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Items: 35


Internalization of Erythrocyte Acylpeptide Hydrolase Is Required for Asexual Replication of Plasmodium falciparum.

Elahi R, Dapper C, Klemba M.

mSphere. 2019 May 8;4(3). pii: e00077-19. doi: 10.1128/mSphere.00077-19.


Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.

Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA.

Sci Rep. 2018 Sep 11;8(1):13578. doi: 10.1038/s41598-018-31715-9.


Two cap residues in the S1 subsite of a Plasmodium falciparum M1-family aminopeptidase promote broad specificity and enhance catalysis.

Rosati M, Dalal S, Klemba M.

Mol Biochem Parasitol. 2017 Oct;217:7-12. doi: 10.1016/j.molbiopara.2017.08.001. Epub 2017 Aug 12.


Integrated quantitative phase and birefringence microscopy for imaging malaria-infected red blood cells.

Li C, Chen S, Klemba M, Zhu Y.

J Biomed Opt. 2016 Sep 1;21(9):90501. doi: 10.1117/1.JBO.21.9.090501.


Parallel inhibition of amino acid efflux and growth of erythrocytic Plasmodium falciparum by mefloquine and non-piperidine analogs: Implication for the mechanism of antimalarial action.

Ghavami M, Dapper CH, Dalal S, Holzschneider K, Klemba M, Carlier PR.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4846-4850. doi: 10.1016/j.bmcl.2016.08.005. Epub 2016 Aug 3.


Comparative Proteomics and Functional Analysis Reveal a Role of Plasmodium falciparum Osmiophilic Bodies in Malaria Parasite Transmission.

Suárez-Cortés P, Sharma V, Bertuccini L, Costa G, Bannerman NL, Sannella AR, Williamson K, Klemba M, Levashina EA, Lasonder E, Alano P.

Mol Cell Proteomics. 2016 Oct;15(10):3243-3255. Epub 2016 Jul 18.


Amino acid efflux by asexual blood-stage Plasmodium falciparum and its utility in interrogating the kinetics of hemoglobin endocytosis and catabolism in vivo.

Dalal S, Klemba M.

Mol Biochem Parasitol. 2015 Jun;201(2):116-22. doi: 10.1016/j.molbiopara.2015.07.002. Epub 2015 Jul 26.


Isoprenoid precursor biosynthesis is the essential metabolic role of the apicoplast during gametocytogenesis in Plasmodium falciparum.

Wiley JD, Merino EF, Krai PM, McLean KJ, Tripathi AK, Vega-Rodríguez J, Jacobs-Lorena M, Klemba M, Cassera MB.

Eukaryot Cell. 2015 Feb;14(2):128-39. doi: 10.1128/EC.00198-14. Epub 2014 Dec 1.


Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodium falciparum.

Krai P, Dalal S, Klemba M.

PLoS One. 2014 Feb 25;9(2):e89771. doi: 10.1371/journal.pone.0089771. eCollection 2014.


Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.

Poreba M, Mihelic M, Krai P, Rajkovic J, Krezel A, Pawelczak M, Klemba M, Turk D, Turk B, Latajka R, Drag M.

Amino Acids. 2014 Apr;46(4):931-43. doi: 10.1007/s00726-013-1654-2. Epub 2014 Jan 1.


A naturally variable residue in the S1 subsite of M1 family aminopeptidases modulates catalytic properties and promotes functional specialization.

Dalal S, Ragheb DR, Schubot FD, Klemba M.

J Biol Chem. 2013 Sep 6;288(36):26004-12. doi: 10.1074/jbc.M113.465625. Epub 2013 Jul 29.


Characterization of a glycerophosphodiesterase with an unusual tripartite distribution and an important role in the asexual blood stages of Plasmodium falciparum.

Denloye T, Dalal S, Klemba M.

Mol Biochem Parasitol. 2012 Nov;186(1):29-37. doi: 10.1016/j.molbiopara.2012.09.004. Epub 2012 Sep 20.


Engagement of the S1, S1' and S2' subsites drives efficient catalysis of peptide bond hydrolysis by the M1-family aminopeptidase from Plasmodium falciparum.

Dalal S, Ragheb DR, Klemba M.

Mol Biochem Parasitol. 2012 May;183(1):70-7. doi: 10.1016/j.molbiopara.2012.02.003. Epub 2012 Feb 13.


Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases.

Harbut MB, Velmourougane G, Dalal S, Reiss G, Whisstock JC, Onder O, Brisson D, McGowan S, Klemba M, Greenbaum DC.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E526-34. doi: 10.1073/pnas.1105601108. Epub 2011 Aug 15.


Distribution and biochemical properties of an M1-family aminopeptidase in Plasmodium falciparum indicate a role in vacuolar hemoglobin catabolism.

Ragheb D, Dalal S, Bompiani KM, Ray WK, Klemba M.

J Biol Chem. 2011 Aug 5;286(31):27255-65. doi: 10.1074/jbc.M111.225318. Epub 2011 Jun 9.


Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Velmourougane G, Harbut MB, Dalal S, McGowan S, Oellig CA, Meinhardt N, Whisstock JC, Klemba M, Greenbaum DC.

J Med Chem. 2011 Mar 24;54(6):1655-66. doi: 10.1021/jm101227t. Epub 2011 Mar 2.


Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1.

Wang F, Krai P, Deu E, Bibb B, Lauritzen C, Pedersen J, Bogyo M, Klemba M.

Mol Biochem Parasitol. 2011 Jan;175(1):10-20. doi: 10.1016/j.molbiopara.2010.08.004. Epub 2010 Sep 15.


Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts.

Deu E, Yang Z, Wang F, Klemba M, Bogyo M.

PLoS One. 2010 Aug 5;5(8):e11985. doi: 10.1371/journal.pone.0011985.


Evidence for catalytic roles for Plasmodium falciparum aminopeptidase P in the food vacuole and cytosol.

Ragheb D, Bompiani K, Dalal S, Klemba M.

J Biol Chem. 2009 Sep 11;284(37):24806-15. doi: 10.1074/jbc.M109.018424. Epub 2009 Jul 2.


On the location of the aminopeptidase N homolog PfA-M1 in Plasmodium falciparum.

Klemba M.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):E55; author reply E56. doi: 10.1073/pnas.0903493106. Epub 2009 May 22. No abstract available.


Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.

Dalal S, Klemba M.

J Biol Chem. 2007 Dec 7;282(49):35978-87. Epub 2007 Sep 25.


Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum.

Klonis N, Tan O, Jackson K, Goldberg D, Klemba M, Tilley L.

Biochem J. 2007 Nov 1;407(3):343-54.


A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast.

Ponpuak M, Klemba M, Park M, Gluzman IY, Lamppa GK, Goldberg DE.

Mol Microbiol. 2007 Jan;63(2):314-34. Epub 2006 Oct 27.


A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation.

Klemba M, Gluzman I, Goldberg DE.

J Biol Chem. 2004 Oct 8;279(41):43000-7. Epub 2004 Aug 10.


Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.

Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH, Rosenthal PJ.

Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8721-6. Epub 2004 May 27.


Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum.

Klemba M, Beatty W, Gluzman I, Goldberg DE.

J Cell Biol. 2004 Jan 5;164(1):47-56. Erratum in: J Cell Biol. 2004 Feb 16;164(4):following 623.


Biological roles of proteases in parasitic protozoa.

Klemba M, Goldberg DE.

Annu Rev Biochem. 2002;71:275-305. Epub 2001 Nov 9. Review.


Aspartic proteases of Plasmodium falciparum and other parasitic protozoa as drug targets.

Coombs GH, Goldberg DE, Klemba M, Berry C, Kay J, Mottram JC.

Trends Parasitol. 2001 Nov;17(11):532-7. Review.


Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.

Banerjee R, Liu J, Beatty W, Pelosof L, Klemba M, Goldberg DE.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):990-5. Epub 2002 Jan 8.


Novel metal-binding proteins by design.

Klemba M, Gardner KH, Marino S, Clarke ND, Regan L.

Nat Struct Biol. 1995 May;2(5):368-73. Erratum in: Nat Struct Biol 1995 Oct;2(10):912.


Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells.

Nicholson DW, Klemba MW, Rasper DM, Metters KM, Zamboni RJ, Ford-Hutchinson AW.

Eur J Biochem. 1992 Oct 15;209(2):725-34.


Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.

Nicholson DW, Ali A, Klemba MW, Munday NA, Zamboni RJ, Ford-Hutchinson AW.

J Biol Chem. 1992 Sep 5;267(25):17849-57.

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