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Items: 1 to 50 of 94

1.

Recurrent convergent evolution at amino acid residue 261 in fish rhodopsin.

Hill J, Enbody ED, Pettersson ME, Sprehn CG, Bekkevold D, Folkvord A, Laikre L, Kleinau G, Scheerer P, Andersson L.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18473-18478. doi: 10.1073/pnas.1908332116. Epub 2019 Aug 26.

2.

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective.

Heyder N, Kleinau G, Szczepek M, Kwiatkowski D, Speck D, Soletto L, Cerdá-Reverter JM, Krude H, Kühnen P, Biebermann H, Scheerer P.

Front Endocrinol (Lausanne). 2019 Jul 31;10:515. doi: 10.3389/fendo.2019.00515. eCollection 2019.

3.

Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin.

Fudim R, Szczepek M, Vierock J, Vogt A, Schmidt A, Kleinau G, Fischer P, Bartl F, Scheerer P, Hegemann P.

Sci Signal. 2019 Mar 19;12(573). pii: eaav4203. doi: 10.1126/scisignal.aav4203.

PMID:
30890657
4.

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes.

Jacobi SF, Khajavi N, Kleinau G, Teumer A, Scheerer P, Homuth G, Völzke H, Wiegand S, Kühnen P, Krude H, Gong M, Raile K, Biebermann H.

Diabetes Obes Metab. 2019 May;21(5):1168-1176. doi: 10.1111/dom.13634. Epub 2019 Feb 19.

PMID:
30784161
5.

Melanocortin Receptor Accessory Protein 2-Induced Adrenocorticotropic Hormone Response of Human Melanocortin 4 Receptor.

Soletto L, Hernández-Balfagó S, Rocha A, Scheerer P, Kleinau G, Cerdá-Reverter JM.

J Endocr Soc. 2018 Dec 6;3(2):314-323. doi: 10.1210/js.2018-00370. eCollection 2019 Feb 1.

6.

Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.

Klein W, Rutz C, Eckhard J, Provinciael B, Specker E, Neuenschwander M, Kleinau G, Scheerer P, von Kries JP, Nazaré M, Vermeire K, Schülein R.

PLoS One. 2018 Dec 13;13(12):e0208641. doi: 10.1371/journal.pone.0208641. eCollection 2018.

7.

A New Multisystem Disorder Caused by the Gαs Mutation p.F376V.

Biebermann H, Kleinau G, Schnabel D, Bockenhauer D, Wilson LC, Tully I, Kiff S, Scheerer P, Reyes M, Paisdzior S, Gregory JW, Allgrove J, Krude H, Mannstadt M, Gardella TJ, Dattani M, Jüppner H, Grüters A.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1079-1089. doi: 10.1210/jc.2018-01250.

PMID:
30312418
8.

Relevance of polymorphisms in MC4R and BDNF in short normal stature.

Herrfurth N, Volckmar AL, Peters T, Kleinau G, Müller A, Cetindag C, Schonnop L, Föcker M, Dempfle A, Wudy SA, Grant SFA, Reinehr T, Cousminer DL, Hebebrand J, Biebermann H, Hinney A.

BMC Pediatr. 2018 Aug 22;18(1):278. doi: 10.1186/s12887-018-1245-1.

9.

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H.

Cell Signal. 2018 Nov;51:13-22. doi: 10.1016/j.cellsig.2018.07.006. Epub 2018 Jul 25.

PMID:
30055232
10.

Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor.

Saleh N, Kleinau G, Heyder N, Clark T, Hildebrand PW, Scheerer P.

Front Pharmacol. 2018 Jun 1;9:560. doi: 10.3389/fphar.2018.00560. eCollection 2018.

11.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
12.

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor.

Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H.

Front Pharmacol. 2018 Mar 12;9:222. doi: 10.3389/fphar.2018.00222. eCollection 2018.

13.

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.

Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H.

Cell Mol Life Sci. 2018 Jun;75(12):2227-2239. doi: 10.1007/s00018-017-2728-1. Epub 2017 Dec 30.

PMID:
29290039
14.

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1.

Mühlhaus J, Dinter J, Jyrch S, Teumer A, Jacobi SF, Homuth G, Kühnen P, Wiegand S, Grüters A, Völzke H, Raile K, Kleinau G, Krude H, Biebermann H.

Front Pharmacol. 2017 Nov 24;8:807. doi: 10.3389/fphar.2017.00807. eCollection 2017.

15.

GPCR-SSFE 2.0-a fragment-based molecular modeling web tool for Class A G-protein coupled receptors.

Worth CL, Kreuchwig F, Tiemann JKS, Kreuchwig A, Ritschel M, Kleinau G, Hildebrand PW, Krause G.

Nucleic Acids Res. 2017 Jul 3;45(W1):W408-W415. doi: 10.1093/nar/gkx399.

16.

Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.

Kleinau G, Worth CL, Kreuchwig A, Biebermann H, Marcinkowski P, Scheerer P, Krause G.

Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017. Review.

17.

Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain.

Press O, Zvagelsky T, Vyazmensky M, Kleinau G, Engel S.

Biophys J. 2016 Dec 20;111(12):2620-2628. doi: 10.1016/j.bpj.2016.11.002.

18.

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83.

Müller A, Berkmann JC, Scheerer P, Biebermann H, Kleinau G.

PLoS One. 2016 Dec 9;11(12):e0168260. doi: 10.1371/journal.pone.0168260. eCollection 2016.

19.

Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist.

Bandholtz S, Erdmann S, von Hacht JL, Exner S, Krause G, Kleinau G, Grötzinger C.

J Med Chem. 2016 Nov 23;59(22):10100-10112. Epub 2016 Nov 4.

PMID:
27791374
20.

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.

Müller A, Niederstadt L, Jonas W, Yi CX, Meyer F, Wiedmer P, Fischer J, Grötzinger C, Schürmann A, Tschöp M, Kleinau G, Grüters A, Krude H, Biebermann H.

Front Endocrinol (Lausanne). 2016 Aug 8;7:109. doi: 10.3389/fendo.2016.00109. eCollection 2016.

21.

Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.

Schonnop L, Kleinau G, Herrfurth N, Volckmar AL, Cetindag C, Müller A, Peters T, Herpertz S, Antel J, Hebebrand J, Biebermann H, Hinney A.

Obesity (Silver Spring). 2016 Sep;24(9):1976-82. doi: 10.1002/oby.21576. Epub 2016 Jul 30.

22.

Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.

Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B.

J Med Chem. 2016 Aug 11;59(15):7152-66. doi: 10.1021/acs.jmedchem.6b00564. Epub 2016 Jul 28.

PMID:
27420737
23.

Minireview: Insights Into the Structural and Molecular Consequences of the TSH-β Mutation C105Vfs114X.

Kleinau G, Kalveram L, Köhrle J, Szkudlinski M, Schomburg L, Biebermann H, Grüters-Kieslich A.

Mol Endocrinol. 2016 Sep;30(9):954-64. doi: 10.1210/me.2016-1065. Epub 2016 Jul 7. Review.

24.

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort.

Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J.

Thyroid. 2016 Sep;26(9):1215-24. doi: 10.1089/thy.2016.0016. Epub 2016 Aug 2.

25.

The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.

Zwanziger D, Schmidt M, Fischer J, Kleinau G, Braun D, Schweizer U, Moeller LC, Biebermann H, Fuehrer D.

Mol Cell Endocrinol. 2016 Oct 15;434:278-87. doi: 10.1016/j.mce.2016.05.017. Epub 2016 May 21.

PMID:
27222294
26.

Oligomerization of GPCRs involved in endocrine regulation.

Kleinau G, Müller A, Biebermann H.

J Mol Endocrinol. 2016 Jul;57(1):R59-80. doi: 10.1530/JME-16-0049. Epub 2016 May 5. Review.

PMID:
27151573
27.

Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.

Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694.

28.

What are they waiting for?-Tethered agonism in G protein-coupled receptors.

Schöneberg T, Kleinau G, Brüser A.

Pharmacol Res. 2016 Jun;108:9-15. doi: 10.1016/j.phrs.2016.03.027. Epub 2016 Apr 16. Review.

PMID:
27095083
29.

The Multitarget Ligand 3-Iodothyronamine Modulates β-Adrenergic Receptor 2 Signaling.

Dinter J, Khajavi N, Mühlhaus J, Wienchol CL, Cöster M, Hermsdorf T, Stäubert C, Köhrle J, Schöneberg T, Kleinau G, Mergler S, Biebermann H.

Eur Thyroid J. 2015 Sep;4(Suppl 1):21-9. doi: 10.1159/000381801. Epub 2015 May 29.

30.

The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases.

Brüser A, Schulz A, Rothemund S, Ricken A, Calebiro D, Kleinau G, Schöneberg T.

J Biol Chem. 2016 Jan 8;291(2):508-20. doi: 10.1074/jbc.M115.701102. Epub 2015 Nov 18.

31.

Differences in Signal Activation by LH and hCG are Mediated by the LH/CG Receptor's Extracellular Hinge Region.

Grzesik P, Kreuchwig A, Rutz C, Furkert J, Wiesner B, Schuelein R, Kleinau G, Gromoll J, Krause G.

Front Endocrinol (Lausanne). 2015 Sep 22;6:140. doi: 10.3389/fendo.2015.00140. eCollection 2015.

32.

A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia.

Vezzoli V, Duminuco P, Vottero A, Kleinau G, Schülein R, Minari R, Bassi I, Bernasconi S, Persani L, Bonomi M.

Hum Mol Genet. 2015 Nov 1;24(21):6003-12. doi: 10.1093/hmg/ddv313. Epub 2015 Aug 5.

33.

Loss-of-Function Variants in a Hungarian Cohort Reveal Structural Insights on TSH Receptor Maturation and Signaling.

Lábadi Á, Grassi ES, Gellén B, Kleinau G, Biebermann H, Ruzsa B, Gelmini G, Rideg O, Miseta A, Kovács GL, Patócs A, Felszeghy E, Nagy EV, Mezősi E, Persani L.

J Clin Endocrinol Metab. 2015 Jul;100(7):E1039-45. doi: 10.1210/jc.2014-4511. Epub 2015 May 15.

PMID:
25978107
34.

TSH Receptor Mutations and Diseases.

Kleinau G, Vassart G.

In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-.
2017 Jul 24.

35.

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Hoefig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.

J Mol Endocrinol. 2015 Jun;54(3):205-16. doi: 10.1530/JME-15-0003. Epub 2015 Apr 15.

PMID:
25878061
36.

Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.

Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H.

PLoS One. 2015 Feb 23;10(2):e0117774. doi: 10.1371/journal.pone.0117774. eCollection 2015.

37.

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

Fischer J, Kleinau G, Müller A, Kühnen P, Zwanziger D, Kinne A, Rehders M, Moeller LC, Führer D, Grüters A, Krude H, Brix K, Biebermann H.

J Mol Endocrinol. 2015 Feb;54(1):39-50. doi: 10.1530/JME-14-0272.

PMID:
25527620
38.

The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.

Müller A, Leinweber B, Fischer J, Müller TD, Grüters A, Tschöp MH, Knäuper V, Biebermann H, Kleinau G.

BMC Res Notes. 2014 Dec 16;7:913. doi: 10.1186/1756-0500-7-913.

39.

Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile.

Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H.

Int J Mol Sci. 2014 Nov 10;15(11):20638-55. doi: 10.3390/ijms151120638.

40.

Constitutive activities in the thyrotropin receptor: regulation and significance.

Kleinau G, Biebermann H.

Adv Pharmacol. 2014;70:81-119. doi: 10.1016/B978-0-12-417197-8.00003-1. Review.

PMID:
24931193
41.

Comprehensive genotyping and clinical characterisation reveal 27 novel NKX2-1 mutations and expand the phenotypic spectrum.

Thorwarth A, Schnittert-Hübener S, Schrumpf P, Müller I, Jyrch S, Dame C, Biebermann H, Kleinau G, Katchanov J, Schuelke M, Ebert G, Steininger A, Bönnemann C, Brockmann K, Christen HJ, Crock P, deZegher F, Griese M, Hewitt J, Ivarsson S, Hübner C, Kapelari K, Plecko B, Rating D, Stoeva I, Ropers HH, Grüters A, Ullmann R, Krude H.

J Med Genet. 2014 Jun;51(6):375-87. doi: 10.1136/jmedgenet-2013-102248. Epub 2014 Apr 8.

42.

Differences between lutropin-mediated and choriogonadotropin-mediated receptor activation.

Grzesik P, Teichmann A, Furkert J, Rutz C, Wiesner B, Kleinau G, Schülein R, Gromoll J, Krause G.

FEBS J. 2014 Mar;281(5):1479-92. doi: 10.1111/febs.12718. Epub 2014 Feb 10.

43.

Germline prokineticin receptor 2 (PROKR2) variants associated with central hypogonadism cause differental modulation of distinct intracellular pathways.

Libri DV, Kleinau G, Vezzoli V, Busnelli M, Guizzardi F, Sinisi AA, Pincelli AI, Mancini A, Russo G, Beck-Peccoz P, Loche S, Crivellaro C, Maghnie M, Krausz C, Persani L, Bonomi M; Italian Study Group on Idiopathic Central Hypogonadism (ICH).

J Clin Endocrinol Metab. 2014 Mar;99(3):E458-63. doi: 10.1210/jc.2013-2431. Epub 2013 Nov 25.

44.

Research resource: novel structural insights bridge gaps in glycoprotein hormone receptor analyses.

Kreuchwig A, Kleinau G, Krause G.

Mol Endocrinol. 2013 Aug;27(8):1357-63. doi: 10.1210/me.2013-1115. Epub 2013 Jun 24.

45.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.

Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968.

46.

Selective and potent agonists and antagonists for investigating the role of mouse oxytocin receptors.

Busnelli M, Bulgheroni E, Manning M, Kleinau G, Chini B.

J Pharmacol Exp Ther. 2013 Aug;346(2):318-27. doi: 10.1124/jpet.113.202994. Epub 2013 May 30.

47.

Structural and functional plasticity of the luteinizing hormone/choriogonadotrophin receptor.

Troppmann B, Kleinau G, Krause G, Gromoll J.

Hum Reprod Update. 2013 Sep-Oct;19(5):583-602. doi: 10.1093/humupd/dmt023. Epub 2013 May 17. Review.

PMID:
23686864
48.

Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.

Piechowski CL, Rediger A, Lagemann C, Mühlhaus J, Müller A, Pratzka J, Tarnow P, Grüters A, Krude H, Kleinau G, Biebermann H.

J Mol Endocrinol. 2013 Jun 29;51(1):109-18. doi: 10.1530/JME-13-0061. Print 2013.

PMID:
23674133
49.

Novel insights on thyroid-stimulating hormone receptor signal transduction.

Kleinau G, Neumann S, Grüters A, Krude H, Biebermann H.

Endocr Rev. 2013 Oct;34(5):691-724. doi: 10.1210/er.2012-1072. Epub 2013 May 3. Review.

50.

G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.

Müller A, Kleinau G, Piechowski CL, Müller TD, Finan B, Pratzka J, Grüters A, Krude H, Tschöp M, Biebermann H.

PLoS One. 2013;8(1):e53347. doi: 10.1371/journal.pone.0053347. Epub 2013 Jan 15.

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