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Regulation of lifespan by neural excitation and REST.

Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, Yankner BA.

Nature. 2019 Oct;574(7778):359-364. doi: 10.1038/s41586-019-1647-8. Epub 2019 Oct 16.


Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse.

Kiyama T, Long Y, Chen CK, Whitaker CM, Shay A, Wu H, Badea TC, Mohsenin A, Parker-Thornburg J, Klein WH, Mills SL, Massey SC, Mao CA.

Cell Rep. 2019 Apr 16;27(3):900-915.e5. doi: 10.1016/j.celrep.2019.03.077.


Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.

Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA.

Mol Neurodegener. 2018 Oct 17;13(1):56. doi: 10.1186/s13024-018-0287-z.


Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina.

Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD.

Development. 2017 May 1;144(9):1698-1711. doi: 10.1242/dev.142042. Epub 2017 Mar 29.


Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development.

Mao CA, Agca C, Mocko-Strand JA, Wang J, Ullrich-Lüter E, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH.

Proc Biol Sci. 2016 Mar 16;283(1826):20152978. doi: 10.1098/rspb.2015.2978.


Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells.

Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S.

Nat Commun. 2015 May 8;6:7089. doi: 10.1038/ncomms8089.


Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation.

Gao Z, Mao CA, Pan P, Mu X, Klein WH.

Dev Neurobiol. 2014 Nov;74(11):1123-40. doi: 10.1002/dneu.22188. Epub 2014 May 22.


The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.

Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4026-35. doi: 10.1073/pnas.1308275110. Epub 2013 Sep 30.


The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.

Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK.

Genes Dev. 2013 May 1;27(9):997-1002. doi: 10.1101/gad.215152.113.


Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.

Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li X, Gao S, Engle JJ, Kuburas A, Fu X, Yu W, Klein WH, Russo AF, Amendt BA.

J Biol Chem. 2013 May 3;288(18):12580-95. doi: 10.1074/jbc.M112.374561. Epub 2013 Mar 20.


Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7.

Mao CA, Cho JH, Wang J, Gao Z, Pan P, Tsai WW, Frishman LJ, Klein WH.

Development. 2013 Feb 1;140(3):541-51. doi: 10.1242/dev.085886.


Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene.

Mandal NA, Tran JT, Saadi A, Rahman AK, Huynh TP, Klein WH, Cho JH.

Exp Eye Res. 2013 Jan;106:24-33. doi: 10.1016/j.exer.2012.10.014. Epub 2012 Nov 8.


Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.

Mizuguchi R, Naritsuka H, Mori K, Mao CA, Klein WH, Yoshihara Y.

J Neurosci. 2012 Jun 27;32(26):8831-44. doi: 10.1523/JNEUROSCI.5746-11.2012. Erratum in: J Neurosci. 2012 Sep 26;32(39):13639. Mao, Chai-An [added]; Klein, William H [added].


Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.

Zou M, Li S, Klein WH, Xiang M.

Dev Biol. 2012 Apr 15;364(2):114-27. doi: 10.1016/j.ydbio.2012.01.021. Epub 2012 Feb 3.


Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus.

Agca C, Elhajj MC, Klein WH, Venuti JM.

J Comp Neurol. 2011 Dec 1;519(17):3566-79. doi: 10.1002/cne.22724.


Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice.

Meadows E, Flynn JM, Klein WH.

PLoS One. 2011 Jan 14;6(1):e16184. doi: 10.1371/journal.pone.0016184.


Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse.

Flynn JM, Meadows E, Fiorotto M, Klein WH.

PLoS One. 2010 Oct 22;5(10):e13535. doi: 10.1371/journal.pone.0013535.


Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development.

Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH.

Dev Biol. 2011 Jan 1;349(1):90-9. doi: 10.1016/j.ydbio.2010.10.008. Epub 2010 Oct 20.


Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate.

Kiyama T, Mao CA, Cho JH, Fu X, Pan P, Mu X, Klein WH.

Vision Res. 2011 Jan 28;51(2):251-9. doi: 10.1016/j.visres.2010.10.016. Epub 2010 Oct 15.


Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.

Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN.

Cell. 2010 Oct 1;143(1):35-45. doi: 10.1016/j.cell.2010.09.004.


Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation.

Agca C, Klein WH, Venuti JM.

Dev Dyn. 2009 Jul;238(7):1777-87. doi: 10.1002/dvdy.22001.


Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus.

Kiyama T, Zhang J, Liang S, Liang S, Klein WH.

Mar Genomics. 2009 Jun;2(2):85-98. doi: 10.1016/j.margen.2009.03.007. Epub 2009 Jul 3.


Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse.

Fu X, Kiyama T, Li R, Russell M, Klein WH, Mu X.

Dev Dyn. 2009 Sep;238(9):2309-17. doi: 10.1002/dvdy.21974.


Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment.

Agca C, Klein WH, Venuti JM.

Mech Dev. 2009 May-Jun;126(5-6):430-42. doi: 10.1016/j.mod.2009.01.005. Epub 2009 Jan 31.


Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice.

Cho JH, Mu X, Wang SW, Klein WH.

Exp Eye Res. 2009 Mar;88(3):542-52. doi: 10.1016/j.exer.2008.11.021. Epub 2008 Dec 6.


A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression.

Tang H, Macpherson P, Marvin M, Meadows E, Klein WH, Yang XJ, Goldman D.

Mol Biol Cell. 2009 Feb;20(4):1120-31. doi: 10.1091/mbc.E08-07-0759. Epub 2008 Dec 24.


Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex.

Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V.

Neuron. 2008 Oct 9;60(1):56-69. doi: 10.1016/j.neuron.2008.09.028.


The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis.

Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honoré JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beauséjour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S.

Nat Med. 2008 Oct;14(10):1067-76. doi: 10.1038/nm.1873. Epub 2008 Oct 5.


Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5.

Mao CA, Wang SW, Pan P, Klein WH.

Development. 2008 Oct;135(20):3379-88. doi: 10.1242/dev.024612. Epub 2008 Sep 11.


Myogenin regulates a distinct genetic program in adult muscle stem cells.

Meadows E, Cho JH, Flynn JM, Klein WH.

Dev Biol. 2008 Oct 15;322(2):406-14. doi: 10.1016/j.ydbio.2008.07.024. Epub 2008 Jul 30.


Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2.

Mu X, Fu X, Beremand PD, Thomas TL, Klein WH.

Proc Natl Acad Sci U S A. 2008 May 13;105(19):6942-7. doi: 10.1073/pnas.0802627105. Epub 2008 May 6.


Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse.

Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH.

Development. 2008 Jan;135(2):271-80. Epub 2007 Dec 12.


Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.

Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH.

Dev Biol. 2007 Nov 15;311(2):650-64. Epub 2007 Aug 16.


Smooth muscle persists in the muscularis externa of developing and adult mouse esophagus.

Rishniw M, Fisher PW, Doran RM, Meadows E, Klein WH, Kotlikoff MI.

J Muscle Res Cell Motil. 2007;28(2-3):153-65. Epub 2007 Jul 19.


Canonical Wnt signaling functions in second heart field to promote right ventricular growth.

Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9319-24. Epub 2007 May 22.


The genome of the sea urchin Strongylocentrotus purpuratus.

Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Bellé R, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Genevière AM, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Hallböök F, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duboc V, Duloquin L, Flytzanis C, Gache C, Lapraz F, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Röttinger E, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R.

Science. 2006 Nov 10;314(5801):941-52. Erratum in: Science. 2007 Feb 9;315(5813):766.


A genomic view of the sea urchin nervous system.

Burke RD, Angerer LM, Elphick MR, Humphrey GW, Yaguchi S, Kiyama T, Liang S, Mu X, Agca C, Klein WH, Brandhorst BP, Rowe M, Wilson K, Churcher AM, Taylor JS, Chen N, Murray G, Wang D, Mellott D, Olinski R, Hallböök F, Thorndyke MC.

Dev Biol. 2006 Dec 1;300(1):434-60. Epub 2006 Aug 10.


Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development.

Fu X, Sun H, Klein WH, Mu X.

Dev Biol. 2006 Nov 15;299(2):424-37. Epub 2006 Aug 10.


Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size.

Knapp JR, Davie JK, Myer A, Meadows E, Olson EN, Klein WH.

Development. 2006 Feb;133(4):601-10. Epub 2006 Jan 11.


A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate.

Mu X, Fu X, Sun H, Beremand PD, Thomas TL, Klein WH.

Dev Biol. 2005 Apr 15;280(2):467-81.


Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins.

Villinski JT, Kiyama T, Dayal S, Zhang N, Liang S, Klein WH.

Dev Genes Evol. 2005 Aug;215(8):410-22. Epub 2005 May 4.


Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2.

Martin SE, Mu X, Klein WH.

Differentiation. 2005 Feb;73(1):18-27.


Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database.

Liang S, Zhao S, Mu X, Thomas T, Klein WH.

Mol Vis. 2004 Oct 8;10:773-86.


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