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Items: 1 to 50 of 110

1.

Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization.

Werwein E, Cibis H, Hess D, Klempnauer KH.

Nucleic Acids Res. 2019 Jan 10;47(1):103-121. doi: 10.1093/nar/gky935.

2.
3.

The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression.

Coulibaly A, Haas A, Steinmann S, Jakobs A, Schmidt TJ, Klempnauer KH.

PLoS One. 2018 Feb 2;13(2):e0190934. doi: 10.1371/journal.pone.0190934. eCollection 2018.

4.

Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ.

Falkenberg KD, Jakobs A, Matern JC, Dörner W, Uttarkar S, Trentmann A, Steinmann S, Coulibaly A, Schomburg C, Mootz HD, Schmidt TJ, Klempnauer KH.

Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1349-1358. doi: 10.1016/j.bbamcr.2017.05.003. Epub 2017 May 2.

5.

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.

Henrich SM, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, Hess D, Klempnauer KH.

Sci Rep. 2017 Jan 27;7:41663. doi: 10.1038/srep41663.

6.

Targeting the transcription factor Myb by small-molecule inhibitors.

Uttarkar S, Frampton J, Klempnauer KH.

Exp Hematol. 2017 Mar;47:31-35. doi: 10.1016/j.exphem.2016.12.003. Epub 2016 Dec 23. Review.

PMID:
28017646
7.
8.

Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells.

Uttarkar S, Piontek T, Dukare S, Schomburg C, Schlenke P, Berdel WE, Müller-Tidow C, Schmidt TJ, Klempnauer KH.

Mol Cancer Ther. 2016 Dec;15(12):2905-2915. Epub 2016 Oct 5.

9.

A conserved patch of hydrophobic amino acids modulates Myb activity by mediating protein-protein interactions.

Dukare S, Klempnauer KH.

Biochim Biophys Acta. 2016 Jul;1859(7):914-21. doi: 10.1016/j.bbagrm.2016.04.004. Epub 2016 Apr 11.

PMID:
27080133
10.

An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells.

Jakobs A, Uttarkar S, Schomburg C, Steinmann S, Coulibaly A, Schlenke P, Berdel WE, Müller-Tidow C, Schmidt TJ, Klempnauer KH.

Leukemia. 2016 Jul;30(7):1612-5. doi: 10.1038/leu.2016.16. Epub 2016 Feb 8. No abstract available.

PMID:
26854027
11.

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.

Uttarkar S, Dassé E, Coulibaly A, Steinmann S, Jakobs A, Schomburg C, Trentmann A, Jose J, Schlenke P, Berdel WE, Schmidt TJ, Müller-Tidow C, Frampton J, Klempnauer KH.

Blood. 2016 Mar 3;127(9):1173-82. doi: 10.1182/blood-2015-09-668632. Epub 2015 Dec 2.

12.

Translation, Pdcd4 and eIF4A.

Biyanee A, Singh P, Klempnauer KH.

Oncoscience. 2015 Aug 10;2(9):731-2. eCollection 2015. No abstract available.

13.

Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA.

Ohnheiser J, Ferlemann E, Haas A, Müller JP, Werwein E, Fehler O, Biyanee A, Klempnauer KH.

Biochim Biophys Acta. 2015 Jul;1853(7):1564-73. doi: 10.1016/j.bbamcr.2015.03.008. Epub 2015 Mar 25.

14.

Naphthol AS-E Phosphate Inhibits the Activity of the Transcription Factor Myb by Blocking the Interaction with the KIX Domain of the Coactivator p300.

Uttarkar S, Dukare S, Bopp B, Goblirsch M, Jose J, Klempnauer KH.

Mol Cancer Ther. 2015 Jun;14(6):1276-85. doi: 10.1158/1535-7163.MCT-14-0662. Epub 2015 Mar 4.

15.

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.

Fehler O, Singh P, Haas A, Ulrich D, Müller JP, Ohnheiser J, Klempnauer KH.

Nucleic Acids Res. 2014;42(17):11107-18. doi: 10.1093/nar/gku800. Epub 2014 Sep 4.

16.

The sigma enigma: in vitro/in silico site-directed mutagenesis studies unveil σ1 receptor ligand binding.

Brune S, Schepmann D, Klempnauer KH, Marson D, Dal Col V, Laurini E, Fermeglia M, Wünsch B, Pricl S.

Biochemistry. 2014 May 13;53(18):2993-3003. doi: 10.1021/bi401575g. Epub 2014 Apr 28.

PMID:
24766040
17.

A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation.

Biyanee A, Ohnheiser J, Singh P, Klempnauer KH.

Oncogene. 2015 Mar 12;34(11):1384-92. doi: 10.1038/onc.2014.83. Epub 2014 Mar 31.

PMID:
24681950
18.

Interaction and cooperation of the CCAAT-box enhancer-binding protein β (C/EBPβ) with the homeodomain-interacting protein kinase 2 (Hipk2).

Steinmann S, Coulibaly A, Ohnheiser J, Jakobs A, Klempnauer KH.

J Biol Chem. 2013 Aug 2;288(31):22257-69. doi: 10.1074/jbc.M113.487769. Epub 2013 Jun 19.

19.

Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.

Kumar N, Wethkamp N, Waters LC, Carr MD, Klempnauer KH.

Oncogenesis. 2013 Jan 14;2:e37. doi: 10.1038/oncsis.2012.37.

20.

PRMT4 is a novel coactivator of c-Myb-dependent transcription in haematopoietic cell lines.

Streubel G, Bouchard C, Berberich H, Zeller MS, Teichmann S, Adamkiewicz J, Müller R, Klempnauer KH, Bauer UM.

PLoS Genet. 2013;9(3):e1003343. doi: 10.1371/journal.pgen.1003343. Epub 2013 Mar 7.

21.

Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships.

Schomburg C, Schuehly W, Da Costa FB, Klempnauer KH, Schmidt TJ.

Eur J Med Chem. 2013 May;63:313-20. doi: 10.1016/j.ejmech.2013.02.018. Epub 2013 Feb 26.

PMID:
23501116
22.

B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.

Werwein E, Dzuganova M, Usadel C, Klempnauer KH.

Cell Death Dis. 2013 Feb 28;4:e511. doi: 10.1038/cddis.2013.36.

23.

Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: molecular features and properties of the complex.

Oka O, Waters LC, Strong SL, Dosanjh NS, Veverka V, Muskett FW, Renshaw PS, Klempnauer KH, Carr MD.

PLoS One. 2012;7(12):e52906. doi: 10.1371/journal.pone.0052906. Epub 2012 Dec 31.

24.

B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).

Werwein E, Schmedt T, Hoffmann H, Usadel C, Obermann N, Singer JD, Klempnauer KH.

Cell Cycle. 2012 Nov 1;11(21):4047-58. doi: 10.4161/cc.22386. Epub 2012 Oct 3.

25.

Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA.

Wedeken L, Singh P, Klempnauer KH.

J Biol Chem. 2011 Dec 16;286(50):42855-62. doi: 10.1074/jbc.M111.269456. Epub 2011 Oct 27.

26.

Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

Bujnicki T, Wilczek C, Schomburg C, Feldmann F, Schlenke P, Müller-Tidow C, Schmidt TJ, Klempnauer KH.

Leukemia. 2012 Apr;26(4):615-22. doi: 10.1038/leu.2011.275. Epub 2011 Oct 11.

PMID:
21986841
27.

Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.

Singh P, Wedeken L, Waters LC, Carr MD, Klempnauer KH.

Oncogene. 2011 Dec 8;30(49):4864-73. doi: 10.1038/onc.2011.202. Epub 2011 Jun 6.

PMID:
21643008
28.

Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.

Waters LC, Strong SL, Ferlemann E, Oka O, Muskett FW, Veverka V, Banerjee S, Schmedt T, Henry AJ, Klempnauer KH, Carr MD.

J Biol Chem. 2011 May 13;286(19):17270-80. doi: 10.1074/jbc.M110.166157. Epub 2011 Mar 16.

29.

Association of Tumor Suppressor Protein Pdcd4 With Ribosomes Is Mediated by Protein-Protein and Protein-RNA Interactions.

Wedeken L, Ohnheiser J, Hirschi B, Wethkamp N, Klempnauer KH.

Genes Cancer. 2010 Mar;1(3):293-301. doi: 10.1177/1947601910364227.

30.

Resonance assignment and secondary structure of the middle MA-3 domain and complete tandem MA-3 region of the tumour suppressor protein Pdcd4.

Waters LC, Oka O, Muskett FW, Strong SL, Schmedt T, Klempnauer KH, Carr MD.

Biomol NMR Assign. 2010 Apr;4(1):49-53. doi: 10.1007/s12104-009-9205-1. Epub 2009 Dec 19.

31.

Myb-induced chromatin remodeling at a dual enhancer/promoter element involves non-coding rna transcription and is disrupted by oncogenic mutations of v-myb.

Wilczek C, Chayka O, Plachetka A, Klempnauer KH.

J Biol Chem. 2009 Dec 18;284(51):35314-24. doi: 10.1074/jbc.M109.066175.

32.

Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta.

Wethkamp N, Klempnauer KH.

J Biol Chem. 2009 Oct 16;284(42):28783-94. doi: 10.1074/jbc.M109.041186. Epub 2009 Aug 18.

33.

Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response.

Singh P, Marikkannu R, Bitomsky N, Klempnauer KH.

Oncogene. 2009 Oct 22;28(42):3758-64. doi: 10.1038/onc.2009.239. Epub 2009 Aug 17.

PMID:
19684621
34.

v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300.

Steinmann S, Schulte K, Beck K, Chachra S, Bujnicki T, Klempnauer KH.

Oncogene. 2009 Jul 2;28(26):2446-55. doi: 10.1038/onc.2009.90. Epub 2009 May 18.

PMID:
19448669
35.

siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expression.

Bitomsky N, Wethkamp N, Marikkannu R, Klempnauer KH.

Oncogene. 2008 Aug 14;27(35):4820-9. doi: 10.1038/onc.2008.115. Epub 2008 Apr 21.

PMID:
18427550
36.

Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity.

Pani E, Menigatti M, Schubert S, Hess D, Gerrits B, Klempnauer KH, Ferrari S.

Biochim Biophys Acta. 2008 Jun;1783(6):1121-8. doi: 10.1016/j.bbamcr.2008.02.020. Epub 2008 Mar 5.

37.

C/EBPbeta induces chromatin opening at a cell-type-specific enhancer.

Plachetka A, Chayka O, Wilczek C, Melnik S, Bonifer C, Klempnauer KH.

Mol Cell Biol. 2008 Mar;28(6):2102-12. doi: 10.1128/MCB.01943-07. Epub 2008 Jan 14.

38.

Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene.

Ivanova O, Braas D, Klempnauer KH.

Nucleic Acids Res. 2007;35(21):7237-47. Epub 2007 Oct 24.

39.

A dual activation mechanism for Myb-responsive genes in myelomonocytic cells.

Yamkamon V, Ivanova O, Braas D, Chayka O, Patmasiriwat P, Klempnauer KH.

Blood Cells Mol Dis. 2008 Mar-Apr;40(2):219-26. Epub 2007 Oct 18.

PMID:
17950008
40.
41.

Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4A.

Waters LC, Veverka V, Böhm M, Schmedt T, Choong PT, Muskett FW, Klempnauer KH, Carr MD.

Oncogene. 2007 Jul 26;26(34):4941-50. Epub 2007 Feb 19.

PMID:
17310995
42.

NMR assignment and secondary structure determination of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4.

Waters LC, Böhm M, Veverka V, Muskett FW, Frenkiel TA, Kelly GP, Prescott A, Dosanjh NS, Klempnauer KH, Carr MD.

J Biomol NMR. 2006;36 Suppl 1:18. No abstract available.

PMID:
16518566
43.

Disruption of B-myb in DT40 cells reveals novel function for B-Myb in the response to DNA-damage.

Ahlbory D, Appl H, Lang D, Klempnauer KH.

Oncogene. 2005 Nov 3;24(48):7127-34.

PMID:
16170378
44.

Regulation of the cyclin D1 and cyclin A1 promoters by B-Myb is mediated by Sp1 binding sites.

Bartusel T, Schubert S, Klempnauer KH.

Gene. 2005 May 23;351:171-80.

PMID:
15922873
45.

v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter.

Chayka O, Kintscher J, Braas D, Klempnauer KH.

Mol Cell Biol. 2005 Jan;25(1):499-511.

46.

The glioma-amplified sequence 41 gene (GAS41) is a direct Myb target gene.

Braas D, Gundelach H, Klempnauer KH.

Nucleic Acids Res. 2004 Sep 8;32(16):4750-7. Print 2004.

47.
48.

Identification of a Myb-responsive enhancer of the chicken C/EBPbeta gene.

Kintscher J, Yamkamon V, Braas D, Klempnauer KH.

Oncogene. 2004 Jul 29;23(34):5807-14.

PMID:
15195136
49.

The cooperation of B-Myb with the coactivator p300 is orchestrated by cyclins A and D1.

Schubert S, Horstmann S, Bartusel T, Klempnauer KH.

Oncogene. 2004 Feb 19;23(7):1392-404.

PMID:
14973551
50.

The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA.

Böhm M, Sawicka K, Siebrasse JP, Brehmer-Fastnacht A, Peters R, Klempnauer KH.

Oncogene. 2003 Jul 31;22(31):4905-10.

PMID:
12894233

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