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Items: 8


Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes.

Lu C, Klement JD, Ibrahim ML, Xiao W, Redd PS, Nayak-Kapoor A, Zhou G, Liu K.

J Immunother Cancer. 2019 Jun 22;7(1):157. doi: 10.1186/s40425-019-0635-8.


SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion.

Lu C, Yang D, Klement JD, Oh IK, Savage NM, Waller JL, Colby AH, Grinstaff MW, Oberlies NH, Pearce CJ, Xie Z, Kulp SK, Coss CC, Phelps MA, Albers T, Lebedyeva IO, Liu K.

Cancer Immunol Res. 2019 Mar;7(3):414-427. doi: 10.1158/2326-6066.CIR-18-0126. Epub 2019 Jan 4.


Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.

Ibrahim ML, Klement JD, Lu C, Redd PS, Xiao W, Yang D, Browning DD, Savage NM, Buckhaults PJ, Morse HC 3rd, Liu K.

Cell Rep. 2018 Dec 11;25(11):3036-3046.e6. doi: 10.1016/j.celrep.2018.11.050.


Loss of Fas Expression and Function Is Coupled with Colon Cancer Resistance to Immune Checkpoint Inhibitor Immunotherapy.

Xiao W, Ibrahim ML, Redd PS, Klement JD, Lu C, Yang D, Savage NM, Liu K.

Mol Cancer Res. 2019 Feb;17(2):420-430. doi: 10.1158/1541-7786.MCR-18-0455. Epub 2018 Nov 14.


An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion.

Klement JD, Paschall AV, Redd PS, Ibrahim ML, Lu C, Yang D, Celis E, Abrams SI, Ozato K, Liu K.

J Clin Invest. 2018 Dec 3;128(12):5549-5560. doi: 10.1172/JCI123360. Epub 2018 Nov 5.


H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells.

Redd PS, Lu C, Klement JD, Ibrahim ML, Zhou G, Kumai T, Celis E, Liu K.

Oncoimmunology. 2018 Jul 23;7(9):e1483302. doi: 10.1080/2162402X.2018.1483302. eCollection 2018.


IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells.

Xiao W, Klement JD, Lu C, Ibrahim ML, Liu K.

J Immunol. 2018 Jul 1;201(1):264-277. doi: 10.4049/jimmunol.1800129. Epub 2018 May 11.


SETD1B Activates iNOS Expression in Myeloid-Derived Suppressor Cells.

Redd PS, Ibrahim ML, Klement JD, Sharman SK, Paschall AV, Yang D, Nayak-Kapoor A, Liu K.

Cancer Res. 2017 Jun 1;77(11):2834-2843. doi: 10.1158/0008-5472.CAN-16-2238. Epub 2017 Apr 5.

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