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Items: 1 to 50 of 345

1.

Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure.

Lewalle A, Land S, Merken JJ, Raafs A, Sepúlveda P, Heymans S, Kleinjans J, Niederer SA.

Biophys J. 2019 Jul 29. pii: S0006-3495(19)30622-8. doi: 10.1016/j.bpj.2019.07.033. [Epub ahead of print]

2.

DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks.

Kuijpers TJM, Wolters JEJ, Kleinjans JCS, Jennen DGJ.

BMC Bioinformatics. 2019 Aug 13;20(1):417. doi: 10.1186/s12859-019-2995-y.

3.

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.

Bohler S, Liu X, Krauskopf J, Caiment F, Aubrecht J, Nicolaes GAF, Kleinjans JCS, Briedé JJ.

Clin Transl Sci. 2019 Jul 15. doi: 10.1111/cts.12663. [Epub ahead of print]

PMID:
31305025
4.

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.

Rodrigues D, Souza T, Jennen DGJ, Lemmens L, Kleinjans JCS, de Kok TM.

Cancer Treat Rev. 2019 Jul;77:57-66. doi: 10.1016/j.ctrv.2019.06.004. Epub 2019 Jun 27. Review.

PMID:
31279169
5.

Correction: MicroRNA regulation of persistent stress-enhanced memory.

Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA.

Mol Psychiatry. 2019 Jun 28. doi: 10.1038/s41380-019-0452-y. [Epub ahead of print]

PMID:
31253953
6.

MicroRNA regulation of persistent stress-enhanced memory.

Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA.

Mol Psychiatry. 2019 May 29. doi: 10.1038/s41380-019-0432-2. [Epub ahead of print] Erratum in: Mol Psychiatry. 2019 Jun 28;:.

PMID:
31142820
7.

Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks.

Krauskopf J, van Veldhoven K, Chadeau-Hyam M, Vermeulen R, Carrasco-Turigas G, Nieuwenhuijsen M, Vineis P, de Kok TM, Kleinjans JC.

Environ Int. 2019 Jul;128:193-200. doi: 10.1016/j.envint.2019.04.063. Epub 2019 May 3.

8.

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.

Jiang J, Messner S, Kelm JM, van Herwijnen M, Jennen DGJ, Kleinjans JC, de Kok TM.

Toxicol Lett. 2019 Sep 15;312:34-44. doi: 10.1016/j.toxlet.2019.05.004. Epub 2019 May 3.

9.

Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females.

Bohler S, Krauskopf J, Espín-Pérez A, Gebel S, Palli D, Rantakokko P, Kiviranta H, Kyrtopoulos SA, Balling R, Kleinjans J.

Environ Pollut. 2019 Jul;250:107-117. doi: 10.1016/j.envpol.2019.04.005. Epub 2019 Apr 8.

PMID:
30991279
10.

DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro.

Verheijen M, Lienhard M, Schrooders Y, Clayton O, Nudischer R, Boerno S, Timmermann B, Selevsek N, Schlapbach R, Gmuender H, Gotta S, Geraedts J, Herwig R, Kleinjans J, Caiment F.

Sci Rep. 2019 Mar 15;9(1):4641. doi: 10.1038/s41598-019-40660-0.

11.

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia.

Georgiadis P, Gavriil M, Rantakokko P, Ladoukakis E, Botsivali M, Kelly RS, Bergdahl IA, Kiviranta H, Vermeulen RCH, Spaeth F, Hebbels DGAJ, Kleinjans JCS, de Kok TMCM, Palli D, Vineis P, Kyrtopoulos SA; EnviroGenomarkers consortium.

Environ Int. 2019 May;126:24-36. doi: 10.1016/j.envint.2019.01.068. Epub 2019 Feb 15.

12.

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs).

Espín-Pérez A, Hebels DGAJ, Kiviranta H, Rantakokko P, Georgiadis P, Botsivali M, Bergdahl IA, Palli D, Späth F, Johansson A, Chadeau-Hyam M, Kyrtopoulos SA, Kleinjans JCS, de Kok TMCM.

Sci Rep. 2019 Jan 24;9(1):746. doi: 10.1038/s41598-018-37449-y.

13.

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens.

Limonciel A, van Breda SG, Jiang X, Tredwell GD, Wilmes A, Aschauer L, Siskos AP, Sachinidis A, Keun HC, Kopp-Schneider A, de Kok TM, Kleinjans JCS, Jennings P.

Front Genet. 2018 Dec 3;9:558. doi: 10.3389/fgene.2018.00558. eCollection 2018.

14.

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury.

Souza T, Trairatphisan P, Piñero J, Furlong LI, Saez-Rodriguez J, Kleinjans J, Jennen D.

Front Genet. 2018 Nov 20;9:527. doi: 10.3389/fgene.2018.00527. eCollection 2018.

15.

Phosphorylation of eIF2α promotes cell survival in response to benzo[a]pyrene exposure.

Smit E, Kleinjans JCS, van den Beucken T.

Toxicol In Vitro. 2019 Feb;54:330-337. doi: 10.1016/j.tiv.2018.10.015. Epub 2018 Oct 29.

16.

Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data.

Espín-Pérez A, Portier C, Chadeau-Hyam M, van Veldhoven K, Kleinjans JCS, de Kok TMCM.

PLoS One. 2018 Aug 30;13(8):e0202947. doi: 10.1371/journal.pone.0202947. eCollection 2018.

17.

Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements: A panel study in four European countries.

Mostafavi N, Vermeulen R, Ghantous A, Hoek G, Probst-Hensch N, Herceg Z, Tarallo S, Naccarati A, Kleinjans JCS, Imboden M, Jeong A, Morley D, Amaral AFS, van Nunen E, Gulliver J, Chadeau-Hyam M, Vineis P, Vlaanderen J.

Environ Int. 2018 Nov;120:11-21. doi: 10.1016/j.envint.2018.07.026. Epub 2018 Jul 25.

18.

Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies.

Espín-Pérez A, Krauskopf J, Chadeau-Hyam M, van Veldhoven K, Chung F, Cullinan P, Piepers J, van Herwijnen M, Kubesch N, Carrasco-Turigas G, Nieuwenhuijsen M, Vineis P, Kleinjans JCS, de Kok TMCM.

Environ Pollut. 2018 Nov;242(Pt A):182-190. doi: 10.1016/j.envpol.2018.06.051. Epub 2018 Jun 20.

19.

Translational regulation is a key determinant of the cellular response to benzo[a]pyrene.

Smit E, Caiment F, Piepers J, Kleinjans JCS, van den Beucken T.

Toxicol Lett. 2018 Oct 1;295:144-152. doi: 10.1016/j.toxlet.2018.06.009. Epub 2018 Jun 12.

PMID:
29906497
20.

Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling.

Verheijen M, Schrooders Y, Gmuender H, Nudischer R, Clayton O, Hynes J, Niederer S, Cordes H, Kuepfer L, Kleinjans J, Caiment F.

Toxicol Lett. 2018 Sep 15;294:184-192. doi: 10.1016/j.toxlet.2018.05.029. Epub 2018 May 24.

21.

Epigenome-wide association study of adiposity and future risk of obesity-related diseases.

Campanella G, Gunter MJ, Polidoro S, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Fiorito G, Guarrera S, Iacoviello L, Bergdahl IA, Melin B, Lenner P, de Kok TMCM, Georgiadis P, Kleinjans JCS, Kyrtopoulos SA, Bueno-de-Mesquita HB, Lillycrop KA, May AM, Onland-Moret NC, Murray R, Riboli E, Verschuren M, Lund E, Mode N, Sandanger TM, Fiano V, Trevisan M, Matullo G, Froguel P, Elliott P, Vineis P, Chadeau-Hyam M.

Int J Obes (Lond). 2018 Dec;42(12):2022-2035. doi: 10.1038/s41366-018-0064-7. Epub 2018 May 1.

PMID:
29713043
22.

Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors.

Bourguignon JP, Parent AS, Kleinjans JCS, Nawrot TS, Schoeters G, Van Larebeke N.

Environ Health. 2018 Apr 23;17(1):42. doi: 10.1186/s12940-018-0385-y.

23.

Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses.

Vermeulen R, Saberi Hosnijeh F, Bodinier B, Portengen L, Liquet B, Garrido-Manriquez J, Lokhorst H, Bergdahl IA, Kyrtopoulos SA, Johansson AS, Georgiadis P, Melin B, Palli D, Krogh V, Panico S, Sacerdote C, Tumino R, Vineis P, Castagné R, Chadeau-Hyam M; EnviroGenoMarkers Consortium Consortium members, Botsivali M, Chatziioannou A, Valavanis I, Kleinjans JCS, de Kok TMCM, Keun HC, Athersuch TJ, Kelly R, Lenner P, Hallmans G, Stephanou EG, Myridakis A, Kogevinas M, Fazzo L, De Santis M, Comba P, Bendinelli B, Kiviranta H, Rantakokko P, Airaksinen R, Ruokojarvi P, Gilthorpe M, Fleming S, Fleming T, Tu YK, Lundh T, Chien KL, Chen WJ, Lee WC, Kate Hsiao C, Kuo PH, Hung H, Liao SF.

Int J Cancer. 2018 Sep 15;143(6):1335-1347. doi: 10.1002/ijc.31536. Epub 2018 Apr 26.

24.

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.

Wolters JEJ, van Breda SGJ, Grossmann J, Fortes C, Caiment F, Kleinjans JCS.

Toxicol Lett. 2018 Jun 1;289:1-13. doi: 10.1016/j.toxlet.2018.02.026. Epub 2018 Mar 6.

25.

A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.

Briedé JJ, Deferme L, Wolters JEJ, Claessen SMH, van den Beucken T, Wagner RJ, van Breda SG, Kleinjans JCS.

Toxicol In Vitro. 2018 Apr;48:318-328. doi: 10.1016/j.tiv.2018.02.006. Epub 2018 Feb 9.

26.

The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution.

Krauskopf J, Caiment F, van Veldhoven K, Chadeau-Hyam M, Sinharay R, Chung KF, Cullinan P, Collins P, Barratt B, Kelly FJ, Vermeulen R, Vineis P, de Kok TM, Kleinjans JC.

Environ Int. 2018 Apr;113:26-34. doi: 10.1016/j.envint.2018.01.014. Epub 2018 Jan 28.

27.

Data on novel DNA methylation changes induced by valproic acid in human hepatocytes.

Wolters J, van Breda S, Claessen S, de Kok T, Kleinjans J.

Data Brief. 2017 Nov 10;16:161-171. doi: 10.1016/j.dib.2017.11.031. eCollection 2018 Feb.

28.

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.

van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS.

Toxicology. 2018 Jan 15;393:160-170. doi: 10.1016/j.tox.2017.11.013. Epub 2017 Nov 14.

29.

Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool.

Espín-Pérez A, Font-Ribera L, van Veldhoven K, Krauskopf J, Portengen L, Chadeau-Hyam M, Vermeulen R, Grimalt JO, Villanueva CM, Vineis P, Kogevinas M, Kleinjans JC, de Kok TM.

Environ Int. 2018 Jan;110:42-50. doi: 10.1016/j.envint.2017.10.003. Epub 2017 Nov 6.

30.

Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks.

Souza TM, Kleinjans JCS, Jennen DGJ.

Front Genet. 2017 Oct 6;8:142. doi: 10.3389/fgene.2017.00142. eCollection 2017.

31.

Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop.

Corvi R, Madia F, Guyton KZ, Kasper P, Rudel R, Colacci A, Kleinjans J, Jennings P.

Toxicol In Vitro. 2017 Dec;45(Pt 3):278-286. doi: 10.1016/j.tiv.2017.09.010. Epub 2017 Sep 12.

32.

Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis.

Georgiadis P, Liampa I, Hebels DG, Krauskopf J, Chatziioannou A, Valavanis I, de Kok TMCM, Kleinjans JCS, Bergdahl IA, Melin B, Spaeth F, Palli D, Vermeulen RCH, Vlaanderen J, Chadeau-Hyam M, Vineis P, Kyrtopoulos SA; EnviroGenomarkers consortium.

BMC Genomics. 2017 Sep 13;18(1):728. doi: 10.1186/s12864-017-4117-4.

33.

Identification of essential transcription factors for adequate DNA damage response after benzo(a)pyrene and aflatoxin B1 exposure by combining transcriptomics with functional genomics.

Smit E, Souza T, Jennen DGJ, Kleinjans JCS, van den Beucken T.

Toxicology. 2017 Sep 1;390:74-82. doi: 10.1016/j.tox.2017.09.002. Epub 2017 Sep 4.

34.

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes.

Wolters JEJ, van Breda SGJ, Caiment F, Claessen SM, de Kok TMCM, Kleinjans JCS.

Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.

35.

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.

Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J.

Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. No abstract available.

36.

DNA methylation and exposure to ambient air pollution in two prospective cohorts.

Plusquin M, Guida F, Polidoro S, Vermeulen R, Raaschou-Nielsen O, Campanella G, Hoek G, Kyrtopoulos SA, Georgiadis P, Naccarati A, Sacerdote C, Krogh V, Bas Bueno-de-Mesquita H, Monique Verschuren WM, Sayols-Baixeras S, Panni T, Peters A, Hebels DGAJ, Kleinjans J, Vineis P, Chadeau-Hyam M.

Environ Int. 2017 Nov;108:127-136. doi: 10.1016/j.envint.2017.08.006. Epub 2017 Aug 24.

37.

MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery.

Krauskopf J, de Kok TM, Hebels DG, Bergdahl IA, Johansson A, Spaeth F, Kiviranta H, Rantakokko P, Kyrtopoulos SA, Kleinjans JC.

Sci Rep. 2017 Aug 23;7(1):9262. doi: 10.1038/s41598-017-10167-7.

38.

The idiosyncratic drug-induced gene expression changes in HepG2 cells.

Jiang J, Mathijs K, Timmermans L, Claessen SM, Hecka A, Weusten J, Peters R, van Delft JH, Kleinjans JCS, Jennen DGJ, de Kok TM.

Data Brief. 2017 Jul 29;14:462-468. doi: 10.1016/j.dib.2017.07.074. eCollection 2017 Oct.

39.

Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure.

Winckelmans E, Nawrot TS, Tsamou M, Den Hond E, Baeyens W, Kleinjans J, Lefebvre W, Van Larebeke N, Peusens M, Plusquin M, Reynders H, Schoeters G, Vanpoucke C, de Kok TM, Vrijens K.

Environ Health. 2017 Aug 18;16(1):87. doi: 10.1186/s12940-017-0292-7.

40.

Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis.

Van den Hof WFPM, Coonen MLJ, van Herwijnen M, Brauers K, Jennen D, Olde Damink SWM, Schaap FG, Kleinjans JCS.

Toxicol In Vitro. 2017 Oct;44:322-329. doi: 10.1016/j.tiv.2017.07.024. Epub 2017 Aug 1.

41.

Inferring transcription factor activity from microarray data reveals novel targets for toxicological investigations.

Souza TM, van den Beucken T, Kleinjans JCS, Jennen DGJ.

Toxicology. 2017 Aug 15;389:101-107. doi: 10.1016/j.tox.2017.07.008. Epub 2017 Jul 22.

PMID:
28743512
42.

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury.

Jiang J, Mathijs K, Timmermans L, Claessen SM, Hecka A, Weusten J, Peters R, van Delft JH, Kleinjans JCS, Jennen DGJ, de Kok TM.

Toxicol Appl Pharmacol. 2017 Oct 1;332:100-108. doi: 10.1016/j.taap.2017.07.014. Epub 2017 Jul 18.

PMID:
28733206
43.

Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort.

Winckelmans E, Vrijens K, Tsamou M, Janssen BG, Saenen ND, Roels HA, Kleinjans J, Lefebvre W, Vanpoucke C, de Kok TM, Nawrot TS.

Environ Health. 2017 Jun 5;16(1):52. doi: 10.1186/s12940-017-0264-y.

44.

Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human.

Krauskopf J, de Kok TM, Schomaker SJ, Gosink M, Burt DA, Chandler P, Warner RL, Johnson KJ, Caiment F, Kleinjans JC, Aubrecht J.

PLoS One. 2017 May 17;12(5):e0177928. doi: 10.1371/journal.pone.0177928. eCollection 2017.

45.

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.

Chatziioannou A, Georgiadis P, Hebels DG, Liampa I, Valavanis I, Bergdahl IA, Johansson A, Palli D, Chadeau-Hyam M, Siskos AP, Keun H, Botsivali M, de Kok TM, Pérez AE, Kleinjans JC, Vineis P, Kyrtopoulos SA; EnviroGenomarkers project consortium.

Sci Rep. 2017 Feb 22;7:42870. doi: 10.1038/srep42870.

46.

Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides.

Mostafavi N, Vlaanderen J, Portengen L, Chadeau-Hyam M, Modig L, Palli D, Bergdahl IA, Brunekreef B, Vineis P, Hebels DG, Kleinjans JC, Krogh V, Hoek G, Georgiadis P, Kyrtopoulos S, Vermeulen R.

Epidemiology. 2017 May;28(3):320-328. doi: 10.1097/EDE.0000000000000628.

47.

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds.

Hendrickx DM, Souza T, Jennen DGJ, Kleinjans JCS.

Arch Toxicol. 2017 Jun;91(6):2343-2352. doi: 10.1007/s00204-016-1922-5. Epub 2016 Dec 28.

48.

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Wolters JE, van Herwijnen MH, Theunissen DH, Jennen DG, Van den Hof WF, de Kok TM, Schaap FG, van Breda SG, Kleinjans JC.

Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174. Epub 2016 Dec 2.

PMID:
27989131
49.

From the exposome to mechanistic understanding of chemical-induced adverse effects.

Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF.

Environ Int. 2017 Feb;99:97-106. doi: 10.1016/j.envint.2016.11.029. Epub 2016 Dec 8. Review.

50.

Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome.

Castagné R, Kelly-Irving M, Campanella G, Guida F, Krogh V, Palli D, Panico S, Sacerdote C, Tumino R, Kleinjans J, de Kok T, Kyrtopoulos SA, Lang T, Stringhini S, Vermeulen R, Vineis P, Delpierre C, Chadeau-Hyam M.

Sci Rep. 2016 Dec 9;6:38705. doi: 10.1038/srep38705.

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