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Items: 1 to 50 of 107

1.

New beauveriolides produced by amino acid-supplemented fermentation of Beauveria sp. FO-6979.

Matsuda D, Namatame I, Tomoda H, Kobayashi S, Zocher R, Kleinkauf H, Omura S.

J Antibiot (Tokyo). 2004 Jan;57(1):1-9.

2.

Directed biosynthesis of new enniatins.

Krause M, Lindemann A, Glinski M, Hornbogen T, Bonse G, Jeschke P, Thielking G, Gau W, Kleinkauf H, Zocher R.

J Antibiot (Tokyo). 2001 Oct;54(10):797-804.

3.

Biosynthesis of PF1022A and related cyclooctadepsipeptides.

Weckwerth W, Miyamoto K, Iinuma K, Krause M, Glinski M, Storm T, Bonse G, Kleinkauf H, Zocher R.

J Biol Chem. 2000 Jun 9;275(23):17909-15.

4.
5.

Editing of non-cognate aminoacyl adenylates by peptide synthetases.

Pavela-Vrancic M, Dieckmann R, Döhren HV, Kleinkauf H.

Biochem J. 1999 Sep 15;342 Pt 3:715-9.

6.

Probing the domain structure and ligand-induced conformational changes by limited proteolysis of tyrocidine synthetase 1.

Dieckmann R, Pavela-Vrancic M, von Döhren H, Kleinkauf H.

J Mol Biol. 1999 Apr 23;288(1):129-40.

PMID:
10329131
8.

The adenylation domain of tyrocidine synthetase 1--structural and functional role of the interdomain linker region and the (S/T)GT(T/S)GXPKG core sequence.

Dieckmann R, Pavela-Vrancic M, Pfeifer E, von Döhren H, Kleinkauf H.

Eur J Biochem. 1997 Aug 1;247(3):1074-82.

9.

Applications of peptide synthetases in the synthesis of peptide analogues.

Kleinkauf H, von Döhren H.

Acta Biochim Pol. 1997;44(4):839-47. Review.

10.

Enzymatic generation of complex peptides.

Kleinkauf H, von Döhren H.

Prog Drug Res. 1997;48:27-53. Review. No abstract available.

PMID:
9204682
11.
12.

A nonribosomal system of peptide biosynthesis.

Kleinkauf H, Von Döhren H.

Eur J Biochem. 1996 Mar 1;236(2):335-51. Review.

13.

Reversible denaturation of cyclosporin synthetase by urea.

Dittmann J, Vaillant F, Kleinkauf H, Lawen A.

FEBS Lett. 1996 Feb 12;380(1-2):157-60.

14.

Linking peptide and polyketide biosynthesis.

Kleinkauf H, von Döhren H.

J Antibiot (Tokyo). 1995 Jul;48(7):563-7. Review. No abstract available.

15.

Characterization of tyrocidine synthetase 1 (TY1): requirement of posttranslational modification for peptide biosynthesis.

Pfeifer E, Pavela-Vrancic M, von Döhren H, Kleinkauf H.

Biochemistry. 1995 Jun 6;34(22):7450-9.

PMID:
7779788
16.

Expression of an active adenylate-forming domain of peptide synthetases corresponding to acyl-CoA-synthetases.

Dieckmann R, Lee YO, van Liempt H, von Döhren H, Kleinkauf H.

FEBS Lett. 1995 Jan 3;357(2):212-6.

17.
18.

Identification of the ATP binding site in tyrocidine synthetase 1 by selective modification with fluorescein 5'-isothiocyanate.

Pavela-Vrancic M, Pfeifer E, Schröder W, von Döhren H, Kleinkauf H.

J Biol Chem. 1994 May 27;269(21):14962-6.

19.

ATP binding in peptide synthetases: determination of contact sites of the adenine moiety by photoaffinity labeling of tyrocidine synthetase 1 with 2-azidoadenosine triphosphate.

Pavela-Vrancic M, Pfeifer E, van Liempt H, Schäfer HJ, von Döhren H, Kleinkauf H.

Biochemistry. 1994 May 24;33(20):6276-83.

PMID:
8193142
20.

Purification and characterization of eucaryotic alanine racemase acting as key enzyme in cyclosporin biosynthesis.

Hoffmann K, Schneider-Scherzer E, Kleinkauf H, Zocher R.

J Biol Chem. 1994 Apr 29;269(17):12710-4.

21.

Mechanism of cyclosporin A biosynthesis. Evidence for synthesis via a single linear undecapeptide precursor.

Dittmann J, Wenger RM, Kleinkauf H, Lawen A.

J Biol Chem. 1994 Jan 28;269(4):2841-6.

22.

Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase, the multienzyme integrating the four primary reactions in beta-lactam biosynthesis, as a model peptide synthetase.

Aharonowitz Y, Bergmeyer J, Cantoral JM, Cohen G, Demain AL, Fink U, Kinghorn J, Kleinkauf H, MacCabe A, Palissa H, et al.

Biotechnology (N Y). 1993 Jul;11(7):807-10. Review.

PMID:
7763859
23.

Two new cyclophilins from Fusarium sambucinum and Aspergillus niger: resistance of cyclophilin/cyclosporin A complexes against proteolysis.

Hornbogen T, Pieper R, Hoffmann K, Kleinkauf H, Zocher R.

Biochem Biophys Res Commun. 1992 Sep 16;187(2):791-6.

PMID:
1530635
24.
25.

Enniatin synthetases from different fusaria exhibiting distinct amino acid specificities.

Pieper R, Kleinkauf H, Zocher R.

J Antibiot (Tokyo). 1992 Aug;45(8):1273-7.

26.

A highly specific D-hydroxyisovalerate dehydrogenase from the enniatin producer Fusarium sambucinum.

Lee C, Görisch H, Kleinkauf H, Zocher R.

J Biol Chem. 1992 Jun 15;267(17):11741-4.

27.

Enzymatic biosynthesis of cyclosporin A and analogues.

Lawen A, Dittmann J, Schmidt B, Riesner D, Kleinkauf H.

Biochimie. 1992 May;74(5):511-6.

PMID:
1637876
28.

Enzymatic characterisation of the multifunctional enzyme delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.

Schwecke T, Aharonowitz Y, Palissa H, von Döhren H, Kleinkauf H, van Liempt H.

Eur J Biochem. 1992 Apr 15;205(2):687-94.

29.

[Biosynthesis of peptides: a non-ribosomal system].

Kleinkauf H, van Liempt H, Palissa H, von Döhren H.

Naturwissenschaften. 1992 Apr;79(4):153-62. Review. German.

PMID:
1589037
30.

Cell-free biosynthesis of cyclosporin A and analogues.

Kleinkauf H, Dittmann J, Lawen A.

Biomed Biochim Acta. 1991;50(10-11):S219-24.

PMID:
1820050
31.

Isolation and partial characterization of cyclosporin synthetase from a cyclosporin non-producing mutant of Beauveria nivea.

Dittmann J, Lawen A, Zocher R, Kleinkauf H.

Biol Chem Hoppe Seyler. 1990 Sep;371(9):829-34.

PMID:
2291810
32.

Nonribosomal biosynthesis of peptide antibiotics.

Kleinkauf H, von Döhren H.

Eur J Biochem. 1990 Aug 28;192(1):1-15. Review.

33.

Antibiotics--cloning of biosynthetic pathways.

Kleinkauf H, von Döhren H.

FEBS Lett. 1990 Aug 1;268(2):405-7. Review.

34.

Nucleotide sequence of the isopenicillin N synthase gene (pcbC) of the gram negative Flavobacterium sp. SC 12,154.

Shiffman D, Cohen G, Aharonowitz Y, Palissa H, von Dohren H, Kleinkauf H, Mevarech M.

Nucleic Acids Res. 1990 Feb 11;18(3):660. No abstract available.

35.

Bioactive peptide analogs: in vivo and in vitro production.

Kleinkauf H, von Doehren H.

Prog Drug Res. 1990;34:287-317. Review. No abstract available.

PMID:
2236567
36.
37.

Proteinchemical and kinetic features of gramicidin S synthetase.

Vater J, Schlumbohm W, Salnikow J, Irrgang KD, Miklus M, Choli T, Kleinkauf H.

Biol Chem Hoppe Seyler. 1989 Sep;370(9):1013-8.

PMID:
2610939
38.

Cell-free biosynthesis of new cyclosporins.

Lawen A, Traber R, Geyl D, Zocher R, Kleinkauf H.

J Antibiot (Tokyo). 1989 Aug;42(8):1283-9.

40.

Regulation by dibutyryl cyclic AMP of carnosine synthesis in astroglia-rich primary cultures kept in serum-free medium.

Schulz M, Hamprecht B, Kleinkauf H, Bauer K.

J Neurochem. 1989 Jan;52(1):229-34.

PMID:
2462017
41.

Covalent coupling of gramicidin S synthetase 2 to water-soluble copolymers.

Heise S, Manecke G, Schroeter-Kermani C, Kleinkauf H.

Biotechnol Bioeng. 1988 Jul 20;32(3):400-3. No abstract available.

PMID:
18584766
42.

Synthesis of beauvericin by a multifunctional enzyme.

Peeters H, Zocher R, Kleinkauf H.

J Antibiot (Tokyo). 1988 Mar;41(3):352-9.

43.

Peptide antibiotics, beta-lactams, and related compounds.

Kleinkauf H, von Döhren H.

Crit Rev Biotechnol. 1988;8(1):1-32. Review.

PMID:
3063387
44.

Aminoacyl-tRNA synthetases catalyze AMP----ADP----ATP exchange reactions, indicating labile covalent enzyme-amino-acid intermediates.

Rapaport E, Remy P, Kleinkauf H, Vater J, Zamecnik PC.

Proc Natl Acad Sci U S A. 1987 Nov;84(22):7891-5.

45.

Peptide uptake by astroglia-rich brain cultures.

Schulz M, Hamprecht B, Kleinkauf H, Bauer K.

J Neurochem. 1987 Sep;49(3):748-55.

PMID:
3612123
46.

Monoclonal antibodies to the multienzyme enniatin synthetase. Production and use in structural studies.

Billich A, Zocher R, Kleinkauf H, Braun DG, Lavanchy D, Hochkeppel HK.

Biol Chem Hoppe Seyler. 1987 May;368(5):521-9.

PMID:
3620105
47.

Formation of D-Phe-Pro-Val-cyclo-Orn by gramicidin S synthetase in the absence of L-leucine.

Vater J, Schlumbohm W, Palacz Z, Salnikow J, Gadow A, Kleinkauf H.

Eur J Biochem. 1987 Mar 2;163(2):297-302.

48.

Biosynthesis of peptide antibiotics.

Kleinkauf H, von Döhren H.

Annu Rev Microbiol. 1987;41:259-89. Review. No abstract available.

PMID:
3318671
50.

Biosynthesis of cyclosporin A: partial purification and properties of a multifunctional enzyme from Tolypocladium inflatum.

Zocher R, Nihira T, Paul E, Madry N, Peeters H, Kleinkauf H, Keller U.

Biochemistry. 1986 Feb 11;25(3):550-3.

PMID:
3955013

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