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Items: 1 to 50 of 358

1.

RGN-259 (thymosin β4) improves clinically important dry eye efficacies in comparison with prescription drugs in a dry eye model.

Kim CE, Kleinman HK, Sosne G, Ousler GW, Kim K, Kang S, Yang J.

Sci Rep. 2018 Jul 12;8(1):10500. doi: 10.1038/s41598-018-28861-5.

2.

Safety and potential efficacy of gemfibrozil as a supportive treatment for children with late infantile neuronal ceroid lipofuscinosis and other lipid storage disorders.

Kim K, Kleinman HK, Lee HJ, Pahan K.

Orphanet J Rare Dis. 2017 Jun 17;12(1):113. doi: 10.1186/s13023-017-0663-8. Review.

3.

Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases.

Sosne G, Rimmer D, Kleinman HK, Ousler G.

Vitam Horm. 2016;102:277-306. doi: 10.1016/bs.vh.2016.04.012. Epub 2016 Jul 5. Review.

PMID:
27450739
4.

Thymosin β4 Promotes Dermal Healing.

Kleinman HK, Sosne G.

Vitam Horm. 2016;102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24. Review.

PMID:
27450738
5.

Imaging of Angiotropism/Vascular Co-Option in a Murine Model of Brain Melanoma: Implications for Melanoma Progression along Extravascular Pathways.

Bentolila LA, Prakash R, Mihic-Probst D, Wadehra M, Kleinman HK, Carmichael TS, Péault B, Barnhill RL, Lugassy C.

Sci Rep. 2016 Apr 6;6:23834. doi: 10.1038/srep23834.

6.

Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries.

Sosne G, Kleinman HK.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5110-7. doi: 10.1167/iovs.15-16890. Review.

PMID:
26241398
7.

Advances in the basic and clinical applications of thymosin β4.

Goldstein AL, Kleinman HK.

Expert Opin Biol Ther. 2015;15 Suppl 1:S139-45. doi: 10.1517/14712598.2015.1011617. Epub 2015 Jun 22. Review.

PMID:
26096726
8.

Thymosin β4 significantly reduces the signs of dryness in a murine controlled adverse environment model of experimental dry eye.

Sosne G, Kim C, Kleinman HK.

Expert Opin Biol Ther. 2015;15 Suppl 1:S155-61. doi: 10.1517/14712598.2015.1019858. Epub 2015 Jun 22.

PMID:
26096547
9.

In vitro microtumors provide a physiologically predictive tool for breast cancer therapeutic screening.

Benton G, DeGray G, Kleinman HK, George J, Arnaoutova I.

PLoS One. 2015 Apr 9;10(4):e0123312. doi: 10.1371/journal.pone.0123312. eCollection 2015.

10.

Angiotropism, pericytic mimicry and extravascular migratory metastasis in melanoma: an alternative to intravascular cancer dissemination.

Lugassy C, Zadran S, Bentolila LA, Wadehra M, Prakash R, Carmichael ST, Kleinman HK, Péault B, Larue L, Barnhill RL.

Cancer Microenviron. 2014 Dec;7(3):139-52. doi: 10.1007/s12307-014-0156-4. Epub 2014 Oct 12.

11.

Matrigel: from discovery and ECM mimicry to assays and models for cancer research.

Benton G, Arnaoutova I, George J, Kleinman HK, Koblinski J.

Adv Drug Deliv Rev. 2014 Dec 15;79-80:3-18. doi: 10.1016/j.addr.2014.06.005. Epub 2014 Jul 2. Review.

PMID:
24997339
12.

Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?

Lugassy C, Péault B, Wadehra M, Kleinman HK, Barnhill RL.

Pigment Cell Melanoma Res. 2013 Sep;26(5):746-54. doi: 10.1111/pcmr.12120. Epub 2013 Jun 27.

PMID:
23789776
13.

Pilot study on "pericytic mimicry" and potential embryonic/stem cell properties of angiotropic melanoma cells interacting with the abluminal vascular surface.

Lugassy C, Wadehra M, Li X, Corselli M, Akhavan D, Binder SW, Péault B, Cochran AJ, Mischel PS, Kleinman HK, Barnhill RL.

Cancer Microenviron. 2013 Apr;6(1):19-29. doi: 10.1007/s12307-012-0128-5. Epub 2012 Dec 29.

14.

Laminin-111-derived peptides and cancer.

Kikkawa Y, Hozumi K, Katagiri F, Nomizu M, Kleinman HK, Koblinski JE.

Cell Adh Migr. 2013 Jan-Feb;7(1):150-256. doi: 10.4161/cam.22827. Epub 2012 Dec 21. Review.

15.

The regenerative peptide thymosin β4 accelerates the rate of dermal healing in preclinical animal models and in patients.

Treadwell T, Kleinman HK, Crockford D, Hardy MA, Guarnera GT, Goldstein AL.

Ann N Y Acad Sci. 2012 Oct;1270:37-44. doi: 10.1111/j.1749-6632.2012.06717.x.

PMID:
23050815
16.

Increased initiation and growth of tumor cell lines, cancer stem cells and biopsy material in mice using basement membrane matrix protein (Cultrex or Matrigel) co-injection.

Fridman R, Benton G, Aranoutova I, Kleinman HK, Bonfil RD.

Nat Protoc. 2012 May 17;7(6):1138-44. doi: 10.1038/nprot.2012.053.

PMID:
22596226
17.

Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications.

Goldstein AL, Hannappel E, Sosne G, Kleinman HK.

Expert Opin Biol Ther. 2012 Jan;12(1):37-51. doi: 10.1517/14712598.2012.634793. Epub 2011 Nov 10.

PMID:
22074294
18.

The potent peptide antagonist to angiogenesis, C16Y, and cisplatin act synergistically in the down-regulation of the Bcl-2/Bax ratio and the induction of apoptosis in human ovarian cancer cells.

Shinagawa A, Yoshida Y, Kurokawa T, Horiuchi Y, Tsuyoshi H, Orisaka M, Sawamura Y, Kleinman HK, Kotsuji F.

Int J Oncol. 2011 Dec;39(6):1359-64. doi: 10.3892/ijo.2011.1134. Epub 2011 Jul 20.

PMID:
21935568
19.

Basement membrane matrix (BME) has multiple uses with stem cells.

Arnaoutova I, George J, Kleinman HK, Benton G.

Stem Cell Rev. 2012 Mar;8(1):163-9. doi: 10.1007/s12015-011-9278-y. Review.

PMID:
21655946
20.

Effects of amelogenins on angiogenesis-associated processes of endothelial cells.

Almqvist S, Kleinman HK, Werthén M, Thomsen P, Agren MS.

J Wound Care. 2011 Feb;20(2):68, 70-5. Erratum in: J Wound Care. 2011 Mar;20(3):143.

PMID:
21378680
21.

Multiple uses of basement membrane-like matrix (BME/Matrigel) in vitro and in vivo with cancer cells.

Benton G, Kleinman HK, George J, Arnaoutova I.

Int J Cancer. 2011 Apr 15;128(8):1751-7. doi: 10.1002/ijc.25781. Review.

22.

Thymosin β4 expression in human tissues and in tumors using tissue microarrays.

Jo JO, Kang YJ, Ock MS, Kleinman HK, Chang HK, Cha HJ.

Appl Immunohistochem Mol Morphol. 2011 Mar;19(2):160-7. doi: 10.1097/PAI.0b013e3181f12237.

PMID:
20975530
23.

Thymosin β4 induces the expression of vascular endothelial growth factor (VEGF) in a hypoxia-inducible factor (HIF)-1α-dependent manner.

Jo JO, Kim SR, Bae MK, Kang YJ, Ock MS, Kleinman HK, Cha HJ.

Biochim Biophys Acta. 2010 Nov;1803(11):1244-51. doi: 10.1016/j.bbamcr.2010.07.005. Epub 2010 Aug 4.

24.

Animal studies with thymosin beta, a multifunctional tissue repair and regeneration peptide.

Philp D, Kleinman HK.

Ann N Y Acad Sci. 2010 Apr;1194:81-6. doi: 10.1111/j.1749-6632.2010.05479.x. Review.

PMID:
20536453
25.

In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract.

Arnaoutova I, Kleinman HK.

Nat Protoc. 2010 Apr;5(4):628-35. doi: 10.1038/nprot.2010.6. Epub 2010 Mar 11.

PMID:
20224563
26.

Effects of isoniazid and niacin on experimental wound-healing.

Weinreich J, Agren MS, Bilali E, Kleinman HK, Coerper S, Königsrainer A, Beckert S.

Surgery. 2010 Jun;147(6):780-8. doi: 10.1016/j.surg.2009.11.003. Epub 2010 Jan 4.

PMID:
20045543
27.

Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth.

Cha HJ, Philp D, Lee SH, Moon HS, Kleinman HK, Nakamura T.

Int J Dev Biol. 2010;54(1):135-40. doi: 10.1387/ijdb.082735hc.

28.

Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: an interplay between immunogenicity and invasive potential.

Voronov E, Reich E, Dotan S, Dransh P, Cohen I, Huszar M, Fogel M, Kleinman HK, White RM, Apte RN.

J Immunotoxicol. 2010 Mar;7(1):27-38. doi: 10.3109/15476910903405528.

PMID:
20001788
29.

Advancing science and technology via 3D culture on basement membrane matrix.

Benton G, George J, Kleinman HK, Arnaoutova IP.

J Cell Physiol. 2009 Oct;221(1):18-25. doi: 10.1002/jcp.21832. Review.

PMID:
19492404
30.

Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoic membrane model.

Lugassy C, Torres-Muñoz JE, Kleinman HK, Ghanem G, Vernon S, Barnhill RL.

J Cutan Pathol. 2009 Dec;36(12):1237-43. doi: 10.1111/j.1600-0560.2009.01273.x.

PMID:
19469865
31.

The endothelial cell tube formation assay on basement membrane turns 20: state of the science and the art.

Arnaoutova I, George J, Kleinman HK, Benton G.

Angiogenesis. 2009;12(3):267-74. doi: 10.1007/s10456-009-9146-4. Epub 2009 Apr 28. Review.

PMID:
19399631
32.

Angiogenic laminin-derived peptides stimulate wound healing.

Malinda KM, Wysocki AB, Koblinski JE, Kleinman HK, Ponce ML.

Int J Biochem Cell Biol. 2008;40(12):2771-80. doi: 10.1016/j.biocel.2008.05.025. Epub 2008 Jun 20.

33.

Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatin.

Yoshida Y, Kurokawa T, Nishikawa Y, Orisa M, Kleinman HK, Kotsuji F.

Int J Oncol. 2008 Mar;32(3):673-81.

PMID:
18292945
34.

Preparation of endothelial cells.

Kleinman HK, Cid MC.

Curr Protoc Cell Biol. 2001 May;Chapter 2:Unit 2.3. doi: 10.1002/0471143030.cb0203s00.

PMID:
18228348
35.

Invasion assays.

Kleinman HK, Jacob K.

Curr Protoc Cell Biol. 2001 May;Chapter 12:Unit 12.2. doi: 10.1002/0471143030.cb1202s00. Review.

PMID:
18228316
36.

Preparation of gelled substrates.

Kleinman HK.

Curr Protoc Cell Biol. 2001 May;Chapter 10:Unit 10.3. doi: 10.1002/0471143030.cb1003s00.

PMID:
18228297
37.

Preparation of basement membrane components from EHS tumors.

Kleinman HK.

Curr Protoc Cell Biol. 2001 May;Chapter 10:Unit 10.2. doi: 10.1002/0471143030.cb1002s00.

PMID:
18228296
38.

Thymosin beta 4 induces hair growth via stem cell migration and differentiation.

Philp D, St-Surin S, Cha HJ, Moon HS, Kleinman HK, Elkin M.

Ann N Y Acad Sci. 2007 Sep;1112:95-103.

PMID:
17947589
39.

C16 laminin peptide increases angiotropic extravascular migration of human melanoma cells in a shell-less chick chorioallantoic membrane assay.

Lugassy C, Kleinman HK, Vernon SE, Welch DR, Barnhill RL.

Br J Dermatol. 2007 Oct;157(4):780-2. Epub 2007 Aug 17.

PMID:
17711523
40.

New method for modeling connective-tissue cell migration: improved accuracy on motility parameters.

Kipper MJ, Kleinman HK, Wang FW.

Biophys J. 2007 Sep 1;93(5):1797-808. Epub 2007 May 4.

41.

Covalent surface chemistry gradients for presenting bioactive peptides.

Kipper MJ, Kleinman HK, Wang FW.

Anal Biochem. 2007 Apr 15;363(2):175-84. Epub 2007 Feb 2.

PMID:
17339030
42.

Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation.

Chen SS, Fitzgerald W, Zimmerberg J, Kleinman HK, Margolis L.

Stem Cells. 2007 Mar;25(3):553-61.

43.

Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT).

Mochizuki M, Philp D, Hozumi K, Suzuki N, Yamada Y, Kleinman HK, Nomizu M.

Arch Biochem Biophys. 2007 Mar 15;459(2):249-55. Epub 2007 Jan 16.

PMID:
17286955
44.

Integrin-dependent cell behavior on ECM peptide-conjugated chitosan membranes.

Mochizuki M, Yamagata N, Philp D, Hozumi K, Watanabe T, Kikkawa Y, Kadoya Y, Kleinman HK, Nomizu M.

Biopolymers. 2007;88(2):122-30.

PMID:
17236208
45.

Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells.

Moon HS, Even-Ram S, Kleinman HK, Cha HJ.

Exp Cell Res. 2006 Oct 15;312(17):3425-31. Epub 2006 Aug 2.

PMID:
16956606
46.

Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors.

Movafagh S, Hobson JP, Spiegel S, Kleinman HK, Zukowska Z.

FASEB J. 2006 Sep;20(11):1924-6. Epub 2006 Aug 4.

PMID:
16891622
47.
48.

Association between increased CCL2 (MCP-1) expression in lesions and persistence of disease activity in giant-cell arteritis.

Cid MC, Hoffman MP, Hernández-Rodríguez J, Segarra M, Elkin M, Sánchez M, Vilardell C, García-Martínez A, Pla-Campo M, Grau JM, Kleinman HK.

Rheumatology (Oxford). 2006 Nov;45(11):1356-63. Epub 2006 Apr 18.

PMID:
16621921
49.

Thymosin beta4 promotes matrix metalloproteinase expression during wound repair.

Philp D, Scheremeta B, Sibliss K, Zhou M, Fine EL, Nguyen M, Wahl L, Hoffman MP, Kleinman HK.

J Cell Physiol. 2006 Jul;208(1):195-200.

PMID:
16607611
50.

Amelogenin-mediated regulation of osteoclastogenesis, and periodontal cell proliferation and migration.

Hatakeyama J, Philp D, Hatakeyama Y, Haruyama N, Shum L, Aragon MA, Yuan Z, Gibson CW, Sreenath T, Kleinman HK, Kulkarni AB.

J Dent Res. 2006 Feb;85(2):144-9.

PMID:
16434732

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