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Items: 48

1.

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation.

Provençal N, Arloth J, Cattaneo A, Anacker C, Cattane N, Wiechmann T, Röh S, Ködel M, Klengel T, Czamara D, Müller NS, Lahti J; PREDO team, Räikkönen K, Pariante CM, Binder EB.

Proc Natl Acad Sci U S A. 2019 Aug 9. pii: 201820842. doi: 10.1073/pnas.1820842116. [Epub ahead of print]

PMID:
31399550
2.

Correction: MicroRNA regulation of persistent stress-enhanced memory.

Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA.

Mol Psychiatry. 2019 Jun 28. doi: 10.1038/s41380-019-0452-y. [Epub ahead of print]

PMID:
31253953
3.

MicroRNA regulation of persistent stress-enhanced memory.

Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA.

Mol Psychiatry. 2019 May 29. doi: 10.1038/s41380-019-0432-2. [Epub ahead of print] Erratum in: Mol Psychiatry. 2019 Jun 28;:.

PMID:
31142820
4.

Sensitive Periods for the Effect of Childhood Adversity on DNA Methylation: Results From a Prospective, Longitudinal Study.

Dunn EC, Soare TW, Zhu Y, Simpkin AJ, Suderman MJ, Klengel T, Smith ADAC, Ressler KJ, Relton CL.

Biol Psychiatry. 2019 May 15;85(10):838-849. doi: 10.1016/j.biopsych.2018.12.023. Epub 2019 Jan 21. Erratum in: Biol Psychiatry. 2019 Jul 1;86(1):76.

PMID:
30905381
5.

A Potential Role for the Noncoding Transcriptome in Psychiatric Disorders.

Klengel T.

Harv Rev Psychiatry. 2018 Nov/Dec;26(6):364-373. doi: 10.1097/HRP.0000000000000206. Review.

PMID:
30407235
6.

Novel Bioinformatics Approach Identifies Transcriptional Profiles of Lineage-Specific Transposable Elements at Distinct Loci in the Human Dorsolateral Prefrontal Cortex.

Guffanti G, Bartlett A, Klengel T, Klengel C, Hunter R, Glinsky G, Macciardi F.

Mol Biol Evol. 2018 Oct 1;35(10):2435-2453. doi: 10.1093/molbev/msy143.

7.

An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells.

Kennedy EM, Goehring GN, Nichols MH, Robins C, Mehta D, Klengel T, Eskin E, Smith AK, Conneely KN.

BMC Genomics. 2018 Jun 19;19(1):476. doi: 10.1186/s12864-018-4842-3.

8.

Does sleep disruption mediate the effects of childhood maltreatment on brain structure?

Teicher MH, Ohashi K, Khan A, Hernandez Garcia LC, Klengel T, Anderson CM, Silveri MM.

Eur J Psychotraumatol. 2018 Mar 28;8(Suppl 7):1450594. doi: 10.1080/20008198.2018.1450594. eCollection 2017.

9.

Exposure to Violence Accelerates Epigenetic Aging in Children.

Jovanovic T, Vance LA, Cross D, Knight AK, Kilaru V, Michopoulos V, Klengel T, Smith AK.

Sci Rep. 2017 Aug 21;7(1):8962. doi: 10.1038/s41598-017-09235-9.

10.

Epigenetic Signatures of Cigarette Smoking.

Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W, Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J, Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L, DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL, Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger M, Deary IJ, Fornage M, Levy D, London SJ.

Circ Cardiovasc Genet. 2016 Oct;9(5):436-447. Epub 2016 Sep 20.

11.

LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family.

Guffanti G, Gaudi S, Klengel T, Fallon JH, Mangalam H, Madduri R, Rodriguez A, DeCrescenzo P, Glovienka E, Sobell J, Klengel C, Pato M, Ressler KJ, Pato C, Macciardi F.

Am J Med Genet B Neuropsychiatr Genet. 2016 Jun;171(4):534-45. doi: 10.1002/ajmg.b.32437. Epub 2016 Mar 16.

PMID:
26990047
12.

Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.

Wingo AP, Almli LM, Stevens JS, Klengel T, Uddin M, Li Y, Bustamante AC, Lori A, Koen N, Stein DJ, Smith AK, Aiello AE, Koenen KC, Wildman DE, Galea S, Bradley B, Binder EB, Jin P, Gibson G, Ressler KJ.

Nat Commun. 2016 Mar 3;7:10958. doi: 10.1038/ncomms10958. No abstract available.

13.

DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.

Wingo AP, Almli LM, Stevens JS, Klengel T, Uddin M, Li Y, Bustamante AC, Lori A, Koen N, Stein DJ, Smith AK, Aiello AE, Koenen KC, Wildman DE, Galea S, Bradley B, Binder EB, Jin P, Gibson G, Ressler KJ.

Nat Commun. 2015 Dec 3;6:10106. doi: 10.1038/ncomms10106. Erratum in: Nat Commun. 2016;7:10958. Stevens, Jennifer J [Corrected to Stevens, Jennifer S].

14.

The transcriptional landscape of age in human peripheral blood.

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, Wilson YA, Kobes S, Tukiainen T; NABEC/UKBEC Consortium, Ramos YF, Göring HH, Fornage M, Liu Y, Gharib SA, Stranger BE, De Jager PL, Aviv A, Levy D, Murabito JM, Munson PJ, Huan T, Hofman A, Uitterlinden AG, Rivadeneira F, van Rooij J, Stolk L, Broer L, Verbiest MM, Jhamai M, Arp P, Metspalu A, Tserel L, Milani L, Samani NJ, Peterson P, Kasela S, Codd V, Peters A, Ward-Caviness CK, Herder C, Waldenberger M, Roden M, Singmann P, Zeilinger S, Illig T, Homuth G, Grabe HJ, Völzke H, Steil L, Kocher T, Murray A, Melzer D, Yaghootkar H, Bandinelli S, Moses EK, Kent JW, Curran JE, Johnson MP, Williams-Blangero S, Westra HJ, McRae AF, Smith JA, Kardia SL, Hovatta I, Perola M, Ripatti S, Salomaa V, Henders AK, Martin NG, Smith AK, Mehta D, Binder EB, Nylocks KM, Kennedy EM, Klengel T, Ding J, Suchy-Dicey AM, Enquobahrie DA, Brody J, Rotter JI, Chen YD, Houwing-Duistermaat J, Kloppenburg M, Slagboom PE, Helmer Q, den Hollander W, Bean S, Raj T, Bakhshi N, Wang QP, Oyston LJ, Psaty BM, Tracy RP, Montgomery GW, Turner ST, Blangero J, Meulenbelt I, Ressler KJ, Yang J, Franke L, Kettunen J, Visscher PM, Neely GG, Korstanje R, Hanson RL, Prokisch H, Ferrucci L, Esko T, Teumer A, van Meurs JB, Johnson AD.

Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570.

15.

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.

Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB.

Biol Psychiatry. 2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12.

PMID:
26410355
16.

Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder.

Kaminsky Z, Wilcox HC, Eaton WW, Van Eck K, Kilaru V, Jovanovic T, Klengel T, Bradley B, Binder EB, Ressler KJ, Smith AK.

Transl Psychiatry. 2015 Aug 25;5:e627. doi: 10.1038/tp.2015.105.

17.

Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice.

Klengel T, Dias BG, Ressler KJ.

Neuropsychopharmacology. 2016 Jan;41(1):219-31. doi: 10.1038/npp.2015.249. Epub 2015 Aug 18. Review.

18.

Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala.

Sawamura T, Klengel T, Armario A, Jovanovic T, Norrholm SD, Ressler KJ, Andero R.

Neuropsychopharmacology. 2016 Feb;41(3):832-46. doi: 10.1038/npp.2015.210. Epub 2015 Jul 15.

19.

Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions.

Klengel T, Binder EB.

Neuron. 2015 Jun 17;86(6):1343-57. doi: 10.1016/j.neuron.2015.05.036. Review.

20.

Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders.

Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC.

Neuron. 2015 Jun 3;86(5):1189-202. doi: 10.1016/j.neuron.2015.05.034.

21.

RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response.

Hennings JM, Uhr M, Klengel T, Weber P, Pütz B, Touma C, Czamara D, Ising M, Holsboer F, Lucae S.

Transl Psychiatry. 2015 Mar 31;5:e538. doi: 10.1038/tp.2015.9.

22.

Epigenetic mechanisms underlying learning and the inheritance of learned behaviors.

Dias BG, Maddox S, Klengel T, Ressler KJ.

Trends Neurosci. 2015 Feb;38(2):96-107. doi: 10.1016/j.tins.2014.12.003. Epub 2014 Dec 24. Review.

23.

FKBP5 allele-specific epigenetic modification in gene by environment interaction.

Klengel T, Binder EB.

Neuropsychopharmacology. 2015 Jan;40(1):244-6. doi: 10.1038/npp.2014.208. Review. No abstract available.

24.

DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain.

Smith AK, Kilaru V, Klengel T, Mercer KB, Bradley B, Conneely KN, Ressler KJ, Binder EB.

Am J Med Genet B Neuropsychiatr Genet. 2015 Jan;168B(1):36-44. doi: 10.1002/ajmg.b.32278. Epub 2014 Oct 29.

25.

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

Sabbagh JJ, O'Leary JC 3rd, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA.

PLoS One. 2014 Sep 5;9(9):e107241. doi: 10.1371/journal.pone.0107241. eCollection 2014.

26.

Hypothalamic-pituitary-adrenocortical axis activity as a potential predictor for withdrawal symptoms in addiction to flupirtine, a nonopiate analgesic.

Hennings JM, Ising M, Klengel T, Knop M, Rosenhagen MC.

J Clin Psychopharmacol. 2014 Dec;34(6):e6-8. doi: 10.1097/JCP.0000000000000096. No abstract available.

PMID:
24633005
27.

Accounting for population stratification in DNA methylation studies.

Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, Klengel T, Mehta D, Binder EB, Epstein MP, Ressler KJ, Conneely KN.

Genet Epidemiol. 2014 Apr;38(3):231-41. doi: 10.1002/gepi.21789. Epub 2014 Jan 29.

28.

The role of DNA methylation in stress-related psychiatric disorders.

Klengel T, Pape J, Binder EB, Mehta D.

Neuropharmacology. 2014 May;80:115-32. doi: 10.1016/j.neuropharm.2014.01.013. Epub 2014 Jan 19. Review.

PMID:
24452011
29.

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC 3rd, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA.

J Clin Invest. 2013 Oct;123(10):4158-69. doi: 10.1172/JCI69003. Epub 2013 Sep 3.

30.

Possible associations of NTRK2 polymorphisms with antidepressant treatment outcome: findings from an extended tag SNP approach.

Hennings JM, Kohli MA, Czamara D, Giese M, Eckert A, Wolf C, Heck A, Domschke K, Arolt V, Baune BT, Horstmann S, Brückl T, Klengel T, Menke A, Müller-Myhsok B, Ising M, Uhr M, Lucae S.

PLoS One. 2013 Jun 4;8(6):e64947. doi: 10.1371/journal.pone.0064947. Print 2013.

31.

Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans.

Sun YV, Smith AK, Conneely KN, Chang Q, Li W, Lazarus A, Smith JA, Almli LM, Binder EB, Klengel T, Cross D, Turner ST, Ressler KJ, Kardia SL.

Hum Genet. 2013 Sep;132(9):1027-37. doi: 10.1007/s00439-013-1311-6. Epub 2013 May 9.

32.

Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder.

Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW, Rex-Haffner M, Loeschner A, Gonik M, Mercer KB, Bradley B, Müller-Myhsok B, Ressler KJ, Binder EB.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8302-7. doi: 10.1073/pnas.1217750110. Epub 2013 Apr 29.

33.

Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder.

Norrholm SD, Jovanovic T, Smith AK, Binder E, Klengel T, Conneely K, Mercer KB, Davis JS, Kerley K, Winkler J, Gillespie CF, Bradley B, Ressler KJ.

Front Behav Neurosci. 2013 Apr 10;7:30. doi: 10.3389/fnbeh.2013.00030. eCollection 2013.

34.

Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders?

Klengel T, Binder EB.

Epigenomics. 2013 Apr;5(2):109-12. doi: 10.2217/epi.13.11. No abstract available.

PMID:
23566086
35.

Gene-environment interactions in major depressive disorder.

Klengel T, Binder EB.

Can J Psychiatry. 2013 Feb;58(2):76-83. Review.

PMID:
23442893
36.

Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression.

Menke A, Klengel T, Rubel J, Brückl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder EB.

Genes Brain Behav. 2013 Apr;12(3):289-96. doi: 10.1111/gbb.12026. Epub 2013 Mar 7.

37.

Gene × environment interactions in the prediction of response to antidepressant treatment.

Klengel T, Binder EB.

Int J Neuropsychopharmacol. 2013 Apr;16(3):701-11. doi: 10.1017/S1461145712001459. Epub 2012 Dec 14. Review.

PMID:
23237009
38.

Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.

Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB.

Nat Neurosci. 2013 Jan;16(1):33-41. doi: 10.1038/nn.3275. Epub 2012 Dec 2.

39.

Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels.

Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, Uhr M, Dose T, Unschuld PG, Zihl J, Binder E, Müller-Myhsok B, Holsboer F, Lucae S.

Eur Neuropsychopharmacol. 2013 Jul;23(7):653-62. doi: 10.1016/j.euroneuro.2012.08.010. Epub 2012 Sep 29.

40.

Epigenetics, depression and antidepressant treatment.

Menke A, Klengel T, Binder EB.

Curr Pharm Des. 2012;18(36):5879-89. Review.

PMID:
22681167
41.

Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients.

Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB.

Neuropsychopharmacology. 2012 May;37(6):1455-64. doi: 10.1038/npp.2011.331. Epub 2012 Jan 11. Erratum in: Neuropsychopharmacology. 2012 Jul;37(8):1972.

42.

Peripheral blood gene expression: it all boils down to the RNA collection tubes.

Menke A, Rex-Haffner M, Klengel T, Binder EB, Mehta D.

BMC Res Notes. 2012 Jan 4;5:1. doi: 10.1186/1756-0500-5-1.

43.

Genome-wide association study of antidepressant treatment-emergent suicidal ideation.

Menke A, Domschke K, Czamara D, Klengel T, Hennings J, Lucae S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Binder EB.

Neuropsychopharmacology. 2012 Feb;37(3):797-807. doi: 10.1038/npp.2011.257. Epub 2011 Oct 26.

44.

Somatization in major depression--clinical features and genetic associations.

Klengel T, Heck A, Pfister H, Brückl T, Hennings JM, Menke A, Czamara D, Müller-Myhsok B, Ising M.

Acta Psychiatr Scand. 2011 Oct;124(4):317-28. doi: 10.1111/j.1600-0447.2011.01743.x. Epub 2011 Aug 13.

PMID:
21838737
45.

Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies.

Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB.

Arch Gen Psychiatry. 2011 Sep;68(9):901-10. doi: 10.1001/archgenpsychiatry.2011.50. Epub 2011 May 2.

46.

Using gene-environment interactions to target personalized treatment in mood disorder.

Klengel T, Binder EB.

Per Med. 2011 Jan;8(1):23-34. doi: 10.2217/pme.10.73.

PMID:
29768787
47.

Cryptococcus neoformans senses CO2 through the carbonic anhydrase Can2 and the adenylyl cyclase Cac1.

Mogensen EG, Janbon G, Chaloupka J, Steegborn C, Fu MS, Moyrand F, Klengel T, Pearson DS, Geeves MA, Buck J, Levin LR, Mühlschlegel FA.

Eukaryot Cell. 2006 Jan;5(1):103-11.

48.

Fungal adenylyl cyclase integrates CO2 sensing with cAMP signaling and virulence.

Klengel T, Liang WJ, Chaloupka J, Ruoff C, Schröppel K, Naglik JR, Eckert SE, Mogensen EG, Haynes K, Tuite MF, Levin LR, Buck J, Mühlschlegel FA.

Curr Biol. 2005 Nov 22;15(22):2021-6. Erratum in: Curr Biol. 2005 Dec 6;15(23):2177.

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