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Items: 1 to 50 of 574

1.

Correction: DLPFC transcriptome defines two molecular subtypes of schizophrenia.

Bowen EFW, Burgess JL, Granger R, Kleinman JE, Rhodes CH.

Transl Psychiatry. 2019 Jun 12;9(1):169. doi: 10.1038/s41398-019-0499-1.

PMID:
31189874
2.

Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia.

Collado-Torres L, Burke EE, Peterson A, Shin J, Straub RE, Rajpurohit A, Semick SA, Ulrich WS; BrainSeq Consortium, Price AJ, Valencia C, Tao R, Deep-Soboslay A, Hyde TM, Kleinman JE, Weinberger DR, Jaffe AE.

Neuron. 2019 May 29. pii: S0896-6273(19)30438-6. doi: 10.1016/j.neuron.2019.05.013. [Epub ahead of print]

PMID:
31174959
3.

Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients.

Pergola G, Di Carlo P, Jaffe AE, Papalino M, Chen Q, Hyde TM, Kleinman JE, Shin JH, Rampino A, Blasi G, Weinberger DR, Bertolino A.

Biol Psychiatry. 2019 Apr 3. pii: S0006-3223(19)31152-7. doi: 10.1016/j.biopsych.2019.03.981. [Epub ahead of print]

PMID:
31126695
4.

DLPFC transcriptome defines two molecular subtypes of schizophrenia.

Bowen EFW, Burgess JL, Granger R, Kleinman JE, Rhodes CH.

Transl Psychiatry. 2019 May 9;9(1):147. doi: 10.1038/s41398-019-0472-z. Erratum in: Transl Psychiatry. 2019 Jun 12;9(1):169.

5.

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications.

Ward CC, Kleinman JI, Brittain SM, Lee PS, Chung CYS, Kim K, Petri Y, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Nomura DK.

ACS Chem Biol. 2019 May 13. doi: 10.1021/acschembio.8b01083. [Epub ahead of print]

PMID:
31059647
6.

Early FAST Examinations during Resuscitation May Compromise Trauma Outcomes.

Kleinman J, Inaba K, Pott E, Matsushima K, Demetriades D, Strumwasser A.

Am Surg. 2018 Oct 1;84(10):1705-1709.

PMID:
30747699
7.

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease.

Semick SA, Bharadwaj RA, Collado-Torres L, Tao R, Shin JH, Deep-Soboslay A, Weiss JR, Weinberger DR, Hyde TM, Kleinman JE, Jaffe AE, Mattay VS.

Acta Neuropathol. 2019 Apr;137(4):557-569. doi: 10.1007/s00401-019-01966-5. Epub 2019 Feb 2.

PMID:
30712078
8.

Neurons with Complex Karyotypes Are Rare in Aged Human Neocortex.

Chronister WD, Burbulis IE, Wierman MB, Wolpert MJ, Haakenson MF, Smith ACB, Kleinman JE, Hyde TM, Weinberger DR, Bekiranov S, McConnell MJ.

Cell Rep. 2019 Jan 22;26(4):825-835.e7. doi: 10.1016/j.celrep.2018.12.107.

9.

Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19).

Ma L, Semick SA, Chen Q, Li C, Tao R, Price AJ, Shin JH, Jia Y; BrainSeq Consortium, Brandon NJ, Cross AJ, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR, Straub RE.

Mol Psychiatry. 2019 Jan 11. doi: 10.1038/s41380-018-0293-0. [Epub ahead of print]

PMID:
30635639
10.

Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes.

Punzi G, Ursini G, Viscanti G, Radulescu E, Shin JH, Quarto T, Catanesi R, Blasi G, Jaffe AE, Deep-Soboslay A, Hyde TM, Kleinman JE, Bertolino A, Weinberger DR.

Biol Psychiatry. 2019 Mar 1;85(5):417-424. doi: 10.1016/j.biopsych.2018.11.002. Epub 2018 Nov 16.

PMID:
30600091
11.

Integrative functional genomic analysis of human brain development and neuropsychiatric risks.

Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF; BrainSpan Consortium; PsychENCODE Consortium; PsychENCODE Developmental Subgroup, Hu M, Jin F, Li Y, Owen MJ, O'Donovan MC, Walters JTR, Posthuma D, Reimers MA, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N.

Science. 2018 Dec 14;362(6420). pii: eaat7615. doi: 10.1126/science.aat7615.

12.

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain.

Radulescu E, Jaffe AE, Straub RE, Chen Q, Shin JH, Hyde TM, Kleinman JE, Weinberger DR.

Mol Psychiatry. 2018 Nov 26. doi: 10.1038/s41380-018-0304-1. [Epub ahead of print]

PMID:
30478419
13.

Gingival squamous cell carcinoma: an unexpected clincal presentation.

Brooks JK, Kleinman JW, Lubek JE, Price JB, Ghita I, Scurnick SA, Basile JR.

Quintessence Int. 2019;50(1):50-57. doi: 10.3290/j.qi.a41334.

PMID:
30411091
14.

Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F.

Nat Commun. 2018 Aug 29;9(1):3560. doi: 10.1038/s41467-018-06062-y.

15.

Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome.

Semick SA, Collado-Torres L, Markunas CA, Shin JH, Deep-Soboslay A, Tao R, Huestis MA, Bierut LJ, Maher BS, Johnson EO, Hyde TM, Weinberger DR, Hancock DB, Kleinman JE, Jaffe AE.

Mol Psychiatry. 2018 Aug 21. doi: 10.1038/s41380-018-0223-1. [Epub ahead of print]

16.

Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia.

Boks MP, Houtepen LC, Xu Z, He Y, Ursini G, Maihofer AX, Rajarajan P, Yu Q, Xu H, Wu Y, Wang S, Shi JP, Hulshoff Pol HE, Strengman E, Rutten BPF, Jaffe AE, Kleinman JE, Baker DG, Hol EM, Akbarian S, Nievergelt CM, De Witte LD, Vinkers CH, Weinberger DR, Yu J, Kahn RS.

NPJ Schizophr. 2018 Aug 21;4(1):16. doi: 10.1038/s41537-018-0058-4.

17.

Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis.

Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich WS, Maher BJ, Deep-Soboslay A; BrainSeq Consortium, Cross AJ, Brandon NJ, Leek JT, Hyde TM, Kleinman JE, Weinberger DR.

Nat Neurosci. 2018 Aug;21(8):1117-1125. doi: 10.1038/s41593-018-0197-y. Epub 2018 Jul 26.

18.

Neurologic Outcome Predictors in Pediatric Intracerebral Hemorrhage: A Prospective Study.

Porcari GS, Beslow LA, Ichord RN, Licht DJ, Kleinman JT, Jordan LC.

Stroke. 2018 Jul;49(7):1755-1758. doi: 10.1161/STROKEAHA.118.021845. Epub 2018 Jun 12.

PMID:
29895534
19.

Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F.

Nat Commun. 2018 Jun 11;9(1):2265. doi: 10.1038/s41467-018-04711-w. Erratum in: Nat Commun. 2018 Aug 29;9(1):3560.

20.

Evaluation of Single- versus Dual-Tube Thoracostomy after Thoracotomy for Trauma.

Hardin J, Strumwasser A, Grabo D, Kleinman J, Inaba K, Demetriades D.

Am Surg. 2017 Oct 1;83(10):1142-1146.

PMID:
29391112
21.

The Dangers of Equivocal FAST in Trauma Resuscitation.

Kleinman J, Strumwasser A, Rosen D, Hardin J, Inaba K, Demetriades D.

Am Surg. 2017 Oct 1;83(10):1127-1131.

PMID:
29391109
22.

Molecular and cellular reorganization of neural circuits in the human lineage.

Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N.

Science. 2017 Nov 24;358(6366):1027-1032. doi: 10.1126/science.aan3456.

23.

Covalent Ligand Discovery against Druggable Hotspots Targeted by Anti-cancer Natural Products.

Grossman EA, Ward CC, Spradlin JN, Bateman LA, Huffman TR, Miyamoto DK, Kleinman JI, Nomura DK.

Cell Chem Biol. 2017 Nov 16;24(11):1368-1376.e4. doi: 10.1016/j.chembiol.2017.08.013. Epub 2017 Sep 14.

24.

qSVA framework for RNA quality correction in differential expression analysis.

Jaffe AE, Tao R, Norris AL, Kealhofer M, Nellore A, Shin JH, Kim D, Jia Y, Hyde TM, Kleinman JE, Straub RE, Leek JT, Weinberger DR.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7130-7135. doi: 10.1073/pnas.1617384114. Epub 2017 Jun 20.

25.

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM.

Mol Psychiatry. 2018 May;23(5):1145-1156. doi: 10.1038/mp.2017.120. Epub 2017 Jun 20.

26.

Early-life decline in neurogenesis markers and age-related changes of TrkB splice variant expression in the human subependymal zone.

Weissleder C, Kondo MA, Yang C, Fung SJ, Rothmond DA, Wong MW, Halliday GM, Herman MM, Kleinman JE, Webster MJ, Shannon Weickert C.

Eur J Neurosci. 2017 Jul;46(2):1768-1778. doi: 10.1111/ejn.13623. Epub 2017 Jul 7.

PMID:
28612959
27.

Implementation and clinical characteristics of a posttraumatic stress disorder brain collection.

Mighdoll MI, Deep-Soboslay A, Bharadwaj RA, Cotoia JA, Benedek DM, Hyde TM, Kleinman JE.

J Neurosci Res. 2018 Jan;96(1):16-20. doi: 10.1002/jnr.24093. Epub 2017 Jun 13.

PMID:
28609565
28.

Altered expression of histamine signaling genes in autism spectrum disorder.

Wright C, Shin JH, Rajpurohit A, Deep-Soboslay A, Collado-Torres L, Brandon NJ, Hyde TM, Kleinman JE, Jaffe AE, Cross AJ, Weinberger DR.

Transl Psychiatry. 2017 May 9;7(5):e1126. doi: 10.1038/tp.2017.87.

29.

Investigating the neuroimmunogenic architecture of schizophrenia.

Birnbaum R, Jaffe AE, Chen Q, Shin JH; BrainSeq Consortium, Kleinman JE, Hyde TM, Weinberger DR.

Mol Psychiatry. 2018 May;23(5):1251-1260. doi: 10.1038/mp.2017.89. Epub 2017 May 9.

PMID:
28485405
30.

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia.

Tao R, Davis KN, Li C, Shin JH, Gao Y, Jaffe AE, Gondré-Lewis MC, Weinberger DR, Kleinman JE, Hyde TM.

Mol Psychiatry. 2018 Jun;23(6):1496-1505. doi: 10.1038/mp.2017.105. Epub 2017 May 9.

PMID:
28485403
31.

Emergent gingival cyst of the adult.

Brooks JK, Kleinman JW, Basile JR.

Gen Dent. 2017 May-Jun;65(3):42-44.

PMID:
28475084
32.

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.

Ward CC, Kleinman JI, Nomura DK.

ACS Chem Biol. 2017 Jun 16;12(6):1478-1483. doi: 10.1021/acschembio.7b00125. Epub 2017 May 1.

PMID:
28445029
33.
34.

Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal.

Kolbach-Mandel AM, Mandel NS, Hoffmann BR, Kleinman JG, Wesson JA.

Urolithiasis. 2017 Aug;45(4):337-346. doi: 10.1007/s00240-017-0969-y. Epub 2017 Mar 17.

35.

High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex.

Lauridsen JK, Olesen RH, Vendelbo J, Hyde TM, Kleinman JE, Bibby BM, Brock B, Rungby J, Larsen A.

Transl Psychiatry. 2017 Feb 28;7(2):e1044. doi: 10.1038/tp.2016.259.

36.

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue.

Hoseth EZ, Ueland T, Dieset I, Birnbaum R, Shin JH, Kleinman JE, Hyde TM, Mørch RH, Hope S, Lekva T, Abraityte AJ, Michelsen AE, Melle I, Westlye LT, Ueland T, Djurovic S, Aukrust P, Weinberger DR, Andreassen OA.

Schizophr Bull. 2017 Jul 1;43(4):881-890. doi: 10.1093/schbul/sbw183.

37.

Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians.

Vendelbo J, Olesen RH, Lauridsen JK, Rungby J, Kleinman JE, Hyde TM, Larsen A.

Pharmacogenomics J. 2018 Jan;18(1):121-126. doi: 10.1038/tpj.2016.74. Epub 2016 Nov 29.

38.

Genetic risk mechanisms of posttraumatic stress disorder in the human brain.

Bharadwaj RA, Jaffe AE, Chen Q, Deep-Soboslay A, Goldman AL, Mighdoll MI, Cotoia JA, Brandtjen AC, Shin J, Hyde TM, Mattay VS, Weinberger DR, Kleinman JE.

J Neurosci Res. 2018 Jan;96(1):21-30. doi: 10.1002/jnr.23957. Epub 2016 Oct 24.

PMID:
27775175
39.

Temporal, Diagnostic, and Tissue-Specific Regulation of NRG3 Isoform Expression in Human Brain Development and Affective Disorders.

Paterson C, Wang Y, Hyde TM, Weinberger DR, Kleinman JE, Law AJ.

Am J Psychiatry. 2017 Mar 1;174(3):256-265. doi: 10.1176/appi.ajp.2016.16060721. Epub 2016 Oct 24.

40.

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals.

Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon RP, Kleinman JE, Hyde TM, Stiller J, Postolache TT, Schwarcz R, Tonelli LH.

J Psychiatry Neurosci. 2016 Oct;41(6):386-394.

41.

Genetic and epigenetic analysis of schizophrenia in blood-a no-brainer?

Jaffe AE, Kleinman JE.

Genome Med. 2016 Sep 21;8(1):96.

42.

Erratum to: Practical impacts of genomic data "cleaning" on biological discovery using surrogate variable analysis.

Jaffe AE, Hyde T, Kleinman J, Weinberger DR, Chenoweth JG, McKay RD, Leek JT, Colantuoni C.

BMC Bioinformatics. 2016 Aug 10;17:302. doi: 10.1186/s12859-016-1152-0. No abstract available.

43.

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons.

Jo J, Xiao Y, Sun AX, Cukuroglu E, Tran HD, Göke J, Tan ZY, Saw TY, Tan CP, Lokman H, Lee Y, Kim D, Ko HS, Kim SO, Park JH, Cho NJ, Hyde TM, Kleinman JE, Shin JH, Weinberger DR, Tan EK, Je HS, Ng HH.

Cell Stem Cell. 2016 Aug 4;19(2):248-257. doi: 10.1016/j.stem.2016.07.005. Epub 2016 Jul 28.

44.

Guaifenesin stone matrix proteomics: a protocol for identifying proteins critical to stone formation.

Kolbach-Mandel AM, Mandel NS, Cohen SR, Kleinman JG, Ahmed F, Mandel IC, Wesson JA.

Urolithiasis. 2017 Apr;45(2):139-149. doi: 10.1007/s00240-016-0907-4. Epub 2016 Jul 19.

PMID:
27435233
45.

Electronic cigarette explosion associated with extensive intraoral injuries.

Brooks JK, Kleinman JW, Brooks JB, Reynolds MA.

Dent Traumatol. 2017 Apr;33(2):149-152. doi: 10.1111/edt.12293. Epub 2016 Jul 10.

PMID:
27397137
46.

Dynamic regulation of RNA editing in human brain development and disease.

Hwang T, Park CK, Leung AK, Gao Y, Hyde TM, Kleinman JE, Rajpurohit A, Tao R, Shin JH, Weinberger DR.

Nat Neurosci. 2016 Aug;19(8):1093-9. doi: 10.1038/nn.4337. Epub 2016 Jun 27.

PMID:
27348216
47.

Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.

Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK.

Biol Psychiatry. 2016 Jul 15;80(2):84-86. doi: 10.1016/j.biopsych.2016.05.004. No abstract available.

48.

Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain.

Olesen RH, Hyde TM, Kleinman JE, Smidt K, Rungby J, Larsen A.

Transl Psychiatry. 2016 Jun 14;6(6):e838. doi: 10.1038/tp.2016.83.

49.

Assessment of genetic risk for distribution of total interstitial white matter neurons in dorsolateral prefrontal cortex: role in schizophrenia.

McFadden WC, Jaffe AE, Ye T, Paltán-Ortiz JD, Hyde TM, Kleinman JE.

Schizophr Res. 2016 Oct;176(2-3):141-143. doi: 10.1016/j.schres.2016.04.007. Epub 2016 May 27. No abstract available.

PMID:
27237599
50.

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.

Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth JG, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR.

Nat Med. 2016 Jun;22(6):649-56. doi: 10.1038/nm.4096. Epub 2016 May 9.

PMID:
27158905

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