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Items: 1 to 50 of 167


Comparing two classes of biological distribution systems using network analysis.

Papadopoulos L, Blinder P, Ronellenfitsch H, Klimm F, Katifori E, Kleinfeld D, Bassett DS.

PLoS Comput Biol. 2018 Sep 7;14(9):e1006428. doi: 10.1371/journal.pcbi.1006428. eCollection 2018 Sep.


Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals.

He Y, Wang M, Chen X, Pohmann R, Polimeni JR, Scheffler K, Rosen BR, Kleinfeld D, Yu X.

Neuron. 2018 Feb 21;97(4):925-939.e5. doi: 10.1016/j.neuron.2018.01.025.


Entrainment of Arteriole Vasomotor Fluctuations by Neural Activity Is a Basis of Blood-Oxygenation-Level-Dependent "Resting-State" Connectivity.

Mateo C, Knutsen PM, Tsai PS, Shih AY, Kleinfeld D.

Neuron. 2017 Nov 15;96(4):936-948.e3. doi: 10.1016/j.neuron.2017.10.012. Epub 2017 Oct 26.


The impact of vessel size, orientation and intravascular contribution on the neurovascular fingerprint of BOLD bSSFP fMRI.

Báez-Yánez MG, Ehses P, Mirkes C, Tsai PS, Kleinfeld D, Scheffler K.

Neuroimage. 2017 Dec;163:13-23. doi: 10.1016/j.neuroimage.2017.09.015. Epub 2017 Sep 8.


Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions.

McElvain LE, Friedman B, Karten HJ, Svoboda K, Wang F, Deschênes M, Kleinfeld D.

Neuroscience. 2018 Jan 1;368:152-170. doi: 10.1016/j.neuroscience.2017.08.034. Epub 2017 Aug 23. Review.


Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.

Bellavance MA, Takatoh J, Lu J, Demers M, Kleinfeld D, Wang F, Deschênes M.

Neuron. 2017 Aug 2;95(3):722-723. doi: 10.1016/j.neuron.2017.07.022. No abstract available.


Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement.

Bellavance MA, Takatoh J, Lu J, Demers M, Kleinfeld D, Wang F, Deschênes M.

Neuron. 2017 Aug 2;95(3):673-682.e4. doi: 10.1016/j.neuron.2017.06.045. Epub 2017 Jul 20.


Correction to 'Precision mapping of the vibrissa representation within murine primary somatosensory cortex'.

Knutsen PM, Mateo C, Kleinfeld D.

Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718). pii: 20170002. doi: 10.1098/rstb.2017.0002. No abstract available.


Coordination of Orofacial Motor Actions into Exploratory Behavior by Rat.

Kurnikova A, Moore JD, Liao SM, Deschênes M, Kleinfeld D.

Curr Biol. 2017 Mar 6;27(5):688-696. doi: 10.1016/j.cub.2017.01.013. Epub 2017 Feb 16.


Depth-dependent flow and pressure characteristics in cortical microvascular networks.

Schmid F, Tsai PS, Kleinfeld D, Jenny P, Weber B.

PLoS Comput Biol. 2017 Feb 14;13(2):e1005392. doi: 10.1371/journal.pcbi.1005392. eCollection 2017 Feb.


The capillary bed offers the largest hemodynamic resistance to the cortical blood supply.

Gould IG, Tsai P, Kleinfeld D, Linninger A.

J Cereb Blood Flow Metab. 2017 Jan;37(1):52-68. Epub 2016 Oct 10.


Roger Tsien 1952-2016.

Kleinfeld D.

Nat Neurosci. 2016 Sep 27;19(10):1269-70. doi: 10.1038/nn.4410. No abstract available.


The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.

Uhlirova H, Kılıç K, Tian P, Sakadžić S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ Jr, Vandenberghe M, Djurovic S, Andreassen OA, Silva GA, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A.

Philos Trans R Soc Lond B Biol Sci. 2016 Oct 5;371(1705). pii: 20150356. doi: 10.1098/rstb.2015.0356. Review.


Precision mapping of the vibrissa representation within murine primary somatosensory cortex.

Knutsen PM, Mateo C, Kleinfeld D.

Philos Trans R Soc Lond B Biol Sci. 2016 Oct 5;371(1705). pii: 20150351. doi: 10.1098/rstb.2015.0351. Erratum in: Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718):.


Analysis of Neuronal Spike Trains, Deconstructed.

Aljadeff J, Lansdell BJ, Fairhall AL, Kleinfeld D.

Neuron. 2016 Jul 20;91(2):221-59. doi: 10.1016/j.neuron.2016.05.039. Review.


Circuits in the Ventral Medulla That Phase-Lock Motoneurons for Coordinated Sniffing and Whisking.

Deschênes M, Kurnikova A, Elbaz M, Kleinfeld D.

Neural Plast. 2016;2016:7493048. doi: 10.1155/2016/7493048. Epub 2016 May 18. Review.


Cell type specificity of neurovascular coupling in cerebral cortex.

Uhlirova H, Kılıç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžić S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A.

Elife. 2016 May 31;5. pii: e14315. doi: 10.7554/eLife.14315.


Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters (CNiFERs) for Optical Detection of Neurotransmitters In Vivo.

Lacin E, Muller A, Fernando M, Kleinfeld D, Slesinger PA.

J Vis Exp. 2016 May 12;(111). doi: 10.3791/53290.


Inhibition, Not Excitation, Drives Rhythmic Whisking.

Deschênes M, Takatoh J, Kurnikova A, Moore JD, Demers M, Elbaz M, Furuta T, Wang F, Kleinfeld D.

Neuron. 2016 Apr 20;90(2):374-87. doi: 10.1016/j.neuron.2016.03.007. Epub 2016 Mar 31.


Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.

Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.


Whisking, Sniffing, and the Hippocampal θ-Rhythm: A Tale of Two Oscillators.

Kleinfeld D, Deschênes M, Ulanovsky N.

PLoS Biol. 2016 Feb 18;14(2):e1002385. doi: 10.1371/journal.pbio.1002385. eCollection 2016 Feb.


MPScope 2.0: A Computer System for Two-Photon Laser Scanning Microscopy with Concurrent Plasma-Mediated Ablation and Electrophysiology.

Nguyen QT, Driscoll J, Dolnick EM, Kleinfeld D.

In: Frostig RD, editor. In Vivo Optical Imaging of Brain Function. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 4.


In Vivo Two-Photon Laser Scanning Microscopy with Concurrent Plasma-Mediated Ablation Principles and Hardware Realization.

Tsai PS, Kleinfeld D.

In: Frostig RD, editor. In Vivo Optical Imaging of Brain Function. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 3.


Vibrissa Self-Motion and Touch Are Reliably Encoded along the Same Somatosensory Pathway from Brainstem through Thalamus.

Moore JD, Mercer Lindsay N, Deschênes M, Kleinfeld D.

PLoS Biol. 2015 Sep 22;13(9):e1002253. doi: 10.1371/journal.pbio.1002253. eCollection 2015.


Monitoring Integrated Activity of Individual Neurons Using FRET-Based Voltage-Sensitive Dyes.

Briggman KL, Kristan WB, González JE, Kleinfeld D, Tsien RY.

Adv Exp Med Biol. 2015;859:149-69. doi: 10.1007/978-3-319-17641-3_6. Review.


Ultra-large field-of-view two-photon microscopy.

Tsai PS, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D.

Opt Express. 2015 Jun 1;23(11):13833-47. doi: 10.1364/OE.23.013833.


The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions.

Kleinfeld D, Moore JD, Wang F, Deschênes M.

Cold Spring Harb Symp Quant Biol. 2014;79:29-39. doi: 10.1101/sqb.2014.79.024794. Epub 2015 Apr 15.


Deflection of a vibrissa leads to a gradient of strain across mechanoreceptors in a mystacial follicle.

Whiteley SJ, Knutsen PM, Matthews DW, Kleinfeld D.

J Neurophysiol. 2015 Jul;114(1):138-45. doi: 10.1152/jn.00179.2015. Epub 2015 Apr 8.


Fluorescently labeled peptide increases identification of degenerated facial nerve branches during surgery and improves functional outcome.

Hussain T, Mastrodimos MB, Raju SC, Glasgow HL, Whitney M, Friedman B, Moore JD, Kleinfeld D, Steinbach P, Messer K, Pu M, Tsien RY, Nguyen QT.

PLoS One. 2015 Mar 9;10(3):e0119600. doi: 10.1371/journal.pone.0119600. eCollection 2015.


Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.

Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Mateo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D.

Microcirculation. 2015 Apr;22(3):204-218. doi: 10.1111/micc.12195. Review.


Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking.

Matthews DW, Deschênes M, Furuta T, Moore JD, Wang F, Karten HJ, Kleinfeld D.

J Comp Neurol. 2015 Apr 15;523(6):921-42. doi: 10.1002/cne.23724. Epub 2015 Jan 30.


The Musculature That Drives Active Touch by Vibrissae and Nose in Mice.

Haidarliu S, Kleinfeld D, Deschênes M, Ahissar E.

Anat Rec (Hoboken). 2015 Jul;298(7):1347-58. doi: 10.1002/ar.23102. Epub 2014 Dec 5.


Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex.

Muller A, Joseph V, Slesinger PA, Kleinfeld D.

Nat Methods. 2014 Dec;11(12):1245-52. doi: 10.1038/nmeth.3151. Epub 2014 Oct 26.


Muscles involved in naris dilation and nose motion in rat.

Deschênes M, Haidarliu S, Demers M, Moore J, Kleinfeld D, Ahissar E.

Anat Rec (Hoboken). 2015 Mar;298(3):546-53. doi: 10.1002/ar.23053. Epub 2014 Oct 3.


Activation and measurement of free whisking in the lightly anesthetized rodent.

Moore JD, Deschênes M, Kurnikova A, Kleinfeld D.

Nat Protoc. 2014 Aug;9(8):1792-802. doi: 10.1038/nprot.2014.119. Epub 2014 Jul 3.


How the brainstem controls orofacial behaviors comprised of rhythmic actions.

Moore JD, Kleinfeld D, Wang F.

Trends Neurosci. 2014 Jul;37(7):370-80. doi: 10.1016/j.tins.2014.05.001. Epub 2014 Jun 2. Review.


More than a rhythm of life: breathing as a binder of orofacial sensation.

Kleinfeld D, Deschênes M, Wang F, Moore JD.

Nat Neurosci. 2014 May;17(5):647-51. doi: 10.1038/nn.3693. Epub 2014 Apr 25. Review.


Spectral methods for functional brain imaging.

Kleinfeld D, Mitra PP.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):248-62. doi: 10.1101/pdb.top081075.


Optically induced occlusion of single blood vessels in rodent neocortex.

Shih AY, Nishimura N, Nguyen J, Friedman B, Lyden PD, Schaffer CB, Kleinfeld D.

Cold Spring Harb Protoc. 2013 Dec 1;2013(12):1153-60. doi: 10.1101/pdb.prot079509.


Mediation of muscular control of rhinarial motility in rats by the nasal cartilaginous skeleton.

Haidarliu S, Kleinfeld D, Ahissar E.

Anat Rec (Hoboken). 2013 Dec;296(12):1821-32. doi: 10.1002/ar.22822. Epub 2013 Oct 29.


The challenge of connecting the dots in the B.R.A.I.N.

Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG.

Neuron. 2013 Oct 16;80(2):270-4. doi: 10.1016/j.neuron.2013.09.008.


All-optical osteotomy to create windows for transcranial imaging in mice.

Jeong DC, Tsai PS, Kleinfeld D.

Opt Express. 2013 Oct 7;21(20):23160-8. doi: 10.1364/OE.21.023160.


ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation.

Lin JY, Knutsen PM, Muller A, Kleinfeld D, Tsien RY.

Nat Neurosci. 2013 Oct;16(10):1499-508. doi: 10.1038/nn.3502. Epub 2013 Sep 1.


Two-photon imaging of blood flow in the rat cortex.

Driscoll JD, Shih AY, Drew PJ, Cauwenberghs G, Kleinfeld D.

Cold Spring Harb Protoc. 2013 Aug 1;2013(8):759-67. doi: 10.1101/pdb.prot076513.


The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow.

Blinder P, Tsai PS, Kaufhold JP, Knutsen PM, Suhl H, Kleinfeld D.

Nat Neurosci. 2013 Jul;16(7):889-97. doi: 10.1038/nn.3426. Epub 2013 Jun 9.


Hierarchy of orofacial rhythms revealed through whisking and breathing.

Moore JD, Deschênes M, Furuta T, Huber D, Smear MC, Demers M, Kleinfeld D.

Nature. 2013 May 9;497(7448):205-10. doi: 10.1038/nature12076. Epub 2013 Apr 28.


All-optical in situ histology of brain tissue with femtosecond laser pulses.

Tsai PS, Blinder P, Squier JA, Kleinfeld D.

Cold Spring Harb Protoc. 2013 Apr 1;2013(4):327-34. doi: 10.1101/pdb.prot073858.


The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit.

Shih AY, Blinder P, Tsai PS, Friedman B, Stanley G, Lyden PD, Kleinfeld D.

Nat Neurosci. 2013 Jan;16(1):55-63. doi: 10.1038/nn.3278. Epub 2012 Dec 16.


Vectorization of optically sectioned brain microvasculature: learning aids completion of vascular graphs by connecting gaps and deleting open-ended segments.

Kaufhold JP, Tsai PS, Blinder P, Kleinfeld D.

Med Image Anal. 2012 Aug;16(6):1241-58. doi: 10.1016/ Epub 2012 Jun 26.

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