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Items: 1 to 50 of 584

1.

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs.

Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, Phan BN, Ulrich WS, Valencia C, Jaishankar A, Price AJ, Rajpurohit A, Semick SA, Bürli RW, Barrow JC, Hiler DJ, Page SC, Martinowich K, Hyde TM, Kleinman JE, Berman KF, Apud JA, Cross AJ, Brandon NJ, Weinberger DR, Maher BJ, McKay RDG, Jaffe AE.

Nat Commun. 2020 Jan 23;11(1):462. doi: 10.1038/s41467-019-14266-z.

2.

Incarceration Rates and Incidence of Sexually Transmitted Infections in US Counties, 2011-2016.

Nowotny KM, Omori M, McKenna M, Kleinman J.

Am J Public Health. 2020 Jan;110(S1):S130-S136. doi: 10.2105/AJPH.2019.305425.

3.

Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation.

Price AJ, Hwang T, Tao R, Burke EE, Rajpurohit A, Shin JH, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR.

Genome Res. 2020 Jan;30(1):1-11. doi: 10.1101/gr.250217.119. Epub 2019 Dec 18.

PMID:
31852722
4.

NURR1 and ERR1 Modulate the Expression of Genes of a DRD2 Coexpression Network Enriched for Schizophrenia Risk.

Torretta S, Rampino A, Basso M, Pergola G, Di Carlo P, Shin JH, Kleinman JE, Hyde TM, Weinberger DR, Masellis R, Blasi G, Pennuto M, Bertolino A.

J Neurosci. 2020 Jan 22;40(4):932-941. doi: 10.1523/JNEUROSCI.0786-19.2019. Epub 2019 Dec 6.

PMID:
31811028
5.

Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain.

Clark MB, Wrzesinski T, Garcia AB, Hall NAL, Kleinman JE, Hyde T, Weinberger DR, Harrison PJ, Haerty W, Tunbridge EM.

Mol Psychiatry. 2020 Jan;25(1):37-47. doi: 10.1038/s41380-019-0583-1. Epub 2019 Nov 6.

6.

African-American and Caucasian participation in postmortem human brain donation for neuropsychiatric research.

Deep-Soboslay A, Mighdoll MI, Jaffe AE, Thomas SB, Herman MM, Sirovatka J, King JP, Fowler DR, Zulauf D, DiAngelo C, Hyde TM, Kleinman JE.

PLoS One. 2019 Oct 23;14(10):e0222565. doi: 10.1371/journal.pone.0222565. eCollection 2019.

7.

Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation.

Price AJ, Collado-Torres L, Ivanov NA, Xia W, Burke EE, Shin JH, Tao R, Ma L, Jia Y, Hyde TM, Kleinman JE, Weinberger DR, Jaffe AE.

Genome Biol. 2019 Sep 26;20(1):196. doi: 10.1186/s13059-019-1805-1.

8.

Correction: Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia.

Hu Z, Gao S, Lindberg D, Panja D, Wakabayashi Y, Li K, Kleinman JE, Zhu J, Li Z.

Transl Psychiatry. 2019 Sep 23;9(1):237. doi: 10.1038/s41398-019-0572-9.

9.

Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia.

Hu Z, Gao S, Lindberg D, Panja D, Wakabayashi Y, Li K, Kleinman JE, Zhu J, Li Z.

Transl Psychiatry. 2019 Aug 20;9(1):196. doi: 10.1038/s41398-019-0538-y. Erratum in: Transl Psychiatry. 2019 Sep 23;9(1):237.

10.

Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq.

Gådin JR, Buil A, Colantuoni C, Jaffe AE, Nielsen J, Shin JH, Hyde TM, Kleinman JE; BrainSeq Consortium, Plath N, Eriksson P, Brunak S, Didriksen M, Weinberger DR, Folkersen L.

PLoS One. 2019 Jun 17;14(6):e0217765. doi: 10.1371/journal.pone.0217765. eCollection 2019.

11.

Correction: DLPFC transcriptome defines two molecular subtypes of schizophrenia.

Bowen EFW, Burgess JL, Granger R, Kleinman JE, Rhodes CH.

Transl Psychiatry. 2019 Jun 12;9(1):169. doi: 10.1038/s41398-019-0499-1.

12.

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia.

Collado-Torres L, Burke EE, Peterson A, Shin J, Straub RE, Rajpurohit A, Semick SA, Ulrich WS; BrainSeq Consortium, Price AJ, Valencia C, Tao R, Deep-Soboslay A, Hyde TM, Kleinman JE, Weinberger DR, Jaffe AE.

Neuron. 2019 Jul 17;103(2):203-216.e8. doi: 10.1016/j.neuron.2019.05.013. Epub 2019 Jun 4.

PMID:
31174959
13.

Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients.

Pergola G, Di Carlo P, Jaffe AE, Papalino M, Chen Q, Hyde TM, Kleinman JE, Shin JH, Rampino A, Blasi G, Weinberger DR, Bertolino A.

Biol Psychiatry. 2019 Jul 1;86(1):45-55. doi: 10.1016/j.biopsych.2019.03.981. Epub 2019 Apr 3.

PMID:
31126695
14.

DLPFC transcriptome defines two molecular subtypes of schizophrenia.

Bowen EFW, Burgess JL, Granger R, Kleinman JE, Rhodes CH.

Transl Psychiatry. 2019 May 9;9(1):147. doi: 10.1038/s41398-019-0472-z. Erratum in: Transl Psychiatry. 2019 Jun 12;9(1):169.

15.

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.

Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK.

ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.

PMID:
31059647
16.

Early FAST Examinations during Resuscitation May Compromise Trauma Outcomes.

Kleinman J, Inaba K, Pott E, Matsushima K, Demetriades D, Strumwasser A.

Am Surg. 2018 Oct 1;84(10):1705-1709.

PMID:
30747699
17.

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease.

Semick SA, Bharadwaj RA, Collado-Torres L, Tao R, Shin JH, Deep-Soboslay A, Weiss JR, Weinberger DR, Hyde TM, Kleinman JE, Jaffe AE, Mattay VS.

Acta Neuropathol. 2019 Apr;137(4):557-569. doi: 10.1007/s00401-019-01966-5. Epub 2019 Feb 2.

PMID:
30712078
18.

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex.

Chronister WD, Burbulis IE, Wierman MB, Wolpert MJ, Haakenson MF, Smith ACB, Kleinman JE, Hyde TM, Weinberger DR, Bekiranov S, McConnell MJ.

Cell Rep. 2019 Jan 22;26(4):825-835.e7. doi: 10.1016/j.celrep.2018.12.107.

19.

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19).

Ma L, Semick SA, Chen Q, Li C, Tao R, Price AJ, Shin JH, Jia Y; BrainSeq Consortium, Brandon NJ, Cross AJ, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR, Straub RE.

Mol Psychiatry. 2019 Jan 11. doi: 10.1038/s41380-018-0293-0. [Epub ahead of print]

PMID:
30635639
20.

Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes.

Punzi G, Ursini G, Viscanti G, Radulescu E, Shin JH, Quarto T, Catanesi R, Blasi G, Jaffe AE, Deep-Soboslay A, Hyde TM, Kleinman JE, Bertolino A, Weinberger DR.

Biol Psychiatry. 2019 Mar 1;85(5):417-424. doi: 10.1016/j.biopsych.2018.11.002. Epub 2018 Nov 16.

PMID:
30600091
21.

Integrative functional genomic analysis of human brain development and neuropsychiatric risks.

Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF; BrainSpan Consortium; PsychENCODE Consortium; PsychENCODE Developmental Subgroup, Hu M, Jin F, Li Y, Owen MJ, O'Donovan MC, Walters JTR, Posthuma D, Reimers MA, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N.

Science. 2018 Dec 14;362(6420). pii: eaat7615. doi: 10.1126/science.aat7615.

22.

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain.

Radulescu E, Jaffe AE, Straub RE, Chen Q, Shin JH, Hyde TM, Kleinman JE, Weinberger DR.

Mol Psychiatry. 2018 Nov 26. doi: 10.1038/s41380-018-0304-1. [Epub ahead of print]

PMID:
30478419
23.

Gingival squamous cell carcinoma: an unexpected clincal presentation.

Brooks JK, Kleinman JW, Lubek JE, Price JB, Ghita I, Scurnick SA, Basile JR.

Quintessence Int. 2019;50(1):50-57. doi: 10.3290/j.qi.a41334.

PMID:
30411091
24.

Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F.

Nat Commun. 2018 Aug 29;9(1):3560. doi: 10.1038/s41467-018-06062-y.

25.

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.

Semick SA, Collado-Torres L, Markunas CA, Shin JH, Deep-Soboslay A, Tao R, Huestis MA, Bierut LJ, Maher BS, Johnson EO, Hyde TM, Weinberger DR, Hancock DB, Kleinman JE, Jaffe AE.

Mol Psychiatry. 2018 Aug 21. doi: 10.1038/s41380-018-0223-1. [Epub ahead of print]

26.

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

Boks MP, Houtepen LC, Xu Z, He Y, Ursini G, Maihofer AX, Rajarajan P, Yu Q, Xu H, Wu Y, Wang S, Shi JP, Hulshoff Pol HE, Strengman E, Rutten BPF, Jaffe AE, Kleinman JE, Baker DG, Hol EM, Akbarian S, Nievergelt CM, De Witte LD, Vinkers CH, Weinberger DR, Yu J, Kahn RS.

NPJ Schizophr. 2018 Aug 21;4(1):16. doi: 10.1038/s41537-018-0058-4.

27.

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis.

Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich WS, Maher BJ, Deep-Soboslay A; BrainSeq Consortium, Cross AJ, Brandon NJ, Leek JT, Hyde TM, Kleinman JE, Weinberger DR.

Nat Neurosci. 2018 Aug;21(8):1117-1125. doi: 10.1038/s41593-018-0197-y. Epub 2018 Jul 26.

28.

Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage: A Prospective Study.

Porcari GS, Beslow LA, Ichord RN, Licht DJ, Kleinman JT, Jordan LC.

Stroke. 2018 Jul;49(7):1755-1758. doi: 10.1161/STROKEAHA.118.021845. Epub 2018 Jun 12.

29.

Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F.

Nat Commun. 2018 Jun 11;9(1):2265. doi: 10.1038/s41467-018-04711-w. Erratum in: Nat Commun. 2018 Aug 29;9(1):3560.

30.

Evaluation of Single- versus Dual-Tube Thoracostomy after Thoracotomy for Trauma.

Hardin J, Strumwasser A, Grabo D, Kleinman J, Inaba K, Demetriades D.

Am Surg. 2017 Oct 1;83(10):1142-1146.

PMID:
29391112
31.

The Dangers of Equivocal FAST in Trauma Resuscitation.

Kleinman J, Strumwasser A, Rosen D, Hardin J, Inaba K, Demetriades D.

Am Surg. 2017 Oct 1;83(10):1127-1131.

PMID:
29391109
32.

Molecular and cellular reorganization of neural circuits in the human lineage.

Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N.

Science. 2017 Nov 24;358(6366):1027-1032. doi: 10.1126/science.aan3456.

33.

Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.

Grossman EA, Ward CC, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK.

Cell Chem Biol. 2017 Nov 16;24(11):1368-1376.e4. doi: 10.1016/j.chembiol.2017.08.013. Epub 2017 Sep 14.

34.

qSVA framework for RNA quality correction in differential expression analysis.

Jaffe AE, Tao R, Norris AL, Kealhofer M, Nellore A, Shin JH, Kim D, Jia Y, Hyde TM, Kleinman JE, Straub RE, Leek JT, Weinberger DR.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7130-7135. doi: 10.1073/pnas.1617384114. Epub 2017 Jun 20.

35.

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM.

Mol Psychiatry. 2018 May;23(5):1145-1156. doi: 10.1038/mp.2017.120. Epub 2017 Jun 20.

36.

Early-life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone.

Weissleder C, Kondo MA, Yang C, Fung SJ, Rothmond DA, Wong MW, Halliday GM, Herman MM, Kleinman JE, Webster MJ, Shannon Weickert C.

Eur J Neurosci. 2017 Jul;46(2):1768-1778. doi: 10.1111/ejn.13623. Epub 2017 Jul 7.

PMID:
28612959
37.

Implementation and clinical characteristics of a posttraumatic stress disorder brain collection.

Mighdoll MI, Deep-Soboslay A, Bharadwaj RA, Cotoia JA, Benedek DM, Hyde TM, Kleinman JE.

J Neurosci Res. 2018 Jan;96(1):16-20. doi: 10.1002/jnr.24093. Epub 2017 Jun 13.

PMID:
28609565
38.

Altered expression of histamine signaling genes in autism spectrum disorder.

Wright C, Shin JH, Rajpurohit A, Deep-Soboslay A, Collado-Torres L, Brandon NJ, Hyde TM, Kleinman JE, Jaffe AE, Cross AJ, Weinberger DR.

Transl Psychiatry. 2017 May 9;7(5):e1126. doi: 10.1038/tp.2017.87.

39.

Investigating the neuroimmunogenic architecture of schizophrenia.

Birnbaum R, Jaffe AE, Chen Q, Shin JH; BrainSeq Consortium, Kleinman JE, Hyde TM, Weinberger DR.

Mol Psychiatry. 2018 May;23(5):1251-1260. doi: 10.1038/mp.2017.89. Epub 2017 May 9.

PMID:
28485405
40.

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

Tao R, Davis KN, Li C, Shin JH, Gao Y, Jaffe AE, Gondré-Lewis MC, Weinberger DR, Kleinman JE, Hyde TM.

Mol Psychiatry. 2018 Jun;23(6):1496-1505. doi: 10.1038/mp.2017.105. Epub 2017 May 9.

PMID:
28485403
41.

Emergent gingival cyst of the adult.

Brooks JK, Kleinman JW, Basile JR.

Gen Dent. 2017 May-Jun;65(3):42-44.

PMID:
28475084
42.

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.

Ward CC, Kleinman JI, Nomura DK.

ACS Chem Biol. 2017 Jun 16;12(6):1478-1483. doi: 10.1021/acschembio.7b00125. Epub 2017 May 1.

PMID:
28445029
43.
44.

Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal.

Kolbach-Mandel AM, Mandel NS, Hoffmann BR, Kleinman JG, Wesson JA.

Urolithiasis. 2017 Aug;45(4):337-346. doi: 10.1007/s00240-017-0969-y. Epub 2017 Mar 17.

45.

High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex.

Lauridsen JK, Olesen RH, Vendelbo J, Hyde TM, Kleinman JE, Bibby BM, Brock B, Rungby J, Larsen A.

Transl Psychiatry. 2017 Feb 28;7(2):e1044. doi: 10.1038/tp.2016.259.

46.

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue.

Hoseth EZ, Ueland T, Dieset I, Birnbaum R, Shin JH, Kleinman JE, Hyde TM, Mørch RH, Hope S, Lekva T, Abraityte AJ, Michelsen AE, Melle I, Westlye LT, Ueland T, Djurovic S, Aukrust P, Weinberger DR, Andreassen OA.

Schizophr Bull. 2017 Jul 1;43(4):881-890. doi: 10.1093/schbul/sbw183.

47.

Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians.

Vendelbo J, Olesen RH, Lauridsen JK, Rungby J, Kleinman JE, Hyde TM, Larsen A.

Pharmacogenomics J. 2018 Jan;18(1):121-126. doi: 10.1038/tpj.2016.74. Epub 2016 Nov 29.

48.

Genetic risk mechanisms of posttraumatic stress disorder in the human brain.

Bharadwaj RA, Jaffe AE, Chen Q, Deep-Soboslay A, Goldman AL, Mighdoll MI, Cotoia JA, Brandtjen AC, Shin J, Hyde TM, Mattay VS, Weinberger DR, Kleinman JE.

J Neurosci Res. 2018 Jan;96(1):21-30. doi: 10.1002/jnr.23957. Epub 2016 Oct 24.

PMID:
27775175
49.

Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.

Paterson C, Wang Y, Hyde TM, Weinberger DR, Kleinman JE, Law AJ.

Am J Psychiatry. 2017 Mar 1;174(3):256-265. doi: 10.1176/appi.ajp.2016.16060721. Epub 2016 Oct 24.

50.

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals.

Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon RP, Kleinman JE, Hyde TM, Stiller J, Postolache TT, Schwarcz R, Tonelli LH.

J Psychiatry Neurosci. 2016 Oct;41(6):386-394.

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