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Micro-structural bone changes are associated with broad-spectrum autoimmunity and predict the onset of rheumatoid arthritis.

Simon D, Kleyer A, Bui CD, Hueber A, Bang H, Ramming A, Rech J, Schett G.

Arthritis Rheumatol. 2020 Feb 18. doi: 10.1002/art.41229. [Epub ahead of print]


JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function.

Adam S, Simon N, Steffen U, Andes FT, Scholtysek C, Müller DIH, Weidner D, Andreev D, Kleyer A, Culemann S, Hahn M, Schett G, Krönke G, Frey S, Hueber AJ.

Sci Transl Med. 2020 Feb 12;12(530). pii: eaay4447. doi: 10.1126/scitranslmed.aay4447.


Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis.

Simon D, Haschka J, Muschitz C, Kocijan A, Baierl A, Kleyer A, Schett G, Kapiotis S, Resch H, Sticherling M, Rech J, Kocijan R.

Osteoporos Int. 2020 Jan 10. doi: 10.1007/s00198-019-05160-x. [Epub ahead of print]


IgA subclasses have different effector functions associated with distinct glycosylation profiles.

Steffen U, Koeleman CA, Sokolova MV, Bang H, Kleyer A, Rech J, Unterweger H, Schicht M, Garreis F, Hahn J, Andes FT, Hartmann F, Hahn M, Mahajan A, Paulsen F, Hoffmann M, Lochnit G, Muñoz LE, Wuhrer M, Falck D, Herrmann M, Schett G.

Nat Commun. 2020 Jan 8;11(1):120. doi: 10.1038/s41467-019-13992-8.


[Imaging of psoriatic arthritis and aspects of radiographic progression].

Baraliakos X, Kleyer A, Simon D, Köhm M, Ohrndorf S, Sewerin P.

Z Rheumatol. 2020 Feb;79(1):40-52. doi: 10.1007/s00393-019-00735-9. Review. German.


[Chondrocalcinosis: idiopathic or manifestation of rare metabolic diseases?]

Knitza J, Kleyer A, Schett G, Manger B.

Orthopade. 2019 Nov;48(11):949-956. doi: 10.1007/s00132-019-03805-7. Review. German.


[Specialist training quo vadis?]

Krusche M, Sewerin P, Kleyer A, Mucke J, Vossen D, Morf H; Rheumadocs und Arbeitskreis Junge Rheumatologie (AGJR).

Z Rheumatol. 2019 Oct;78(8):692-697. doi: 10.1007/s00393-019-00690-5. Review. German.


T2 Mapping as a New Method for Quantitative Assessment of Cartilage Damage in Rheumatoid Arthritis.

Renner N, Kleyer A, Krönke G, Simon D, Söllner S, Rech J, Uder M, Janka R, Schett G, Welsch GH, Pachowsky ML.

J Rheumatol. 2019 Aug 15. pii: jrheum.180728. doi: 10.3899/jrheum.180728. [Epub ahead of print]


Locally renewing resident synovial macrophages provide a protective barrier for the joint.

Culemann S, Grüneboom A, Nicolás-Ávila JÁ, Weidner D, Lämmle KF, Rothe T, Quintana JA, Kirchner P, Krljanac B, Eberhardt M, Ferrazzi F, Kretzschmar E, Schicht M, Fischer K, Gelse K, Faas M, Pfeifle R, Ackermann JA, Pachowsky M, Renner N, Simon D, Haseloff RF, Ekici AB, Bäuerle T, Blasig IE, Vera J, Voehringer D, Kleyer A, Paulsen F, Schett G, Hidalgo A, Krönke G.

Nature. 2019 Aug;572(7771):670-675. doi: 10.1038/s41586-019-1471-1. Epub 2019 Aug 7.


German Mobile Apps in Rheumatology: Review and Analysis Using the Mobile Application Rating Scale (MARS).

Knitza J, Tascilar K, Messner EM, Meyer M, Vossen D, Pulla A, Bosch P, Kittler J, Kleyer A, Sewerin P, Mucke J, Haase I, Simon D, Krusche M.

JMIR Mhealth Uhealth. 2019 Aug 5;7(8):e14991. doi: 10.2196/14991.


Effects of Conventional Uric Acid-Lowering Therapy on Monosodium Urate Crystal Deposits.

Ellmann H, Bayat S, Araujo E, Manger B, Kleyer A, Cavallaro A, Lell M, Schenker H, Simon D, Tascilar K, Baraf HSB, Schett G, Rech J.

Arthritis Rheumatol. 2020 Jan;72(1):150-156. doi: 10.1002/art.41063. Epub 2019 Dec 10.


Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation-data from the prospective IVEPSA study.

Kampylafka E, Simon D, d'Oliveira I, Linz C, Lerchen V, Englbrecht M, Rech J, Kleyer A, Sticherling M, Schett G, Hueber AJ.

Arthritis Res Ther. 2019 Jul 26;21(1):178. doi: 10.1186/s13075-019-1957-0.


Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients.

Simon D, Kleyer A, Bayat S, Tascilar K, Kampylafka E, Meinderink T, Schuster L, Petrov R, Liphardt AM, Rech J, Schett G, Hueber AJ.

Arthritis Res Ther. 2019 Jul 3;21(1):162. doi: 10.1186/s13075-019-1938-3.


Calcium pyrophosphate deposition disease induced inflammatory back pain.

Kleyer A, Knitza J, Schett G, Manger B.

Rheumatology (Oxford). 2020 Feb 1;59(2):456. doi: 10.1093/rheumatology/kez225. No abstract available.


Development of Joint Erosions in the Preclinical Phase of Rheumatoid Arthritis Depicted by Cinematic Rendering.

Simon D, Schett G, Kleyer A.

Arthritis Rheumatol. 2019 Sep;71(9):1592. doi: 10.1002/art.41001. Epub 2019 Jul 22. No abstract available.


The ageing joint-standard age- and sex-related values of bone erosions and osteophytes in the hand joints of healthy individuals.

Berlin A, Simon D, Tascilar K, Figueiredo C, Bayat S, Finzel S, Klaus E, Rech J, Hueber AJ, Kleyer A, Schett G.

Osteoarthritis Cartilage. 2019 Jul;27(7):1043-1047. doi: 10.1016/j.joca.2019.01.019. Epub 2019 Mar 16.


["Virtual rheumatology" : A new teaching concept for rheumatology of the future?]

Kleyer A, Simon D, Hartmann F, Schuster L, Hueber AJ.

Z Rheumatol. 2019 Mar;78(2):112-115. doi: 10.1007/s00393-019-0594-y. German. No abstract available.


Modular Lattice Constructs for Biological Joint Resurfacing.

Gelse K, Biggemann J, Stumpf M, Halmheu M, Grüneboom A, Kleyer A, Scholtysek C, Pachowsky ML, Hueber A, Krönke G, Fey T.

Tissue Eng Part A. 2019 Jul;25(13-14):1053-1062. doi: 10.1089/ten.TEA.2018.0231. Epub 2019 Mar 18.


[Use of medical apps and online platforms among German rheumatologists : Results of the 2016 and 2018 DGRh conference surveys and research conducted by rheumadocs].

Knitza J, Vossen D, Geffken I, Krusche M, Meyer M, Sewerin P, Kleyer A, Hueber AJ; Arbeitskreis Junge Rheumatologen.

Z Rheumatol. 2019 Nov;78(9):839-846. doi: 10.1007/s00393-018-0578-3. German.


Cost-effective Tapering Algorithm in Patients with Rheumatoid Arthritis: Combination of Multibiomarker Disease Activity Score and Autoantibody Status.

Hagen M, Englbrecht M, Haschka J, Reiser M, Kleyer A, Hueber A, Manger B, Figueiredo C, Cobra JF, Tony HP, Finzel S, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Lorenz HM, Nüsslein H, Alten R, Henes J, Krüger K, Schett G, Rech J.

J Rheumatol. 2019 May;46(5):460-466. doi: 10.3899/jrheum.180028. Epub 2018 Dec 1.


Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration.

Simon D, Kleyer A, Faustini F, Englbrecht M, Haschka J, Berlin A, Kraus S, Hueber AJ, Kocijan R, Sticherling M, Rech J, Schett G.

Arthritis Res Ther. 2018 Aug 31;20(1):203. doi: 10.1186/s13075-018-1691-z.


Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis.

Neumann A, Haschka J, Kleyer A, Schuster L, Englbrecht M, Berlin A, Figueiredo CP, Simon D, Muschitz C, Kocijan R, Resch H, Rech J, Schett G.

Arthritis Res Ther. 2018 Aug 30;20(1):202. doi: 10.1186/s13075-018-1620-1.


Resolution of synovitis and arrest of catabolic and anabolic bone changes in patients with psoriatic arthritis by IL-17A blockade with secukinumab: results from the prospective PSARTROS study.

Kampylafka E, d'Oliveira I, Linz C, Lerchen V, Stemmler F, Simon D, Englbrecht M, Sticherling M, Rech J, Kleyer A, Schett G, Hueber AJ.

Arthritis Res Ther. 2018 Jul 27;20(1):153. doi: 10.1186/s13075-018-1653-5.


A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin.

Simon D, Kleyer A, Englbrecht M, Stemmler F, Simon C, Berlin A, Kocijan R, Haschka J, Hirschmann S, Atreya R, Neurath MF, Sticherling M, Rech J, Hueber AJ, Engelke K, Schett G.

Bone. 2018 Nov;116:87-93. doi: 10.1016/j.bone.2018.07.017. Epub 2018 Jul 23.


Effects of ustekinumab versus tumor necrosis factor inhibition on enthesitis: Results from the enthesial clearance in psoriatic arthritis (ECLIPSA) study.

Araujo EG, Englbrecht M, Hoepken S, Finzel S, Kampylafka E, Kleyer A, Bayat S, Schoenau V, Hueber A, Rech J, Schett G.

Semin Arthritis Rheum. 2019 Feb;48(4):632-637. doi: 10.1016/j.semarthrit.2018.05.011. Epub 2018 Jun 13.


Quantitative T2 Mapping Shows Increased Degeneration in Adjacent Intervertebral Discs Following Kyphoplasty.

Pachowsky ML, Kleyer A, Wagner L, Langenbach A, Simon D, Janka R, May M, Welsch GH.

Cartilage. 2018 Mar 1:1947603518758434. doi: 10.1177/1947603518758434. [Epub ahead of print]


Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures.

Stemmler F, Simon D, Liphardt AM, Englbrecht M, Rech J, Hueber AJ, Engelke K, Schett G, Kleyer A.

Ann Rheum Dis. 2018 Jul;77(7):973-980. doi: 10.1136/annrheumdis-2017-212404. Epub 2018 Feb 23.


[Big data in imaging].

Sewerin P, Ostendorf B, Hueber AJ, Kleyer A.

Z Rheumatol. 2018 Apr;77(3):203-208. doi: 10.1007/s00393-018-0422-9. Review. German.


Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis.

Soare A, Weber S, Maul L, Rauber S, Gheorghiu AM, Luber M, Houssni I, Kleyer A, von Pickardt G, Gado M, Simon D, Rech J, Schett G, Distler JHW, Ramming A.

J Immunol. 2018 Feb 15;200(4):1249-1254. doi: 10.4049/jimmunol.1700596. Epub 2018 Jan 12.


Methods for segmentation of rheumatoid arthritis bone erosions in high-resolution peripheral quantitative computed tomography (HR-pQCT).

Figueiredo CP, Kleyer A, Simon D, Stemmler F, d'Oliveira I, Weissenfels A, Museyko O, Friedberger A, Hueber AJ, Haschka J, Englbrecht M, Pereira RMR, Rech J, Schett G, Engelke K.

Semin Arthritis Rheum. 2018 Apr;47(5):611-618. doi: 10.1016/j.semarthrit.2017.09.011. Epub 2017 Sep 23.


Hard palate hyperpigmentation-a rare side effect of antimalarials.

Manger K, von Streitberg U, Seitz G, Kleyer A, Manger B.

Arthritis Rheumatol. 2018 Jan;70(1):152. doi: 10.1002/art.40327. Epub 2017 Nov 28. No abstract available.


Reply to: Osteoporosis: An Independent Determinant of Bone Erosions in Rheumatoid Arthritis?

Simon D, Simon C, Kleyer A, Schett G.

J Bone Miner Res. 2017 Oct;32(10):2144. doi: 10.1002/jbmr.3208. Epub 2017 Sep 20. No abstract available.


Early Changes of the Cortical Micro-Channel System in the Bare Area of the Joints of Patients With Rheumatoid Arthritis.

Werner D, Simon D, Englbrecht M, Stemmler F, Simon C, Berlin A, Haschka J, Renner N, Buder T, Engelke K, Hueber AJ, Rech J, Schett G, Kleyer A.

Arthritis Rheumatol. 2017 Aug;69(8):1580-1587. doi: 10.1002/art.40148. Epub 2017 Jun 26.


Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage.

Kleyer A, Beyer L, Simon C, Stemmler F, Englbrecht M, Beyer C, Rech J, Manger B, Krönke G, Schett G, Hueber AJ.

Arthritis Res Ther. 2017 Feb 10;19(1):34. doi: 10.1186/s13075-017-1234-z.


Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.

Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G.

Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7.


Age- and Sex-Dependent Changes of Intra-articular Cortical and Trabecular Bone Structure and the Effects of Rheumatoid Arthritis.

Simon D, Kleyer A, Stemmler F, Simon C, Berlin A, Hueber AJ, Haschka J, Renner N, Figueiredo C, Neuhuber W, Buder T, Englbrecht M, Rech J, Engelke K, Schett G.

J Bone Miner Res. 2017 Apr;32(4):722-730. doi: 10.1002/jbmr.3025. Epub 2016 Nov 18.


High prevalence of tenosynovial inflammation before onset of rheumatoid arthritis and its link to progression to RA-A combined MRI/CT study.

Kleyer A, Krieter M, Oliveira I, Faustini F, Simon D, Kaemmerer N, Cavalcante A, Tabosa T, Rech J, Hueber A, Schett G.

Semin Arthritis Rheum. 2016 Oct;46(2):143-150. doi: 10.1016/j.semarthrit.2016.05.002. Epub 2016 May 18.


Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs.

Figueiredo CP, Bang H, Cobra JF, Englbrecht M, Hueber AJ, Haschka J, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nuesslein H, Alten R, Henes J, Krueger K, Rech J, Schett G.

Ann Rheum Dis. 2017 Feb;76(2):399-407. doi: 10.1136/annrheumdis-2016-209297. Epub 2016 Jun 20.


Th2 and eosinophil responses suppress inflammatory arthritis.

Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G, Bozec A.

Nat Commun. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596.


Quantification and Impact of Secondary Osteoarthritis in Patients With Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis.

Figueiredo CP, Simon D, Englbrecht M, Haschka J, Kleyer A, Bayat S, Hueber A, Pereira RM, Rech J, Schett G.

Arthritis Rheumatol. 2016 Sep;68(9):2114-21. doi: 10.1002/art.39698.


Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis.

Faustini F, Simon D, Oliveira I, Kleyer A, Haschka J, Englbrecht M, Cavalcante AR, Kraus S, Tabosa TP, Figueiredo C, Hueber AJ, Kocijan R, Cavallaro A, Schett G, Sticherling M, Rech J.

Ann Rheum Dis. 2016 Dec;75(12):2068-2074. doi: 10.1136/annrheumdis-2015-208821. Epub 2016 Feb 25.


High-resolution Quantitative Computed Tomography Demonstrates Structural Defects in Cortical and Trabecular Bone in IBD Patients.

Haschka J, Hirschmann S, Kleyer A, Englbrecht M, Faustini F, Simon D, Figueiredo CP, Schuster L, Muschitz C, Kocijan R, Resch H, Atreya R, Rech J, Neurath MF, Schett G.

J Crohns Colitis. 2016 May;10(5):532-40. doi: 10.1093/ecco-jcc/jjw012. Epub 2016 Jan 27.


Tophus resolution with pegloticase: a prospective dual-energy CT study.

Araujo EG, Bayat S, Petsch C, Englbrecht M, Faustini F, Kleyer A, Hueber AJ, Cavallaro A, Lell M, Dalbeth N, Manger B, Schett G, Rech J.

RMD Open. 2015 Jun 17;1(1):e000075. doi: 10.1136/rmdopen-2015-000075. eCollection 2015.


Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment.

Rech J, Hueber AJ, Finzel S, Englbrecht M, Haschka J, Manger B, Kleyer A, Reiser M, Cobra JF, Figueiredo C, Tony HP, Kleinert S, Wendler J, Schuch F, Ronneberger M, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Lorenz HM, Nuesslein H, Alten R, Henes J, Krueger K, Schett G.

Ann Rheum Dis. 2016 Sep;75(9):1637-44. doi: 10.1136/annrheumdis-2015-207900. Epub 2015 Oct 19.


Does subclinical inflammation contribute to impairment of function of knee joints in aged individuals? High prevalence of ultrasound inflammatory findings.

D'Agostino MA, Iagnocco A, Aegerter P, Kleyer A, Zwerina J, Perricone C, Lorenzini R, Aschenbrenner F, Willeit J, Kiechl S, Schett G.

Rheumatology (Oxford). 2015 Sep;54(9):1622-9. doi: 10.1093/rheumatology/kev032. Epub 2015 Apr 13.


A comparative analysis of magnetic resonance imaging and high-resolution peripheral quantitative computed tomography of the hand for the detection of erosion repair in rheumatoid arthritis.

Regensburger A, Rech J, Englbrecht M, Finzel S, Kraus S, Hecht K, Kleyer A, Haschka J, Hueber AJ, Cavallaro A, Schett G, Faustini F.

Rheumatology (Oxford). 2015 Sep;54(9):1573-81. doi: 10.1093/rheumatology/kev031. Epub 2015 Mar 31.


Quantitative and Qualitative Changes of Bone in Psoriasis and Psoriatic Arthritis Patients.

Kocijan R, Englbrecht M, Haschka J, Simon D, Kleyer A, Finzel S, Kraus S, Resch H, Muschitz C, Engelke K, Sticherling M, Rech J, Schett G.

J Bone Miner Res. 2015 Oct;30(10):1775-83. doi: 10.1002/jbmr.2521. Epub 2015 May 10.


Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study.

Haschka J, Englbrecht M, Hueber AJ, Manger B, Kleyer A, Reiser M, Finzel S, Tony HP, Kleinert S, Feuchtenberger M, Fleck M, Manger K, Ochs W, Schmitt-Haendle M, Wendler J, Schuch F, Ronneberger M, Lorenz HM, Nuesslein H, Alten R, Demary W, Henes J, Schett G, Rech J.

Ann Rheum Dis. 2016 Jan;75(1):45-51. doi: 10.1136/annrheumdis-2014-206439. Epub 2015 Feb 6.


Analysis of periarticular bone changes in patients with cutaneous psoriasis without associated psoriatic arthritis.

Simon D, Faustini F, Kleyer A, Haschka J, Englbrecht M, Kraus S, Hueber AJ, Kocijan R, Sticherling M, Schett G, Rech J.

Ann Rheum Dis. 2016 Apr;75(4):660-6. doi: 10.1136/annrheumdis-2014-206347. Epub 2015 Feb 4.


The efficacy of mineralized allograft cortical and cancellous chips in maxillary sinus augmentations.

Nevins M, Parma-Benfenati S, Janke UW, Kleyer A, Rasperini G, Tinti C, Schupbach P, Kim DM.

Int J Periodontics Restorative Dent. 2014 Nov-Dec;34(6):789-93. doi: 10.11607/prd.1720.


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