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Items: 49

1.

[Data-guided learning from suicidal incidents by using KEHR SUICIDE. A practice example in a Dutch mental health care facility].

de Groot MH, Kleppe RT, Pols E, de Winter RFP, Kerkhof AJFM.

Tijdschr Psychiatr. 2018;60(9):581-591. Dutch.

2.

Mathematical Modelling of Nitric Oxide/Cyclic GMP/Cyclic AMP Signalling in Platelets.

Kleppe R, Jonassen I, Døskeland SO, Selheim F.

Int J Mol Sci. 2018 Feb 19;19(2). pii: E612. doi: 10.3390/ijms19020612.

3.

Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.

Jorge-Finnigan A, Kleppe R, Jung-Kc K, Ying M, Marie M, Rios-Mondragon I, Salvatore MF, Saraste J, Martinez A.

J Biol Chem. 2017 Aug 25;292(34):14092-14107. doi: 10.1074/jbc.M116.762344. Epub 2017 Jun 21.

4.

In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins.

Pakdaman Y, Sanchez-Guixé M, Kleppe R, Erdal S, Bustad HJ, Bjørkhaug L, Haugarvoll K, Tzoulis C, Heimdal K, Knappskog PM, Johansson S, Aukrust I.

Biosci Rep. 2017 Apr 28;37(2). pii: BSR20170251. doi: 10.1042/BSR20170251. Print 2017 Apr 30.

5.

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.

Waløen K, Kleppe R, Martinez A, Haavik J.

Expert Opin Ther Targets. 2017 Feb;21(2):167-180. doi: 10.1080/14728222.2017.1272581. Epub 2016 Dec 26. Review.

PMID:
27973928
6.

Exome chip analyses in adult attention deficit hyperactivity disorder.

Zayats T, Jacobsen KK, Kleppe R, Jacob CP, Kittel-Schneider S, Ribasés M, Ramos-Quiroga JA, Richarte V, Casas M, Mota NR, Grevet EH, Klein M, Corominas J, Bralten J, Galesloot T, Vasquez AA, Herms S, Forstner AJ, Larsson H, Breen G, Asherson P, Gross-Lesch S, Lesch KP, Cichon S, Gabrielsen MB, Holmen OL, Bau CH, Buitelaar J, Kiemeney L, Faraone SV, Cormand B, Franke B, Reif A, Haavik J, Johansson S.

Transl Psychiatry. 2016 Oct 18;6(10):e923. doi: 10.1038/tp.2016.196.

7.

Increased microvascular permeability in mice lacking Epac1 (Rapgef3).

Kopperud RK, Rygh CB, Karlsen TV, Krakstad C, Kleppe R, Hoivik EA, Bakke M, Tenstad O, Selheim F, Lidén Å, Madsen L, Pavlin T, Taxt T, Kristiansen K, Curry FE, Reed RK, Døskeland SO.

Acta Physiol (Oxf). 2017 Feb;219(2):441-452. doi: 10.1111/apha.12697. Epub 2016 May 17.

8.

Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.

Ghorbani S, Fossbakk A, Jorge-Finnigan A, Flydal MI, Haavik J, Kleppe R.

Amino Acids. 2016 May;48(5):1221-9. doi: 10.1007/s00726-015-2157-0. Epub 2016 Jan 29.

9.

Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.

Kleppe R, Herfindal L, Døskeland SO.

Mar Drugs. 2015 Oct 22;13(10):6505-20. doi: 10.3390/md13106505. Review.

10.

Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression.

Winge I, Teigen K, Fossbakk A, Mahootchi E, Kleppe R, Sköldberg F, Kämpe O, Haavik J.

Neurochem Int. 2015 Nov;90:173-84. doi: 10.1016/j.neuint.2015.08.013. Epub 2015 Sep 1.

11.

Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE.

Jacobsen KK, Kleppe R, Johansson S, Zayats T, Haavik J.

Am J Med Genet B Neuropsychiatr Genet. 2015 Sep;168(6):423-432. doi: 10.1002/ajmg.b.32339. Epub 2015 Jul 14.

12.

Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ.

Kleppe R, Rosati S, Jorge-Finnigan A, Alvira S, Ghorbani S, Haavik J, Valpuesta JM, Heck AJ, Martinez A.

Mol Cell Proteomics. 2014 Aug;13(8):2017-30. doi: 10.1074/mcp.M113.035709. Epub 2014 Jun 19.

13.

Time-dependent inhibitory effects of cGMP-analogues on thrombin-induced platelet-derived microparticles formation, platelet aggregation, and P-selectin expression.

Nygaard G, Herfindal L, Kopperud R, Aragay AM, Holmsen H, Døskeland SO, Kleppe R, Selheim F.

Biochem Biophys Res Commun. 2014 Jul 4;449(3):357-63. doi: 10.1016/j.bbrc.2014.05.032. Epub 2014 May 17.

PMID:
24845383
14.

Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia.

Fossbakk A, Kleppe R, Knappskog PM, Martinez A, Haavik J.

Hum Mutat. 2014 Jul;35(7):880-90. doi: 10.1002/humu.22565. Epub 2014 Jun 3.

15.

Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3.

Herfindal L, Krakstad C, Myhren L, Hagland H, Kopperud R, Teigen K, Schwede F, Kleppe R, Døskeland SO.

PLoS One. 2014 Apr 16;9(4):e94926. doi: 10.1371/journal.pone.0094926. eCollection 2014.

16.

Modelling cellular signal communication mediated by phosphorylation dependent interaction with 14-3-3 proteins.

Kleppe R, Ghorbani S, Martinez A, Haavik J.

FEBS Lett. 2014 Jan 3;588(1):92-8. doi: 10.1016/j.febslet.2013.11.012. Epub 2013 Nov 20.

17.

Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis.

Gausdal G, Wergeland A, Skavland J, Nguyen E, Pendino F, Rouhee N, McCormack E, Herfindal L, Kleppe R, Havemann U, Schwede F, Bruserud O, Gjertsen BT, Lanotte M, Ségal-Bendirdjian E, Døskeland SO.

Cell Death Dis. 2013 Feb 28;4:e516. doi: 10.1038/cddis.2013.39.

18.

Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription.

Huseby S, Gausdal G, Keen TJ, Kjærland E, Krakstad C, Myhren L, Brønstad K, Kunick C, Schwede F, Genieser HG, Kleppe R, Døskeland SO.

Cell Death Dis. 2011 Dec 8;2:e237. doi: 10.1038/cddis.2011.124.

19.

The 14-3-3 proteins in regulation of cellular metabolism.

Kleppe R, Martinez A, Døskeland SO, Haavik J.

Semin Cell Dev Biol. 2011 Sep;22(7):713-9. doi: 10.1016/j.semcdb.2011.08.008. Epub 2011 Aug 22. Review.

20.

The cAMP-dependent protein kinase pathway as therapeutic target: possibilities and pitfalls.

Kleppe R, Krakstad C, Selheim F, Kopperud R, Døskeland SO.

Curr Top Med Chem. 2011;11(11):1393-405. Review.

PMID:
21513494
21.

Nostocyclopeptide-M1: a potent, nontoxic inhibitor of the hepatocyte drug transporters OATP1B3 and OATP1B1.

Herfindal L, Myhren L, Kleppe R, Krakstad C, Selheim F, Jokela J, Sivonen K, Døskeland SO.

Mol Pharm. 2011 Apr 4;8(2):360-7. doi: 10.1021/mp1002224. Epub 2011 Jan 24.

PMID:
21214185
22.

Dipyridamole synergizes with nitric oxide to prolong inhibition of thrombin-induced platelet shape change.

Jensen BO, Kleppe R, Kopperud R, Nygaard G, Døskeland SO, Holmsen H, Selheim F.

Platelets. 2011;22(1):8-19. doi: 10.3109/09537104.2010.517581. Epub 2010 Oct 19.

PMID:
20958117
23.

Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes.

Halskau Ø Jr, Ying M, Baumann A, Kleppe R, Rodriguez-Larrea D, Almås B, Haavik J, Martinez A.

J Biol Chem. 2009 Nov 20;284(47):32758-69. doi: 10.1074/jbc.M109.027706. Epub 2009 Sep 28.

24.

[Schizophrenia and antipsychotics associated with the metabolic syndrome. An overview].

Scheepers-Hoeks AM, Wessels-Basten SJ, Scherders MJ, Bravenboer B, Loonen AJ, Kleppe RT, Grouls RJ.

Tijdschr Psychiatr. 2008;50(10):645-54. Review. Dutch.

25.

Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding.

Winge I, McKinney JA, Ying M, D'Santos CS, Kleppe R, Knappskog PM, Haavik J.

Biochem J. 2008 Feb 15;410(1):195-204.

PMID:
17973628
26.

Oxygen dependence of tyrosine hydroxylase.

Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J.

Amino Acids. 2008 Apr;34(3):455-64. Epub 2007 May 23.

PMID:
17520326
27.

Does isoform diversity explain functional differences in the 14-3-3 protein family?

Kjarland E, Keen TJ, Kleppe R.

Curr Pharm Biotechnol. 2006 Jun;7(3):217-23. Review.

PMID:
16789906
28.

Proteomic and computational methods in systems modeling of cellular signaling.

Kleppe R, Kjarland E, Selheim F.

Curr Pharm Biotechnol. 2006 Jun;7(3):135-45. Review.

PMID:
16789899
29.
30.

Phosphorylation of tyrosine hydroxylase in isolated mice adrenal glands.

Toska K, Kleppe R, Cohen P, Haavik J.

Ann N Y Acad Sci. 2002 Oct;971:66-8.

PMID:
12438091
31.

Regulation of tyrosine hydroxylase by stress-activated protein kinases.

Toska K, Kleppe R, Armstrong CG, Morrice NA, Cohen P, Haavik J.

J Neurochem. 2002 Nov;83(4):775-83.

32.

[Why do mutations cause disease--a protein chemical perspective].

Kleppe R, Knappskog PM, Haavik J.

Tidsskr Nor Laegeforen. 2001 Sep 30;121(23):2717-20. Review. Norwegian.

PMID:
11699380
33.
34.

Urea-induced denaturation of human phenylalanine hydroxylase.

Kleppe R, Uhlemann K, Knappskog PM, Haavik J.

J Biol Chem. 1999 Nov 19;274(47):33251-8.

35.

Xeroderma pigmentosum: in vitro complementation of DNA repair endonuclease.

Helland D, Kleppe R, Lillehaug JR, Kleppe K.

Carcinogenesis. 1984 Jun;5(6):833-6.

PMID:
6233045
36.

Effect of polyamines on enzymes involved in DNA repair.

Kleppe K, Osland A, Fosse V, Male R, Lossius I, Helland D, Lillehaug JR, Raae AJ, Kleppe RK, Nes IF.

Med Biol. 1981 Dec;59(5-6):374-80.

PMID:
6279978
37.

Effect of caffeine on DNA polymerase I from Escherichia coli: studies in vitro and in vivo.

Solberg KA, Ovrebø S, Kleppe RK, Kleppe K.

Mutat Res. 1978 Jul;51(1):1-10.

PMID:
353536
38.

Phosphorylation of double-stranded DNAs by T4 polynucleotide kinase.

Lillehaug JR, Kleppe RK, Kleppe K.

Biochemistry. 1976 May 4;15(9):1858-65.

PMID:
178357
40.

Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction.

Khorana HG, Agarwal KL, Besmer P, Büchi H, Caruthers MH, Cashion PJ, Fridkin M, Jay E, Kleppe K, Kleppe R, Kumar A, Loewen PC, Miller RC, Minamoto K, Panet A, RajBhandary UL, Ramamoorthy B, Sekiya T, Takeya T, van de Sande JH.

J Biol Chem. 1976 Feb 10;251(3):565-70.

41.

Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 11. Enzymatic joining to form the total DNA duplex.

Kleppe R, Sekiya T, Loewen PC, Kleppe K, Agarwal KL, Büchi H, Besmer P, Caruthers MH, Cashion PJ, Fridkin M, Jay E, Kumar A, Miller RC, Minamoto K, Panet A, RajBhandary UL, Ramamoorthy B, Sidorova N, Takeya T, van de Sande JH, Khorana HG.

J Biol Chem. 1976 Feb 10;251(3):667-75.

43.
44.

Kinetics and effect of salts and polyamines on T4 polynucleotide ligase.

Raae AJ, Kleppe RK, Kleppe K.

Eur J Biochem. 1975 Dec 15;60(2):437-43.

45.

Preparation and separation of d(pT)-10-n oligonucleotides.

Raae AJ, Lillehaug JR, Kleppe RK, Kleppe K.

Nucleic Acids Res. 1975 Mar;2(3):423-9.

46.

Influence of salt on transcription by T4 core RNA polymerase.

Kleppe RK.

FEBS Lett. 1975 Mar 1;51(1):237-41. No abstract available.

47.
48.

Studies on polynucleotides. XCVI. Repair replications of short synthetic DNA's as catalyzed by DNA polymerases.

Kleppe K, Ohtsuka E, Kleppe R, Molineux I, Khorana HG.

J Mol Biol. 1971 Mar 14;56(2):341-61. No abstract available.

PMID:
4927950
49.

Messenger RNA concentration and protein synthesis during T4 infection of Escherichia coli B.

Kleppe RK, Nygaard AP.

Biochim Biophys Acta. 1969 Sep 17;190(1):202-10. No abstract available.

PMID:
4898490

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