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Items: 1 to 50 of 409

1.

Formation of Microbubbles for Targeted Ultrasound Contrast Imaging: Practical Translation Considerations.

Unnikrishnan S, Du Z, Diakova G, Klibanov AL.

Langmuir. 2018 Dec 3. doi: 10.1021/acs.langmuir.8b03551. [Epub ahead of print]

PMID:
30509068
2.

Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction.

Nagalakshmi VK, Li M, Shah S, Gigliotti JC, Klibanov AL, Epstein FH, Chevalier RL, Gomez RA, Sequeira-Lopez MLS.

Clin Sci (Lond). 2018 Dec 5;132(23):2519-2545. doi: 10.1042/CS20180623. Print 2018 Dec 12.

PMID:
30442812
3.

A flow focusing microfluidic device with an integrated Coulter particle counter for production, counting and size characterization of monodisperse microbubbles.

Rickel JMR, Dixon AJ, Klibanov AL, Hossack JA.

Lab Chip. 2018 Aug 21;18(17):2653-2664. doi: 10.1039/c8lc00496j.

PMID:
30070301
4.

Plectin-targeted liposomes enhance the therapeutic efficacy of a PARP inhibitor in the treatment of ovarian cancer.

Dasa SSK, Diakova G, Suzuki R, Mills AM, Gutknecht MF, Klibanov AL, Slack-Davis JK, Kelly KA.

Theranostics. 2018 Apr 11;8(10):2782-2798. doi: 10.7150/thno.23050. eCollection 2018.

5.

Klf4 has an unexpected protective role in perivascular cells within the microvasculature.

Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK.

Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H402-H414. doi: 10.1152/ajpheart.00084.2018. Epub 2018 Apr 6.

PMID:
29631369
6.

Targeting of microbubbles: contrast agents for ultrasound molecular imaging.

Wang S, Hossack JA, Klibanov AL.

J Drug Target. 2018 Jun - Jul;26(5-6):420-434. doi: 10.1080/1061186X.2017.1419362. Epub 2018 Jan 9.

PMID:
29258335
7.

In Vitro Sonothrombolysis Enhancement by Transiently Stable Microbubbles Produced by a Flow-Focusing Microfluidic Device.

Dixon AJ, Rickel JMR, Shin BD, Klibanov AL, Hossack JA.

Ann Biomed Eng. 2018 Feb;46(2):222-232. doi: 10.1007/s10439-017-1965-7. Epub 2017 Nov 30.

PMID:
29192346
8.

Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis.

Günther F, Heidt T, Kramer M, Khanicheh E, Klibanov AL, Geibel-Zehender A, Ferrante EA, Hilgendorf I, Wolf D, Zirlik A, Reinöhl J, Bode C, Peter K, Kaufmann BA, Mühlen CVZ.

Sci Rep. 2017 Nov 2;7(1):14898. doi: 10.1038/s41598-017-15080-7.

9.

Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice.

Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z.

Free Radic Biol Med. 2017 Dec;113:212-223. doi: 10.1016/j.freeradbiomed.2017.09.029. Epub 2017 Oct 2.

10.

Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs.

Dasa SSK, Suzuki R, Mugler E, Chen L, Jansson-Löfmark R, Michaëlsson E, Lindfors L, Klibanov AL, French BA, Kelly KA.

Nanomedicine. 2017 Nov;13(8):2565-2574. doi: 10.1016/j.nano.2017.07.005. Epub 2017 Jul 25.

11.

Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification.

Kooiman K, van Rooij T, Qin B, Mastik F, Vos HJ, Versluis M, Klibanov AL, de Jong N, Villanueva FS, Chen X.

PLoS One. 2017 Jul 7;12(7):e0180747. doi: 10.1371/journal.pone.0180747. eCollection 2017.

12.

Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model.

Mead BP, Kim N, Miller GW, Hodges D, Mastorakos P, Klibanov AL, Mandell JW, Hirsh J, Suk JS, Hanes J, Price RJ.

Nano Lett. 2017 Jun 14;17(6):3533-3542. doi: 10.1021/acs.nanolett.7b00616. Epub 2017 May 18.

13.

Ultrasound Molecular Imaging of Inflammation in Mouse Abdominal Aorta.

Wang S, Unnikrishnan S, Herbst EB, Klibanov AL, Mauldin FW Jr, Hossack JA.

Invest Radiol. 2017 Sep;52(9):499-506. doi: 10.1097/RLI.0000000000000373.

14.

Bulky Polar Additives That Greatly Reduce the Viscosity of Concentrated Solutions of Therapeutic Monoclonal Antibodies.

Larson AM, Weight AK, Love K, Bonificio A, Wescott CR, Klibanov AM.

J Pharm Sci. 2017 May;106(5):1211-1217. doi: 10.1016/j.xphs.2017.01.018. Epub 2017 Jan 28.

PMID:
28137697
15.

Viscosity-Reducing Bulky-Salt Excipients Prevent Gelation of Protein, but Not Carbohydrate, Solutions.

Kumar A, Klibanov AM.

Appl Biochem Biotechnol. 2017 Aug;182(4):1491-1496. doi: 10.1007/s12010-017-2413-8. Epub 2017 Jan 23.

PMID:
28116573
16.

Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II.

Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH.

J Am Soc Nephrol. 2017 Jun;28(6):1826-1837. doi: 10.1681/ASN.2016060675. Epub 2017 Jan 6.

17.

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation.

Han CZ, Juncadella IJ, Kinchen JM, Buckley MW, Klibanov AL, Dryden K, Onengut-Gumuscu S, Erdbrügger U, Turner SD, Shim YM, Tung KS, Ravichandran KS.

Nature. 2016 Nov 24;539(7630):570-574. doi: 10.1038/nature20141. Epub 2016 Nov 7.

18.

Ultra-Low-Dose Ultrasound Molecular Imaging for the Detection of Angiogenesis in a Mouse Murine Tumor Model: How Little Can We See?

Wang S, Herbst EB, Mauldin FW Jr, Diakova GB, Klibanov AL, Hossack JA.

Invest Radiol. 2016 Dec;51(12):758-766.

19.

Plasma-Treated Microplates with Enhanced Protein Recoveries and Minimized Extractables.

Weikart CM, Klibanov AM, Breeland AP, Taha AH, Maurer BR, Martin SP.

SLAS Technol. 2017 Feb;22(1):98-105. doi: 10.1177/2211068216666258. Epub 2016 Sep 26.

20.

The Use of Acoustic Radiation Force Decorrelation-Weighted Pulse Inversion for Enhanced Ultrasound Contrast Imaging.

Herbst EB, Unnikrishnan S, Wang S, Klibanov AL, Hossack JA, Mauldin FW Jr.

Invest Radiol. 2017 Feb;52(2):95-102. doi: 10.1097/RLI.0000000000000313.

21.

Non-Invasive, Focal Disconnection of Brain Circuitry Using Magnetic Resonance-Guided Low-Intensity Focused Ultrasound to Deliver a Neurotoxin.

Zhang Y, Tan H, Bertram EH, Aubry JF, Lopes MB, Roy J, Dumont E, Xie M, Zuo Z, Klibanov AL, Lee KS, Wintermark M.

Ultrasound Med Biol. 2016 Sep;42(9):2261-9. doi: 10.1016/j.ultrasmedbio.2016.04.019. Epub 2016 May 31.

PMID:
27260243
22.

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation.

Rocha SM, Saraiva T, Cristóvão AC, Ferreira R, Santos T, Esteves M, Saraiva C, Je G, Cortes L, Valero J, Alves G, Klibanov A, Kim YS, Bernardino L.

J Neuroinflammation. 2016 Jun 4;13(1):137. doi: 10.1186/s12974-016-0600-0.

23.

Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke.

Fernández-López D, Faustino J, Klibanov AL, Derugin N, Blanchard E, Simon F, Leib SL, Vexler ZS.

J Neurosci. 2016 Mar 9;36(10):2881-93. doi: 10.1523/JNEUROSCI.0140-15.2016.

24.

Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound.

Mead BP, Mastorakos P, Suk JS, Klibanov AL, Hanes J, Price RJ.

J Control Release. 2016 Feb 10;223:109-117. doi: 10.1016/j.jconrel.2015.12.034. Epub 2015 Dec 28.

25.

Synthesis and Testing of Modular Dual-Modality Nanoparticles for Magnetic Resonance and Multispectral Photoacoustic Imaging.

Bogdanov AA Jr, Dixon AJ, Gupta S, Zhang L, Zheng S, Shazeeb MS, Zhang S, Klibanov AL.

Bioconjug Chem. 2016 Feb 17;27(2):383-90. doi: 10.1021/acs.bioconjchem.5b00633. Epub 2015 Dec 10.

26.

Regulation of L-selectin-dependent hydrodynamic shear thresholding by leukocyte deformability and shear dependent bond number.

Paschall CD, Klibanov AL, Lawrence MB.

Biorheology. 2015;52(5-6):415-32. doi: 10.3233/BIR-15064.

PMID:
26600268
27.

Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles.

Suzuki R, Klibanov AL.

Adv Exp Med Biol. 2016;880:205-20. doi: 10.1007/978-3-319-22536-4_12. Review.

PMID:
26486340
28.

Microbubble-mediated intravascular ultrasound imaging and drug delivery.

Dixon AJ, Kilroy JP, Dhanaliwala AH, Chen JL, Phillips LC, Ragosta M, Klibanov AL, Wamhoff BR, Hossack JA.

IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Sep;62(9):1674-85. doi: 10.1109/TUFFC.2015.007143.

PMID:
26415129
29.

Markedly lowering the viscosity of aqueous solutions of DNA by additives.

Elkin I, Weight AK, Klibanov AM.

Int J Pharm. 2015 Oct 15;494(1):66-72. doi: 10.1016/j.ijpharm.2015.08.019. Epub 2015 Aug 7.

PMID:
26260229
30.

Low-Transition-Temperature Mixtures (LTTMs) for Dissolving Proteins and for Drug Formulation.

Su E, Klibanov AM.

Appl Biochem Biotechnol. 2015 Oct;177(3):753-8. doi: 10.1007/s12010-015-1777-x. Epub 2015 Aug 4.

PMID:
26239446
31.

Ultrasound in Radiology: From Anatomic, Functional, Molecular Imaging to Drug Delivery and Image-Guided Therapy.

Klibanov AL, Hossack JA.

Invest Radiol. 2015 Sep;50(9):657-70. doi: 10.1097/RLI.0000000000000188. Review.

32.

Size Exclusion HPLC Detection of Small-Size Impurities as a Complementary Means for Quality Analysis of Extracellular Vesicles.

Huang T, Banizs AB, Shi W, Klibanov AL, He J.

J Circ Biomark. 2015 Jul 10;4:6. doi: 10.5772/61148. eCollection 2015 Jan-Dec.

33.

Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.

Wang S, Wang CY, Unnikrishnan S, Klibanov AL, Hossack JA, Mauldin FW Jr.

Invest Radiol. 2015 Nov;50(11):772-84. doi: 10.1097/RLI.0000000000000185.

34.

Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction.

Dasa SSK, Suzuki R, Gutknecht M, Brinton LT, Tian Y, Michaelsson E, Lindfors L, Klibanov AL, French BA, Kelly KA.

J Control Release. 2015 Dec 28;220(Pt A):556-567. doi: 10.1016/j.jconrel.2015.06.017. Epub 2015 Jun 27.

35.

Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic.

Sarkar S, Quinn BA, Shen XN, Dash R, Das SK, Emdad L, Klibanov AL, Wang XY, Pellecchia M, Sarkar D, Fisher PB.

Oncotarget. 2015 May 10;6(13):10712-27.

36.

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.

Cronk JC, Derecki NC, Ji E, Xu Y, Lampano AE, Smirnov I, Baker W, Norris GT, Marin I, Coddington N, Wolf Y, Turner SD, Aderem A, Klibanov AL, Harris TH, Jung S, Litvak V, Kipnis J.

Immunity. 2015 Apr 21;42(4):679-91. doi: 10.1016/j.immuni.2015.03.013.

37.

Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles.

Kilroy JP, Dhanaliwala AH, Klibanov AL, Bowles DK, Wamhoff BR, Hossack JA.

Ann Biomed Eng. 2015 Nov;43(11):2642-51. doi: 10.1007/s10439-015-1315-6. Epub 2015 Apr 17.

38.

Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles.

Dixon AJ, Hu S, Klibanov AL, Hossack JA.

Small. 2015 Jul 1;11(25):3066-77. doi: 10.1002/smll.201403398. Epub 2015 Feb 20.

39.

In vivo imaging of microfluidic-produced microbubbles.

Dhanaliwala AH, Dixon AJ, Lin D, Chen JL, Klibanov AL, Hossack JA.

Biomed Microdevices. 2015 Feb;17(1):23. doi: 10.1007/s10544-014-9914-9.

PMID:
25663444
40.

Why do some immobilized N-alkylated polyethylenimines far surpass others in inactivating influenza viruses?

Liu H, Elkin I, Chen J, Klibanov AM.

Biomacromolecules. 2015 Jan 12;16(1):351-6. doi: 10.1021/bm5015427. Epub 2014 Dec 22.

PMID:
25486335
41.

The local effects of ovarian diathermy in an ovine model of polycystic ovary syndrome.

Connolly F, Rae MT, Butler M, Klibanov AL, Sboros V, McNeilly AS, Duncan WC.

PLoS One. 2014 Oct 24;9(10):e111280. doi: 10.1371/journal.pone.0111280. eCollection 2014.

42.

Inactivation of bacteria by electric current in the presence of carbon nanotubes embedded within a polymeric membrane.

Zhu A, Liu HK, Long F, Su E, Klibanov AM.

Appl Biochem Biotechnol. 2015 Jan;175(2):666-76. doi: 10.1007/s12010-014-1318-z. Epub 2014 Oct 24.

PMID:
25342266
43.

Ultrasound-based measurement of molecular marker concentration in large blood vessels: a feasibility study.

Wang S, Mauldin FW Jr, Klibanov AL, Hossack JA.

Ultrasound Med Biol. 2015 Jan;41(1):222-34. doi: 10.1016/j.ultrasmedbio.2014.07.001. Epub 2014 Oct 11.

44.

Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.

Kilroy JP, Klibanov AL, Wamhoff BR, Bowles DK, Hossack JA.

Ultrasound Med Biol. 2014 Oct;40(10):2458-67. doi: 10.1016/j.ultrasmedbio.2014.04.007. Epub 2014 Aug 15.

45.

Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy.

Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K.

J Control Release. 2014 Oct 28;192:243-8. doi: 10.1016/j.jconrel.2014.07.051. Epub 2014 Aug 6.

PMID:
25107692
46.

Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound.

Nance E, Timbie K, Miller GW, Song J, Louttit C, Klibanov AL, Shih TY, Swaminathan G, Tamargo RJ, Woodworth GF, Hanes J, Price RJ.

J Control Release. 2014 Sep 10;189:123-132. doi: 10.1016/j.jconrel.2014.06.031. Epub 2014 Jun 28.

47.

Imaging flow cytometry elucidates limitations of microparticle analysis by conventional flow cytometry.

Erdbrügger U, Rudy CK, Etter ME, Dryden KA, Yeager M, Klibanov AL, Lannigan J.

Cytometry A. 2014 Sep;85(9):756-70. doi: 10.1002/cyto.a.22494. Epub 2014 Jun 5.

48.

Nucleic acid delivery with microbubbles and ultrasound.

Rychak JJ, Klibanov AL.

Adv Drug Deliv Rev. 2014 Jun;72:82-93. doi: 10.1016/j.addr.2014.01.009. Epub 2014 Jan 31. Review.

49.

Binding dynamics of targeted microbubbles in response to modulated acoustic radiation force.

Wang S, Hossack JA, Klibanov AL, Mauldin FW Jr.

Phys Med Biol. 2014 Jan 20;59(2):465-84. doi: 10.1088/0031-9155/59/2/465. Epub 2013 Dec 30.

50.

Synthesis and characterization of transiently stable albumin-coated microbubbles via a flow-focusing microfluidic device.

Chen JL, Dhanaliwala AH, Dixon AJ, Klibanov AL, Hossack JA.

Ultrasound Med Biol. 2014 Feb;40(2):400-9. doi: 10.1016/j.ultrasmedbio.2013.09.024. Epub 2013 Dec 15.

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