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Items: 1 to 50 of 107

1.

Anti-OspA DNA-Encoded Monoclonal Antibody Prevents Transmission of Spirochetes in Tick Challenge Providing Sterilizing Immunity in Mice.

Wang Y, Esquivel R, Flingai S, Schiller ZA, Kern A, Agarwal S, Chu J, Patel A, Sullivan K, Wise MC, Broderick KE, Hu L, Weiner DB, Klempner MS.

J Infect Dis. 2019 Mar 15;219(7):1146-1150. doi: 10.1093/infdis/jiy627.

PMID:
30476132
2.

Correction for Giuntini et al., "Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection".

Giuntini S, Stoppato M, Sedic M, Ejemel M, Pondish JR, Wisheart D, Schiller ZA, Thomas WD Jr, Barry EM, Cavacini LA, Klempner MS, Wang Y.

Infect Immun. 2018 Nov 20;86(12). pii: e00713-18. doi: 10.1128/IAI.00713-18. Print 2018 Dec. No abstract available.

3.

Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis against Enterotoxigenic Escherichia coli Infection.

Giuntini S, Stoppato M, Sedic M, Ejemel M, Pondish JR, Wisheart D, Schiller ZA, Thomas WD Jr, Barry EM, Cavacini LA, Klempner MS, Wang Y.

Infect Immun. 2018 Jul 23;86(8). pii: e00355-18. doi: 10.1128/IAI.00355-18. Print 2018 Aug. Erratum in: Infect Immun. 2018 Nov 20;86(12):.

4.

Structural and molecular analysis of a protective epitope of Lyme disease antigen OspA and antibody interactions.

Shandilya S, Kurt Yilmaz N, Sadowski A, Monir E, Schiller ZA, Thomas WD Jr, Klempner MS, Schiffer CA, Wang Y.

J Mol Recognit. 2017 May;30(5). doi: 10.1002/jmr.2595. Epub 2016 Nov 16.

5.

Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes.

Wang Y, Kern A, Boatright NK, Schiller ZA, Sadowski A, Ejemel M, Souders CA, Reimann KA, Hu L, Thomas WD Jr, Klempner MS.

J Infect Dis. 2016 Jul 15;214(2):205-11. doi: 10.1093/infdis/jiw151. Epub 2016 Apr 18.

6.

Association of immune response to endothelial cell growth factor with early disseminated and late manifestations of Lyme disease but not posttreatment Lyme disease syndrome.

Tang KS, Klempner MS, Wormser GP, Marques AR, Alaedini A.

Clin Infect Dis. 2015 Dec 1;61(11):1703-6. doi: 10.1093/cid/civ638. Epub 2015 Jul 28.

7.

A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life.

Souders CA, Nelson SC, Wang Y, Crowley AR, Klempner MS, Thomas W Jr.

MAbs. 2015;7(5):912-21. doi: 10.1080/19420862.2015.1054585.

8.

The reply.

Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, Halperin JJ, Wormser GP.

Am J Med. 2014 Feb;127(2):e11-2. doi: 10.1016/j.amjmed.2013.09.029. Epub 2013 Oct 15. No abstract available.

PMID:
24462014
9.

Reply to Blair et al.: Dose-dependent effects and oxidative stress responses in antibiotic tolerance in Salmonella typhimurium.

Vega NM, Allison KR, Samuels AN, Klempner MS, Collins JJ.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4570. No abstract available.

10.

Salmonella typhimurium intercepts Escherichia coli signaling to enhance antibiotic tolerance.

Vega NM, Allison KR, Samuels AN, Klempner MS, Collins JJ.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14420-5. doi: 10.1073/pnas.1308085110. Epub 2013 Aug 14.

11.

Treatment trials for post-Lyme disease symptoms revisited.

Klempner MS, Baker PJ, Shapiro ED, Marques A, Dattwyler RJ, Halperin JJ, Wormser GP.

Am J Med. 2013 Aug;126(8):665-9. doi: 10.1016/j.amjmed.2013.02.014. Epub 2013 Jun 10. Review.

12.

Lyme borreliosis: the challenge of accuracy.

Klempner MS, Halperin JJ, Baker PJ, Shapiro ED, O'Connell S, Fingerle V, Wormser GP.

Neth J Med. 2012 Jan;70(1):3-5. No abstract available.

13.

Case records of the Massachusetts General Hospital. Case 25-2010. A 24-year-old woman with abdominal pain and shock.

Klempner MS, Talbot EA, Lee SI, Zaki S, Ferraro MJ.

N Engl J Med. 2010 Aug 19;363(8):766-77. doi: 10.1056/NEJMcpc1003887. No abstract available.

PMID:
20818879
14.

Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms.

Chandra A, Wormser GP, Klempner MS, Trevino RP, Crow MK, Latov N, Alaedini A.

Brain Behav Immun. 2010 Aug;24(6):1018-24. doi: 10.1016/j.bbi.2010.03.002. Epub 2010 Mar 18.

15.

A critical appraisal of "chronic Lyme disease".

Feder HM Jr, Johnson BJ, O'Connell S, Shapiro ED, Steere AC, Wormser GP; Ad Hoc International Lyme Disease Group, Agger WA, Artsob H, Auwaerter P, Dumler JS, Bakken JS, Bockenstedt LK, Green J, Dattwyler RJ, Munoz J, Nadelman RB, Schwartz I, Draper T, McSweegan E, Halperin JJ, Klempner MS, Krause PJ, Mead P, Morshed M, Porwancher R, Radolf JD, Smith RP Jr, Sood S, Weinstein A, Wong SJ, Zemel L.

N Engl J Med. 2007 Oct 4;357(14):1422-30. Review. No abstract available. Erratum in: N Engl J Med. 2008 Mar 6;358(10):1084. Agger, WA [added]; Artsob, H [added]; Auwaerter, P [added]; Dumler, JS [added]; Bakken, JS [added]; Bockenstedt, LK [added]; Green, J [added]; Dattwyler, RJ [added]; Munoz, J [added]; Nadelman, RB [added]; Schwartz, I [added]; Draper, T [added]; McSweegan,.

PMID:
17914043
16.

Taking a bite out of vector-transmitted infectious diseases.

Klempner MS, Unnasch TR, Hu LT.

N Engl J Med. 2007 Jun 21;356(25):2567-9. No abstract available.

17.

Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.

Zhao Z, McCloud B, Fleming R, Klempner MS.

Biochem Biophys Res Commun. 2007 Jun 29;358(2):528-33. Epub 2007 May 2.

PMID:
17485071
18.
19.

The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America.

Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB.

Clin Infect Dis. 2006 Nov 1;43(9):1089-134. Epub 2006 Oct 2. Erratum in: Clin Infect Dis. 2007 Oct 1;45(7):941.

PMID:
17029130
20.

Characterization of the surface enhanced raman scattering (SERS) of bacteria.

Premasiri WR, Moir DT, Klempner MS, Krieger N, Jones G 2nd, Ziegler LD.

J Phys Chem B. 2005 Jan 13;109(1):312-20.

PMID:
16851017
21.

A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease.

Klempner MS, Wormser GH, Wade K, Trevino RP, Tang J, Kaslow RA, Schmid C.

J Infect Dis. 2005 Sep 15;192(6):1010-3. Epub 2005 Aug 4.

PMID:
16107953
22.

Disaster, water, cholera, vaccines, and hope.

Drazen JM, Klempner MS.

N Engl J Med. 2005 Feb 24;352(8):827. No abstract available.

PMID:
15728816
23.

Pre-treatment and post-treatment assessment of the C(6) test in patients with persistent symptoms and a history of Lyme borreliosis.

Fleming RV, Marques AR, Klempner MS, Schmid CH, Dally LG, Martin DS, Philipp MT.

Eur J Clin Microbiol Infect Dis. 2004 Aug;23(8):615-8. Epub 2004 Jul 8.

PMID:
15243815
24.

Crossing the species barrier--one small step to man, one giant leap to mankind.

Klempner MS, Shapiro DS.

N Engl J Med. 2004 Mar 18;350(12):1171-2. Epub 2004 Feb 25. No abstract available.

25.
26.

Selective up-regulation of matrix metalloproteinase-9 expression in human erythema migrans skin lesions of acute lyme disease.

Zhao Z, Chang H, Trevino RP, Whren K, Bhawan J, Klempner MS.

J Infect Dis. 2003 Oct 15;188(8):1098-104. Epub 2003 Oct 6.

PMID:
14551878
27.

Cognitive function in post-treatment Lyme disease: do additional antibiotics help?

Kaplan RF, Trevino RP, Johnson GM, Levy L, Dornbush R, Hu LT, Evans J, Weinstein A, Schmid CH, Klempner MS.

Neurology. 2003 Jun 24;60(12):1916-22.

PMID:
12821733
28.

Controlled trials of antibiotic treatment in patients with post-treatment chronic Lyme disease.

Klempner MS.

Vector Borne Zoonotic Dis. 2002 Winter;2(4):255-63. Review.

PMID:
12804167
29.

Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease.

Klempner MS, Hu LT, Evans J, Schmid CH, Johnson GM, Trevino RP, Norton D, Levy L, Wall D, McCall J, Kosinski M, Weinstein A.

N Engl J Med. 2001 Jul 12;345(2):85-92.

30.

Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment.

Lin B, Kidder JM, Noring R, Steere AC, Klempner MS, Hu LT.

J Infect Dis. 2001 Jul 15;184(2):174-80. Epub 2001 Jun 25.

PMID:
11424014
31.
32.

Update on the prevention, diagnosis, and treatment of Lyme disease.

Hu LT, Klempner MS.

Adv Intern Med. 2001;46:247-75. Review.

PMID:
11270961
33.

Intralaboratory reliability of serologic and urine testing for Lyme disease.

Klempner MS, Schmid CH, Hu L, Steere AC, Johnson G, McCloud B, Noring R, Weinstein A.

Am J Med. 2001 Feb 15;110(3):217-9. No abstract available.

PMID:
11182109
34.

Soluble CD14 levels in the serum, synovial fluid, and cerebrospinal fluid of patients with various stages of Lyme disease.

Lin B, Noring R, Steere AC, Klempner MS, Hu LT.

J Infect Dis. 2000 Mar;181(3):1185-8.

PMID:
10720552
35.

Borrelia burgdorferi induces matrix metalloproteinases by neural cultures.

Perides G, Tanner-Brown LM, Eskildsen MA, Klempner MS.

J Neurosci Res. 1999 Dec 15;58(6):779-90.

PMID:
10583909
36.

Is it thee or me?--autoimmunity in Lyme disease.

Klempner MS, Huber BT.

Nat Med. 1999 Dec;5(12):1346-7. No abstract available.

PMID:
10581067
37.

Beyond us versus them.

Klempner MS.

J Gen Intern Med. 1999 Aug;14(8):514-5. No abstract available.

38.

Recombinant human interleukin-11 does not affect functions of purified human neutrophils in vitro.

Bozza M, Kyvelos D, Trepicchio WL, Collins M, Klempner MS, Dorner AJ.

J Interferon Cytokine Res. 1998 Oct;18(10):889-95.

PMID:
9809625
39.

A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Consortium.

Sigal LH, Zahradnik JM, Lavin P, Patella SJ, Bryant G, Haselby R, Hilton E, Kunkel M, Adler-Klein D, Doherty T, Evans J, Molloy PJ, Seidner AL, Sabetta JR, Simon HJ, Klempner MS, Mays J, Marks D, Malawista SE.

N Engl J Med. 1998 Jul 23;339(4):216-22. Erratum in: N Engl J Med 1998 Aug 20;339(8):571.

40.

Fellowship training in infectious diseases: a report from the regional and national meetings of infectious diseases division chiefs and program directors.

Joiner KA, Powderly WG, Blaser MJ, Klempner MS, Locksley RM, Mandell GL, Preheim LC, Remington JS, Slama TG, Steigbigel NH, Bartlett JG.

Clin Infect Dis. 1998 May;26(5):1060-5.

PMID:
9597224
41.
42.

Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis.

Perides G, Charness ME, Tanner LM, P├ęter O, Satz N, Steere AC, Klempner MS.

J Infect Dis. 1998 Feb;177(2):401-8.

PMID:
9466528
43.

Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi.

Hu LT, Pratt SD, Perides G, Katz L, Rogers RA, Klempner MS.

Infect Immun. 1997 Dec;65(12):4989-95.

44.

Host-pathogen interactions in the immunopathogenesis of Lyme disease.

Hu LT, Klempner MS.

J Clin Immunol. 1997 Sep;17(5):354-65. Review.

PMID:
9327334
45.

Detection of a 130-kD matrix metalloproteinase in cerebrospinal fluid from a patient with Lyme neuroborreliosis.

Hu LT, Perides G, Tanner LM, Klempner MS.

Clin Infect Dis. 1997 Jun;24(6):1276-7. No abstract available.

PMID:
9195108
46.

Phase I trial of interleukin 2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera.

Trehu EG, Mier JW, Dubois JS, Sorce D, Klempner MS, Epstein M, Dinarello CA, Shapiro L, Kappler K, Ronayne L, Atkins MB.

Clin Cancer Res. 1996 Aug;2(8):1341-51.

47.

Binding of human urokinase type plasminogen activator and plasminogen to Borrelia species.

Klempner MS, Noring R, Epstein MP, McCloud B, Rogers RA.

J Infect Dis. 1996 Jul;174(1):97-104.

PMID:
8656020
48.

Babesiosis in patients with AIDS: a chronic infection presenting as fever of unknown origin.

Falagas ME, Klempner MS.

Clin Infect Dis. 1996 May;22(5):809-12.

PMID:
8722936
49.

Inhibition of Borrelia burgdorferi-bound fibrinolytic enzymes by alpha2-antiplasmin, PAI-1 and PAI-2.

Perides G, Noring R, Klempner MS.

Biochem Biophys Res Commun. 1996 Feb 27;219(3):690-5.

PMID:
8645243
50.

Binding of human plasminogen to Borrelia burgdorferi.

Hu LT, Perides G, Noring R, Klempner MS.

Infect Immun. 1995 Sep;63(9):3491-6.

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