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Items: 49


Risk factors for vertebral compression fracture after spine stereotactic body radiation therapy: Long-term results of a prospective phase 2 study.

Mantel F, Sweeney RA, Klement RJ, Hawkins MA, Belderbos J, Ahmed M, Toussaint A, Polat B, Flentje M, Guckenberger M.

Radiother Oncol. 2019 Sep 13. pii: S0167-8140(19)33072-5. doi: 10.1016/j.radonc.2019.08.026. [Epub ahead of print]


Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy.

Klement RJ, Sonke JJ, Allgäuer M, Andratschke N, Appold S, Belderbos J, Belka C, Dieckmann K, Eich HT, Flentje M, Grills I, Eble M, Hope A, Grosu AL, Semrau S, Sweeney RA, Hörner-Rieber J, Werner-Wasik M, Engenhart-Cabillic R, Ye H, Guckenberger M.

Radiother Oncol. 2019 Aug 17. pii: S0167-8140(19)32998-6. doi: 10.1016/j.radonc.2019.07.008. [Epub ahead of print]


The Impact of Serum Glucose in the Treatment of Locoregionally Advanced Pancreatic Cancer.

Iarrobino NA, Gill BS, Klement RJ, Bernard ME, Champ CE.

Am J Clin Oncol. 2019 Sep;42(9):692-697. doi: 10.1097/COC.0000000000000580.


Wilhelm Brünings' forgotten contribution to the metabolic treatment of cancer utilizing hypoglycemia and a very low carbohydrate (ketogenic) diet.

Klement RJ.

J Tradit Complement Med. 2018 Aug 20;9(3):192-200. doi: 10.1016/j.jtcme.2018.06.002. eCollection 2019 Jul. Review.


Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention.

Gross EC, Klement RJ, Schoenen J, D'Agostino DP, Fischer D.

Nutrients. 2019 Apr 10;11(4). pii: E811. doi: 10.3390/nu11040811. Review.


Impact of Different Types of Diet on Gut Microbiota Profiles and Cancer Prevention and Treatment.

Klement RJ, Pazienza V.

Medicina (Kaunas). 2019 Mar 29;55(4). pii: E84. doi: 10.3390/medicina55040084. Review.


External validation of a prognostic score predicting overall survival for patients with brain metastases based on extracranial factors.

Lewitzki V, Klement RJ, Hess S, Kosmala R, Nieder C, Flentje M.

Clin Transl Radiat Oncol. 2019 Feb 27;16:15-20. doi: 10.1016/j.ctro.2019.02.005. eCollection 2019 May.


In Regard to Britton et al.

Champ CE, Klement RJ.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1282-1283. doi: 10.1016/j.ijrobp.2018.12.016. Epub 2019 Mar 13. No abstract available.


The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases.

Klement RJ, Abbasi-Senger N, Adebahr S, Alheid H, Allgaeuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Eble MJ, Ernst I, Gerum S, Habermehl D, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl H, Klass ND, Krempien R, Lewitzki V, Lohaus F, Ostheimer C, Papachristofilou A, Petersen C, Rieber J, Schneider T, Schrade E, Semrau R, Wachter S, Wittig A, Guckenberger M, Andratschke N.

BMC Cancer. 2019 Feb 26;19(1):173. doi: 10.1186/s12885-019-5362-5.


Comment to Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials.

Matuschek C, Krug D, Klement RJ, Baumann R.

Strahlenther Onkol. 2019 Apr;195(4):306-307. doi: 10.1007/s00066-018-1411-2. No abstract available.


The emerging role of ketogenic diets in cancer treatment.

Klement RJ.

Curr Opin Clin Nutr Metab Care. 2019 Mar;22(2):129-134. doi: 10.1097/MCO.0000000000000540.


A fatal case of Fournier's gangrene during neoadjuvant radiotherapy for rectal cancer.

Klement RJ, Schäfer G, Sweeney RA.

Strahlenther Onkol. 2019 May;195(5):441-446. doi: 10.1007/s00066-018-1401-4. Epub 2018 Nov 23.


Application of Bayesian evidence synthesis to modelling the effect of ketogenic therapy on survival of high grade glioma patients.

Klement RJ, Bandyopadhyay PS, Champ CE, Walach H.

Theor Biol Med Model. 2018 Aug 20;15(1):12. doi: 10.1186/s12976-018-0084-y.


The Impact of Serum Glucose, Anti-Diabetic Agents, and Statin Usage in Non-small Cell Lung Cancer Patients Treated With Definitive Chemoradiation.

Iarrobino NA, Gill BS, Bernard M, Klement RJ, Werner-Wasik M, Champ CE.

Front Oncol. 2018 Jul 27;8:281. doi: 10.3389/fonc.2018.00281. eCollection 2018.


Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation.

Bartmann C, Janaki Raman SR, Flöter J, Schulze A, Bahlke K, Willingstorfer J, Strunz M, Wöckel A, Klement RJ, Kapp M, Djuzenova CS, Otto C, Kämmerer U.

Cancer Metab. 2018 Jun 11;6:8. doi: 10.1186/s40170-018-0180-9. eCollection 2018.


[Unjustified recommendations regarding the ketogenic diet].

Klement RJ.

Urologe A. 2018 May;57(5):605-606. doi: 10.1007/s00120-018-0632-4. German. No abstract available.


The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases.

Andratschke N, Alheid H, Allgäuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Gerum S, Guckenberger M, Hildebrandt G, Klement RJ, Lewitzki V, Ostheimer C, Papachristofilou A, Petersen C, Schneider T, Semrau R, Wachter S, Habermehl D.

BMC Cancer. 2018 Mar 13;18(1):283. doi: 10.1186/s12885-018-4191-2.


Stereotactic body radiotherapy (SBRT) for multiple pulmonary oligometastases: Analysis of number and timing of repeat SBRT as impact factors on treatment safety and efficacy.

Klement RJ, Hoerner-Rieber J, Adebahr S, Andratschke N, Blanck O, Boda-Heggemann J, Duma M, Eble MJ, Eich HC, Flentje M, Gerum S, Hass P, Henkenberens C, Hildebrandt G, Imhoff D, Kahl KH, Klass ND, Krempien R, Lohaus F, Petersen C, Schrade E, Wendt TG, Wittig A, Guckenberger M.

Radiother Oncol. 2018 May;127(2):246-252. doi: 10.1016/j.radonc.2018.02.016. Epub 2018 Mar 3.


The inflammation paradox: Why are Tsimane protected against Western diseases while Westerners are not?

Freese J, Klement RJ, Lötzerich H.

Version 2. F1000Res. 2018 Mar 1 [revised 2018 Jan 1];7:252. doi: 10.12688/f1000research.14052.2. eCollection 2018.


The sedentary (r)evolution: Have we lost our metabolic flexibility?

Freese J, Klement RJ, Ruiz-Núñez B, Schwarz S, Lötzerich H.

Version 2. F1000Res. 2017 Oct 2 [revised 2018 Jan 1];6:1787. doi: 10.12688/f1000research.12724.2. eCollection 2017.


Fasting, Fats, and Physics: Combining Ketogenic and Radiation Therapy against Cancer.

Klement RJ.

Complement Med Res. 2018;25(2):102-113. doi: 10.1159/000484045. Epub 2017 Nov 9. Review. No abstract available.


Assessing Changes in the Activity Levels of Breast Cancer Patients During Radiation Therapy.

Champ CE, Ohri N, Klement RJ, Cantor M, Beriwal S, Glaser SM, Smith RP.

Clin Breast Cancer. 2018 Feb;18(1):e1-e6. doi: 10.1016/j.clbc.2017.08.009. Epub 2017 Aug 24.


The influence of ketogenic therapy on the 5 R's of radiobiology.

Klement RJ.

Int J Radiat Biol. 2019 Apr;95(4):394-407. doi: 10.1080/09553002.2017.1380330. Epub 2017 Oct 9. Review.


Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation.

Klement RJ.

Med Oncol. 2017 Aug;34(8):132. doi: 10.1007/s12032-017-0991-5. Epub 2017 Jun 26. Review.


Impact of a ketogenic diet intervention during radiotherapy on body composition: II. Protocol of a randomised phase I study (KETOCOMP).

Klement RJ, Sweeney RA.

Clin Nutr ESPEN. 2016 Apr;12:e1-e6. doi: 10.1016/j.clnesp.2015.11.001. Epub 2016 Jan 15.


Need for new review of article on ketogenic dietary regimes for cancer patients.

Klement RJ, Feinman RD, Gross EC, Champ CE, D'Agostino DP, Fine EJ, Kämmerer U, Poff A, Rho JM, Seyfried TN, Scheck AC.

Med Oncol. 2017 Jun;34(6):108. doi: 10.1007/s12032-017-0968-4. Epub 2017 Apr 27. No abstract available.


Diazoxide for Lowering Insulin Levels in Breast Cancer Patients.

Fink MK, Klement RJ.

Oncologist. 2017 Apr;22(4):491. doi: 10.1634/theoncologist.2016-0402. No abstract available.


Radiobiological parameters of liver and lung metastases derived from tumor control data of 3719 metastases.

Klement RJ.

Radiother Oncol. 2017 May;123(2):218-226. doi: 10.1016/j.radonc.2017.03.014. Epub 2017 Mar 28.


Stereotactic body radiotherapy for oligo-metastatic liver disease - Influence of pre-treatment chemotherapy and histology on local tumor control.

Klement RJ, Guckenberger M, Alheid H, Allgäuer M, Becker G, Blanck O, Boda-Heggemann J, Brunner T, Duma M, Gerum S, Habermehl D, Hildebrandt G, Lewitzki V, Ostheimer C, Papachristofilou A, Petersen C, Schneider T, Semrau R, Wachter S, Andratschke N.

Radiother Oncol. 2017 May;123(2):227-233. doi: 10.1016/j.radonc.2017.01.013. Epub 2017 Mar 6.


Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels.

Klement RJ, Champ CE.

Brain. 2017 Mar 1;140(3):e16. doi: 10.1093/brain/aww324. No abstract available.


Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis.

Klement RJ, Champ CE, Otto C, Kämmerer U.

PLoS One. 2016 May 9;11(5):e0155050. doi: 10.1371/journal.pone.0155050. eCollection 2016.


Prediction of Early Death in Patients with Early-Stage NSCLC-Can We Select Patients without a Potential Benefit of SBRT as a Curative Treatment Approach?

Klement RJ, Belderbos J, Grills I, Werner-Wasik M, Hope A, Giuliani M, Ye H, Sonke JJ, Peulen H, Guckenberger M.

J Thorac Oncol. 2016 Jul;11(7):1132-9. doi: 10.1016/j.jtho.2016.03.016. Epub 2016 Apr 7.


Fortifying the Treatment of Prostate Cancer with Physical Activity.

Champ CE, Francis L, Klement RJ, Dickerman R, Smith RP.

Prostate Cancer. 2016;2016:9462975. doi: 10.1155/2016/9462975. Epub 2016 Feb 10. Review.


Bayesian Cure Rate Modeling of Local Tumor Control: Evaluation in Stereotactic Body Radiation Therapy for Pulmonary Metastases.

Klement RJ, Allgäuer M, Andratschke N, Blanck O, Boda-Heggemann J, Dieckmann K, Duma M, Ernst I, Flentje M, Ganswindt U, Hass P, Henkenberens C, Imhoff D, Kahl HK, Krempien R, Lohaus F, Nestle U, Nevinny-Stickel M, Petersen C, Schmitt V, Semrau S, Sterzing F, Streblow J, Wendt TG, Wittig A, Guckenberger M.

Int J Radiat Oncol Biol Phys. 2016 Mar 15;94(4):841-9. doi: 10.1016/j.ijrobp.2015.12.004. Epub 2015 Dec 15.


Dietary and pharmacological modification of the insulin/IGF-1 system: exploiting the full repertoire against cancer.

Klement RJ, Fink MK.

Oncogenesis. 2016 Feb 15;5:e193. doi: 10.1038/oncsis.2016.2. Review.


Local tumor control probability modeling of primary and secondary lung tumors in stereotactic body radiotherapy.

Guckenberger M, Klement RJ, Allgäuer M, Andratschke N, Blanck O, Boda-Heggemann J, Dieckmann K, Duma M, Ernst I, Ganswindt U, Hass P, Henkenberens C, Holy R, Imhoff D, Kahl HK, Krempien R, Lohaus F, Nestle U, Nevinny-Stickel M, Petersen C, Semrau S, Streblow J, Wendt TG, Wittig A, Flentje M, Sterzing F.

Radiother Oncol. 2016 Mar;118(3):485-91. doi: 10.1016/j.radonc.2015.09.008. Epub 2015 Sep 15.


TKTL1 expression in human malign and benign cell lines.

Kämmerer U, Gires O, Pfetzer N, Wiegering A, Klement RJ, Otto C.

BMC Cancer. 2015 Jun 10;15:2. doi: 10.1186/1471-2407-15-2.


Commentary on "Strong adverse prognostic impact of hyperglycemic episodes during adjuvant chemoradiotherapy of glioblastoma multiforme".

Champ CE, Klement RJ.

Strahlenther Onkol. 2015 Mar;191(3):281-2. doi: 10.1007/s00066-014-0788-9. No abstract available.


Restricting carbohydrates to fight head and neck cancer-is this realistic?

Klement RJ.

Cancer Biol Med. 2014 Sep;11(3):145-61. doi: 10.7497/j.issn.2095-3941.2014.03.001. Review.


Mimicking caloric restriction: what about macronutrient manipulation? A response to Meynet and Ricci.

Klement RJ.

Trends Mol Med. 2014 Sep;20(9):471-2. doi: 10.1016/j.molmed.2014.07.001. Epub 2014 Jul 21.


Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation.

Klement RJ, Champ CE.

Cancer Metastasis Rev. 2014 Mar;33(1):217-29. doi: 10.1007/s10555-014-9495-3. Review.


Support vector machine-based prediction of local tumor control after stereotactic body radiation therapy for early-stage non-small cell lung cancer.

Klement RJ, Allgäuer M, Appold S, Dieckmann K, Ernst I, Ganswindt U, Holy R, Nestle U, Nevinny-Stickel M, Semrau S, Sterzing F, Wittig A, Andratschke N, Guckenberger M.

Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):732-8. doi: 10.1016/j.ijrobp.2013.11.216. Epub 2014 Jan 7.


Applicability of the linear-quadratic formalism for modeling local tumor control probability in high dose per fraction stereotactic body radiotherapy for early stage non-small cell lung cancer.

Guckenberger M, Klement RJ, Allgäuer M, Appold S, Dieckmann K, Ernst I, Ganswindt U, Holy R, Nestle U, Nevinny-Stickel M, Semrau S, Sterzing F, Wittig A, Andratschke N, Flentje M.

Radiother Oncol. 2013 Oct;109(1):13-20. doi: 10.1016/j.radonc.2013.09.005. Epub 2013 Oct 30.


Calorie or carbohydrate restriction? The ketogenic diet as another option for supportive cancer treatment.

Klement RJ.

Oncologist. 2013;18(9):1056. doi: 10.1634/theoncologist.2013-0032. No abstract available.


Lack of a dose-effect relationship for pulmonary function changes after stereotactic body radiation therapy for early-stage non-small cell lung cancer.

Guckenberger M, Klement RJ, Kestin LL, Hope AJ, Belderbos J, Werner-Wasik M, Yan D, Sonke JJ, Bissonnette JP, Xiao Y, Grills IS.

Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1074-81. doi: 10.1016/j.ijrobp.2012.09.016. Epub 2012 Nov 12.


Is there a role for carbohydrate restriction in the treatment and prevention of cancer?

Klement RJ, Kämmerer U.

Nutr Metab (Lond). 2011 Oct 26;8:75. doi: 10.1186/1743-7075-8-75.


A giant planet around a metal-poor star of extragalactic origin.

Setiawan J, Klement RJ, Henning T, Rix HW, Rochau B, Rodmann J, Schulze-Hartung T.

Science. 2010 Dec 17;330(6011):1642-4. doi: 10.1126/science.1193342. Epub 2010 Nov 18.

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