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Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells.

Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth SG, Klotz L.

Neurology. 2018 Nov 7. pii: 10.1212/WNL.0000000000006648. doi: 10.1212/WNL.0000000000006648. [Epub ahead of print]


Polarity-specific modulation of pain processing by transcranial direct current stimulation - a blinded longitudinal fMRI study.

Naegel S, Biermann J, Theysohn N, Kleinschnitz C, Diener HC, Katsarava Z, Obermann M, Holle D.

J Headache Pain. 2018 Oct 24;19(1):99. doi: 10.1186/s10194-018-0924-5.


Postacute Delivery of GABAA α5 Antagonist Promotes Postischemic Neurological Recovery and Peri-infarct Brain Remodeling.

Wang YC, Dzyubenko E, Sanchez-Mendoza EH, Sardari M, Silva de Carvalho T, Doeppner TR, Kaltwasser B, Machado P, Kleinschnitz C, Bassetti CL, Hermann DM.

Stroke. 2018 Oct;49(10):2495-2503. doi: 10.1161/STROKEAHA.118.021378.


Gute Ernährung reduziert MS-Symptome.

Pul R, Kleinschnitz C.

MMW Fortschr Med. 2018 Oct;160(18):42. doi: 10.1007/s15006-018-1026-7. Review. German. No abstract available.


Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions.

Kleiter I, Gahlen A, Borisow N, Fischer K, Wernecke KD, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Stellmann JP, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Krumbholz M, Zeltner L, Ziemann U, Linker R, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl UK, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C; NEMOS (Neuromyelitis Optica Study Group).

Neurol Neuroimmunol Neuroinflamm. 2018 Sep 26;5(6):e504. doi: 10.1212/NXI.0000000000000504. eCollection 2018 Nov.


Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review.

Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Roos A, Sure U.

Neurosurg Rev. 2018 Oct 10. doi: 10.1007/s10143-018-1037-y. [Epub ahead of print] Review.


Feasibility and safety of intrathecal treatment with nusinersen in adult patients with spinal muscular atrophy.

Stolte B, Totzeck A, Kizina K, Bolz S, Pietruck L, Mönninghoff C, Guberina N, Oldenburg D, Forsting M, Kleinschnitz C, Hagenacker T.

Ther Adv Neurol Disord. 2018 Oct 5;11:1756286418803246. doi: 10.1177/1756286418803246. eCollection 2018.


Role of polymorphonuclear neutrophils in the reperfused ischemic brain: insights from cell-type-specific immunodepletion and fluorescence microscopy studies.

Hermann DM, Kleinschnitz C, Gunzer M.

Ther Adv Neurol Disord. 2018 Sep 14;11:1756286418798607. doi: 10.1177/1756286418798607. eCollection 2018. Review.


Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry.

Rommer PS, Eichstädt K, Ellenberger D, Flachenecker P, Friede T, Haas J, Kleinschnitz C, Pöhlau D, Rienhoff O, Stahmann A, Zettl UK.

Mult Scler. 2018 Sep 19:1352458518799580. doi: 10.1177/1352458518799580. [Epub ahead of print]


Automated ASPECT rating: comparison between the Frontier ASPECT Score software and the Brainomix software.

Goebel J, Stenzel E, Guberina N, Wanke I, Koehrmann M, Kleinschnitz C, Umutlu L, Forsting M, Moenninghoff C, Radbruch A.

Neuroradiology. 2018 Sep 15. doi: 10.1007/s00234-018-2098-x. [Epub ahead of print]


CIDP, myasthenia gravis, and membranous glomerulonephritis - three autoimmune disorders in one patient: a case report.

Bolz S, Totzeck A, Amann K, Stettner M, Kleinschnitz C, Hagenacker T.

BMC Neurol. 2018 Aug 14;18(1):113. doi: 10.1186/s12883-018-1120-6.


The Coagulation Factors Fibrinogen, Thrombin, and Factor XII in Inflammatory Disorders-A Systematic Review.

Göbel K, Eichler S, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Front Immunol. 2018 Jul 26;9:1731. doi: 10.3389/fimmu.2018.01731. eCollection 2018.


Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis.

Simon M, Ipek R, Homola GA, Rovituso DM, Schampel A, Kleinschnitz C, Kuerten S.

J Neuroinflammation. 2018 Aug 11;15(1):225. doi: 10.1186/s12974-018-1263-9.


Decreasing longitudinal use of glucocorticosteroids in multiple sclerosis.

Ellenberger D, Eichstädt K, Flachenecker P, Friede T, Haas J, Kleinschnitz C, Pöhlau D, Rienhoff O, Stahmann A, Zettl UK, Rommer PS.

Mult Scler Relat Disord. 2018 Oct;25:173-174. doi: 10.1016/j.msard.2018.07.040. Epub 2018 Jul 24. No abstract available.


Topological remodeling of cortical perineuronal nets in focal cerebral ischemia and mild hypoperfusion.

Dzyubenko E, Manrique-Castano D, Kleinschnitz C, Faissner A, Hermann DM.

Matrix Biol. 2018 Aug 6. pii: S0945-053X(18)30187-2. doi: 10.1016/j.matbio.2018.08.001. [Epub ahead of print]


Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis.

Mausberg AK, Szepanowski F, Odoardi F, Flügel A, Kleinschnitz C, Stettner M, Kieseier BC.

J Neuroinflammation. 2018 Aug 1;15(1):217. doi: 10.1186/s12974-018-1259-5.


Detection of early infarction signs with machine learning-based diagnosis by means of the Alberta Stroke Program Early CT score (ASPECTS) in the clinical routine.

Guberina N, Dietrich U, Radbruch A, Goebel J, Deuschl C, Ringelstein A, Köhrmann M, Kleinschnitz C, Forsting M, Mönninghoff C.

Neuroradiology. 2018 Sep;60(9):889-901. doi: 10.1007/s00234-018-2066-5. Epub 2018 Jul 31.


Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.

Sauter RJ, Sauter M, Reis ES, Emschermann FN, Nording H, Ebenhöch S, Kraft P, Münzer P, Mauler M, Rheinlaender J, Madlung J, Edlich F, Schäffer TE, Meuth SG, Dürschmied D, Geisler T, Borst O, Gawaz M, Kleinschnitz C, Lambris JD, Langer HF.

Circulation. 2018 Oct 16;138(16):1720-1735. doi: 10.1161/CIRCULATIONAHA.118.034600.


Immunotherapy of experimental and human stroke with agents approved for multiple sclerosis: a systematic review.

Dreikorn M, Milacic Z, Pavlovic V, Meuth SG, Kleinschnitz C, Kraft P.

Ther Adv Neurol Disord. 2018 Apr 20;11:1756286418770626. doi: 10.1177/1756286418770626. eCollection 2018. Review.


Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination.

Cerina M, Narayanan V, Delank A, Meuth P, Graebenitz S, Göbel K, Herrmann AM, Albrecht S, Daldrup T, Seidenbecher T, Gorji A, Kuhlmann T, Wiendl H, Kleinschnitz C, Speckmann EJ, Pape HC, Meuth SG, Budde T.

Brain Struct Funct. 2018 May 9. doi: 10.1007/s00429-018-1680-7. [Epub ahead of print]


Implications of polymorphonuclear neutrophils for ischemic stroke and intracerebral hemorrhage: Predictive value, pathophysiological consequences and utility as therapeutic target.

Hermann DM, Kleinschnitz C, Gunzer M.

J Neuroimmunol. 2018 Aug 15;321:138-143. doi: 10.1016/j.jneuroim.2018.04.015. Epub 2018 Apr 24. Review.


Alemtuzumab as rescue therapy in a cohort of 50 relapsing-remitting MS patients with breakthrough disease on fingolimod: a multi-center observational study.

Huhn K, Bayas A, Doerck S, Frank B, Gerbershagen K, Hellwig K, Kallmann B, Kleinschnitz C, Kleiter I, Lee DH, Limmroth V, Mäurer M, Meuth S, Rieckmann P, Ruck T, Gold R, Linker RA.

J Neurol. 2018 Jul;265(7):1521-1527. doi: 10.1007/s00415-018-8871-2. Epub 2018 Apr 25.


Oxaliplatin Modulates the Characteristics of Voltage-Gated Calcium Channels and Action Potentials in Small Dorsal Root Ganglion Neurons of Rats.

Schmitt LI, Leo M, Kleinschnitz C, Hagenacker T.

Mol Neurobiol. 2018 Dec;55(12):8842-8855. doi: 10.1007/s12035-018-1029-5. Epub 2018 Mar 30.


Advances in Multiple Sclerosis 2017.

Göbel K, Kleinschnitz C, Meuth SG.

Int J Mol Sci. 2018 Mar 19;19(3). pii: E901. doi: 10.3390/ijms19030901.


Risk Factors for and Clinical Consequences of Multiple Intracranial Aneurysms: A Systematic Review and Meta-Analysis.

Jabbarli R, Dinger TF, Darkwah Oppong M, Pierscianek D, Dammann P, Wrede KH, Kaier K, Köhrmann M, Forsting M, Kleinschnitz C, Sure U.

Stroke. 2018 Apr;49(4):848-855. doi: 10.1161/STROKEAHA.117.020342. Epub 2018 Mar 6.


A diseasome cluster-based drug repurposing of soluble guanylate cyclase activators from smooth muscle relaxation to direct neuroprotection.

Langhauser F, Casas AI, Dao VT, Guney E, Menche J, Geuss E, Kleikers PWM, López MG, Barabási AL, Kleinschnitz C, Schmidt HHHW.

NPJ Syst Biol Appl. 2018 Feb 5;4:8. doi: 10.1038/s41540-017-0039-7. eCollection 2018.


[Coagulation factors and multiple sclerosis : Key factors in the pathogenesis?]

Göbel K, Kleinschnitz C, Meuth SG.

Nervenarzt. 2018 Aug;89(8):908-912. doi: 10.1007/s00115-018-0491-7. Review. German.


Cerebral gray matter changes in persistent postural perceptual dizziness.

Wurthmann S, Naegel S, Schulte Steinberg B, Theysohn N, Diener HC, Kleinschnitz C, Obermann M, Holle D.

J Psychosom Res. 2017 Dec;103:95-101. doi: 10.1016/j.jpsychores.2017.10.007. Epub 2017 Oct 16.


Cisplatin alters the function and expression of N-type voltage-gated calcium channels in the absence of morphological damage of sensory neurons.

Leo M, Schmitt LI, Jastrow H, Thomale J, Kleinschnitz C, Hagenacker T.

Mol Pain. 2017 Jan-Dec;13:1744806917746565. doi: 10.1177/1744806917746565. Epub 2017 Nov 22.


NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.

Casas AI, Geuss E, Kleikers PWM, Mencl S, Herrmann AM, Buendia I, Egea J, Meuth SG, Lopez MG, Kleinschnitz C, Schmidt HHHW.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12315-12320. doi: 10.1073/pnas.1705034114. Epub 2017 Oct 31.


Depletion of CD11c+ Cells Does Not Influence Outcomes in Mice Subjected to Transient Middle Cerebral Artery Occlusion.

Kraft P, Scholtyschik K, Schuhmann MK, Kleinschnitz C.

Neuroimmunomodulation. 2017;24(3):123-131. doi: 10.1159/000481311. Epub 2017 Oct 31.


Stimulation of the mesencephalic locomotor region for gait recovery after stroke.

Fluri F, Malzahn U, Homola GA, Schuhmann MK, Kleinschnitz C, Volkmann J.

Ann Neurol. 2017 Nov;82(5):828-840. doi: 10.1002/ana.25086. Epub 2017 Nov 11.


Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA1 signaling.

Szepanowski F, Szepanowski LP, Mausberg AK, Kleinschnitz C, Kieseier BC, Stettner M.

Neurosci Lett. 2018 Jan 1;662:136-141. doi: 10.1016/j.neulet.2017.10.023. Epub 2017 Oct 16.


Stroke-induced chronic systolic dysfunction driven by sympathetic overactivity.

Bieber M, Werner RA, Tanai E, Hofmann U, Higuchi T, Schuh K, Heuschmann PU, Frantz S, Ritter O, Kraft P, Kleinschnitz C.

Ann Neurol. 2017 Nov;82(5):729-743. doi: 10.1002/ana.25073. Epub 2017 Nov 6.


Rivaroxaban ameliorates disease course in an animal model of multiple sclerosis.

Merker M, Eichler S, Herrmann AM, Wiendl H, Kleinschnitz C, Göbel K, Meuth SG.

J Neuroimmunol. 2017 Dec 15;313:125-128. doi: 10.1016/j.jneuroim.2017.08.013. Epub 2017 Sep 21.


CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis.

Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O.

Blood. 2017 Dec 21;130(25):2774-2785. doi: 10.1182/blood-2017-05-784413. Epub 2017 Sep 19.


Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior.

Leo M, Schulte M, Schmitt LI, Schäfers M, Kleinschnitz C, Hagenacker T.

Mediators Inflamm. 2017;2017:2786427. doi: 10.1155/2017/2786427. Epub 2017 Aug 2.


Feasibility and diagnostic accuracy of point-of-care handheld echocardiography in acute ischemic stroke patients - a pilot study.

Kraft P, Fleischer A, Wiedmann S, Rücker V, Mackenrodt D, Morbach C, Malzahn U, Kleinschnitz C, Störk S, Heuschmann PU.

BMC Neurol. 2017 Aug 11;17(1):159. doi: 10.1186/s12883-017-0937-8.


Hypercholesterolemia induced cerebral small vessel disease.

Kraft P, Schuhmann MK, Garz C, Jandke S, Urlaub D, Mencl S, Zernecke A, Heinze HJ, Carare RO, Kleinschnitz C, Schreiber S.

PLoS One. 2017 Aug 10;12(8):e0182822. doi: 10.1371/journal.pone.0182822. eCollection 2017.


Differential effects of FTY720 on the B cell compartment in a mouse model of multiple sclerosis.

Bail K, Notz Q, Rovituso DM, Schampel A, Wunsch M, Koeniger T, Schropp V, Bharti R, Scholz CJ, Foerstner KU, Kleinschnitz C, Kuerten S.

J Neuroinflammation. 2017 Jul 24;14(1):148. doi: 10.1186/s12974-017-0924-4.


Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease.

Denorme F, Kraft P, Pareyn I, Drechsler C, Deckmyn H, Vanhoorelbeke K, Kleinschnitz C, De Meyer SF.

PLoS One. 2017 Jun 7;12(6):e0179258. doi: 10.1371/journal.pone.0179258. eCollection 2017.


B cells do not have a major pathophysiologic role in acute ischemic stroke in mice.

Schuhmann MK, Langhauser F, Kraft P, Kleinschnitz C.

J Neuroinflammation. 2017 Jun 2;14(1):112. doi: 10.1186/s12974-017-0890-x.


Immunotherapies in neuromyelitis optica spectrum disorder: efficacy and predictors of response.

Stellmann JP, Krumbholz M, Friede T, Gahlen A, Borisow N, Fischer K, Hellwig K, Pache F, Ruprecht K, Havla J, Kümpfel T, Aktas O, Hartung HP, Ringelstein M, Geis C, Kleinschnitz C, Berthele A, Hemmer B, Angstwurm K, Young KL, Schuster S, Stangel M, Lauda F, Tumani H, Mayer C, Zeltner L, Ziemann U, Linker RA, Schwab M, Marziniak M, Then Bergh F, Hofstadt-van Oy U, Neuhaus O, Zettl U, Faiss J, Wildemann B, Paul F, Jarius S, Trebst C, Kleiter I; NEMOS (Neuromyelitis Optica Study Group).

J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):639-647. doi: 10.1136/jnnp-2017-315603. Epub 2017 Jun 1.


The Role of Peripheral Myelin Protein 2 in Remyelination.

Stettner M, Zenker J, Klingler F, Szepanowski F, Hartung HP, Mausberg AK, Kleinschnitz C, Chrast R, Kieseier BC.

Cell Mol Neurobiol. 2018 Mar;38(2):487-496. doi: 10.1007/s10571-017-0494-0. Epub 2017 Apr 26.


Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa.

Hopp S, Nolte MW, Stetter C, Kleinschnitz C, Sirén AL, Albert-Weissenberger C.

J Neuroinflammation. 2017 Feb 20;14(1):39. doi: 10.1186/s12974-017-0815-8.


Gain-of-function STAT1 mutations are associated with intracranial aneurysms.

Dadak M, Jacobs R, Skuljec J, Jirmo AC, Yildiz Ö, Donnerstag F, Baerlecken NT, Schmidt RE, Lanfermann H, Skripuletz T, Schwenkenbecher P, Kleinschnitz C, Tumani H, Stangel M, Pul R.

Clin Immunol. 2017 May;178:79-85. doi: 10.1016/j.clim.2017.01.012. Epub 2017 Feb 2.


Blocking of platelet glycoprotein receptor Ib reduces "thrombo-inflammation" in mice with acute ischemic stroke.

Schuhmann MK, Guthmann J, Stoll G, Nieswandt B, Kraft P, Kleinschnitz C.

J Neuroinflammation. 2017 Jan 21;14(1):18. doi: 10.1186/s12974-017-0792-y.


Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway.

Szepanowski F, Donaldson DM, Hartung HP, Mausberg AK, Kleinschnitz C, Kieseier BC, Stettner M.

Acta Neuropathol. 2017 Mar;133(3):489-491. doi: 10.1007/s00401-017-1676-z. Epub 2017 Jan 20. No abstract available.


Coagulation Testing in Acute Ischemic Stroke Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants.

Purrucker JC, Haas K, Rizos T, Khan S, Poli S, Kraft P, Kleinschnitz C, Dziewas R, Binder A, Palm F, Jander S, Soda H, Heuschmann PU, Veltkamp R; RASUNOA Investigators (Registry of Acute Stroke Under New Oral Anticoagulants).

Stroke. 2017 Jan;48(1):152-158. doi: 10.1161/STROKEAHA.116.014963. Epub 2016 Nov 29.


NOX4 is an early initiator of neuropathic pain.

Geis C, Geuss E, Sommer C, Schmidt HH, Kleinschnitz C.

Exp Neurol. 2017 Feb;288:94-103. doi: 10.1016/j.expneurol.2016.11.008. Epub 2016 Nov 14.


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