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Items: 34

1.

Impact of Brain Insulin Signaling on Dopamine Function, Food Intake, Reward, and Emotional Behavior.

Kleinridders A, Pothos EN.

Curr Nutr Rep. 2019 Jun;8(2):83-91. doi: 10.1007/s13668-019-0276-z. Review.

PMID:
31001792
2.

Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function.

Chudoba C, Wardelmann K, Kleinridders A.

Biol Chem. 2019 Feb 28. pii: /j/bchm.ahead-of-print/hsz-2018-0477/hsz-2018-0477.xml. doi: 10.1515/hsz-2018-0477. [Epub ahead of print] Review.

PMID:
30730834
3.

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain.

Wardelmann K, Blümel S, Rath M, Alfine E, Chudoba C, Schell M, Cai W, Hauffe R, Warnke K, Flore T, Ritter K, Weiß J, Kahn CR, Kleinridders A.

Mol Metab. 2019 Mar;21:68-81. doi: 10.1016/j.molmet.2019.01.001. Epub 2019 Jan 6.

4.

Editorial: Crosstalk of Mitochondria With Brain Insulin and Leptin Signaling.

Kleinridders A, Ferris HA, Tovar S.

Front Endocrinol (Lausanne). 2018 Dec 14;9:761. doi: 10.3389/fendo.2018.00761. eCollection 2018. No abstract available.

5.

Soybean Oil-Derived Poly-Unsaturated Fatty Acids Enhance Liver Damage in NAFLD Induced by Dietary Cholesterol.

Henkel J, Alfine E, Saín J, Jöhrens K, Weber D, Castro JP, König J, Stuhlmann C, Vahrenbrink M, Jonas W, Kleinridders A, Püschel GP.

Nutrients. 2018 Sep 18;10(9). pii: E1326. doi: 10.3390/nu10091326.

6.

Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?

Castro JP, Wardelmann K, Grune T, Kleinridders A.

Front Endocrinol (Lausanne). 2018 Apr 26;9:196. doi: 10.3389/fendo.2018.00196. eCollection 2018.

7.

Regional differences in brain glucose metabolism determined by imaging mass spectrometry.

Kleinridders A, Ferris HA, Reyzer ML, Rath M, Soto M, Manier ML, Spraggins J, Yang Z, Stanton RC, Caprioli RM, Kahn CR.

Mol Metab. 2018 Jun;12:113-121. doi: 10.1016/j.molmet.2018.03.013. Epub 2018 Apr 6.

8.

Insulin regulates astrocyte gliotransmission and modulates behavior.

Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR.

J Clin Invest. 2018 Jul 2;128(7):2914-2926. doi: 10.1172/JCI99366. Epub 2018 Jun 4.

9.

Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.

Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR.

Nat Commun. 2017 Mar 27;8:14892. doi: 10.1038/ncomms14892.

10.

Deciphering Brain Insulin Receptor and Insulin-Like Growth Factor 1 Receptor Signalling.

Kleinridders A.

J Neuroendocrinol. 2016 Nov;28(11). doi: 10.1111/jne.12433.

11.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC.

Cell. 2016 Aug 25;166(5):1338-1340. doi: 10.1016/j.cell.2016.08.010. No abstract available.

12.

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR.

J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15.

13.

Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function.

Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR.

Diabetes. 2016 Aug;65(8):2201-13. doi: 10.2337/db16-0212. Epub 2016 May 13.

14.

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC.

Cell. 2016 May 5;165(4):882-95. doi: 10.1016/j.cell.2016.03.033. Epub 2016 Apr 28. Erratum in: Cell. 2016 Aug 25;166(5):1338-1340.

15.

Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts.

Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN.

Stem Cells Transl Med. 2015 Oct;4(10):1101-8. doi: 10.5966/sctm.2014-0217. Epub 2015 Aug 7.

16.

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.

Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3463-8. doi: 10.1073/pnas.1500877112. Epub 2015 Mar 2.

17.

Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity.

Vienberg SG, Kleinridders A, Suzuki R, Kahn CR.

Mol Metab. 2014 Nov 13;4(2):144-50. doi: 10.1016/j.molmet.2014.11.003. eCollection 2015 Feb.

18.

Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.

Boucher J, Charalambous M, Zarse K, Mori MA, Kleinridders A, Ristow M, Ferguson-Smith AC, Kahn CR.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14512-7. doi: 10.1073/pnas.1415475111. Epub 2014 Sep 22.

19.

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR.

Sci Transl Med. 2014 Jul 30;6(247):247ra103. doi: 10.1126/scitranslmed.3008490.

20.

Insulin action in brain regulates systemic metabolism and brain function.

Kleinridders A, Ferris HA, Cai W, Kahn CR.

Diabetes. 2014 Jul;63(7):2232-43. doi: 10.2337/db14-0568. Epub 2014 Jun 15. Review.

21.

Insulin receptor signaling in normal and insulin-resistant states.

Boucher J, Kleinridders A, Kahn CR.

Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1). pii: a009191. doi: 10.1101/cshperspect.a009191. Review.

22.

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.

Kleinridders A, Lauritzen HP, Ussar S, Christensen JH, Mori MA, Bross P, Kahn CR.

J Clin Invest. 2013 Nov;123(11):4667-80.

23.

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation.

Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, Bain JR, Lee KY, Verdin EM, Newgard CB, Gibson BW, Kahn CR.

Diabetes. 2013 Oct;62(10):3404-17. doi: 10.2337/db12-1650. Epub 2013 Jul 8.

24.

Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis.

Könner AC, Hess S, Tovar S, Mesaros A, Sánchez-Lasheras C, Evers N, Verhagen LA, Brönneke HS, Kleinridders A, Hampel B, Kloppenburg P, Brüning JC.

Cell Metab. 2011 Jun 8;13(6):720-8. doi: 10.1016/j.cmet.2011.03.021.

25.

Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing.

Mende Y, Jakubik M, Riessland M, Schoenen F, Rossbach K, Kleinridders A, Köhler C, Buch T, Wirth B.

Hum Mol Genet. 2010 Jun 1;19(11):2154-67. doi: 10.1093/hmg/ddq094. Epub 2010 Feb 27.

PMID:
20190275
26.

Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.

Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, von Freyend MJ, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC.

J Biol Chem. 2010 Feb 26;285(9):6198-207. doi: 10.1074/jbc.M109.056648. Epub 2009 Dec 7.

27.

CNS-targets in control of energy and glucose homeostasis.

Kleinridders A, Könner AC, Brüning JC.

Curr Opin Pharmacol. 2009 Dec;9(6):794-804. doi: 10.1016/j.coph.2009.10.006. Epub 2009 Oct 31. Review.

PMID:
19884043
28.

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.

Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC.

Cell Metab. 2009 Oct;10(4):249-59. doi: 10.1016/j.cmet.2009.08.013.

29.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

30.

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M.

Nature. 2009 Aug 27;460(7259):1159-63. doi: 10.1038/nature08206. Epub 2009 Jul 29.

PMID:
19641494
31.

VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding.

Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC, Oldenburg J.

Thromb Haemost. 2009 Jun;101(6):1044-50.

PMID:
19492146
32.

PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis.

Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, Brüning JC.

Mol Cell Biol. 2009 Jun;29(11):3173-85. doi: 10.1128/MCB.01807-08. Epub 2009 Mar 23.

33.

Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus.

Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG.

Cell Metab. 2009 Feb;9(2):140-51. doi: 10.1016/j.cmet.2008.12.005.

34.

Reversible gene knockdown in mice using a tight, inducible shRNA expression system.

Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, Schwenk F.

Nucleic Acids Res. 2007;35(7):e54. Epub 2007 Mar 21.

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