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A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases.

Choi HW, Wang L, Powell AF, Strickler SR, Wang D, Dempsey DA, Schroeder FC, Klessig DF.

Sci Rep. 2019 Sep 11;9(1):13084. doi: 10.1038/s41598-019-49234-6.


Mimicking the Host Regulation of Salicylic Acid: A Virulence Strategy by the Clubroot Pathogen Plasmodiophora brassicae.

Djavaheri M, Ma L, Klessig DF, Mithöfer A, Gropp G, Borhan H.

Mol Plant Microbe Interact. 2019 Mar;32(3):296-305. doi: 10.1094/MPMI-07-18-0192-R. Epub 2019 Feb 4.


Systemic Acquired Resistance and Salicylic Acid: Past, Present, and Future.

Klessig DF, Choi HW, Dempsey DA.

Mol Plant Microbe Interact. 2018 Sep;31(9):871-888. doi: 10.1094/MPMI-03-18-0067-CR. Epub 2018 Jul 10. Review.


Members of the abscisic acid co-receptor PP2C protein family mediate salicylic acid-abscisic acid crosstalk.

Manohar M, Wang D, Manosalva PM, Choi HW, Kombrink E, Klessig DF.

Plant Direct. 2017 Nov 6;1(5):e00020. doi: 10.1002/pld3.20. eCollection 2017 Nov.


MORC Proteins: Novel Players in Plant and Animal Health.

Koch A, Kang HG, Steinbrenner J, Dempsey DA, Klessig DF, Kogel KH.

Front Plant Sci. 2017 Oct 18;8:1720. doi: 10.3389/fpls.2017.01720. eCollection 2017. Review.


Plant and Human MORC Proteins Have DNA-Modifying Activities Similar to Type II Topoisomerases, but Require One or More Additional Factors for Full Activity.

Manohar M, Choi HW, Manosalva P, Austin CA, Peters JE, Klessig DF.

Mol Plant Microbe Interact. 2017 Feb;30(2):87-100. doi: 10.1094/MPMI-10-16-0208-R. Epub 2017 Feb 3.


DAMPs, MAMPs, and NAMPs in plant innate immunity.

Choi HW, Klessig DF.

BMC Plant Biol. 2016 Oct 26;16(1):232. Review.


Pathogen Infection and MORC Proteins Affect Chromatin Accessibility of Transposable Elements and Expression of Their Proximal Genes in Arabidopsis.

Bordiya Y, Zheng Y, Nam JC, Bonnard AC, Choi HW, Lee BK, Kim J, Klessig DF, Fei Z, Kang HG.

Mol Plant Microbe Interact. 2016 Sep;29(9):674-687. Epub 2016 Sep 26.


Multiple Targets of Salicylic Acid and Its Derivatives in Plants and Animals.

Klessig DF, Tian M, Choi HW.

Front Immunol. 2016 May 26;7:206. doi: 10.3389/fimmu.2016.00206. eCollection 2016. Review.


Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid.

Choi HW, Manohar M, Manosalva P, Tian M, Moreau M, Klessig DF.

PLoS Pathog. 2016 Mar 23;12(3):e1005518. doi: 10.1371/journal.ppat.1005518. eCollection 2016 Mar.


Newly Identified Targets of Aspirin and Its Primary Metabolite, Salicylic Acid.

Klessig DF.

DNA Cell Biol. 2016 Apr;35(4):163-6. doi: 10.1089/dna.2016.3260. Epub 2016 Mar 8.


Human GAPDH Is a Target of Aspirin's Primary Metabolite Salicylic Acid and Its Derivatives.

Choi HW, Tian M, Manohar M, Harraz MM, Park SW, Schroeder FC, Snyder SH, Klessig DF.

PLoS One. 2015 Nov 25;10(11):e0143447. doi: 10.1371/journal.pone.0143447. eCollection 2015.


Conserved nematode signalling molecules elicit plant defenses and pathogen resistance.

Manosalva P, Manohar M, von Reuss SH, Chen S, Koch A, Kaplan F, Choe A, Micikas RJ, Wang X, Kogel KH, Sternberg PW, Williamson VM, Schroeder FC, Klessig DF.

Nat Commun. 2015 Jul 23;6:7795. doi: 10.1038/ncomms8795.


Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.

Choi HW, Tian M, Song F, Venereau E, Preti A, Park SW, Hamilton K, Swapna GV, Manohar M, Moreau M, Agresti A, Gorzanelli A, De Marchis F, Wang H, Antonyak M, Micikas RJ, Gentile DR, Cerione RA, Schroeder FC, Montelione GT, Bianchi ME, Klessig DF.

Mol Med. 2015 Jun 18;21:526-35. doi: 10.2119/molmed.2015.00148.


The GHKL ATPase MORC1 Modulates Species-Specific Plant Immunity in Solanaceae.

Manosalva P, Manohar M, Kogel KH, Kang HG, Klessig DF.

Mol Plant Microbe Interact. 2015 Aug;28(8):927-42. doi: 10.1094/MPMI-12-14-0401-R. Epub 2015 Jul 20.


Identification of multiple salicylic acid-binding proteins using two high throughput screens.

Manohar M, Tian M, Moreau M, Park SW, Choi HW, Fei Z, Friso G, Asif M, Manosalva P, von Dahl CC, Shi K, Ma S, Dinesh-Kumar SP, O'Doherty I, Schroeder FC, van Wijk KJ, Klessig DF.

Front Plant Sci. 2015 Jan 12;5:777. doi: 10.3389/fpls.2014.00777. eCollection 2014.


Salicylic Acid Inhibits the Replication of Tomato bushy stunt virus by Directly Targeting a Host Component in the Replication Complex.

Tian M, Sasvari Z, Gonzalez PA, Friso G, Rowland E, Liu XM, van Wijk KJ, Nagy PD, Klessig DF.

Mol Plant Microbe Interact. 2015 Apr;28(4):379-86. doi: 10.1094/MPMI-09-14-0259-R.


Salicylic acid binding of mitochondrial alpha-ketoglutarate dehydrogenase E2 affects mitochondrial oxidative phosphorylation and electron transport chain components and plays a role in basal defense against tobacco mosaic virus in tomato.

Liao Y, Tian M, Zhang H, Li X, Wang Y, Xia X, Zhou J, Zhou Y, Yu J, Shi K, Klessig DF.

New Phytol. 2015 Feb;205(3):1296-307. doi: 10.1111/nph.13137. Epub 2014 Nov 3.


Structure of the Arabidopsis thaliana TOP2 oligopeptidase.

Wang R, Rajagopalan K, Sadre-Bazzaz K, Moreau M, Klessig DF, Tong L.

Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):555-9. doi: 10.1107/S2053230X14006128. Epub 2014 Apr 15.


The compromised recognition of turnip crinkle virus1 subfamily of microrchidia ATPases regulates disease resistance in barley to biotrophic and necrotrophic pathogens.

Langen G, von Einem S, Koch A, Imani J, Pai SB, Manohar M, Ehlers K, Choi HW, Claar M, Schmidt R, Mang HG, Bordiya Y, Kang HG, Klessig DF, Kogel KH.

Plant Physiol. 2014 Feb;164(2):866-78. doi: 10.1104/pp.113.227488. Epub 2014 Jan 3.


Double-stranded RNA-binding protein 4 is required for resistance signaling against viral and bacterial pathogens.

Zhu S, Jeong RD, Lim GH, Yu K, Wang C, Chandra-Shekara AC, Navarre D, Klessig DF, Kachroo A, Kachroo P.

Cell Rep. 2013 Sep 26;4(6):1168-84. doi: 10.1016/j.celrep.2013.08.018. Epub 2013 Sep 19.


CRT1 is a nuclear-translocated MORC endonuclease that participates in multiple levels of plant immunity.

Kang HG, Hyong WC, von Einem S, Manosalva P, Ehlers K, Liu PP, Buxa SV, Moreau M, Mang HG, Kachroo P, Kogel KH, Klessig DF.

Nat Commun. 2012;3:1297. doi: 10.1038/ncomms2279. Erratum in: Nat Commun. 2013;4:1297. Mang, Hyong-Gon [corrected to Mang, Hyung-Gon].


The combined use of photoaffinity labeling and surface plasmon resonance-based technology identifies multiple salicylic acid-binding proteins.

Tian M, von Dahl CC, Liu PP, Friso G, van Wijk KJ, Klessig DF.

Plant J. 2012 Dec;72(6):1027-38. doi: 10.1111/tpj.12016. Epub 2012 Oct 22.


Salicylic acid binds NPR3 and NPR4 to regulate NPR1-dependent defense responses.

Moreau M, Tian M, Klessig DF.

Cell Res. 2012 Dec;22(12):1631-3. doi: 10.1038/cr.2012.100. Epub 2012 Jun 26.


SOS - too many signals for systemic acquired resistance?

Dempsey DA, Klessig DF.

Trends Plant Sci. 2012 Sep;17(9):538-45. doi: 10.1016/j.tplants.2012.05.011. Epub 2012 Jun 29. Review.


Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation.

Zheng XY, Spivey NW, Zeng W, Liu PP, Fu ZQ, Klessig DF, He SY, Dong X.

Cell Host Microbe. 2012 Jun 14;11(6):587-96. doi: 10.1016/j.chom.2012.04.014.


Abscisic acid deficiency antagonizes high-temperature inhibition of disease resistance through enhancing nuclear accumulation of resistance proteins SNC1 and RPS4 in Arabidopsis.

Mang HG, Qian W, Zhu Y, Qian J, Kang HG, Klessig DF, Hua J.

Plant Cell. 2012 Mar;24(3):1271-84. doi: 10.1105/tpc.112.096198. Epub 2012 Mar 27.


Salicylic Acid biosynthesis and metabolism.

Dempsey DA, Vlot AC, Wildermuth MC, Klessig DF.

Arabidopsis Book. 2011;9:e0156. doi: 10.1199/tab.0156. Epub 2011 Dec 20.


The extent to which methyl salicylate is required for signaling systemic acquired resistance is dependent on exposure to light after infection.

Liu PP, von Dahl CC, Klessig DF.

Plant Physiol. 2011 Dec;157(4):2216-26. doi: 10.1104/pp.111.187773. Epub 2011 Oct 21.


Interconnection between methyl salicylate and lipid-based long-distance signaling during the development of systemic acquired resistance in Arabidopsis and tobacco.

Liu PP, von Dahl CC, Park SW, Klessig DF.

Plant Physiol. 2011 Apr;155(4):1762-8. doi: 10.1104/pp.110.171694. Epub 2011 Feb 10. No abstract available.


Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato.

Manosalva PM, Park SW, Forouhar F, Tong L, Fry WE, Klessig DF.

Mol Plant Microbe Interact. 2010 Sep;23(9):1151-63. doi: 10.1094/MPMI-23-9-1151.


Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase.

Jeong RD, Chandra-Shekara AC, Barman SR, Navarre D, Klessig DF, Kachroo A, Kachroo P.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13538-43. doi: 10.1073/pnas.1004529107. Epub 2010 Jul 12.


Endosome-associated CRT1 functions early in resistance gene-mediated defense signaling in Arabidopsis and tobacco.

Kang HG, Oh CS, Sato M, Katagiri F, Glazebrook J, Takahashi H, Kachroo P, Martin GB, Klessig DF.

Plant Cell. 2010 Mar;22(3):918-36. doi: 10.1105/tpc.109.071662. Epub 2010 Mar 23.


The lesion-mimic mutant cpr22 shows alterations in abscisic acid signaling and abscisic acid insensitivity in a salicylic acid-dependent manner.

Mosher S, Moeder W, Nishimura N, Jikumaru Y, Joo SH, Urquhart W, Klessig DF, Kim SK, Nambara E, Yoshioka K.

Plant Physiol. 2010 Apr;152(4):1901-13. doi: 10.1104/pp.109.152603. Epub 2010 Feb 17.


Systemic acquired resistance is induced by R gene-mediated responses independent of cell death.

Liu PP, Bhattacharjee S, Klessig DF, Moffett P.

Mol Plant Pathol. 2010 Jan;11(1):155-60. doi: 10.1111/j.1364-3703.2009.00564.x.


Altering expression of benzoic acid/salicylic acid carboxyl methyltransferase 1 compromises systemic acquired resistance and PAMP-triggered immunity in arabidopsis.

Liu PP, Yang Y, Pichersky E, Klessig DF.

Mol Plant Microbe Interact. 2010 Jan;23(1):82-90. doi: 10.1094/MPMI-23-1-0082.


NO synthesis and signaling in plants--where do we stand?

Moreau M, Lindermayr C, Durner J, Klessig DF.

Physiol Plant. 2010 Apr;138(4):372-83. doi: 10.1111/j.1399-3054.2009.01308.x. Epub 2009 Oct 15. Review.


Salicylic Acid, a multifaceted hormone to combat disease.

Vlot AC, Dempsey DA, Klessig DF.

Annu Rev Phytopathol. 2009;47:177-206. doi: 10.1146/annurev.phyto.050908.135202. Review.


Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1, RAR1, NPR1 and JAR1.

Kawamura Y, Takenaka S, Hase S, Kubota M, Ichinose Y, Kanayama Y, Nakaho K, Klessig DF, Takahashi H.

Plant Cell Physiol. 2009 May;50(5):924-34. doi: 10.1093/pcp/pcp044. Epub 2009 Mar 20.


Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance.

Park SW, Liu PP, Forouhar F, Vlot AC, Tong L, Tietjen K, Klessig DF.

J Biol Chem. 2009 Mar 13;284(11):7307-17. doi: 10.1074/jbc.M807968200. Epub 2009 Jan 8.


High level expression of a virus resistance gene, RCY1, confers extreme resistance to Cucumber mosaic virus in Arabidopsis thaliana.

Sekine KT, Kawakami S, Hase S, Kubota M, Ichinose Y, Shah J, Kang HG, Klessig DF, Takahashi H.

Mol Plant Microbe Interact. 2008 Nov;21(11):1398-407. doi: 10.1094/MPMI-21-11-1398.


The structure of YqeH. An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition.

Sudhamsu J, Lee GI, Klessig DF, Crane BR.

J Biol Chem. 2008 Nov 21;283(47):32968-76. doi: 10.1074/jbc.M804837200. Epub 2008 Sep 18.


AtNOS/AtNOA1 is a functional Arabidopsis thaliana cGTPase and not a nitric-oxide synthase.

Moreau M, Lee GI, Wang Y, Crane BR, Klessig DF.

J Biol Chem. 2008 Nov 21;283(47):32957-67. doi: 10.1074/jbc.M804838200. Epub 2008 Sep 18.


HRT-mediated hypersensitive response and resistance to Turnip crinkle virus in Arabidopsis does not require the function of TIP, the presumed guardee protein.

Jeong RD, Chandra-Shekara AC, Kachroo A, Klessig DF, Kachroo P.

Mol Plant Microbe Interact. 2008 Oct;21(10):1316-24. doi: 10.1094/MPMI-21-10-1316.


Identification of likely orthologs of tobacco salicylic acid-binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana.

Vlot AC, Liu PP, Cameron RK, Park SW, Yang Y, Kumar D, Zhou F, Padukkavidana T, Gustafsson C, Pichersky E, Klessig DF.

Plant J. 2008 Nov;56(3):445-56. doi: 10.1111/j.1365-313X.2008.03618.x. Epub 2008 Jul 9.


Systemic acquired resistance: the elusive signal(s).

Vlot AC, Klessig DF, Park SW.

Curr Opin Plant Biol. 2008 Aug;11(4):436-42. doi: 10.1016/j.pbi.2008.05.003. Epub 2008 Jul 9. Review.


Inactive methyl indole-3-acetic acid ester can be hydrolyzed and activated by several esterases belonging to the AtMES esterase family of Arabidopsis.

Yang Y, Xu R, Ma CJ, Vlot AC, Klessig DF, Pichersky E.

Plant Physiol. 2008 Jul;147(3):1034-45. doi: 10.1104/pp.108.118224. Epub 2008 May 8.

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