Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 165

1.

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.

Xie Z, Shapiro LP, Cahill ME, Russell TA, Lacor PN, Klein WL, Penzes P.

Eur J Neurosci. 2019 May;49(9):1091-1101. doi: 10.1111/ejn.14311. Epub 2019 Jan 20.

PMID:
30565792
2.

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.

Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL.

J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29.

PMID:
30565253
3.

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.

Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra E Silva NM, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alves-Leon S, Marcondes J, Assirati JA Jr, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A.

J Neurosci Methods. 2018 Sep 1;307:203-209. doi: 10.1016/j.jneumeth.2018.05.021. Epub 2018 May 31.

PMID:
29859877
4.

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.

Cline EN, Bicca MA, Viola KL, Klein WL.

J Alzheimers Dis. 2018;64(s1):S567-S610. doi: 10.3233/JAD-179941. Review.

5.

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Pathol. 2018 May;245(1):85-100. doi: 10.1002/path.5056. Epub 2018 Apr 2.

6.

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL.

Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9.

7.

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers.

Sebollela A, Cline EN, Popova I, Luo K, Sun X, Ahn J, Barcelos MA, Bezerra VN, Lyra E Silva NM, Patel J, Pinheiro NR, Qin LA, Kamel JM, Weng A, DiNunno N, Bebenek AM, Velasco PT, Viola KL, Lacor PN, Ferreira ST, Klein WL.

J Neurochem. 2017 Sep;142(6):934-947. doi: 10.1111/jnc.14118. Epub 2017 Aug 2.

8.

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME.

Acta Neuropathol. 2017 Nov;134(5):769-788. doi: 10.1007/s00401-017-1737-3. Epub 2017 Jun 13.

9.

Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.

DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL.

Yale J Biol Med. 2017 Mar 29;90(1):45-61. eCollection 2017 Mar.

10.

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.

Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG.

J Biol Chem. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525. Epub 2017 Mar 16.

11.

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease.

Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X.

Mol Neurobiol. 2018 Mar;55(3):1977-1987. doi: 10.1007/s12035-017-0467-9. Epub 2017 Mar 2.

12.

A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls.

Savioz A, Giannakopoulos P, Herrmann FR, Klein WL, Kövari E, Bouras C, Giacobini E.

Neurodegener Dis. 2016;16(5-6):398-406. doi: 10.1159/000446283. Epub 2016 Jul 12.

PMID:
27400224
13.

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes.

Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW.

Neurol Neuroimmunol Neuroinflamm. 2016 May 10;3(3):e237. doi: 10.1212/NXI.0000000000000237. eCollection 2016 Jun.

14.

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers.

Umeda T, Ono K, Sakai A, Yamashita M, Mizuguchi M, Klein WL, Yamada M, Mori H, Tomiyama T.

Brain. 2016 May;139(Pt 5):1568-86. doi: 10.1093/brain/aww042. Epub 2016 Mar 28.

PMID:
27020329
15.

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S.

Acta Neuropathol Commun. 2016 Feb 25;4:16. doi: 10.1186/s40478-016-0282-y.

16.

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.

Wilcox KC, Marunde MR, Das A, Velasco PT, Kuhns BD, Marty MT, Jiang H, Luan CH, Sligar SG, Klein WL.

PLoS One. 2015 Apr 30;10(4):e0125263. doi: 10.1371/journal.pone.0125263. eCollection 2015.

17.

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.

Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C.

Brain. 2015 Jun;138(Pt 6):1722-37. doi: 10.1093/brain/awv024. Epub 2015 Mar 1.

18.

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG.

EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183.

19.

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis.

Viola KL, Klein WL.

Acta Neuropathol. 2015 Feb;129(2):183-206. doi: 10.1007/s00401-015-1386-3. Epub 2015 Jan 22. Review.

20.

Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease.

Viola KL, Sbarboro J, Sureka R, De M, Bicca MA, Wang J, Vasavada S, Satpathy S, Wu S, Joshi H, Velasco PT, MacRenaris K, Waters EA, Lu C, Phan J, Lacor P, Prasad P, Dravid VP, Klein WL.

Nat Nanotechnol. 2015 Jan;10(1):91-8. doi: 10.1038/nnano.2014.254. Epub 2014 Dec 22.

21.

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S.

Mol Psychiatry. 2015 Feb;20(1):109-17. doi: 10.1038/mp.2014.135. Epub 2014 Oct 28.

22.

Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.

Sebollela A, Mustata GM, Luo K, Velasco PT, Viola KL, Cline EN, Shekhawat GS, Wilcox KC, Dravid VP, Klein WL.

ACS Chem Neurosci. 2014 Dec 17;5(12):1238-45. doi: 10.1021/cn500156r. Epub 2014 Nov 7.

23.

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014.

24.

Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes.

Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WL, Eckermann AL, Meade TJ.

Chembiochem. 2014 Jul 21;15(11):1584-9. doi: 10.1002/cbic.201402201. Epub 2014 Jun 24.

25.

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.

Iulita MF, Allard S, Richter L, Munter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC.

Acta Neuropathol Commun. 2014 Jun 5;2:61. doi: 10.1186/2051-5960-2-61.

26.

Accumulation of intraneuronal amyloid-β is common in normal brain.

Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG.

Curr Alzheimer Res. 2014 May;11(4):317-24.

PMID:
24597504
27.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG.

Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

28.

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.

Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, Jung YK.

J Clin Invest. 2013 Jul;123(7):2791-802. doi: 10.1172/JCI66827. Epub 2013 Jun 10.

29.

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST.

J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013.

30.

Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease.

Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM.

Neurobiol Aging. 2013 Sep;34(9):2081-90. doi: 10.1016/j.neurobiolaging.2012.12.028. Epub 2013 Apr 9.

PMID:
23582659
31.

Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice.

Xiao C, Davis FJ, Chauhan BC, Viola KL, Lacor PN, Velasco PT, Klein WL, Chauhan NB.

J Alzheimers Dis. 2013;35(4):777-88. doi: 10.3233/JAD-122419.

32.

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.

Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, Kadoya C, Nakano R, Watanabe D, Maruyama K, Hori O, Hibino S, Choshi T, Nakahata T, Hioki H, Kaneko T, Naitoh M, Yoshikawa K, Yamawaki S, Suzuki S, Hata R, Ueno S, Seki T, Kobayashi K, Toda T, Murakami K, Irie K, Klein WL, Mori H, Asada T, Takahashi R, Iwata N, Yamanaka S, Inoue H.

Cell Stem Cell. 2013 Apr 4;12(4):487-96. doi: 10.1016/j.stem.2013.01.009. Epub 2013 Feb 21.

33.

Nanodisc-solubilized membrane protein library reflects the membrane proteome.

Marty MT, Wilcox KC, Klein WL, Sligar SG.

Anal Bioanal Chem. 2013 May;405(12):4009-16. doi: 10.1007/s00216-013-6790-8. Epub 2013 Feb 12.

34.

Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies.

Velasco PT, Heffern MC, Sebollela A, Popova IA, Lacor PN, Lee KB, Sun X, Tiano BN, Viola KL, Eckermann AL, Meade TJ, Klein WL.

ACS Chem Neurosci. 2012 Nov 21;3(11):972-81. doi: 10.1021/cn300122k. Epub 2012 Oct 23.

35.

Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols.

Pitt J, Thorner M, Brautigan D, Larner J, Klein WL.

FASEB J. 2013 Jan;27(1):199-207. doi: 10.1096/fj.12-211896. Epub 2012 Oct 16.

36.
37.

Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model.

Bitel CL, Kasinathan C, Kaswala RH, Klein WL, Frederikse PH.

J Alzheimers Dis. 2012;32(2):291-305. doi: 10.3233/JAD-2012-120571.

PMID:
22785400
38.

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers.

Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, Rego AC, Pereira CM.

Aging Cell. 2012 Oct;11(5):823-33. doi: 10.1111/j.1474-9726.2012.00848.x. Epub 2012 Jul 16.

39.

Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.

Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG.

J Biol Chem. 2012 Jun 1;287(23):19377-85. doi: 10.1074/jbc.M111.321448. Epub 2012 Apr 13.

40.

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG.

J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256.

41.

Aβ oligomers-induced toxicity is attenuated in cells cultured with NbActiv4™ medium.

Zhou Y, Klein WL.

Neurotox Res. 2012 Nov;22(4):335-44. Epub 2012 Mar 23.

42.

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice.

Umeda T, Tomiyama T, Kitajima E, Idomoto T, Nomura S, Lambert MP, Klein WL, Mori H.

Life Sci. 2012 Dec 10;91(23-24):1169-76. doi: 10.1016/j.lfs.2011.12.022. Epub 2012 Jan 17.

PMID:
22273754
43.

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease.

Ferreira ST, Klein WL.

Neurobiol Learn Mem. 2011 Nov;96(4):529-43. doi: 10.1016/j.nlm.2011.08.003. Epub 2011 Sep 6. Review.

44.

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity.

Bao F, Wicklund L, Lacor PN, Klein WL, Nordberg A, Marutle A.

Neurobiol Aging. 2012 Apr;33(4):825.e1-13. doi: 10.1016/j.neurobiolaging.2011.05.003. Epub 2011 Jun 17.

PMID:
21683475
45.

Aβ oligomer-induced synapse degeneration in Alzheimer's disease.

Wilcox KC, Lacor PN, Pitt J, Klein WL.

Cell Mol Neurobiol. 2011 Aug;31(6):939-48. doi: 10.1007/s10571-011-9691-4. Epub 2011 May 3. Review.

46.

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo.

Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, Klein WL, Mori H.

J Neurosci Res. 2011 Jul;89(7):1031-42. doi: 10.1002/jnr.22640. Epub 2011 Apr 12.

PMID:
21488093
47.

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease.

Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC.

Neurobiol Aging. 2012 Jul;33(7):1329-42. doi: 10.1016/j.neurobiolaging.2011.01.007. Epub 2011 Mar 16.

PMID:
21414686
48.

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.

Saraiva LM, Seixas da Silva GS, Galina A, da-Silva WS, Klein WL, Ferreira ST, De Felice FG.

PLoS One. 2010 Dec 16;5(12):e15230. doi: 10.1371/journal.pone.0015230.

49.

Transgenic mice as a model of pre-clinical Alzheimer's disease.

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC.

Curr Alzheimer Res. 2011 Feb;8(1):4-23.

PMID:
21143159
50.

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers.

Decker H, Jürgensen S, Adrover MF, Brito-Moreira J, Bomfim TR, Klein WL, Epstein AL, De Felice FG, Jerusalinsky D, Ferreira ST.

J Neurochem. 2010 Dec;115(6):1520-9. doi: 10.1111/j.1471-4159.2010.07058.x. Epub 2010 Nov 11.

Supplemental Content

Loading ...
Support Center