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Items: 37

1.

An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein.

Nebenzahl-Sharon K, Sharf R, Amer J, Shalata H, Khoury-Haddad H, Sohn SY, Ayoub N, Hearing P, Kleinberger T.

J Virol. 2019 Sep 12;93(19). pii: e02253-18. doi: 10.1128/JVI.02253-18. Print 2019 Oct 1.

PMID:
31315986
2.

Selective elimination of cancer cells by the adenovirus E4orf4 protein in a Drosophila cancer model: a new paradigm for cancer therapy.

Rosen H, Sharf R, Pechkovsky A, Salzberg A, Kleinberger T.

Cell Death Dis. 2019 Jun 11;10(6):455. doi: 10.1038/s41419-019-1680-4.

3.

Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.

Nebenzahl-Sharon K, Shalata H, Sharf R, Amer J, Khoury-Haddad H, Sohn SY, Ayoub N, Hearing P, Kleinberger T.

J Virol. 2019 May 1;93(10). pii: e01365-18. doi: 10.1128/JVI.01365-18. Print 2019 May 15.

PMID:
30842317
4.

The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.

Brestovitsky A, Nebenzahl-Sharon K, Kechker P, Sharf R, Kleinberger T.

PLoS Pathog. 2016 Feb 11;12(2):e1005420. doi: 10.1371/journal.ppat.1005420. eCollection 2016 Feb.

5.

Mechanisms of cancer cell killing by the adenovirus E4orf4 protein.

Kleinberger T.

Viruses. 2015 May 7;7(5):2334-57. doi: 10.3390/v7052334. Review.

6.

Induction of cancer-specific cell death by the adenovirus E4orf4 protein.

Kleinberger T.

Adv Exp Med Biol. 2014;818:61-97. doi: 10.1007/978-1-4471-6458-6_4. Review.

PMID:
25001532
7.

NTPDASE4 gene products cooperate with the adenovirus E4orf4 protein through PP2A-dependent and -independent mechanisms and contribute to induction of cell death.

Avital-Shacham M, Sharf R, Kleinberger T.

J Virol. 2014 Jun;88(11):6318-28. doi: 10.1128/JVI.00381-14. Epub 2014 Mar 26.

8.

The adenovirus E4orf4 protein induces a unique mode of cell death while inhibiting classical apoptosis.

Pechkovsky A, Salzberg A, Kleinberger T.

Cell Cycle. 2013 Aug 1;12(15):2343-4. doi: 10.4161/cc.25707. Epub 2013 Jul 11. No abstract available.

9.

E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways.

Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1724-33. doi: 10.1073/pnas.1220282110. Epub 2013 Apr 23.

10.

Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit.

Horowitz B, Sharf R, Avital-Shacham M, Pechkovsky A, Kleinberger T.

J Biol Chem. 2013 May 10;288(19):13718-27. doi: 10.1074/jbc.M112.343756. Epub 2013 Mar 25.

11.
12.

The adenovirus E4orf4 protein targets PP2A to the ACF chromatin-remodeling factor and induces cell death through regulation of SNF2h-containing complexes.

Brestovitsky A, Sharf R, Mittelman K, Kleinberger T.

Nucleic Acids Res. 2011 Aug;39(15):6414-27. doi: 10.1093/nar/gkr231. Epub 2011 May 5.

13.

The cytosolic tail of the Golgi apyrase Ynd1 mediates E4orf4-induced toxicity in Saccharomyces cerevisiae.

Mittelman K, Ziv K, Maoz T, Kleinberger T.

PLoS One. 2010 Nov 22;5(11):e15539. doi: 10.1371/journal.pone.0015539.

14.

Adenovirus E4orf4 protein downregulates MYC expression through interaction with the PP2A-B55 subunit.

Ben-Israel H, Sharf R, Rechavi G, Kleinberger T.

J Virol. 2008 Oct;82(19):9381-8. doi: 10.1128/JVI.00791-08. Epub 2008 Jul 23.

15.

YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.

Maoz T, Koren R, Ben-Ari I, Kleinberger T.

J Biol Chem. 2005 Dec 16;280(50):41270-7. Epub 2005 Oct 14.

16.
17.

Induction of transformed cell-specific apoptosis by the adenovirus E4orf4 protein.

Kleinberger T.

Prog Mol Subcell Biol. 2004;36:245-67. Review. No abstract available.

PMID:
15171615
18.

Using the Ras Recruitment System to identify PP2A-B55-interacting proteins.

Barr HM, Sharf R, Kleinberger T.

Methods Enzymol. 2003;366:175-87.

PMID:
14674249
19.

Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability.

Liu B, Liang MH, Kuo YL, Liao W, Boros I, Kleinberger T, Blancato J, Giam CZ.

Mol Cell Biol. 2003 Aug;23(15):5269-81.

20.

Adenovirus and cell cycle control.

Ben-Israel H, Kleinberger T.

Front Biosci. 2002 May 1;7:d1369-95. Review.

PMID:
11991831
22.
23.

Selection of apoptosis-deficient adenovirus E4orf4 mutants in Saccharomyces cerevisiae.

Afifi R, Sharf R, Shtrichman R, Kleinberger T.

J Virol. 2001 May;75(9):4444-7. Erratum in: J Virol 2001 Jun;75(12):5719.

24.

Induction of apoptosis by adenovirus E4orf4 protein.

Kleinberger T.

Apoptosis. 2000 Jun;5(3):211-5. Review.

PMID:
11225841
25.

The adenovirus E4-ORF4 splicing enhancer protein interacts with a subset of phosphorylated SR proteins.

Estmer Nilsson C, Petersen-Mahrt S, Durot C, Shtrichman R, Krainer AR, Kleinberger T, Akusjärvi G.

EMBO J. 2001 Feb 15;20(4):864-71.

26.
28.

Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.

Shtrichman R, Sharf R, Barr H, Dobner T, Kleinberger T.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10080-5.

29.
31.
32.

A protein kinase is present in a complex with adenovirus E1A proteins.

Kleinberger T, Shenk T.

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11143-7.

33.

Carcinogen-mediated co-activation of two independent genes in Chinese hamster cells.

Kleinberger T, Sahar E, Lavi S.

Carcinogenesis. 1988 Jun;9(6):979-85.

PMID:
2836108
34.

Carcinogen-induced trans activation of gene expression.

Kleinberger T, Flint YB, Blank M, Etkin S, Lavi S.

Mol Cell Biol. 1988 Mar;8(3):1366-70.

35.
36.

The integrated SV40 genome in permissive transformed monkey cells.

Krieg P, Amtmann E, Sauer G, Lavi S, Kleinberger T, Winocour E.

Virology. 1981 Jan 30;108(2):453-61. No abstract available.

PMID:
6258298
37.

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