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Items: 13

1.

Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.

Liu Z, Zhang C, Lee S, Kim W, Klevstig M, Harzandi AM, Sikanic N, Arif M, Ståhlman M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.

Metab Eng. 2019 Mar;52:263-272. doi: 10.1016/j.ymben.2019.01.001. Epub 2019 Jan 4.

PMID:
30615941
2.

Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.

Benfeitas R, Bidkhori G, Mukhopadhyay B, Klevstig M, Arif M, Zhang C, Lee S, Cinar R, Nielsen J, Uhlen M, Boren J, Kunos G, Mardinoglu A.

EBioMedicine. 2018 Dec 31. pii: S2352-3964(18)30635-2. doi: 10.1016/j.ebiom.2018.12.057. [Epub ahead of print]

3.

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.

Bidkhori G, Benfeitas R, Klevstig M, Zhang C, Nielsen J, Uhlen M, Boren J, Mardinoglu A.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11874-E11883. doi: 10.1073/pnas.1807305115. Epub 2018 Nov 27.

PMID:
30482855
4.

Network analyses identify liver-specific targets for treating liver diseases.

Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.

Mol Syst Biol. 2017 Aug 21;13(8):938. doi: 10.15252/msb.20177703.

5.

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.

Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC.

Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12.

PMID:
28811250
6.

Antioxidant tempol suppresses heart cytosolic phospholipase A2α stimulated by chronic intermittent hypoxia.

Míčová P, Klevstig M, Holzerová K, Vecka M, Žurmanová J, Neckář J, Kolář F, Nováková O, Novotný J, Hlaváčková M.

Can J Physiol Pharmacol. 2017 Aug;95(8):920-927. doi: 10.1139/cjpp-2017-0022. Epub 2017 Apr 30.

PMID:
28459156
7.

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.

Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.

8.

Perilipin 5 is protective in the ischemic heart.

Drevinge C, Dalen KT, Mannila MN, Täng MS, Ståhlman M, Klevstig M, Lundqvist A, Mardani I, Haugen F, Fogelstrand P, Adiels M, Asin-Cayuela J, Ekestam C, Gådin JR, Lee YK, Nebb H, Svedlund S, Johansson BR, Hultén LM, Romeo S, Redfors B, Omerovic E, Levin M, Gan LM, Eriksson P, Andersson L, Ehrenborg E, Kimmel AR, Borén J, Levin MC.

Int J Cardiol. 2016 Sep 15;219:446-54. doi: 10.1016/j.ijcard.2016.06.037. Epub 2016 Jun 16.

9.

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart.

Klevstig M, Ståhlman M, Lundqvist A, Scharin Täng M, Fogelstrand P, Adiels M, Andersson L, Kolesnick R, Jeppsson A, Borén J, Levin MC.

J Mol Cell Cardiol. 2016 Apr;93:69-72. doi: 10.1016/j.yjmcc.2016.02.019. Epub 2016 Feb 28.

10.

Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.

Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L.

Vascul Pharmacol. 2015 Oct;73:45-56. doi: 10.1016/j.vph.2015.08.013. Epub 2015 Aug 22.

PMID:
26304700
11.

Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats.

Klevstig M, Manakov D, Kasparova D, Brabcova I, Papousek F, Zurmanova J, Zidek V, Silhavy J, Neckar J, Pravenec M, Kolar F, Novakova O, Novotny J.

Pflugers Arch. 2013 Oct;465(10):1477-86. doi: 10.1007/s00424-013-1281-5. Epub 2013 May 1.

PMID:
23636771
12.

CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.

Neckář J, Šilhavy J, Zídek V, Landa V, Mlejnek P, Šimáková M, Seidman JG, Seidman C, Kazdová L, Klevstig M, Novák F, Vecka M, Papoušek F, Houštěk J, Drahota Z, Kurtz TW, Kolář F, Pravenec M.

Physiol Genomics. 2012 Feb 1;44(2):173-82. doi: 10.1152/physiolgenomics.00083.2011. Epub 2011 Nov 29.

13.

Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats.

Klevstig MJ, Markova I, Burianova J, Kazdova L, Pravenec M, Novakova O, Novak F.

Mol Cell Biochem. 2011 Nov;357(1-2):163-9. doi: 10.1007/s11010-011-0886-2. Epub 2011 May 31.

PMID:
21625957

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