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Items: 1 to 50 of 423

1.

Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.

Green CA, Sande CJ, Scarselli E, Capone S, Vitelli A, Nicosia A, Silva-Reyes L, Thompson AJ, de Lara CM, Taylor KS, Haworth K, Hutchings CL, Cargill T, Angus B, Klenerman P, Pollard AJ.

J Infect. 2019 Feb 8. pii: S0163-4453(19)30038-6. doi: 10.1016/j.jinf.2019.02.003. [Epub ahead of print]

PMID:
30742894
2.

Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF dependent mechanism.

Bánki Z, Krabbendam L, Klaver D, Leng T, Kruis S, Mehta H, Müllauer B, Orth-Höller D, Stoiber H, Willberg CB, Klenerman P.

Immunol Cell Biol. 2019 Jan 29. doi: 10.1111/imcb.12239. [Epub ahead of print]

PMID:
30695101
3.

Validation of Multiplex Serology for human hepatitis viruses B and C, human T-lymphotropic virus 1 and Toxoplasma gondii.

Brenner N, Mentzer AJ, Butt J, Braband KL, Michel A, Jeffery K, Klenerman P, Gärtner B, Schnitzler P, Hill A, Taylor G, Demontis MA, Guy E, Hadfield SJ, Almond R, Allen N, Pawlita M, Waterboer T.

PLoS One. 2019 Jan 7;14(1):e0210407. doi: 10.1371/journal.pone.0210407. eCollection 2019.

4.

Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection.

Juno JA, Phetsouphanh C, Klenerman P, Kent SJ.

Curr Opin HIV AIDS. 2019 Mar;14(2):77-84. doi: 10.1097/COH.0000000000000526.

PMID:
30585802
5.

Correction: Synergistic activation of pro-inflammatory type-2 CD8 + T lymphocytes by lipid mediators in severe eosinophilic asthma.

Hilvering B, Hinks TSC, Stöger L, Marchi E, Salimi M, Shrimanker R, Liu W, Chen W, Luo J, Go S, Powell T, Cane J, Thulborn S, Kurioka A, Leng T, Matthews J, Connolly C, Borg C, Bafadhel M, Willberg CB, Ramasamy A, Djukanović R, Ogg G, Pavord ID, Klenerman P, Xue L.

Mucosal Immunol. 2019 Mar;12(2):581. doi: 10.1038/s41385-018-0121-5.

PMID:
30518781
6.

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H.

Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3.

PMID:
30510168
7.

MAIT cells contribute to protection against lethal influenza infection in vivo.

Wilgenburg BV, Loh L, Chen Z, Pediongco TJ, Wang H, Shi M, Zhao Z, Koutsakos M, Nüssing S, Sant S, Wang Z, D'Souza C, Jia X, Almeida CF, Kostenko L, Eckle SBG, Meehan BS, Kallies A, Godfrey DI, Reading PC, Corbett AJ, McCluskey J, Klenerman P, Kedzierska K, Hinks TSC.

Nat Commun. 2018 Nov 9;9(1):4706. doi: 10.1038/s41467-018-07207-9.

8.

Memory inflation following adenoviral vaccination depends on IL-21.

Gordon CL, Hutchings CL, Highton AJ, Colston JM, Provine NM, Klenerman P.

Vaccine. 2018 Nov 12;36(46):7011-7016. doi: 10.1016/j.vaccine.2018.09.061. Epub 2018 Sep 29.

9.

High MDR-1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR-1 substrates.

Fergusson JR, Ussher JE, Kurioka A, Klenerman P, Walker LJ.

Clin Exp Immunol. 2018 Nov;194(2):180-191. doi: 10.1111/cei.13165. Epub 2018 Sep 19.

10.

Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort.

Adland E, Jesuthasan G, Downs L, Wharton V, Wilde G, McNaughton AL, Collier J, Barnes E, Klenerman P, Andersson M, Jeffery K, Matthews PC.

BMC Infect Dis. 2018 Sep 14;18(1):461. doi: 10.1186/s12879-018-3367-3.

11.

Humoral and cellular immunity to RSV in infants, children and adults.

Green CA, Sande CJ, de Lara C, Thompson AJ, Silva-Reyes L, Napolitano F, Pierantoni A, Capone S, Vitelli A, Klenerman P, Pollard AJ.

Vaccine. 2018 Oct 1;36(41):6183-6190. doi: 10.1016/j.vaccine.2018.08.056. Epub 2018 Aug 31.

PMID:
30177258
12.

Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations.

Karamitros T, van Wilgenburg B, Wills M, Klenerman P, Magiorkinis G.

BMC Genomics. 2018 Aug 2;19(1):577. doi: 10.1186/s12864-018-4949-6.

13.

Hepatitis B Virus Adaptation to the CD8+ T Cell Response: Consequences for Host and Pathogen.

Lumley SF, McNaughton AL, Klenerman P, Lythgoe KA, Matthews PC.

Front Immunol. 2018 Jul 16;9:1561. doi: 10.3389/fimmu.2018.01561. eCollection 2018. Review.

14.

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells.

Garner LC, Klenerman P, Provine NM.

Front Immunol. 2018 Jun 28;9:1478. doi: 10.3389/fimmu.2018.01478. eCollection 2018. Review.

15.

Prolonged Evolution of Virus-Specific Memory T Cell Immunity after Severe Avian Influenza A (H7N9) Virus Infection.

Zhao M, Chen J, Tan S, Dong T, Jiang H, Zheng J, Quan C, Liao Q, Zhang H, Wang X, Wang Q, Bi Y, Liu F, Feng L, Horby PW, Klenerman P, Gao GF, Liu WJ, Yu H.

J Virol. 2018 Aug 16;92(17). pii: e01024-18. doi: 10.1128/JVI.01024-18. Print 2018 Sep 1.

PMID:
29925664
16.

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.

Hilvering B, Hinks TSC, Stöger L, Marchi E, Salimi M, Shrimanker R, Liu W, Chen W, Luo J, Go S, Powell T, Cane J, Thulborn S, Kurioka A, Leng T, Matthews J, Connolly C, Borg C, Bafadhel M, Willberg CB, Ramasamy A, Djukanović R, Ogg G, Pavord ID, Klenerman P, Xue L.

Mucosal Immunol. 2018 Sep;11(5):1408-1419. doi: 10.1038/s41385-018-0049-9. Epub 2018 Jun 15. Erratum in: Mucosal Immunol. 2018 Dec 5;:.

PMID:
29907870
17.

Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

Quaranta M, Wilson R, Gonçalves Serra E, Pandey S, Schwerd T, Gilmour K, Klenerman P, Powrie F, Keshav S, Travis SPL, Anderson CA, Uhlig HH.

Gastroenterology. 2018 Jul;155(1):231-234. doi: 10.1053/j.gastro.2018.03.069. Epub 2018 Jun 9. No abstract available.

PMID:
29894681
18.

MAIT cells: the end of the beginning?

Pellicci DG, Klenerman P.

Immunol Cell Biol. 2018 Jul;96(6):562-563. doi: 10.1111/imcb.12056. Epub 2018 Jun 2. No abstract available.

PMID:
29860721
19.

CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA.

Martin GE, Pace M, Thornhill JP, Phetsouphanh C, Meyerowitz J, Gossez M, Brown H, Olejniczak N, Lwanga J, Ramjee G, Kaleebu P, Porter K, Willberg CB, Klenerman P, Nwokolo N, Fox J, Fidler S, Frater J.

Front Immunol. 2018 May 4;9:928. doi: 10.3389/fimmu.2018.00928. eCollection 2018.

20.

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency.

Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TKH, Fui ACY, Hoong CW, Chan JKY, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SES, Tan HKK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DSW, Tan IB, Ginhoux F, Newell EW.

Immunity. 2018 May 15;48(5):1060. doi: 10.1016/j.immuni.2018.04.028. No abstract available.

PMID:
29768165
21.

Unique and Common Features of Innate-Like Human Vδ2+ γδT Cells and Mucosal-Associated Invariant T Cells.

Provine NM, Binder B, FitzPatrick MEB, Schuch A, Garner LC, Williamson KD, van Wilgenburg B, Thimme R, Klenerman P, Hofmann M.

Front Immunol. 2018 Apr 23;9:756. doi: 10.3389/fimmu.2018.00756. eCollection 2018.

22.

Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome.

Lucas M, Deshpande P, James I, Rauch A, Pfafferott K, Gaylard E, Merani S, Plauzolles A, Lucas A, McDonnell W, Kalams S, Pilkinton M, Chastain C, Barnett L, Prosser A, Mallal S, Fitzmaurice K, Drummer H, Ansari MA, Pedergnana V, Barnes E, John M, Kelleher D, Klenerman P, Gaudieri S.

Sci Rep. 2018 May 8;8(1):7224. doi: 10.1038/s41598-018-25559-6.

23.

Impact of Interferon-α Receptor-1 Promoter Polymorphisms on the Transcriptome of the Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Karamitros T, Papatheodoridis G, Paraskevis D, Hatzakis A, Mbisa JL, Georgopoulou U, Klenerman P, Magiorkinis G.

Front Immunol. 2018 Apr 16;9:777. doi: 10.3389/fimmu.2018.00777. eCollection 2018.

24.

CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells.

Kurioka A, Cosgrove C, Simoni Y, van Wilgenburg B, Geremia A, Björkander S, Sverremark-Ekström E, Thurnheer C, Günthard HF, Khanna N; Swiss HIV Cohort Study; Oxford IBD Cohort Investigators, Walker LJ, Arancibia-Cárcamo CV, Newell EW, Willberg CB, Klenerman P.

Front Immunol. 2018 Apr 9;9:486. doi: 10.3389/fimmu.2018.00486. eCollection 2018.

25.

Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines.

Gordon CL, Lee LN, Swadling L, Hutchings C, Zinser M, Highton AJ, Capone S, Folgori A, Barnes E, Klenerman P.

Cell Rep. 2018 Apr 17;23(3):768-782. doi: 10.1016/j.celrep.2018.03.074.

26.

The (gradual) rise of memory inflation.

Klenerman P.

Immunol Rev. 2018 May;283(1):99-112. doi: 10.1111/imr.12653. Review.

27.

Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis.

Jeffery HC, Braitch MK, Bagnall C, Hodson J, Jeffery LE, Wawman RE, Wong LL, Birtwistle J, Bartlett H, Lohse AW, Hirschfield GM, Dyson J, Jones D, Hubscher SG, Klenerman P, Adams DH, Oo YH.

Hepatol Commun. 2018 Feb 26;2(4):421-436. doi: 10.1002/hep4.1163. eCollection 2018 Apr.

28.

Killer T cells show their kinder side.

Klenerman P, Ogg G.

Nature. 2018 Mar 29;555(7698):594-595. doi: 10.1038/d41586-018-03510-z. No abstract available.

PMID:
29595806
29.

Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes.

Kurioka A, Klenerman P, Willberg CB.

Immunology. 2018 Mar 14. doi: 10.1111/imm.12925. [Epub ahead of print] Review.

30.

Impact of IFNL4 genotype on Interferon-stimulated Gene Expression during DAA therapy for Hepatitis C.

Ramamurthy N, Marchi E, Ansari MA, Pedergnana V, Mclean A, Hudson E; STOP HCV consortium, Bowden R, Spencer CCA, Barnes E, Klenerman P.

Hepatology. 2018 Mar 13. doi: 10.1002/hep.29877. [Epub ahead of print]

31.

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.

Panagioti E, Klenerman P, Lee LN, van der Burg SH, Arens R.

Front Immunol. 2018 Feb 16;9:276. doi: 10.3389/fimmu.2018.00276. eCollection 2018. Review.

32.

Oxford Screening CSF and Respiratory samples ('OSCAR'): results of a pilot study to screen clinical samples from a diagnostic microbiology laboratory for viruses using Illumina next generation sequencing.

Sharp C, Golubchik T, Gregory WF, McNaughton AL, Gow N, Selvaratnam M, Mirea A, Foster D, Andersson M, Klenerman P, Jeffery K, Matthews PC.

BMC Res Notes. 2018 Feb 9;11(1):120. doi: 10.1186/s13104-018-3234-8.

33.

Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation.

Zinser ME, Highton AJ, Kurioka A, Kronsteiner B, Hagel J, Leng T, Marchi E, Phetsouphanh C, Willberg CB, Dunachie SJ, Klenerman P.

Immunol Cell Biol. 2018 Jul;96(6):666-674. doi: 10.1111/imcb.12020. Epub 2018 Mar 9.

34.

MAIT cells and viruses.

Ussher JE, Willberg CB, Klenerman P.

Immunol Cell Biol. 2018 Jul;96(6):630-641. doi: 10.1111/imcb.12008. Epub 2018 Feb 10. Review.

35.

The immune system of the liver: 50 years of strangeness.

Lucas M, Kallies A, Klenerman P.

Clin Transl Immunology. 2017 Dec 8;6(12):e164. doi: 10.1038/cti.2017.53. eCollection 2017 Dec. No abstract available.

36.

Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order.

Lee LN, Bolinger B, Banki Z, de Lara C, Highton AJ, Colston JM, Hutchings C, Klenerman P.

PLoS Pathog. 2017 Dec 27;13(12):e1006782. doi: 10.1371/journal.ppat.1006782. eCollection 2017 Dec.

37.

Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.

Kurioka A, van Wilgenburg B, Javan RR, Hoyle R, van Tonder AJ, Harrold CL, Leng T, Howson LJ, Shepherd D, Cerundolo V, Brueggemann AB, Klenerman P.

J Infect Dis. 2018 Mar 5;217(6):988-999. doi: 10.1093/infdis/jix647.

38.

The Human Cell Atlas.

Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, Enard W, Farmer A, Fugger L, Göttgens B, Hacohen N, Haniffa M, Hemberg M, Kim S, Klenerman P, Kriegstein A, Lein E, Linnarsson S, Lundberg E, Lundeberg J, Majumder P, Marioni JC, Merad M, Mhlanga M, Nawijn M, Netea M, Nolan G, Pe'er D, Phillipakis A, Ponting CP, Quake S, Reik W, Rozenblatt-Rosen O, Sanes J, Satija R, Schumacher TN, Shalek A, Shapiro E, Sharma P, Shin JW, Stegle O, Stratton M, Stubbington MJT, Theis FJ, Uhlen M, van Oudenaarden A, Wagner A, Watt F, Weissman J, Wold B, Xavier R, Yosef N; Human Cell Atlas Meeting Participants.

Elife. 2017 Dec 5;6. pii: e27041. doi: 10.7554/eLife.27041.

39.

The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes.

von Delft A, Donnison TA, Lourenço J, Hutchings C, Mullarkey CE, Brown A, Pybus OG, Klenerman P, Chinnakannan S, Barnes E.

Vaccine. 2018 Jan 4;36(2):313-321. doi: 10.1016/j.vaccine.2017.10.079. Epub 2017 Dec 2.

40.

Cytometric Gating Stringency Impacts Studies of Type 2 Innate Lymphoid Cells in Asthma.

Hinks TSC, Batty P, Klenerman P, Pavord ID, Xue L.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):745-747. doi: 10.1165/rcmb.2017-0201LE. No abstract available.

41.

Mucosa-associated invariant T cells link intestinal immunity with antibacterial immune defects in alcoholic liver disease.

Riva A, Patel V, Kurioka A, Jeffery HC, Wright G, Tarff S, Shawcross D, Ryan JM, Evans A, Azarian S, Bajaj JS, Fagan A, Patel V, Mehta K, Lopez C, Simonova M, Katzarov K, Hadzhiolova T, Pavlova S, Wendon JA, Oo YH, Klenerman P, Williams R, Chokshi S.

Gut. 2018 May;67(5):918-930. doi: 10.1136/gutjnl-2017-314458. Epub 2017 Nov 2.

42.

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

Leitman EM, Palmer CD, Buus S, Chen F, Riddell L, Sims S, Klenerman P, Sáez-Cirión A, Walker BD, Hess PR, Altfeld M, Matthews PC, Goulder PJR.

PLoS One. 2017 Oct 11;12(10):e0184496. doi: 10.1371/journal.pone.0184496. eCollection 2017.

43.

Cytomegalovirus (CMV) Epitope-Specific CD4+ T Cells Are Inflated in HIV+ CMV+ Subjects.

Abana CO, Pilkinton MA, Gaudieri S, Chopra A, McDonnell WJ, Wanjalla C, Barnett L, Gangula R, Hager C, Jung DK, Engelhardt BG, Jagasia MH, Klenerman P, Phillips EJ, Koelle DM, Kalams SA, Mallal SA.

J Immunol. 2017 Nov 1;199(9):3187-3201. doi: 10.4049/jimmunol.1700851. Epub 2017 Oct 2.

44.

Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state.

Afik S, Yates KB, Bi K, Darko S, Godec J, Gerdemann U, Swadling L, Douek DC, Klenerman P, Barnes EJ, Sharpe AH, Haining WN, Yosef N.

Nucleic Acids Res. 2017 Sep 19;45(16):e148. doi: 10.1093/nar/gkx615.

45.

Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets.

Kurioka A, Jahun AS, Hannaway RF, Walker LJ, Fergusson JR, Sverremark-Ekström E, Corbett AJ, Ussher JE, Willberg CB, Klenerman P.

Front Immunol. 2017 Aug 30;8:1031. doi: 10.3389/fimmu.2017.01031. eCollection 2017.

46.

Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing.

van der Ree MH, Stelma F, Willemse SB, Brown A, Swadling L, van der Valk M, Sinnige MJ, van Nuenen AC, de Vree JML, Klenerman P, Barnes E, Kootstra NA, Reesink HW.

Antiviral Res. 2017 Oct;146:139-145. doi: 10.1016/j.antiviral.2017.08.016. Epub 2017 Aug 24.

47.

The impact of immunoglobulin in acute HIV infection on the HIV reservoir: a randomized controlled trial.

Tiraboschi J, Ray S, Patel K, Teague A, Pace M, Phalora P, Robinson N, Hopkins E, Meyerowitz J, Wang Y, Cason J, Kaye S, Sanderson J, Klenerman P, Fidler S, Frater J, Fox J.

HIV Med. 2017 Nov;18(10):777-781. doi: 10.1111/hiv.12524. Epub 2017 Jul 18.

PMID:
28719012
48.

Immunology taught by rats.

Klenerman P, Barnes EJ.

Science. 2017 Jul 14;357(6347):129-130. doi: 10.1126/science.aao0184. No abstract available.

PMID:
28706025
49.

PARV4 prevalence, phylogeny, immunology and coinfection with HIV, HBV and HCV in a multicentre African cohort.

Sharp CP, Gregory WF, Hattingh L, Malik A, Adland E, Daniels S, van Zyl A, Carlson JM, Wareing S, Ogwu A, Shapiro R, Riddell L, Chen F, Ndung'u T, Goulder PJR, Klenerman P, Simmonds P, Jooste P, Matthews PC.

Wellcome Open Res. 2017 Apr 7;2:26. doi: 10.12688/wellcomeopenres.11135.1.

50.

Expression of lectin-like transcript-1 in human tissues.

Llibre A, Garner L, Partridge A, Freeman GJ, Klenerman P, Willberg CB.

F1000Res. 2016 Dec 29;5:2929. doi: 10.12688/f1000research.10009.1. eCollection 2016.

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