.

ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens.

Parzmair GP, Gereke M, Haberkorn O, Annemann M, Podlasly L, Kliche S, Reinhold A, Schraven B, Bruder D.

J Leukoc Biol. 2017 Feb;101(2):407-419. doi: 10.1189/jlb.1A0216-090RR. Epub 2016 Sep 7.

PMID:
27605210
15.

A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice.

Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S, Willers M, Mihai S, Parsch H, Wirtz S, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J.

Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.

16.

Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.

Kuropka B, Schraven B, Kliche S, Krause E, Freund C.

Expert Rev Proteomics. 2016 Jun;13(6):545-54. doi: 10.1080/14789450.2016.1187565. Review.

PMID:
27258783
17.

Atypical IκB proteins in immune cell differentiation and function.

Annemann M, Plaza-Sirvent C, Schuster M, Katsoulis-Dimitriou K, Kliche S, Schraven B, Schmitz I.

Immunol Lett. 2016 Mar;171:26-35. doi: 10.1016/j.imlet.2016.01.006. Epub 2016 Jan 22. Review.

PMID:
26804211
18.

Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.

Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C.

Mol Cell Proteomics. 2015 Nov;14(11):2961-72. doi: 10.1074/mcp.M115.048249. Epub 2015 Aug 5.

19.

Quantitative analysis of the human T cell palmitome.

Morrison E, Kuropka B, Kliche S, Brügger B, Krause E, Freund C.

Sci Rep. 2015 Jun 26;5:11598. doi: 10.1038/srep11598.

20.

The adhesion- and degranulation-promoting adaptor protein and its role in the modulation of experimental autoimmune encephalomyelitis.

Engelmann S, Togni M, Kliche S, Reinhold D, Schraven B, Reinhold A.

Crit Rev Immunol. 2015;35(1):1-14. Review.

PMID:
25746044
21.

Metallic wear debris may regulate CXCR4 expression in vitro and in vivo.

Drynda A, Singh G, Buchhorn GH, Awiszus F, Ruetschi M, Feuerstein B, Kliche S, Lohmann CH.

J Biomed Mater Res A. 2015 Jun;103(6):1940-8. doi: 10.1002/jbm.a.35330. Epub 2014 Sep 17.

PMID:
25205627
22.

The adapter proteins ADAP and Nck cooperate in T cell adhesion.

Lettau M, Kliche S, Kabelitz D, Janssen O.

Mol Immunol. 2014 Jul;60(1):72-9. doi: 10.1016/j.molimm.2014.03.017. Epub 2014 Apr 24.

PMID:
24769494
23.

The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth.

Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Meineke BM, Freund C, Budinger E, Stork O.

J Neurosci. 2014 Apr 9;34(15):5342-54. doi: 10.1523/JNEUROSCI.2728-13.2014.

24.

Clinically relevant doses of FLT3-kinase inhibitors quizartinib and midostaurin do not impair T-cell reactivity and function.

Wolleschak D, Mack TS, Perner F, Frey S, Schnöder TM, Wagner MC, Höding C, Pils MC, Parkner A, Kliche S, Schraven B, Hebel K, Brunner-Weinzierl M, Ranjan S, Isermann B, Lipka DB, Fischer T, Heidel FH.

Haematologica. 2014 Jun;99(6):e90-3. doi: 10.3324/haematol.2014.104331. Epub 2014 Mar 14. No abstract available.

25.

T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice.

Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, Schraven B, Reinhold A.

J Immunol. 2013 Nov 15;191(10):4950-9. doi: 10.4049/jimmunol.1203340. Epub 2013 Oct 7.

26.

The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow.

Lek HS, Morrison VL, Conneely M, Campbell PA, McGloin D, Kliche S, Watts C, Prescott A, Fagerholm SC.

J Biol Chem. 2013 May 24;288(21):14698-708. doi: 10.1074/jbc.M112.430918. Epub 2013 Apr 12.

27.

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth.

Hansen W, Hutzler M, Abel S, Alter C, Stockmann C, Kliche S, Albert J, Sparwasser T, Sakaguchi S, Westendorf AM, Schadendorf D, Buer J, Helfrich I.

J Exp Med. 2012 Oct 22;209(11):2001-16. doi: 10.1084/jem.20111497. Epub 2012 Oct 8.

28.

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury.

Block H, Herter JM, Rossaint J, Stadtmann A, Kliche S, Lowell CA, Zarbock A.

J Exp Med. 2012 Feb 13;209(2):407-21. doi: 10.1084/jem.20111493. Epub 2012 Jan 30.

29.

CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules.

Kliche S, Worbs T, Wang X, Degen J, Patzak I, Meineke B, Togni M, Moser M, Reinhold A, Kiefer F, Freund C, Förster R, Schraven B.

Blood. 2012 Jan 19;119(3):777-85. doi: 10.1182/blood-2011-06-362269. Epub 2011 Nov 23.

PMID:
22117043
30.

The SLP-76 Src homology 2 domain is required for T cell development and activation.

Burns JC, Corbo E, Degen J, Gohil M, Anterasian C, Schraven B, Koretzky GA, Kliche S, Jordan MS.

J Immunol. 2011 Nov 1;187(9):4459-66. doi: 10.4049/jimmunol.0903379. Epub 2011 Sep 26.

31.

TCR-induced activation of Ras proceeds at the plasma membrane and requires palmitoylation of N-Ras.

Rubio I, Grund S, Song SP, Biskup C, Bandemer S, Fricke M, Förster M, Graziani A, Wittig U, Kliche S.

J Immunol. 2010 Sep 15;185(6):3536-43. doi: 10.4049/jimmunol.1000334. Epub 2010 Aug 16.

32.

Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.

Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, Grossmann A, Stelzl U, Schraven B, Krause E, Freund C.

PLoS One. 2010 Jul 22;5(7):e11708. doi: 10.1371/journal.pone.0011708. Erratum in: PLoS One. 2010;5(8). doi. 10.1371/annotation/84d00e99-8566-4e44-b68f-a8d5b46db459.

33.

Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta.

Nishanth G, Sakowicz-Burkiewicz M, Händel U, Kliche S, Wang X, Naumann M, Deckert M, Schlüter D.

Infect Immun. 2010 Aug;78(8):3454-64. doi: 10.1128/IAI.01407-09. Epub 2010 May 24.

34.

Src homology 2-domain containing leukocyte-specific phosphoprotein of 76 kDa is mandatory for TCR-mediated inside-out signaling, but dispensable for CXCR4-mediated LFA-1 activation, adhesion, and migration of T cells.

Horn J, Wang X, Reichardt P, Stradal TE, Warnecke N, Simeoni L, Gunzer M, Yablonski D, Schraven B, Kliche S.

J Immunol. 2009 Nov 1;183(9):5756-67. doi: 10.4049/jimmunol.0900649. Epub 2009 Oct 7.

35.

RETRACTED: Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells.

Bajbouj K, Poehlmann A, Kuester D, Drewes T, Haase K, Hartig R, Teller A, Kliche S, Walluscheck D, Ivanovska J, Chakilam S, Ulitzsch A, Bommhardt U, Leverkus M, Roessner A, Schneider-Stock R.

Am J Pathol. 2009 Aug;175(2):557-70. doi: 10.2353/ajpath.2009.080853. Epub 2009 Jul 23. Retraction in: Am J Pathol. 2017 Jan;187(1):225.

36.

Dynamics of proximal signaling events after TCR/CD8-mediated induction of proliferation or apoptosis in mature CD8+ T cells.

Wang X, Simeoni L, Lindquist JA, Saez-Rodriguez J, Ambach A, Gilles ED, Kliche S, Schraven B.

J Immunol. 2008 May 15;180(10):6703-12.

37.

Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.

Waibler Z, Sender LY, Merten C, Hartig R, Kliche S, Gunzer M, Reichardt P, Kalinke U, Schraven B.

PLoS One. 2008 Mar 5;3(3):e1708. doi: 10.1371/journal.pone.0001708.

38.

A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration.

Posevitz-Fejfár A, Smída M, Kliche S, Hartig R, Schraven B, Lindquist JA.

Eur J Immunol. 2008 Jan;38(1):250-9.

39.

In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76/Gads interaction.

Jordan MS, Maltzman JS, Kliche S, Shabason J, Smith JE, Obstfeld A, Schraven B, Koretzky GA.

Eur J Immunol. 2007 Oct;37(10):2961-72.

40.

Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.

Ménasché G, Kliche S, Bezman N, Schraven B.

Immunol Rev. 2007 Aug;218:82-91. Review.

PMID:
17624945
41.

RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.

Ménasché G, Kliche S, Chen EJ, Stradal TE, Schraven B, Koretzky G.

Mol Cell Biol. 2007 Jun;27(11):4070-81. Epub 2007 Apr 2.

42.

Molecular regulation of cytoskeletal rearrangements during T cell signalling.

Stradal TE, Pusch R, Kliche S.

Results Probl Cell Differ. 2006;43:219-44. Review.

PMID:
17068974
43.

The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.

Kliche S, Breitling D, Togni M, Pusch R, Heuer K, Wang X, Freund C, Kasirer-Friede A, Menasche G, Koretzky GA, Schraven B.

Mol Cell Biol. 2006 Oct;26(19):7130-44.

44.

Lipid-binding hSH3 domains in immune cell adapter proteins.

Heuer K, Sylvester M, Kliche S, Pusch R, Thiemke K, Schraven B, Freund C.

J Mol Biol. 2006 Aug 4;361(1):94-104. Epub 2006 Jun 19.

PMID:
16831444
45.

Normal T-cell development and immune functions in TRIM-deficient mice.

Kölsch U, Arndt B, Reinhold D, Lindquist JA, Jüling N, Kliche S, Pfeffer K, Bruyns E, Schraven B, Simeoni L.

Mol Cell Biol. 2006 May;26(9):3639-48.

46.

Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.

Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A.

Mol Cell Biol. 2005 Sep;25(18):8052-63.

47.

Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells.

von Wichert G, Haeussler U, Greten FR, Kliche S, Dralle H, Böhm BO, Adler G, Seufferlein T.

Oncogene. 2005 Feb 10;24(7):1284-9.

PMID:
15580291
48.

Transmembrane adapters: structure, biochemistry and biology.

Kliche S, Lindquist JA, Schraven B.

Semin Immunol. 2004 Dec;16(6):367-77. Review.

PMID:
15541652
49.

The role of adaptor proteins in lymphocyte activation.

Togni M, Lindquist J, Gerber A, Kölsch U, Hamm-Baarke A, Kliche S, Schraven B.

Mol Immunol. 2004 Jul;41(6-7):615-30. Review.

PMID:
15219999
50.

Adaptors and linkers in T and B cells.

Simeoni L, Kliche S, Lindquist J, Schraven B.

Curr Opin Immunol. 2004 Jun;16(3):304-13. Review.

PMID:
15134779

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