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Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of 'quasi-ordered' states.

Clouser AF, Baughman HE, Basanta B, Guttman M, Nath A, Klevit RE.

Elife. 2019 Oct 1;8. pii: e50259. doi: 10.7554/eLife.50259.


Cbl interacts with multiple E2s in vitro and in cells.

Liyasova MS, Ma K, Voeller D, Ryan PE, Chen J, Klevit RE, Lipkowitz S.

PLoS One. 2019 May 23;14(5):e0216967. doi: 10.1371/journal.pone.0216967. eCollection 2019.


Mechanisms of Small Heat Shock Proteins.

Janowska MK, Baughman HER, Woods CN, Klevit RE.

Cold Spring Harb Perspect Biol. 2019 Oct 1;11(10). pii: a034025. doi: 10.1101/cshperspect.a034025. Review.


Small heat shock proteins: multifaceted proteins with important implications for life.

Carra S, Alberti S, Benesch JLP, Boelens W, Buchner J, Carver JA, Cecconi C, Ecroyd H, Gusev N, Hightower LE, Klevit RE, Lee HO, Liberek K, Lockwood B, Poletti A, Timmerman V, Toth ME, Vierling E, Wu T, Tanguay RM.

Cell Stress Chaperones. 2019 Mar;24(2):295-308. doi: 10.1007/s12192-019-00979-z. Epub 2019 Feb 13.


HSPB5 engages multiple states of a destabilized client to enhance chaperone activity in a stress-dependent manner.

Delbecq SP, Klevit RE.

J Biol Chem. 2019 Mar 1;294(9):3261-3270. doi: 10.1074/jbc.RA118.003156. Epub 2018 Dec 19.


Mechanistic insights revealed by a UBE2A mutation linked to intellectual disability.

de Oliveira JF, do Prado PFV, da Costa SS, Sforça ML, Canateli C, Ranzani AT, Maschietto M, de Oliveira PSL, Otto PA, Klevit RE, Krepischi ACV, Rosenberg C, Franchini KG.

Nat Chem Biol. 2019 Jan;15(1):62-70. doi: 10.1038/s41589-018-0177-2. Epub 2018 Dec 10.


The ubiquitin ligase SspH1 from Salmonella uses a modular and dynamic E3 domain to catalyze substrate ubiquitylation.

Cook M, Delbecq SP, Schweppe TP, Guttman M, Klevit RE, Brzovic PS.

J Biol Chem. 2019 Jan 18;294(3):783-793. doi: 10.1074/jbc.RA118.004247. Epub 2018 Nov 20.


A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation.

DaRosa PA, Harrison JS, Zelter A, Davis TN, Brzovic P, Kuhlman B, Klevit RE.

Mol Cell. 2018 Nov 15;72(4):753-765.e6. doi: 10.1016/j.molcel.2018.09.029. Epub 2018 Nov 1.


Characterization of RING-Between-RING E3 Ubiquitin Transfer Mechanisms.

Reiter KH, Klevit RE.

Methods Mol Biol. 2018;1844:3-17. doi: 10.1007/978-1-4939-8706-1_1.


Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector.

Akturk A, Wasilko DJ, Wu X, Liu Y, Zhang Y, Qiu J, Luo ZQ, Reiter KH, Brzovic PS, Klevit RE, Mao Y.

Nature. 2018 May;557(7707):729-733. doi: 10.1038/s41586-018-0147-6. Epub 2018 May 23.


Structural basis for tankyrase-RNF146 interaction reveals noncanonical tankyrase-binding motifs.

DaRosa PA, Klevit RE, Xu W.

Protein Sci. 2018 Jun;27(6):1057-1067. doi: 10.1002/pro.3413. Epub 2018 Apr 25.


Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.

Tuttle LM, Pacheco D, Warfield L, Luo J, Ranish J, Hahn S, Klevit RE.

Cell Rep. 2018 Mar 20;22(12):3251-3264. doi: 10.1016/j.celrep.2018.02.097.


De novo mutation in RING1 with epigenetic effects on neurodevelopment.

Pierce SB, Stewart MD, Gulsuner S, Walsh T, Dhall A, McClellan JM, Klevit RE, King MC.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1558-1563. doi: 10.1073/pnas.1721290115. Epub 2018 Jan 31.


BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes.

Stewart MD, Zelin E, Dhall A, Walsh T, Upadhyay E, Corn JE, Chatterjee C, King MC, Klevit RE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1316-1321. doi: 10.1073/pnas.1715467115. Epub 2018 Jan 24.


Solution structure of sperm lysin yields novel insights into molecular dynamics of rapid protein evolution.

Wilburn DB, Tuttle LM, Klevit RE, Swanson WJ.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1310-1315. doi: 10.1073/pnas.1709061115. Epub 2018 Jan 18.


HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation.

Baughman HER, Clouser AF, Klevit RE, Nath A.

J Biol Chem. 2018 Feb 23;293(8):2687-2700. doi: 10.1074/jbc.M117.803411. Epub 2018 Jan 3.


RING-Between-RING E3 Ligases: Emerging Themes amid the Variations.

Dove KK, Klevit RE.

J Mol Biol. 2017 Nov 10;429(22):3363-3375. doi: 10.1016/j.jmb.2017.08.008. Epub 2017 Aug 19. Review.


Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development.

Dove KK, Kemp HA, Di Bona KR, Reiter KH, Milburn LJ, Camacho D, Fay DS, Miller DL, Klevit RE.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6576-E6584. doi: 10.1073/pnas.1705060114. Epub 2017 Jul 24.


Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1.

Dove KK, Olszewski JL, Martino L, Duda DM, Wu XS, Miller DJ, Reiter KH, Rittinger K, Schulman BA, Klevit RE.

Structure. 2017 Jun 6;25(6):890-900.e5. doi: 10.1016/j.str.2017.04.013. Epub 2017 May 25.


The growing world of small heat shock proteins: from structure to functions.

Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJJM, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, Goloubinoff P, Gusev N, Haslbeck M, Hightower LE, Kampinga HH, Klevit RE, Liberek K, Mchaourab HS, McMenimen KA, Poletti A, Quinlan R, Strelkov SV, Toth ME, Vierling E, Tanguay RM.

Cell Stress Chaperones. 2017 Jul;22(4):601-611. doi: 10.1007/s12192-017-0787-8. Epub 2017 Mar 31. Review.


pH-dependent structural modulation is conserved in the human small heat shock protein HSBP1.

Clouser AF, Klevit RE.

Cell Stress Chaperones. 2017 Jul;22(4):569-575. doi: 10.1007/s12192-017-0783-z. Epub 2017 Mar 22.


Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms.

Stewart MD, Duncan ED, Coronado E, DaRosa PA, Pruneda JN, Brzovic PS, Klevit RE.

Protein Sci. 2017 Mar;26(3):475-483. doi: 10.1002/pro.3091. Epub 2017 Jan 23.


Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

Harrison JS, Cornett EM, Goldfarb D, DaRosa PA, Li ZM, Yan F, Dickson BM, Guo AH, Cantu DV, Kaustov L, Brown PJ, Arrowsmith CH, Erie DA, Major MB, Klevit RE, Krajewski K, Kuhlman B, Strahl BD, Rothbart SB.

Elife. 2016 Sep 6;5. pii: e17101. doi: 10.7554/eLife.17101.


Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease.

Pierce SB, Gulsuner S, Stapleton GA, Walsh T, Lee MK, Mandell JB, Morales A, Klevit RE, King MC, Rogers RC.

Cold Spring Harb Mol Case Stud. 2016 Jul;2(4):a001107. doi: 10.1101/mcs.a001107.


Structural insights into SAM domain-mediated tankyrase oligomerization.

DaRosa PA, Ovchinnikov S, Xu W, Klevit RE.

Protein Sci. 2016 Sep;25(9):1744-52. doi: 10.1002/pro.2968. Epub 2016 Jul 4.


Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms.

Dove KK, Stieglitz B, Duncan ED, Rittinger K, Klevit RE.

EMBO Rep. 2016 Aug;17(8):1221-35. doi: 10.15252/embr.201642641. Epub 2016 Jun 16.


E2 enzymes: more than just middle men.

Stewart MD, Ritterhoff T, Klevit RE, Brzovic PS.

Cell Res. 2016 Apr;26(4):423-40. doi: 10.1038/cr.2016.35. Epub 2016 Mar 22. Review.


Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.

Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE.

Science. 2015 Nov 6;350(6261):674-7. doi: 10.1126/science.aac9145.


pUBLically unzipping Parkin: how phosphorylation exposes a ligase bit by bit.

Dove KK, Klevit RE, Rittinger K.

EMBO J. 2015 Oct 14;34(20):2486-8. doi: 10.15252/embj.201592857. Epub 2015 Sep 7. No abstract available.


Structure of the α-crystallin domain from the redox-sensitive chaperone, HSPB1.

Rajagopal P, Liu Y, Shi L, Clouser AF, Klevit RE.

J Biomol NMR. 2015 Oct;63(2):223-8. doi: 10.1007/s10858-015-9973-0. Epub 2015 Aug 5. No abstract available.


Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases.

Vittal V, Stewart MD, Brzovic PS, Klevit RE.

J Biol Chem. 2015 Aug 28;290(35):21244-51. doi: 10.1074/jbc.R115.675165. Epub 2015 Jul 17. Review.


A Mechanism of Subunit Recruitment in Human Small Heat Shock Protein Oligomers.

Delbecq SP, Rosenbaum JC, Klevit RE.

Biochemistry. 2015 Jul 21;54(28):4276-84. doi: 10.1021/acs.biochem.5b00490. Epub 2015 Jul 7.


Acidic pH and divalent cation sensing by PhoQ are dispensable for systemic salmonellae virulence.

Hicks KG, Delbecq SP, Sancho-Vaello E, Blanc MP, Dove KK, Prost LR, Daley ME, Zeth K, Klevit RE, Miller SI.

Elife. 2015 May 23;4:e06792. doi: 10.7554/eLife.06792.


A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.

Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE.

Elife. 2015 May 11;4. doi: 10.7554/eLife.07304.


Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage.

Wu W, Nishikawa H, Fukuda T, Vittal V, Asano M, Miyoshi Y, Klevit RE, Ohta T.

Cancer Res. 2015 Apr 1;75(7):1311-21. doi: 10.1158/0008-5472.CAN-14-2796. Epub 2015 Jan 29.


Intrinsic disorder drives N-terminal ubiquitination by Ube2w.

Vittal V, Shi L, Wenzel DM, Scaglione KM, Duncan ED, Basrur V, Elenitoba-Johnson KS, Baker D, Paulson HL, Brzovic PS, Klevit RE.

Nat Chem Biol. 2015 Jan;11(1):83-9. doi: 10.1038/nchembio.1700. Epub 2014 Dec 1.


Mutations in Twinkle primase-helicase cause Perrault syndrome with neurologic features.

Morino H, Pierce SB, Matsuda Y, Walsh T, Ohsawa R, Newby M, Hiraki-Kamon K, Kuramochi M, Lee MK, Klevit RE, Martin A, Maruyama H, King MC, Kawakami H.

Neurology. 2014 Nov 25;83(22):2054-61. doi: 10.1212/WNL.0000000000001036. Epub 2014 Oct 29.


Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.

DaRosa PA, Wang Z, Jiang X, Pruneda JN, Cong F, Klevit RE, Xu W.

Nature. 2015 Jan 8;517(7533):223-6. doi: 10.1038/nature13826. Epub 2014 Oct 19.


A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface.

Warfield L, Tuttle LM, Pacheco D, Klevit RE, Hahn S.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3506-13. doi: 10.1073/pnas.1412088111. Epub 2014 Aug 13.


The ubiquitin-conjugating enzyme, UbcM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of E2 and Lys48 of ubiquitin.

Nguyen L, Plafker KS, Starnes A, Cook M, Klevit RE, Plafker SM.

Biochemistry. 2014 Jun 24;53(24):4004-14. doi: 10.1021/bi500072v. Epub 2014 Jun 13.


Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy.

Navon Elkan P, Pierce SB, Segel R, Walsh T, Barash J, Padeh S, Zlotogorski A, Berkun Y, Press JJ, Mukamel M, Voth I, Hashkes PJ, Harel L, Hoffer V, Ling E, Yalcinkaya F, Kasapcopur O, Lee MK, Klevit RE, Renbaum P, Weinberg-Shukron A, Sener EF, Schormair B, Zeligson S, Marek-Yagel D, Strom TM, Shohat M, Singer A, Rubinow A, Pras E, Winkelmann J, Tekin M, Anikster Y, King MC, Levy-Lahad E.

N Engl J Med. 2014 Mar 6;370(10):921-31. doi: 10.1056/NEJMoa1307362. Epub 2014 Feb 19.


Proof of principle for epitope-focused vaccine design.

Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, Connell MJ, Stevens E, Schroeter A, Chen M, Macpherson S, Serra AM, Adachi Y, Holmes MA, Li Y, Klevit RE, Graham BS, Wyatt RT, Baker D, Strong RK, Crowe JE Jr, Johnson PR, Schief WR.

Nature. 2014 Mar 13;507(7491):201-6. doi: 10.1038/nature12966. Epub 2014 Feb 5.


E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.

Pruneda JN, Smith FD, Daurie A, Swaney DL, Villén J, Scott JD, Stadnyk AW, Le Trong I, Stenkamp RE, Klevit RE, Rohde JR, Brzovic PS.

EMBO J. 2014 Mar 3;33(5):437-49. doi: 10.1002/embj.201386386. Epub 2014 Jan 20.


Flavonoid regulation of HCN2 channels.

Carlson AE, Rosenbaum JC, Brelidze TI, Klevit RE, Zagotta WN.

J Biol Chem. 2013 Nov 15;288(46):33136-45. doi: 10.1074/jbc.M113.501759. Epub 2013 Oct 1.


Structural Biology: Parkin's Serpentine Shape Revealed in the Year of the Snake.

Dove KK, Klevit RE.

Curr Biol. 2013 Aug 19;23(16):R691-3. doi: 10.1016/j.cub.2013.07.039.


RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination.

Metzger MB, Pruneda JN, Klevit RE, Weissman AM.

Biochim Biophys Acta. 2014 Jan;1843(1):47-60. doi: 10.1016/j.bbamcr.2013.05.026. Epub 2013 Jun 6. Review.


Biochemical and structural characterization of the ubiquitin-conjugating enzyme UBE2W reveals the formation of a noncovalent homodimer.

Vittal V, Wenzel DM, Brzovic PS, Klevit RE.

Cell Biochem Biophys. 2013 Sep;67(1):103-10. doi: 10.1007/s12013-013-9633-5.


Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.

Soss SE, Klevit RE, Chazin WJ.

Biochemistry. 2013 Apr 30;52(17):2991-9. doi: 10.1021/bi3015949. Epub 2013 Apr 15.


Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome.

Pierce SB, Gersak K, Michaelson-Cohen R, Walsh T, Lee MK, Malach D, Klevit RE, King MC, Levy-Lahad E.

Am J Hum Genet. 2013 Apr 4;92(4):614-20. doi: 10.1016/j.ajhg.2013.03.007. Epub 2013 Mar 28.


Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.

Starita LM, Pruneda JN, Lo RS, Fowler DM, Kim HJ, Hiatt JB, Shendure J, Brzovic PS, Fields S, Klevit RE.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1263-72. doi: 10.1073/pnas.1303309110. Epub 2013 Mar 18.

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