Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 195

1.

N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of their Oligomers by the Proteasome Holoenzyme.

Ye Y, Klenerman D, Finley D.

J Mol Biol. 2019 Sep 10. pii: S0022-2836(19)30545-5. doi: 10.1016/j.jmb.2019.08.021. [Epub ahead of print]

2.

Imaging rRNA Methylation in Bacteria by MR-FISH.

Ganzinger KA, Challand MR, Spencer J, Klenerman D, Ranasinghe RT.

Methods Mol Biol. 2019;2038:89-107. doi: 10.1007/978-1-4939-9674-2_7.

PMID:
31407280
3.

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D.

Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4.

4.

A cell topography-based mechanism for ligand discrimination by the T cell receptor.

Fernandes RA, Ganzinger KA, Tzou JC, Jönsson P, Lee SF, Palayret M, Santos AM, Carr AR, Ponjavic A, Chang VT, Macleod C, Lagerholm BC, Lindsay AE, Dushek O, Tilevik A, Davis SJ, Klenerman D.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14002-14010. doi: 10.1073/pnas.1817255116. Epub 2019 Jun 20.

5.

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.

Sang JC, Lee JE, Dear AJ, De S, Meisl G, Thackray AM, Bujdoso R, Knowles TPJ, Klenerman D.

Chem Sci. 2019 Mar 25;10(17):4588-4597. doi: 10.1039/c8sc05627g. eCollection 2019 May 7.

6.

Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever.

Ponjavic A, Ye Y, Laue E, Lee SF, Klenerman D.

Biomed Opt Express. 2018 Nov 2;9(12):5863-5880. doi: 10.1364/BOE.9.005863. eCollection 2018 Dec 1.

7.

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.

Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P.

Sci Adv. 2019 Apr 17;5(4):eaau3112. doi: 10.1126/sciadv.aau3112. eCollection 2019 Apr.

8.

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D.

Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3.

9.

Citrullination of HP1γ chromodomain affects association with chromatin.

Wiese M, Bannister AJ, Basu S, Boucher W, Wohlfahrt K, Christophorou MA, Nielsen ML, Klenerman D, Laue ED, Kouzarides T.

Epigenetics Chromatin. 2019 Apr 2;12(1):21. doi: 10.1186/s13072-019-0265-x.

10.

Spectrally Resolved Photodynamics of Individual Emitters in Large-Area Monolayers of Hexagonal Boron Nitride.

Stern HL, Wang R, Fan Y, Mizuta R, Stewart JC, Needham LM, Roberts TD, Wai R, Ginsberg NS, Klenerman D, Hofmann S, Lee SF.

ACS Nano. 2019 Apr 23;13(4):4538-4547. doi: 10.1021/acsnano.9b00274. Epub 2019 Mar 20.

PMID:
30865421
11.

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S.

ACS Chem Neurosci. 2019 May 15;10(5):2374-2384. doi: 10.1021/acschemneuro.8b00676. Epub 2019 Mar 8.

PMID:
30793584
12.

Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme.

Cliffe R, Sang JC, Kundel F, Finley D, Klenerman D, Ye Y.

Cell Rep. 2019 Feb 19;26(8):2140-2149.e3. doi: 10.1016/j.celrep.2019.01.096.

13.

Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease.

De S, Klenerman D.

Biochim Biophys Acta Proteins Proteom. 2019 Oct;1867(10):870-878. doi: 10.1016/j.bbapap.2018.12.010. Epub 2019 Jan 3. Review.

14.

Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.

Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D.

Nano Lett. 2018 Dec 12;18(12):7494-7501. doi: 10.1021/acs.nanolett.8b02916. Epub 2018 Nov 7.

15.

Quantifying Co-Oligomer Formation by α-Synuclein.

Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D.

ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29.

16.

Direct Observation of Murine Prion Protein Replication in Vitro.

Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D.

J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23.

17.

Correction to: Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.

Hughes CD, Choi ML, Ryten M, Hopkins L, Drews A, Botía JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D.

Acta Neuropathol. 2019 Jan;137(1):121. doi: 10.1007/s00401-018-1919-7.

PMID:
30328509
18.

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.

Hughes CD, Choi ML, Ryten M, Hopkins L, Drews A, Botía JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D.

Acta Neuropathol. 2019 Jan;137(1):103-120. doi: 10.1007/s00401-018-1907-y. Epub 2018 Sep 17. Erratum in: Acta Neuropathol. 2018 Oct 17;:.

19.

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D.

Anal Chem. 2018 Sep 4;90(17):10385-10393. doi: 10.1021/acs.analchem.8b02226. Epub 2018 Aug 13.

20.

Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.

Whiten DR, Zuo Y, Calo L, Choi ML, De S, Flagmeier P, Wirthensohn DC, Kundel F, Ranasinghe RT, Sanchez SE, Athauda D, Lee SF, Dobson CM, Gandhi S, Spillantini MG, Klenerman D, Horrocks MH.

Chembiochem. 2018 Oct 4;19(19):2033-2038. doi: 10.1002/cbic.201800209. Epub 2018 Sep 11.

21.

FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells.

Basu S, Needham LM, Lando D, Taylor EJR, Wohlfahrt KJ, Shah D, Boucher W, Tan YL, Bates LE, Tkachenko O, Cramard J, Lagerholm BC, Eggeling C, Hendrich B, Klenerman D, Lee SF, Laue ED.

Nat Commun. 2018 Jun 28;9(1):2520. doi: 10.1038/s41467-018-04486-0.

22.

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

Kjaergaard M, Dear AJ, Kundel F, Qamar S, Meisl G, Knowles TPJ, Klenerman D.

ACS Chem Neurosci. 2018 Dec 19;9(12):3060-3071. doi: 10.1021/acschemneuro.8b00250. Epub 2018 Jul 17.

23.

Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers.

Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Ecroyd H, Dobson CM, Klenerman D, Wilson MR.

Cell Rep. 2018 Jun 19;23(12):3492-3500. doi: 10.1016/j.celrep.2018.05.074.

24.

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.

Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S.

Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2.

25.

Single-Molecule Light-Sheet Imaging of Suspended T Cells.

Ponjavic A, McColl J, Carr AR, Santos AM, Kulenkampff K, Lippert A, Davis SJ, Klenerman D, Lee SF.

Biophys J. 2018 May 8;114(9):2200-2211. doi: 10.1016/j.bpj.2018.02.044.

26.

Weighing one protein with light.

Lee SF, Klenerman D.

Science. 2018 Apr 27;360(6387):378-379. doi: 10.1126/science.aat5851. No abstract available.

PMID:
29700252
27.

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.

Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, Kaminski Schierle GS, Kaminski CF, Holt CE, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P.

Cell. 2018 Apr 19;173(3):720-734.e15. doi: 10.1016/j.cell.2018.03.056.

28.

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.

Lando D, Basu S, Stevens TJ, Riddell A, Wohlfahrt KJ, Cao Y, Boucher W, Leeb M, Atkinson LP, Lee SF, Hendrich B, Klenerman D, Laue ED.

Nat Protoc. 2018 May;13(5):1034-1061. doi: 10.1038/nprot.2018.017. Epub 2018 Apr 19.

PMID:
29674753
29.

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.

30.

Capturing resting T cells: the perils of PLL.

Santos AM, Ponjavic A, Fritzsche M, Fernandes RA, de la Serna JB, Wilcock MJ, Schneider F, Urbančič I, McColl J, Anzilotti C, Ganzinger KA, Aßmann M, Depoil D, Cornall RJ, Dustin ML, Klenerman D, Davis SJ, Eggeling C, Lee SF.

Nat Immunol. 2018 Mar;19(3):203-205. doi: 10.1038/s41590-018-0048-8. Epub 2018 Feb 23. No abstract available.

PMID:
29476188
31.

Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates.

Kundel F, Tosatto L, Whiten DR, Wirthensohn DC, Horrocks MH, Klenerman D.

FEBS J. 2018 Oct;285(19):3604-3630. doi: 10.1111/febs.14409. Epub 2018 Mar 4. Review.

32.

Detecting RNA base methylations in single cells by in situ hybridization.

Ranasinghe RT, Challand MR, Ganzinger KA, Lewis BW, Softley C, Schmied WH, Horrocks MH, Shivji N, Chin JW, Spencer J, Klenerman D.

Nat Commun. 2018 Feb 13;9(1):655. doi: 10.1038/s41467-017-02714-7.

33.

The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.

Cox D, Whiten DR, Brown JWP, Horrocks MH, San Gil R, Dobson CM, Klenerman D, van Oijen AM, Ecroyd H.

J Biol Chem. 2018 Mar 23;293(12):4486-4497. doi: 10.1074/jbc.M117.813865. Epub 2018 Jan 30.

34.

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub.

Latty SL, Sakai J, Hopkins L, Verstak B, Paramo T, Berglund NA, Cammarota E, Cicuta P, Gay NJ, Bond PJ, Klenerman D, Bryant CE.

Elife. 2018 Jan 24;7. pii: e31377. doi: 10.7554/eLife.31377.

35.

Optical Structural Analysis of Individual α-Synuclein Oligomers.

Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee SF.

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4886-4890. doi: 10.1002/anie.201710779. Epub 2018 Mar 23.

36.

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.

Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D.

ACS Chem Biol. 2018 Mar 16;13(3):636-646. doi: 10.1021/acschembio.7b01039. Epub 2018 Jan 17.

37.

Inhibiting the Ca2+ Influx Induced by Human CSF.

Drews A, De S, Flagmeier P, Wirthensohn DC, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, Gandhi S, Klenerman D.

Cell Rep. 2017 Dec 12;21(11):3310-3316. doi: 10.1016/j.celrep.2017.11.057.

38.

Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations.

Felce JH, Davis SJ, Klenerman D.

Trends Pharmacol Sci. 2018 Feb;39(2):96-108. doi: 10.1016/j.tips.2017.10.005. Epub 2017 Nov 6. Review.

PMID:
29122289
39.

Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.

40.

Nanopore extended field-effect transistor for selective single-molecule biosensing.

Ren R, Zhang Y, Nadappuram BP, Akpinar B, Klenerman D, Ivanov AP, Edel JB, Korchev Y.

Nat Commun. 2017 Sep 19;8(1):586. doi: 10.1038/s41467-017-00549-w.

41.

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.

Felce JH, Latty SL, Knox RG, Mattick SR, Lui Y, Lee SF, Klenerman D, Davis SJ.

Cell Rep. 2017 Sep 12;20(11):2654-2665. doi: 10.1016/j.celrep.2017.08.072.

42.

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D.

BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6.

43.

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.

Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D.

Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7750-7754. doi: 10.1002/anie.201700966. Epub 2017 May 5.

44.

Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function.

Carr AR, Ponjavic A, Basu S, McColl J, Santos AM, Davis S, Laue ED, Klenerman D, Lee SF.

Biophys J. 2017 Apr 11;112(7):1444-1454. doi: 10.1016/j.bpj.2017.02.023.

45.

3D structures of individual mammalian genomes studied by single-cell Hi-C.

Stevens TJ, Lando D, Basu S, Atkinson LP, Cao Y, Lee SF, Leeb M, Wohlfahrt KJ, Boucher W, O'Shaughnessy-Kirwan A, Cramard J, Faure AJ, Ralser M, Blanco E, Morey L, Sansó M, Palayret MGS, Lehner B, Di Croce L, Wutz A, Hendrich B, Klenerman D, Laue ED.

Nature. 2017 Apr 6;544(7648):59-64. doi: 10.1038/nature21429. Epub 2017 Mar 13.

46.

Monitoring Ca2+ elevations in individual astrocytes upon local release of amyloid beta in acute brain slices.

Tyurikova O, Zheng K, Rings A, Drews A, Klenerman D, Rusakov DA.

Brain Res Bull. 2018 Jan;136:85-90. doi: 10.1016/j.brainresbull.2016.12.007. Epub 2016 Dec 21.

47.

Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.

Bongiovanni MN, Godet J, Horrocks MH, Tosatto L, Carr AR, Wirthensohn DC, Ranasinghe RT, Lee JE, Ponjavic A, Fritz JV, Dobson CM, Klenerman D, Lee SF.

Nat Commun. 2016 Dec 8;7:13544. doi: 10.1038/ncomms13544.

48.

Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein.

Iljina M, Tosatto L, Choi ML, Sang JC, Ye Y, Hughes CD, Bryant CE, Gandhi S, Klenerman D.

Sci Rep. 2016 Sep 27;6:33928. doi: 10.1038/srep33928.

49.

Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness.

Clarke RW, Novak P, Zhukov A, Tyler EJ, Cano-Jaimez M, Drews A, Richards O, Volynski K, Bishop C, Klenerman D.

Soft Matter. 2016 Oct 14;12(38):7953-8. doi: 10.1039/c6sm01106c. Epub 2016 Sep 5.

50.

A microfluidic platform for trapping, releasing and super-resolution imaging of single cells.

Zhou Y, Basu S, Wohlfahrt KJ, Lee SF, Klenerman D, Laue ED, Seshia AA.

Sens Actuators B Chem. 2016 Sep;232:680-691.

Supplemental Content

Loading ...
Support Center