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Computer aided diagnosis for ASPECT rating: initial experiences with the Frontier ASPECT Score software.

Goebel J, Stenzel E, Zuelow S, Kleinschnitz C, Forsting M, Moenninghoff C, Radbruch A.

Acta Radiol. 2019 Apr 24:284185119842465. doi: 10.1177/0284185119842465. [Epub ahead of print]


Comparison of L-Methyl-11C-Methionine PET With Magnetic Resonance Spectroscopy in Detecting Newly Diagnosed Glioma.

Kebir S, Lazaridis L, Weber M, Deuschl C, Stoppek AK, Schmidt T, Mönninghoff C, Blau T, Keyvani K, Umutlu L, Pierscianek D, Forsting M, Stuschke M, Antoch G, Sure U, Kleinschnitz C, Scheffler B, Colletti PM, Rubello D, Herrmann K, Glas M.

Clin Nucl Med. 2019 Jun;44(6):e375-e381. doi: 10.1097/RLU.0000000000002577.


Modeling Vascular Risk Factors for the Development of Ischemic Stroke Therapies.

Hermann DM, Kleinschnitz C.

Stroke. 2019 May;50(5):1310-1317. doi: 10.1161/STROKEAHA.118.024673. No abstract available.


Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors.

Schäfer N, Gielen GH, Rauschenbach L, Kebir S, Till A, Reinartz R, Simon M, Niehusmann P, Kleinschnitz C, Herrlinger U, Pietsch T, Scheffler B, Glas M.

J Transl Med. 2019 Mar 20;17(1):96. doi: 10.1186/s12967-019-1846-y.


Neuroprotection Induced by Energy and Protein-Energy Undernutrition Is Phase-Dependent After Focal Cerebral Ischemia in Mice.

de Carvalho TS, Sanchez-Mendoza EH, Nascentes Melo LM, Schultz Moreira AR, Sardari M, Dzyubenko E, Kleinschnitz C, Hermann DM.

Transl Stroke Res. 2019 Mar 18. doi: 10.1007/s12975-019-00700-3. [Epub ahead of print]


Relative health-related quality of life after treatment of unruptured intracranial aneurysms: long-term outcomes and influencing factors.

Dammann P, Wittek P, Darkwah Oppong M, Hütter BO, Jabbarli R, Wrede K, Wanke I, Mönninghoff C, Kaier K, Frank B, Müller O, Kleinschnitz C, Forsting M, Sure U.

Ther Adv Neurol Disord. 2019 Mar 8;12:1756286419833492. doi: 10.1177/1756286419833492. eCollection 2019.


Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke.

Casas AI, Kleikers PW, Geuss E, Langhauser F, Adler T, Busch DH, Gailus-Durner V, de Angelis MH, Egea J, Lopez MG, Kleinschnitz C, Schmidt HH.

J Clin Invest. 2019 Mar 18;130:1772-1778. doi: 10.1172/JCI124283. eCollection 2019 Mar 18.


Radiation exposure of image-guided intrathecal administration of nusinersen to adult patients with spinal muscular atrophy.

Oldenburg D, Guberina N, Stolte B, Kizina K, Stenzel E, Radbruch A, Kleinschnitz C, Hagenacker T, Forsting M, Mönninghoff C.

Neuroradiology. 2019 May;61(5):565-574. doi: 10.1007/s00234-019-02189-x. Epub 2019 Mar 14.


Sleep-Disordered Breathing in Hospitalized Geriatric Patients with Mild Dementia and Its Association with Cognition, Emotion and Mobility.

Gronewold J, Haensel R, Kleinschnitz C, Frohnhofen H, Hermann DM.

Int J Environ Res Public Health. 2019 Mar 9;16(5). pii: E863. doi: 10.3390/ijerph16050863.


Immunology of stroke: from animal models to clinical trials.

Schmidt-Pogoda A, Minnerup J, Kleinschnitz C.

Ther Adv Neurol Disord. 2019 Feb 21;12:1756286419830862. doi: 10.1177/1756286419830862. eCollection 2019. No abstract available.


Regorafenib in patients with recurrent high-grade astrocytoma.

Kebir S, Rauschenbach L, Radbruch A, Lazaridis L, Schmidt T, Stoppek AK, Pierscianek D, Stuschke M, Forsting M, Sure U, Keyvani K, Kleinschnitz C, Scheffler B, Glas M.

J Cancer Res Clin Oncol. 2019 Apr;145(4):1037-1042. doi: 10.1007/s00432-019-02868-5. Epub 2019 Feb 28.


A fatal case of daclizumab-induced liver failure in a patient with MS.

Stettner M, Gross CC, Mausberg AK, Pul R, Junker A, Baba HA, Schulte-Mecklenbeck A, Wiendl H, Kleinschnitz C, Meuth SG.

Neurol Neuroimmunol Neuroinflamm. 2019 Jan 21;6(2):e539. doi: 10.1212/NXI.0000000000000539. eCollection 2019 Mar. No abstract available.


Overcoming trivialization: The neuroimmune response after acute central nervous system injury.

Schwab JM, Kleinschnitz C.

J Neuroimmunol. 2019 May 15;330:28-30. doi: 10.1016/j.jneuroim.2019.01.018. Epub 2019 Jan 31. No abstract available.


Animal models of ischemic stroke and their impact on drug discovery.

Hermann DM, Popa-Wagner A, Kleinschnitz C, Doeppner TR.

Expert Opin Drug Discov. 2019 Mar;14(3):315-326. doi: 10.1080/17460441.2019.1573984. Epub 2019 Feb 4.


Intracranial Aneurysms in Sickle Cell Disease.

Jabbarli R, Dinger TF, Pierscianek D, Oppong MD, Chen B, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Sure U.

Curr Neurovasc Res. 2019;16(1):63-76. doi: 10.2174/1567202616666190131160847.


Feasibility of intra-arterial chemotherapy for retinoblastoma: experiences in a large single center cohort study.

Stenzel E, Göricke S, Temming P, Biewald E, Zülow S, Göbel J, Wanke I, Umutlu L, Kleinschnitz C, Bornfeld N, Forsting M, Radbruch A, Mönninghoff C.

Neuroradiology. 2019 Mar;61(3):351-357. doi: 10.1007/s00234-019-02153-9. Epub 2019 Jan 14.


Role of immune responses for extracellular matrix remodeling in the ischemic brain.

Dzyubenko E, Manrique-Castano D, Kleinschnitz C, Faissner A, Hermann DM.

Ther Adv Neurol Disord. 2018 Dec 17;11:1756286418818092. doi: 10.1177/1756286418818092. eCollection 2018. Review.


[Treatment evaluation in patients with 5q-associated spinal muscular atrophy : Real-world experience].

Walter MC, Dräger B, Günther R, Hermann A, Hagenacker T, Kleinschnitz C, Löscher W, Meyer T, Schrank B, Schwersenz I, Wurster CD, Ludolph AC, Kirschner J.

Nervenarzt. 2019 Apr;90(4):343-351. doi: 10.1007/s00115-018-0653-7. Review. German.


Effectiveness of Endovascular Recanalization Treatment for M2 Segment Occlusion: Comparison Between Intracranial ICA, M1, and M2 Segment Thrombectomy.

Goebel J, Stenzel E, Wanke I, Paech D, Koehrmann M, Kleinschnitz C, Forsting M, Radbruch A, Moenninghoff C.

Acad Radiol. 2018 Dec 24. pii: S1076-6332(18)30538-5. doi: 10.1016/j.acra.2018.11.019. [Epub ahead of print]


Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function.

Bieber M, Schuhmann MK, Volz J, Kumar GJ, Vaidya JR, Nieswandt B, Pham M, Stoll G, Kleinschnitz C, Kraft P.

Stroke. 2019 Feb;50(2):478-486. doi: 10.1161/STROKEAHA.118.023664.


Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release.

Göbel K, Asaridou CM, Merker M, Eichler S, Herrmann AM, Geuß E, Ruck T, Schüngel L, Groeneweg L, Narayanan V, Schneider-Hohendorf T, Gross CC, Wiendl H, Kehrel BE, Kleinschnitz C, Meuth SG.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):271-276. doi: 10.1073/pnas.1810020116. Epub 2018 Dec 17.


Post-treatment Antiplatelet Therapy Reduces Risk for Delayed Cerebral Ischemia due to Aneurysmal Subarachnoid Hemorrhage.

Darkwah Oppong M, Gembruch O, Pierscianek D, Köhrmann M, Kleinschnitz C, Deuschl C, Mönninghoff C, Kaier K, Forsting M, Sure U, Jabbarli R.

Neurosurgery. 2018 Dec 13. doi: 10.1093/neuros/nyy550. [Epub ahead of print]


Hybrid 11C-MET PET/MRI Combined With "Machine Learning" in Glioma Diagnosis According to the Revised Glioma WHO Classification 2016.

Kebir S, Weber M, Lazaridis L, Deuschl C, Schmidt T, Mönninghoff C, Keyvani K, Umutlu L, Pierscianek D, Forsting M, Sure U, Stuschke M, Kleinschnitz C, Scheffler B, Colletti PM, Rubello D, Rischpler C, Glas M.

Clin Nucl Med. 2019 Mar;44(3):214-220. doi: 10.1097/RLU.0000000000002398.


Efficacy and safety of alemtuzumab versus fingolimod in RRMS after natalizumab cessation.

Pfeuffer S, Schmidt R, Straeten FA, Pul R, Kleinschnitz C, Wieshuber M, Lee DH, Linker RA, Doerck S, Straeten V, Windhagen S, Pawlitzki M, Aufenberg C, Lang M, Eienbroeker C, Tackenberg B, Limmroth V, Wildemann B, Haas J, Klotz L, Wiendl H, Ruck T, Meuth SG.

J Neurol. 2019 Jan;266(1):165-173. doi: 10.1007/s00415-018-9117-z. Epub 2018 Nov 16.


Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination.

Szepanowski F, Szepanowski LP, Mausberg AK, Albrecht P, Kleinschnitz C, Kieseier BC, Stettner M.

Acta Neuropathol. 2018 Dec;136(6):979-982. doi: 10.1007/s00401-018-1938-4. Epub 2018 Nov 16. No abstract available.


How is the formation of microthrombi after traumatic brain injury linked to inflammation?

Albert-Weissenberger C, Hopp S, Nieswandt B, Sirén AL, Kleinschnitz C, Stetter C.

J Neuroimmunol. 2019 Jan 15;326:9-13. doi: 10.1016/j.jneuroim.2018.10.011. Epub 2018 Oct 31. Review.


Absence of Regulatory T Cells Causes Phenotypic and Functional Switch in Murine Peritoneal Macrophages.

Skuljec J, Jirmo AC, Habener A, Talbot SR, Pul R, Grychtol R, Aydin M, Kleinschnitz C, Happle C, Hansen G.

Front Immunol. 2018 Oct 31;9:2458. doi: 10.3389/fimmu.2018.02458. eCollection 2018.


Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells.

Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth SG, Klotz L.

Neurology. 2018 Dec 11;91(24):e2233-e2237. doi: 10.1212/WNL.0000000000006648. Epub 2018 Nov 7.


Polarity-specific modulation of pain processing by transcranial direct current stimulation - a blinded longitudinal fMRI study.

Naegel S, Biermann J, Theysohn N, Kleinschnitz C, Diener HC, Katsarava Z, Obermann M, Holle D.

J Headache Pain. 2018 Oct 24;19(1):99. doi: 10.1186/s10194-018-0924-5.


Postacute Delivery of GABAA α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling.

Wang YC, Dzyubenko E, Sanchez-Mendoza EH, Sardari M, Silva de Carvalho T, Doeppner TR, Kaltwasser B, Machado P, Kleinschnitz C, Bassetti CL, Hermann DM.

Stroke. 2018 Oct;49(10):2495-2503. doi: 10.1161/STROKEAHA.118.021378.


Gute Ernährung reduziert MS-Symptome.

Pul R, Kleinschnitz C.

MMW Fortschr Med. 2018 Oct;160(18):42. doi: 10.1007/s15006-018-1026-7. Review. German. No abstract available.


Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions.

Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Krumbholz M, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl UK, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C; NEMOS (Neuromyelitis Optica Study Group).

Neurol Neuroimmunol Neuroinflamm. 2018 Sep 26;5(6):e504. doi: 10.1212/NXI.0000000000000504. eCollection 2018 Nov.


Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review.

Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Roos A, Sure U.

Neurosurg Rev. 2018 Oct 10. doi: 10.1007/s10143-018-1037-y. [Epub ahead of print] Review.


Feasibility and safety of intrathecal treatment with nusinersen in adult patients with spinal muscular atrophy.

Stolte B, Totzeck A, Kizina K, Bolz S, Pietruck L, Mönninghoff C, Guberina N, Oldenburg D, Forsting M, Kleinschnitz C, Hagenacker T.

Ther Adv Neurol Disord. 2018 Oct 5;11:1756286418803246. doi: 10.1177/1756286418803246. eCollection 2018.


Role of polymorphonuclear neutrophils in the reperfused ischemic brain: insights from cell-type-specific immunodepletion and fluorescence microscopy studies.

Hermann DM, Kleinschnitz C, Gunzer M.

Ther Adv Neurol Disord. 2018 Sep 14;11:1756286418798607. doi: 10.1177/1756286418798607. eCollection 2018. Review.


Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry.

Rommer PS, Eichstädt K, Ellenberger D, Flachenecker P, Friede T, Haas J, Kleinschnitz C, Pöhlau D, Rienhoff O, Stahmann A, Zettl UK.

Mult Scler. 2018 Sep 19:1352458518799580. doi: 10.1177/1352458518799580. [Epub ahead of print]


Automated ASPECT rating: comparison between the Frontier ASPECT Score software and the Brainomix software.

Goebel J, Stenzel E, Guberina N, Wanke I, Koehrmann M, Kleinschnitz C, Umutlu L, Forsting M, Moenninghoff C, Radbruch A.

Neuroradiology. 2018 Dec;60(12):1267-1272. doi: 10.1007/s00234-018-2098-x. Epub 2018 Sep 15.


CIDP, myasthenia gravis, and membranous glomerulonephritis - three autoimmune disorders in one patient: a case report.

Bolz S, Totzeck A, Amann K, Stettner M, Kleinschnitz C, Hagenacker T.

BMC Neurol. 2018 Aug 14;18(1):113. doi: 10.1186/s12883-018-1120-6.


The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review.

Göbel K, Eichler S, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Front Immunol. 2018 Jul 26;9:1731. doi: 10.3389/fimmu.2018.01731. eCollection 2018.


Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis.

Simon M, Ipek R, Homola GA, Rovituso DM, Schampel A, Kleinschnitz C, Kuerten S.

J Neuroinflammation. 2018 Aug 11;15(1):225. doi: 10.1186/s12974-018-1263-9.


Decreasing longitudinal use of glucocorticosteroids in multiple sclerosis.

Ellenberger D, Eichstädt K, Flachenecker P, Friede T, Haas J, Kleinschnitz C, Pöhlau D, Rienhoff O, Stahmann A, Zettl UK, Rommer PS.

Mult Scler Relat Disord. 2018 Oct;25:173-174. doi: 10.1016/j.msard.2018.07.040. Epub 2018 Jul 24. No abstract available.


Topological remodeling of cortical perineuronal nets in focal cerebral ischemia and mild hypoperfusion.

Dzyubenko E, Manrique-Castano D, Kleinschnitz C, Faissner A, Hermann DM.

Matrix Biol. 2018 Dec;74:121-132. doi: 10.1016/j.matbio.2018.08.001. Epub 2018 Aug 6.


Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis.

Mausberg AK, Szepanowski F, Odoardi F, Flügel A, Kleinschnitz C, Stettner M, Kieseier BC.

J Neuroinflammation. 2018 Aug 1;15(1):217. doi: 10.1186/s12974-018-1259-5.


Detection of early infarction signs with machine learning-based diagnosis by means of the Alberta Stroke Program Early CT score (ASPECTS) in the clinical routine.

Guberina N, Dietrich U, Radbruch A, Goebel J, Deuschl C, Ringelstein A, Köhrmann M, Kleinschnitz C, Forsting M, Mönninghoff C.

Neuroradiology. 2018 Sep;60(9):889-901. doi: 10.1007/s00234-018-2066-5. Epub 2018 Jul 31.


Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.

Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Dürschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF.

Circulation. 2018 Oct 16;138(16):1720-1735. doi: 10.1161/CIRCULATIONAHA.118.034600. Erratum in: Circulation. 2019 Jan 15;139(3):e8.


Immunotherapy of experimental and human stroke with agents approved for multiple sclerosis: a systematic review.

Dreikorn M, Milacic Z, Pavlovic V, Meuth SG, Kleinschnitz C, Kraft P.

Ther Adv Neurol Disord. 2018 Apr 20;11:1756286418770626. doi: 10.1177/1756286418770626. eCollection 2018. Review.


Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination.

Cerina M, Narayanan V, Delank A, Meuth P, Graebenitz S, Göbel K, Herrmann AM, Albrecht S, Daldrup T, Seidenbecher T, Gorji A, Kuhlmann T, Wiendl H, Kleinschnitz C, Speckmann EJ, Pape HC, Meuth SG, Budde T.

Brain Struct Funct. 2018 Sep;223(7):3091-3106. doi: 10.1007/s00429-018-1680-7. Epub 2018 May 9.


Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target.

Hermann DM, Kleinschnitz C, Gunzer M.

J Neuroimmunol. 2018 Aug 15;321:138-143. doi: 10.1016/j.jneuroim.2018.04.015. Epub 2018 Apr 24. Review.


Alemtuzumab as rescue therapy in a cohort of 50 relapsing-remitting MS patients with breakthrough disease on fingolimod: a multi-center observational study.

Huhn K, Bayas A, Doerck S, Frank B, Gerbershagen K, Hellwig K, Kallmann B, Kleinschnitz C, Kleiter I, Lee DH, Limmroth V, Mäurer M, Meuth S, Rieckmann P, Ruck T, Gold R, Linker RA.

J Neurol. 2018 Jul;265(7):1521-1527. doi: 10.1007/s00415-018-8871-2. Epub 2018 Apr 25.


Oxaliplatin Modulates the Characteristics of Voltage-Gated Calcium Channels and Action Potentials in Small Dorsal Root Ganglion Neurons of Rats.

Schmitt LI, Leo M, Kleinschnitz C, Hagenacker T.

Mol Neurobiol. 2018 Dec;55(12):8842-8855. doi: 10.1007/s12035-018-1029-5. Epub 2018 Mar 30.


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