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Items: 1 to 50 of 174

1.

Plasma Levels of the Bioactive Sphingolipid Metabolite S1P in Adult Cystic Fibrosis Patients: Potential Target for Immunonutrition?

Halilbasic E, Fuerst E, Heiden D, Japtok L, Diesner SC, Trauner M, Kulu A, Jaksch P, Hoetzenecker K, Kleuser B, Kazemi-Shirazi L, Untersmayr E.

Nutrients. 2020 Mar 14;12(3). pii: E765. doi: 10.3390/nu12030765.

2.

S1P and plasmalogen derived fatty aldehydes in cellular signaling and functions.

Ebenezer DL, Fu P, Ramchandran R, Ha AW, Putherickal V, Sudhadevi T, Harijith A, Schumacher F, Kleuser B, Natarajan V.

Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Mar 12;1865(7):158681. doi: 10.1016/j.bbalip.2020.158681. [Epub ahead of print] Review.

PMID:
32171908
3.

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.

Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS.

Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8.

4.

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.

Naser E, Kadow S, Schumacher F, Mohamed ZH, Kappe C, Hessler G, Pollmeier B, Kleuser B, Arenz C, Becker KA, Gulbins E, Carpinteiro A.

J Lipid Res. 2020 Mar 10. pii: jlr.RA120000682. doi: 10.1194/jlr.RA120000682. [Epub ahead of print]

5.

Being Born Large for Gestational Age is Associated with Increased Global Placental DNA Methylation.

Dwi Putra SE, Reichetzeder C, Hasan AA, Slowinski T, Chu C, Krämer BK, Kleuser B, Hocher B.

Sci Rep. 2020 Jan 22;10(1):927. doi: 10.1038/s41598-020-57725-0.

6.

Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.

Wetzel A, Scholtka B, Gerecke C, Kleuser B.

Cell Mol Life Sci. 2020 Jan 18. doi: 10.1007/s00018-020-03451-9. [Epub ahead of print]

PMID:
31955243
7.

Clinical Development of Sphingosine as Anti-Bacterial Drug: Inhalation of Sphingosine in Mini Pigs has no Adverse Side Effects.

Carstens H, Schumacher F, Keitsch S, Kramer M, Kühn C, Sehl C, Soddemann M, Wilker B, Herrmann D, Swaidan A, Kleuser B, Verhaegh R, Hilken G, Edwards MJ, Dubicanac M, Carpinteiro A, Wissmann A, Becker KA, Kamler M, Gulbins E.

Cell Physiol Biochem. 2019;53(6):1015-1028. doi: 10.33594/000000194.

8.

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease.

Beckmann N, Becker KA, Kadow S, Schumacher F, Kramer M, Kühn C, Schulz-Schaeffer WJ, Edwards MJ, Kleuser B, Gulbins E, Carpinteiro A.

Int J Mol Sci. 2019 Dec 11;20(24). pii: E6253. doi: 10.3390/ijms20246253.

9.

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis.

Börtlein C, Schumacher F, Kleuser B, Dölken L, Avota E.

Front Cell Dev Biol. 2019 Oct 15;7:226. doi: 10.3389/fcell.2019.00226. eCollection 2019.

10.

Use of Acid Ceramidase and Sphingosine Kinase Inhibitors as Antiviral Compounds Against Measles Virus Infection of Lymphocytes in vitro.

Grafen A, Schumacher F, Chithelen J, Kleuser B, Beyersdorf N, Schneider-Schaulies J.

Front Cell Dev Biol. 2019 Oct 1;7:218. doi: 10.3389/fcell.2019.00218. eCollection 2019.

11.

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry.

Wigger D, Gulbins E, Kleuser B, Schumacher F.

Front Cell Dev Biol. 2019 Oct 1;7:210. doi: 10.3389/fcell.2019.00210. eCollection 2019.

12.

Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells.

Gerecke C, Schumacher F, Berndzen A, Homann T, Kleuser B.

Epigenetics. 2020 Mar;15(3):307-322. doi: 10.1080/15592294.2019.1666652. Epub 2019 Sep 17.

13.

Dermal Delivery of the High-Molecular-Weight Drug Tacrolimus by Means of Polyglycerol-Based Nanogels.

Rancan F, Volkmann H, Giulbudagian M, Schumacher F, Stanko JI, Kleuser B, Blume-Peytavi U, Calderón M, Vogt A.

Pharmaceutics. 2019 Aug 5;11(8). pii: E394. doi: 10.3390/pharmaceutics11080394.

14.

Acid sphingomyelinase - a regulator of canonical transient receptor potential channel 6 (TRPC6) activity.

Zeitler S, Ye L, Andreyeva A, Schumacher F, Monti J, Nürnberg B, Nowak G, Kleuser B, Reichel M, Fejtová A, Kornhuber J, Rhein C, Friedland K.

J Neurochem. 2019 Sep;150(6):678-690. doi: 10.1111/jnc.14823. Epub 2019 Aug 22.

PMID:
31310676
15.

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis.

Meiners J, Palmieri V, Klopfleisch R, Ebel JF, Japtok L, Schumacher F, Yusuf AM, Becker KA, Zöller J, Hose M, Kleuser B, Hermann DM, Kolesnick RN, Buer J, Hansen W, Westendorf AM.

Front Immunol. 2019 Jun 19;10:1386. doi: 10.3389/fimmu.2019.01386. eCollection 2019.

16.

Measles Virus Infection Fosters Dendritic Cell Motility in a 3D Environment to Enhance Transmission to Target Cells in the Respiratory Epithelium.

Derakhshani S, Kurz A, Japtok L, Schumacher F, Pilgram L, Steinke M, Kleuser B, Sauer M, Schneider-Schaulies S, Avota E.

Front Immunol. 2019 Jun 5;10:1294. doi: 10.3389/fimmu.2019.01294. eCollection 2019.

17.

Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia.

Seitz AP, Schumacher F, Baker J, Soddemann M, Wilker B, Caldwell CC, Gobble RM, Kamler M, Becker KA, Beck S, Kleuser B, Edwards MJ, Gulbins E.

J Mol Med (Berl). 2019 Aug;97(8):1195-1211. doi: 10.1007/s00109-019-01800-1. Epub 2019 Jun 20.

18.

Qualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug Penetration.

Wanjiku B, Yamamoto K, Klossek A, Schumacher F, Pischon H, Mundhenk L, Rancan F, Judd MM, Ahmed M, Zoschke C, Kleuser B, Rühl E, Schäfer-Korting M.

Anal Chem. 2019 Jun 4;91(11):7208-7214. doi: 10.1021/acs.analchem.9b00519. Epub 2019 May 15.

PMID:
31090401
19.

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.

Gohlke S, Zagoriy V, Cuadros Inostroza A, Méret M, Mancini C, Japtok L, Schumacher F, Kuhlow D, Graja A, Stephanowitz H, Jähnert M, Krause E, Wernitz A, Petzke KJ, Schürmann A, Kleuser B, Schulz TJ.

Mol Metab. 2019 Jun;24:1-17. doi: 10.1016/j.molmet.2019.03.011. Epub 2019 Apr 4.

20.

Mechanisms of GLP-1 receptor-independent renoprotective effects of the dipeptidyl peptidase type 4 inhibitor linagliptin in GLP-1 receptor knockout mice with 5/6 nephrectomy.

Hasan AA, von Websky K, Reichetzeder C, Tsuprykov O, Gaballa MMS, Guo J, Zeng S, Delić D, Tammen H, Klein T, Kleuser B, Hocher B.

Kidney Int. 2019 Jun;95(6):1373-1388. doi: 10.1016/j.kint.2019.01.010. Epub 2019 Feb 27.

21.

Methionine restriction prevents onset of type 2 diabetes in NZO mice.

Castaño-Martinez T, Schumacher F, Schumacher S, Kochlik B, Weber D, Grune T, Biemann R, McCann A, Abraham K, Weikert C, Kleuser B, Schürmann A, Laeger T.

FASEB J. 2019 Jun;33(6):7092-7102. doi: 10.1096/fj.201900150R. Epub 2019 Mar 6.

22.

Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake.

Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M.

Sci Rep. 2019 Feb 27;9(1):2913. doi: 10.1038/s41598-019-39770-6.

23.

Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin.

Frombach J, Unbehauen M, Kurniasih IN, Schumacher F, Volz P, Hadam S, Rancan F, Blume-Peytavi U, Kleuser B, Haag R, Alexiev U, Vogt A.

J Control Release. 2019 Apr 10;299:138-148. doi: 10.1016/j.jconrel.2019.02.028. Epub 2019 Feb 21.

PMID:
30797867
24.

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation.

Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Füchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO, Kornhuber J.

Front Psychiatry. 2018 Oct 16;9:496. doi: 10.3389/fpsyt.2018.00496. eCollection 2018.

25.

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M, Müller-Redetzky HC.

Crit Care. 2018 Oct 29;22(1):282. doi: 10.1186/s13054-018-2213-8.

26.

The Enigma of Sphingolipids in Health and Disease.

Kleuser B.

Int J Mol Sci. 2018 Oct 12;19(10). pii: E3126. doi: 10.3390/ijms19103126. No abstract available.

27.

Fatal gastric distension in a gold thioglucose mouse model of obesity.

Nitezki T, Kleuser B, Krämer S.

Lab Anim. 2019 Feb;53(1):89-94. doi: 10.1177/0023677218803384. Epub 2018 Oct 5.

PMID:
30290722
28.

Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells.

Gerecke C, Schumacher F, Edlich A, Wetzel A, Yealland G, Neubert LK, Scholtka B, Homann T, Kleuser B.

Oncotarget. 2018 Aug 28;9(67):32822-32840. doi: 10.18632/oncotarget.25999. eCollection 2018 Aug 28.

29.

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery.

Zabihi F, Graff P, Schumacher F, Kleuser B, Hedtrich S, Haag R.

Nanoscale. 2018 Sep 13;10(35):16848-16856. doi: 10.1039/c8nr05536j.

PMID:
30168550
30.

Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.

Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E.

Mol Psychiatry. 2018 Dec;23(12):2324-2346. doi: 10.1038/s41380-018-0090-9. Epub 2018 Jul 23.

31.

Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins.

Schoenauer R, Larpin Y, Babiychuk EB, Drücker P, Babiychuk VS, Avota E, Schneider-Schaulies S, Schumacher F, Kleuser B, Köffel R, Draeger A.

FASEB J. 2019 Jan;33(1):275-285. doi: 10.1096/fj.201800033R. Epub 2018 Jul 6.

PMID:
29979630
32.

Pathological manifestations of Farber disease in a new mouse model.

Beckmann N, Kadow S, Schumacher F, Göthert JR, Kesper S, Draeger A, Schulz-Schaeffer WJ, Wang J, Becker JU, Kramer M, Kühn C, Kleuser B, Becker KA, Gulbins E, Carpinteiro A.

Biol Chem. 2018 Sep 25;399(10):1183-1202. doi: 10.1515/hsz-2018-0170.

33.

Sphingolipids as targets for inhalation treatment of cystic fibrosis.

Becker KA, Riethmüller J, Seitz AP, Gardner A, Boudreau R, Kamler M, Kleuser B, Schuchman E, Caldwell CC, Edwards MJ, Grassmé H, Brodlie M, Gulbins E.

Adv Drug Deliv Rev. 2018 Aug;133:66-75. doi: 10.1016/j.addr.2018.04.015. Epub 2018 Apr 24. Review.

PMID:
29698625
34.

Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

Müller SM, Finke H, Ebert F, Kopp JF, Schumacher F, Kleuser B, Francesconi KA, Raber G, Schwerdtle T.

Arch Toxicol. 2018 May;92(5):1751-1765. doi: 10.1007/s00204-018-2194-z. Epub 2018 Mar 30.

PMID:
29602950
35.

Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes.

Laeger T, Castaño-Martinez T, Werno MW, Japtok L, Baumeier C, Jonas W, Kleuser B, Schürmann A.

Diabetologia. 2018 Jun;61(6):1459-1469. doi: 10.1007/s00125-018-4595-1. Epub 2018 Mar 17.

36.

Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease.

Kleuser B.

Int J Mol Sci. 2018 Mar 3;19(3). pii: E722. doi: 10.3390/ijms19030722. Review.

37.

Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin.

Edlich A, Volz P, Brodwolf R, Unbehauen M, Mundhenk L, Gruber AD, Hedtrich S, Haag R, Alexiev U, Kleuser B.

Biomaterials. 2018 Apr;162:60-70. doi: 10.1016/j.biomaterials.2018.01.058. Epub 2018 Feb 3.

PMID:
29438881
38.

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus.

Lu YP, Reichetzeder C, Prehn C, von Websky K, Slowinski T, Chen YP, Yin LH, Kleuser B, Yang XS, Adamski J, Hocher B.

Cell Physiol Biochem. 2018;45(2):625-638. doi: 10.1159/000487119. Epub 2018 Jan 29.

39.

Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells.

Schwiebs A, Thomas D, Kleuser B, Pfeilschifter JM, Radeke HH.

Mediators Inflamm. 2017;2017:5187368. doi: 10.1155/2017/5187368. Epub 2017 Dec 11.

40.

Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2.

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group.

Crit Care Med. 2018 Mar;46(3):e258-e267. doi: 10.1097/CCM.0000000000002916.

PMID:
29298188
41.

Breaking the Barrier - Potent Anti-Inflammatory Activity following Efficient Topical Delivery of Etanercept using Thermoresponsive Nanogels.

Giulbudagian M, Yealland G, Hönzke S, Edlich A, Geisendörfer B, Kleuser B, Hedtrich S, Calderón M.

Theranostics. 2018 Jan 1;8(2):450-463. doi: 10.7150/thno.21668. eCollection 2018.

42.

Enhanced topical delivery of dexamethasone by β-cyclodextrin decorated thermoresponsive nanogels.

Giulbudagian M, Hönzke S, Bergueiro J, Işık D, Schumacher F, Saeidpour S, Lohan SB, Meinke MC, Teutloff C, Schäfer-Korting M, Yealland G, Kleuser B, Hedtrich S, Calderón M.

Nanoscale. 2017 Dec 21;10(1):469-479. doi: 10.1039/c7nr04480a.

PMID:
29227500
43.

Etoposide Upregulates Survival Favoring Sphingosine-1-Phosphate in Etoposide-Resistant Retinoblastoma Cells.

Kakkassery V, Skosyrski S, Lüth A, Kleuser B, van der Giet M, Tate R, Reinhard J, Faissner A, Joachim SC, Kociok N.

Pathol Oncol Res. 2019 Jan;25(1):391-399. doi: 10.1007/s12253-017-0360-x. Epub 2017 Nov 15.

44.

How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?

Pischon H, Radbruch M, Ostrowski A, Schumacher F, Hönzke S, Kleuser B, Hedtrich S, Fluhr JW, Gruber AD, Mundhenk L.

J Invest Dermatol. 2018 Feb;138(2):455-458. doi: 10.1016/j.jid.2017.09.019. Epub 2017 Sep 22. No abstract available.

45.

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.

Fayyaz S, Japtok L, Schumacher F, Wigger D, Schulz TJ, Haubold K, Gulbins E, Völler H, Kleuser B.

Cell Physiol Biochem. 2017;43(2):445-456. doi: 10.1159/000480470. Epub 2017 Sep 1.

46.

Enhanced Acid Sphingomyelinase Activity Drives Immune Evasion and Tumor Growth in Non-Small Cell Lung Carcinoma.

Kachler K, Bailer M, Heim L, Schumacher F, Reichel M, Holzinger CD, Trump S, Mittler S, Monti J, Trufa DI, Rieker RJ, Hartmann A, Sirbu H, Kleuser B, Kornhuber J, Finotto S.

Cancer Res. 2017 Nov 1;77(21):5963-5976. doi: 10.1158/0008-5472.CAN-16-3313. Epub 2017 Sep 7.

47.

Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice.

Speckmann B, Schulz S, Hiller F, Hesse D, Schumacher F, Kleuser B, Geisel J, Obeid R, Grune T, Kipp AP.

J Nutr Biochem. 2017 Oct;48:112-119. doi: 10.1016/j.jnutbio.2017.07.002. Epub 2017 Jul 9.

48.

The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitro.

Schumacher F, Neuber C, Finke H, Nieschalke K, Baesler J, Gulbins E, Kleuser B.

J Lipid Res. 2017 Aug;58(8):1648-1660. doi: 10.1194/jlr.M076562. Epub 2017 Jun 6.

49.

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents.

Wallmeyer L, Dietert K, Sochorová M, Gruber AD, Kleuser B, Vávrová K, Hedtrich S.

Sci Rep. 2017 Apr 4;7(1):774. doi: 10.1038/s41598-017-00670-2.

50.

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

McVey MJ, Kim M, Tabuchi A, Srbely V, Japtok L, Arenz C, Rotstein O, Kleuser B, Semple JW, Kuebler WM.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L625-L637. doi: 10.1152/ajplung.00317.2016. Epub 2017 Mar 10.

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