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Items: 1 to 50 of 55

1.

Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription.

Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL.

Cell Discov. 2018 May 29;4:26. doi: 10.1038/s41421-018-0024-3. eCollection 2018.

2.

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.

Liu C, Han T, Stachura DL, Wang H, Vaisman BL, Kim J, Klemke RL, Remaley AT, Rana TM, Traver D, Miller YI.

Nat Commun. 2018 Apr 3;9(1):1310. doi: 10.1038/s41467-018-03775-y.

3.

The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres.

Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL.

Sci Rep. 2018 Feb 14;8(1):2982. doi: 10.1038/s41598-018-21358-1.

4.

ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma.

Noriega-Guerra H, Cruz MC, Ribeiro PRL, Strnadel J, Wang H, Klemke RL, Jaeger RG, Freitas VM.

Exp Cell Res. 2018 Feb 15;363(2):271-282. doi: 10.1016/j.yexcr.2018.01.017. Epub 2018 Jan 31.

PMID:
29355494
5.

KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop.

Fujimura K, Wang H, Watson F, Klemke RL.

Cancer Res. 2018 Mar 15;78(6):1444-1456. doi: 10.1158/0008-5472.CAN-17-2873. Epub 2018 Jan 10.

6.

eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.

Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL.

Cancer Res. 2017 Apr 15;77(8):1997-2007. doi: 10.1158/0008-5472.CAN-16-2594. Epub 2017 Apr 5.

7.

PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer.

Agajanian M, Campeau A, Hoover M, Hou A, Brambilla D, Kim SL, Klemke RL, Kelber JA.

PLoS One. 2015 Aug 12;10(8):e0135748. doi: 10.1371/journal.pone.0135748. eCollection 2015.

8.

A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.

Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA, Klemke RL.

Cancer Res. 2014 Nov 15;74(22):6671-81. doi: 10.1158/0008-5472.CAN-14-1031. Epub 2014 Sep 26.

9.

Proteomic and biochemical methods to study the cytoskeletome.

Klemke RL, Jiang X, Choi S, Kelber JA.

Methods Mol Biol. 2013;1046:203-18. doi: 10.1007/978-1-62703-538-5_12.

10.

Role of connexins in metastatic breast cancer and melanoma brain colonization.

Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR, Klemke RL.

J Cell Sci. 2013 Feb 15;126(Pt 4):904-13. doi: 10.1242/jcs.112748. Epub 2013 Jan 15.

11.

Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover.

Bristow JM, Reno TA, Jo M, Gonias SL, Klemke RL.

J Biol Chem. 2013 Jan 4;288(1):123-31. doi: 10.1074/jbc.M112.410910. Epub 2012 Oct 26.

12.

Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits.

Klemke RL.

Curr Opin Cell Biol. 2012 Oct;24(5):662-9. doi: 10.1016/j.ceb.2012.08.005. Epub 2012 Sep 11. Review.

13.

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness.

Soman P, Kelber JA, Lee JW, Wright TN, Vecchio KS, Klemke RL, Chen S.

Biomaterials. 2012 Oct;33(29):7064-70. doi: 10.1016/j.biomaterials.2012.06.012. Epub 2012 Jul 16.

14.

KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer.

Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL.

Cancer Res. 2012 May 15;72(10):2554-64. doi: 10.1158/0008-5472.CAN-11-3552.

15.

Proteomics method for identification of pseudopodium phosphotyrosine proteins.

Wang Y, Klemke RL.

Methods Mol Biol. 2012;757:349-65. doi: 10.1007/978-1-61779-166-6_21.

PMID:
21909922
16.

Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells.

Wang Y, Yang F, Gritsenko MA, Wang Y, Clauss T, Liu T, Shen Y, Monroe ME, Lopez-Ferrer D, Reno T, Moore RJ, Klemke RL, Camp DG 2nd, Smith RD.

Proteomics. 2011 May;11(10):2019-26. doi: 10.1002/pmic.201000722. Epub 2011 Apr 18.

17.

Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction.

Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG 2nd, Smith RD, Klemke RL.

J Biol Chem. 2011 May 20;286(20):18190-201. doi: 10.1074/jbc.M111.236133. Epub 2011 Mar 28.

18.

PEAK1, a novel kinase target in the fight against cancer.

Kelber JA, Klemke RL.

Oncotarget. 2010 Jul;1(3):219-23. No abstract available.

19.

A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting.

Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA.

Blood. 2010 Dec 16;116(25):5773-83. doi: 10.1182/blood-2010-07-296210. Epub 2010 Sep 8.

20.

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].

Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR 3rd, Klemke RL.

Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10920-5. doi: 10.1073/pnas.0914776107. Epub 2010 Jun 1. Erratum in: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13556.

21.

Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.

Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, Jin Y, Klemke RL, Sauder JM, Burley SK.

J Mol Biol. 2010 Apr 9;397(4):883-92. doi: 10.1016/j.jmb.2010.02.017. Epub 2010 Feb 13.

22.

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF.

Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, Klemke RL, Vogt PK, Arnold L, Wrasidlo W, Cheresh DA.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4299-304. doi: 10.1073/pnas.0909299107. Epub 2010 Feb 12.

23.

Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization.

Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL.

PLoS One. 2009 Aug 21;4(8):e6713. doi: 10.1371/journal.pone.0006713.

24.

Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish.

Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI.

Circ Res. 2009 Apr 24;104(8):952-60. doi: 10.1161/CIRCRESAHA.108.189803. Epub 2009 Mar 5.

25.

Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography.

Ding SJ, Wang Y, Jacobs JM, Qian WJ, Yang F, Tolmachev AV, Du X, Wang W, Moore RJ, Monroe ME, Purvine SO, Waters K, Heibeck TH, Adkins JN, Camp DG 2nd, Klemke RL, Smith RD.

J Proteome Res. 2008 Oct;7(10):4215-24. doi: 10.1021/pr7007785. Epub 2008 Sep 12.

26.

The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8.

Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2313-8. doi: 10.1073/pnas.0712198105. Epub 2008 Feb 11.

27.

Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network.

Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG 2nd, Smith RD, Klemke RL.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1931-6. doi: 10.1073/pnas.0706545105. Epub 2008 Feb 1.

28.

PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets.

Wang Y, Klemke RL.

Mol Cell Proteomics. 2008 Jan;7(1):145-62. Epub 2007 Oct 13.

29.

Methods for pseudopodia purification and proteomic analysis.

Wang Y, Ding SJ, Wang W, Yang F, Jacobs JM, Camp D 2nd, Smith RD, Klemke RL.

Sci STKE. 2007 Aug 21;2007(400):pl4.

PMID:
17712138
30.

Profiling signaling polarity in chemotactic cells.

Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG 2nd, Smith RD, Klemke RL.

Proc Natl Acad Sci U S A. 2007 May 15;104(20):8328-33. Epub 2007 May 9.

31.

Biochemical purification of pseudopodia from migratory cells.

Wang Y, Klemke RL.

Methods Mol Biol. 2007;370:55-66.

PMID:
17416987
32.
33.

Spatiotemporal dynamics of RhoA activity in migrating cells.

Pertz O, Hodgson L, Klemke RL, Hahn KM.

Nature. 2006 Apr 20;440(7087):1069-72. Epub 2006 Mar 19.

PMID:
16547516
34.

Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII.

Holcomb M, Rufini A, Barilà D, Klemke RL.

J Biol Chem. 2006 Feb 3;281(5):2430-40. Epub 2005 Nov 1.

35.

R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho.

Wozniak MA, Kwong L, Chodniewicz D, Klemke RL, Keely PJ.

Mol Biol Cell. 2005 Jan;16(1):84-96. Epub 2004 Nov 3.

36.

Guiding cell migration through directed extension and stabilization of pseudopodia.

Chodniewicz D, Klemke RL.

Exp Cell Res. 2004 Nov 15;301(1):31-7. Review.

PMID:
15501442
37.

Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold.

Chodniewicz D, Klemke RL.

Biochim Biophys Acta. 2004 Jul 5;1692(2-3):63-76. Review.

38.

Regulation of cell migration and survival by focal adhesion targeting of Lasp-1.

Lin YH, Park ZY, Lin D, Brahmbhatt AA, Rio MC, Yates JR 3rd, Klemke RL.

J Cell Biol. 2004 May 10;165(3):421-32.

39.

Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion.

Kain KH, Gooch S, Klemke RL.

Oncogene. 2003 Sep 4;22(38):6071-80.

PMID:
12955086
40.

Assay for neurite outgrowth quantification.

Smit M, Leng J, Klemke RL.

Biotechniques. 2003 Aug;35(2):254-6. No abstract available.

41.

ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis.

Brahmbhatt AA, Klemke RL.

J Biol Chem. 2003 Apr 11;278(15):13016-25. Epub 2003 Feb 5.

42.
43.

Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells.

Ting AY, Kain KH, Klemke RL, Tsien RY.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15003-8.

44.

Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes.

Kain KH, Klemke RL.

J Biol Chem. 2001 May 11;276(19):16185-92. Epub 2001 Jan 19.

45.

Molecular signaling mechanisms of cell migration and invasion.

Stupack DG, Cho SY, Klemke RL.

Immunol Res. 2000;21(2-3):83-8. Review.

PMID:
10852105
47.

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases.

Spencer KS, Graus-Porta D, Leng J, Hynes NE, Klemke RL.

J Cell Biol. 2000 Jan 24;148(2):385-97.

48.

Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase.

Leng J, Klemke RL, Reddy AC, Cheresh DA.

J Biol Chem. 1999 Dec 31;274(53):37855-61.

49.

Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells.

Cheresh DA, Leng J, Klemke RL.

J Cell Biol. 1999 Sep 6;146(5):1107-16.

50.

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