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Items: 25

1.

Rapid Quaternary subsidence in the northwestern German North Sea.

Arfai J, Franke D, Lutz R, Reinhardt L, Kley J, Gaedicke C.

Sci Rep. 2018 Aug 1;8(1):11524. doi: 10.1038/s41598-018-29638-6.

2.

Structural basis for the disaggregase activity and regulation of Hsp104.

Heuck A, Schitter-Sollner S, Suskiewicz MJ, Kurzbauer R, Kley J, Schleiffer A, Rombaut P, Herzog F, Clausen T.

Elife. 2016 Nov 30;5. pii: e21516. doi: 10.7554/eLife.21516.

3.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.

Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6.

PMID:
26112443
4.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.

Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29.

PMID:
26105194
5.

Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.

Roth GJ, Heckel A, Kley JT, Lehmann T, Müller SG, Oost T, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Schindler M, Thomas L, Stenkamp D.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3270-4. doi: 10.1016/j.bmcl.2015.05.074. Epub 2015 May 30.

PMID:
26077492
6.

Cardiomyocyte specific peroxisome proliferator-activated receptor-α overexpression leads to irreversible damage in ischemic murine heart.

Duerr GD, Heinemann JC, Arnoldi V, Feisst A, Kley J, Ghanem A, Welz A, Dewald O.

Life Sci. 2014 May 2;102(2):88-97. doi: 10.1016/j.lfs.2014.03.019. Epub 2014 Mar 21.

PMID:
24657893
7.

Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.

Kley JT, Mack J, Hamilton B, Scheuerer S, Redemann N.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7. doi: 10.1016/j.bmcl.2011.07.083. Epub 2011 Aug 9.

PMID:
21873051
8.

Structural adaptation of the plant protease Deg1 to repair photosystem II during light exposure.

Kley J, Schmidt B, Boyanov B, Stolt-Bergner PC, Kirk R, Ehrmann M, Knopf RR, Naveh L, Adam Z, Clausen T.

Nat Struct Mol Biol. 2011 Jun;18(6):728-31. doi: 10.1038/nsmb.2055. Epub 2011 May 1.

PMID:
21532594
9.

Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI).

Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P, Mennerich D, Schnapp A, Park JE.

J Med Chem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a.

PMID:
20919678
10.

Isolating intact chloroplasts from small Arabidopsis samples for proteomic studies.

Kley J, Heil M, Muck A, Svatos A, Boland W.

Anal Biochem. 2010 Mar 15;398(2):198-202. doi: 10.1016/j.ab.2009.11.016. Epub 2009 Nov 14.

PMID:
19917261
11.

Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120).

Roth GJ, Heckel A, Colbatzky F, Handschuh S, Kley J, Lehmann-Lintz T, Lotz R, Tontsch-Grunt U, Walter R, Hilberg F.

J Med Chem. 2009 Jul 23;52(14):4466-80. doi: 10.1021/jm900431g.

PMID:
19522465
12.

Cytotoxic efficacy and influence on cellular phospholipid metabolism of 2-hydroxy- and 2-O-acetyl-octadecylphosphocholines.

Hildenbrand B, Kley JT, Haberstroh F, Freudenberg MA, Azemar M, Unger C, Massing U.

Anticancer Res. 2006 Nov-Dec;26(6B):4255-62.

13.

[Ultrasound diagnosis of ruptured abdominal aortic aneurysm in renal colic].

Bohrer T, Kley J, Stopinski J.

Urologe A. 2005 Feb;44(2):166-8. German.

PMID:
15614438
14.

Characterization and comparative evaluation of a novel PAI-1 inhibitor.

Gils A, Stassen JM, Nar H, Kley JT, Wienen W, Ries UJ, Declerck PJ.

Thromb Haemost. 2002 Jul;88(1):137-43.

PMID:
12152654
15.

Paraneoplastic pemphigus as the initial presentation of chronic lymphocytic leukemia.

van Mook WNK, Fickers MM, Theunissen PH, van der Kley JA, Duijvestijn JA, Pas HH, Flikweert DC.

Ann Oncol. 2001 Jan;12(1):115-8.

PMID:
11249037
16.

Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro.

Benzinger P, Martiny-Baron G, Reusch P, Siemeister G, Kley JT, Marmé D, Unger C, Massing U.

Biochim Biophys Acta. 2000 Jun 1;1466(1-2):71-8.

17.

A simple approach to DOTAP and its analogs bearing different fatty acids.

Massing U, Kley JT, Gürtesch L, Fankhaenel S.

Chem Phys Lipids. 2000 Apr;105(2):189-91.

PMID:
10823466
18.

A case of herpes-like Sweet's syndrome in acute myelogenous leukemia during treatment with G-CSF.

van Mook WN, Fickers MM, van der Kley JA, Theunissen PH.

Neth J Med. 1999 Nov;55(5):235-41.

PMID:
10593134
19.

Synthesis and PLA2-inhibitory properties of 2(R)-acetamido-alkylphosphomethanols with a variable aggregate anchor.

Kley JT, von Kiedrowski G, Unger C, Massing U.

Bioorg Med Chem Lett. 1999 Jan 18;9(2):261-4.

PMID:
10021941
20.

Inhibition of 14-kDa PLA2 by 2-acylamino-alkylphospholipids: the influence of amide acidity.

Kley JT, Unger C, Massing U.

Biochim Biophys Acta. 1998 Jun 15;1392(2-3):193-201.

PMID:
9630626
21.

Expression of cytoplasmic retinoic acid-binding proteins and nuclear receptors in squamous-cell carcinomas in vitro.

Kley J, Hoffmann W, Bamberg M, Rodemann HP.

Int J Cancer. 1997 Feb 7;70(4):478-80. No abstract available.

22.

The syndrome of autosomal recessive pontocerebellar hypoplasia, microcephaly, and extrapyramidal dyskinesia (pontocerebellar hypoplasia type 2): compiled data from 10 pedigrees.

Barth PG, Blennow G, Lenard HG, Begeer JH, van der Kley JM, Hanefeld F, Peters AC, Valk J.

Neurology. 1995 Feb;45(2):311-7.

PMID:
7854532
23.

Testosterone treatment of men with idiopathic hemochromatosis.

Kley HK, Stremmel W, Kley JB, Schlaghecke R.

Clin Investig. 1992 Jul;70(7):566-72.

PMID:
1392425
24.

Frequency of allergic reactions to methyldibromoglutaronitrile (1,2-dibromo-2,4-dicyanobutane) in The Netherlands.

de Groot AC, Bruynzeel DP, Coenraads PJ, Crijns MB, van Ginkel CJ, van Joost T, van der Kley JJ, Meinardi MM, Smeenk G, Weyland JW.

Contact Dermatitis. 1991 Oct;25(4):270-1. No abstract available.

PMID:
1799994
25.

Geschiedenis der geneeskunde; het post of propter van goed gevolg in de strijd tegen de pokken.

KLEY JJ.

Geneeskd Gids. 1948 May 6;26(10):209-13. Undetermined Language. No abstract available.

PMID:
18864325

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