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Items: 1 to 50 of 243

1.

Pharmacogenomics Clinical Annotation Tool (PharmCAT).

Sangkuhl K, Whirl-Carrillo M, Whaley RM, Woon M, Lavertu A, Altman RB, Carter L, Verma A, Ritchie MD, Klein TE.

Clin Pharmacol Ther. 2019 Jul 15. doi: 10.1002/cpt.1568. [Epub ahead of print]

PMID:
31306493
2.

Pharmacogenomics in dermatology: tools for understanding gene-drug associations.

Daneshjou R, Huddart R, Klein TE, Altman RB.

Semin Cutan Med Surg. 2019 Mar 1;38(1):E19-E24. doi: 10.12788/j.sder.2019.009.

PMID:
31051019
3.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy.

Desta Z, Gammal RS, Gong L, Whirl-Carrillo M, Gaur AH, Sukasem C, Hockings J, Myers A, Swart M, Tyndale RF, Masimirembwa C, Iwuchukwu OF, Chirwa S, Lennox J, Gaedigk A, Klein TE, Haas DW.

Clin Pharmacol Ther. 2019 Apr 21. doi: 10.1002/cpt.1477. [Epub ahead of print]

PMID:
31006110
4.

Are Randomized Controlled Trials Necessary to Establish the Value of Implementing Pharmacogenomics in the Clinic?

Huddart R, Sangkuhl K, Whirl-Carrillo M, Klein TE.

Clin Pharmacol Ther. 2019 Apr 12. doi: 10.1002/cpt.1420. [Epub ahead of print] No abstract available.

PMID:
30977517
5.

PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics.

Stevens T, Sangkuhl K, Brown JT, Altman RB, Klein TE.

Pharmacogenet Genomics. 2019 Aug;29(6):136-154. doi: 10.1097/FPC.0000000000000376. No abstract available.

PMID:
30950912
6.

Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.

Brown JT, Bishop JR, Sangkuhl K, Nurmi EL, Mueller DJ, Dinh JC, Gaedigk A, Klein TE, Caudle KE, McCracken JT, de Leon J, Leeder JS.

Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13. Review.

PMID:
30801677
7.

PharmGKB summary: Ondansetron and tropisetron pathways, pharmacokinetics and pharmacodynamics.

Huddart R, Altman RB, Klein TE.

Pharmacogenet Genomics. 2019 Jun;29(4):91-97. doi: 10.1097/FPC.0000000000000369. No abstract available.

PMID:
30672837
8.

Considerations for pharmacogenomic testing in a health system.

Gammal RS, Caudle KE, Klein TE, Relling MV.

Genet Med. 2019 Jan 9. doi: 10.1038/s41436-018-0421-x. [Epub ahead of print] No abstract available.

PMID:
30631112
9.

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression.

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.

J Neural Transm (Vienna). 2019 Jan;126(1):35-45. doi: 10.1007/s00702-018-01966-x. Epub 2019 Jan 4.

PMID:
30610379
10.

The ACCOuNT Consortium: A Model for the Discovery, Translation, and Implementation of Precision Medicine in African Americans.

Friedman PN, Shaazuddin M, Gong L, Grossman RL, Harralson AF, Klein TE, Lee NH, Miller DC, Nutescu EA, O'Brien TJ, O'Donnell PH, O'Leary KJ, Tuck M, Meltzer DO, Perera MA.

Clin Transl Sci. 2019 May;12(3):209-217. doi: 10.1111/cts.12608. Epub 2019 Feb 12. Review.

11.

The Evolution of PharmVar.

Gaedigk A, Sangkuhl K, Whirl-Carrillo M, Twist GP, Klein TE, Miller NA; PharmVar Steering Committee.

Clin Pharmacol Ther. 2019 Jan;105(1):29-32. doi: 10.1002/cpt.1275. Epub 2018 Dec 7. No abstract available.

12.

Standardized Biogeographic Grouping System for Annotating Populations in Pharmacogenetic Research.

Huddart R, Fohner AE, Whirl-Carrillo M, Wojcik GL, Gignoux CR, Popejoy AB, Bustamante CD, Altman RB, Klein TE.

Clin Pharmacol Ther. 2019 May;105(5):1256-1262. doi: 10.1002/cpt.1322. Epub 2019 Jan 21.

PMID:
30506572
13.

Pharmacogene Variation Consortium Gene Introduction: NUDT15.

Yang JJ, Whirl-Carrillo M, Scott SA, Turner AJ, Schwab M, Tanaka Y, Suarez-Kurtz G, Schaeffeler E, Klein TE, Miller NA, Gaedigk A.

Clin Pharmacol Ther. 2019 May;105(5):1091-1094. doi: 10.1002/cpt.1268. Epub 2018 Dec 4. No abstract available.

14.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for the Use of Potent Volatile Anesthetic Agents and Succinylcholine in the Context of RYR1 or CACNA1S Genotypes.

Gonsalves SG, Dirksen RT, Sangkuhl K, Pulk R, Alvarellos M, Vo T, Hikino K, Roden D, Klein TE, Poler SM, Patel S, Caudle KE, Gordon R, Brandom B, Biesecker LG.

Clin Pharmacol Ther. 2019 Jun;105(6):1338-1344. doi: 10.1002/cpt.1319. Epub 2019 Jan 24.

PMID:
30499100
15.

The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children.

Gammal RS, Caudle KE, Quinn CT, Wang WC, Gaedigk A, Prows CA, Haidar CE, Taylor AK, Klein TE, Sangkuhl K, Hankins JS, Crews KR.

Clin Pharmacol Ther. 2019 Jun;105(6):1300-1302. doi: 10.1002/cpt.1260. Epub 2018 Nov 22. No abstract available.

PMID:
30467830
16.

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update.

Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, Moyer AM, Evans WE, Klein TE, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ.

Clin Pharmacol Ther. 2019 May;105(5):1095-1105. doi: 10.1002/cpt.1304. Epub 2019 Jan 20.

PMID:
30447069
17.

Essential Characteristics of Pharmacogenomics Study Publications.

Thorn CF, Whirl-Carrillo M, Hachad H, Johnson JA, McDonagh EM, Ratain MJ, Relling MV, Scott SA, Altman RB, Klein TE.

Clin Pharmacol Ther. 2019 Jan;105(1):86-91. doi: 10.1002/cpt.1279. Review.

PMID:
30406943
18.

PharmGKB summary: oxycodone pathway, pharmacokinetics.

Huddart R, Clarke M, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Oct;28(10):230-237. doi: 10.1097/FPC.0000000000000351. No abstract available.

PMID:
30222708
19.

PharmGKB summary: clozapine pathway, pharmacokinetics.

Thorn CF, Müller DJ, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Sep;28(9):214-222. doi: 10.1097/FPC.0000000000000347. No abstract available.

PMID:
30134346
20.

Substitutions for arginine at position 780 in triple helical domain of the α1(I) chain alter folding of the type I procollagen molecule and cause osteogenesis imperfecta.

Makareeva E, Sun G, Mirigian LS, Mertz EL, Vera JC, Espinoza NA, Yang K, Chen D, Klein TE, Byers PH, Leikin S.

PLoS One. 2018 Jul 10;13(7):e0200264. doi: 10.1371/journal.pone.0200264. eCollection 2018.

21.

Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward.

Caudle KE, Keeling NJ, Klein TE, Whirl-Carrillo M, Pratt VM, Hoffman JM.

Pharmacogenomics. 2018 Jul 1;19(10):847-860. doi: 10.2217/pgs-2018-0028. Epub 2018 Jun 19. Review.

22.

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17. Review.

23.

Pharmacogenomics and big genomic data: from lab to clinic and back again.

Lavertu A, McInnes G, Daneshjou R, Whirl-Carrillo M, Klein TE, Altman RB.

Hum Mol Genet. 2018 May 1;27(R1):R72-R78. doi: 10.1093/hmg/ddy116. Review.

24.

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder.

Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT.

Front Psychiatry. 2018 Mar 6;9:65. doi: 10.3389/fpsyt.2018.00065. eCollection 2018.

25.

PharmGKB summary: clobazam pathway, pharmacokinetics.

Huddart R, Leeder JS, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 Apr;28(4):110-115. doi: 10.1097/FPC.0000000000000327. No abstract available.

26.

PharmGKB summary: atazanavir pathway, pharmacokinetics/pharmacodynamics.

Alvarellos M, Guillemette C, Altman RB, Klein TE.

Pharmacogenet Genomics. 2018 May;28(5):127-137. doi: 10.1097/FPC.0000000000000331. No abstract available.

27.

PharmGKB: A worldwide resource for pharmacogenomic information.

Barbarino JM, Whirl-Carrillo M, Altman RB, Klein TE.

Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. doi: 10.1002/wsbm.1417. Epub 2018 Feb 23. Review.

28.

Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.

Volpi S, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Rodriguez LL, Aronson S, Cavallari LH, Denny JC, Dressler LG, Johnson JA, Klein TE, Leeder JS, Piquette-Miller M, Perera M, Rasmussen-Torvik LJ, Rehm HL, Ritchie MD, Skaar TC, Wagle N, Weinshilboum R, Weitzel KW, Wildin R, Wilson J, Manolio TA, Relling MV.

Clin Pharmacol Ther. 2018 May;103(5):778-786. doi: 10.1002/cpt.1048. Epub 2018 Mar 30. Review.

29.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.

Goetz MP, Sangkuhl K, Guchelaar HJ, Schwab M, Province M, Whirl-Carrillo M, Symmans WF, McLeod HL, Ratain MJ, Zembutsu H, Gaedigk A, van Schaik RH, Ingle JN, Caudle KE, Klein TE.

Clin Pharmacol Ther. 2018 May;103(5):770-777. doi: 10.1002/cpt.1007. Epub 2018 Jan 31.

30.

PharmCAT: A Pharmacogenomics Clinical Annotation Tool.

Klein TE, Ritchie MD.

Clin Pharmacol Ther. 2018 Jul;104(1):19-22. doi: 10.1002/cpt.928. Epub 2017 Dec 1.

31.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update.

Amstutz U, Henricks LM, Offer SM, Barbarino J, Schellens JHM, Swen JJ, Klein TE, McLeod HL, Caudle KE, Diasio RB, Schwab M.

Clin Pharmacol Ther. 2018 Feb;103(2):210-216. doi: 10.1002/cpt.911. Epub 2017 Nov 20.

32.

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.

Gaedigk A, Ingelman-Sundberg M, Miller NA, Leeder JS, Whirl-Carrillo M, Klein TE; PharmVar Steering Committee.

Clin Pharmacol Ther. 2018 Mar;103(3):399-401. doi: 10.1002/cpt.910. Epub 2017 Nov 14.

33.

Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group.

Bank PCD, Caudle KE, Swen JJ, Gammal RS, Whirl-Carrillo M, Klein TE, Relling MV, Guchelaar HJ.

Clin Pharmacol Ther. 2018 Apr;103(4):599-618. doi: 10.1002/cpt.762. Epub 2017 Oct 10. Review.

34.

PharmGKB summary: very important pharmacogene information for ABCG2.

Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Nov;27(11):420-427. doi: 10.1097/FPC.0000000000000305. Review. No abstract available. Erratum in: Pharmacogenet Genomics. 2018 May;28(5):138.

35.

New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine.

Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM.

Clin Pharmacol Ther. 2017 Dec;102(6):897-902. doi: 10.1002/cpt.755. Epub 2017 Aug 10.

36.

Response to "Impact of CYP3A4 Genotype on Voriconazole Exposure: New Insights Into the Contribution of CYP3A4*22 to Metabolism of Voriconazole".

Walsh TJ, Moriyama B, Penzak SR, Klein TE, Caudle KE.

Clin Pharmacol Ther. 2018 Feb;103(2):187. doi: 10.1002/cpt.811. Epub 2017 Nov 16. No abstract available.

PMID:
28786218
37.

PharmGKB summary: pazopanib pathway, pharmacokinetics.

Thorn CF, Sharma MR, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Aug;27(8):307-312. doi: 10.1097/FPC.0000000000000292. Review. No abstract available.

38.

Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges.

Daneshjou R, Wang Y, Bromberg Y, Bovo S, Martelli PL, Babbi G, Lena PD, Casadio R, Edwards M, Gifford D, Jones DT, Sundaram L, Bhat RR, Li X, Pal LR, Kundu K, Yin Y, Moult J, Jiang Y, Pejaver V, Pagel KA, Li B, Mooney SD, Radivojac P, Shah S, Carraro M, Gasparini A, Leonardi E, Giollo M, Ferrari C, Tosatto SCE, Bachar E, Azaria JR, Ofran Y, Unger R, Niroula A, Vihinen M, Chang B, Wang MH, Franke A, Petersen BS, Pirooznia M, Zandi P, McCombie R, Potash JB, Altman RB, Klein TE, Hoskins RA, Repo S, Brenner SE, Morgan AA.

Hum Mutat. 2017 Sep;38(9):1182-1192. doi: 10.1002/humu.23280. Epub 2017 Jul 7.

39.

Response to "Pharmacogenetics of Voriconazole: CYP2C19 but Also CYP3A4 Need to Be Genotyped" - The Role of CYP3A4 and CYP3A5 Polymorphisms in Clinical Pharmacokinetics of Voriconazole.

Walsh TJ, Moriyama B, Penzak SR, Klein TE, Caudle KE.

Clin Pharmacol Ther. 2017 Aug;102(2):190. doi: 10.1002/cpt.681. Epub 2017 Apr 29. No abstract available.

PMID:
28455946
40.

PharmGKB summary: sorafenib pathways.

Gong L, Giacomini MM, Giacomini C, Maitland ML, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Jun;27(6):240-246. doi: 10.1097/FPC.0000000000000279. Review. No abstract available.

41.

PharmGKB summary: voriconazole pathway, pharmacokinetics.

Barbarino JM, Owusu Obeng A, Klein TE, Altman RB.

Pharmacogenet Genomics. 2017 May;27(5):201-209. doi: 10.1097/FPC.0000000000000276. No abstract available. Erratum in: Pharmacogenet Genomics. 2018 Aug;28(8):198.

42.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update.

Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, Lee MT, Gage BF, Kimmel SE, Perera MA, Anderson JL, Pirmohamed M, Klein TE, Limdi NA, Cavallari LH, Wadelius M.

Clin Pharmacol Ther. 2017 Sep;102(3):397-404. doi: 10.1002/cpt.668. Epub 2017 Apr 4.

43.

PharmGKB summary: Macrolide antibiotic pathway, pharmacokinetics/pharmacodynamics.

Fohner AE, Sparreboom A, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Apr;27(4):164-167. doi: 10.1097/FPC.0000000000000270. No abstract available.

44.

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.

Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, O'Donnell PH, Altman RB, Pereira N, Ratain MJ, Roden DM, Embi PJ, Sadee W, Klein TE, Johnson JA, Relling MV, Wang L, Weinshilboum RM, Shuldiner AR, Freimuth RR; Pharmacogenomics Research Network Translational Pharmacogenetics Program.

Clin Pharmacol Ther. 2017 Sep;102(3):502-510. doi: 10.1002/cpt.630. Epub 2017 Jun 9.

45.

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and use of ondansetron and tropisetron.

Bell GC, Caudle KE, Whirl-Carrillo M, Gordon RJ, Hikino K, Prows CA, Gaedigk A, Agundez J, Sadhasivam S, Klein TE, Schwab M.

Clin Pharmacol Ther. 2017 Aug;102(2):213-218. doi: 10.1002/cpt.598. Epub 2017 Apr 6. Review. No abstract available.

46.

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.

Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC.

Clin Pharmacol Ther. 2017 Jul;102(1):37-44. doi: 10.1002/cpt.597. Epub 2017 Feb 13. No abstract available.

47.

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C19 and Voriconazole Therapy.

Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agúndez J, Wingard JR, McLeod HL, Klein TE, Cross SJ, Caudle KE, Walsh TJ.

Clin Pharmacol Ther. 2017 Jul;102(1):45-51. doi: 10.1002/cpt.583. Epub 2017 Apr 18. Erratum in: Clin Pharmacol Ther. 2018 Feb;103(2):349.

48.

Evidence and resources to implement pharmacogenetic knowledge for precision medicine.

Caudle KE, Gammal RS, Whirl-Carrillo M, Hoffman JM, Relling MV, Klein TE.

Am J Health Syst Pharm. 2016 Dec 1;73(23):1977-1985. Review.

49.

Recommendations for reporting of secondary findings in clinical exome and genome sequencing, 2016 update (ACMG SF v2.0): a policy statement of the American College of Medical Genetics and Genomics.

Kalia SS, Adelman K, Bale SJ, Chung WK, Eng C, Evans JP, Herman GE, Hufnagel SB, Klein TE, Korf BR, McKelvey KD, Ormond KE, Richards CS, Vlangos CN, Watson M, Martin CL, Miller DT.

Genet Med. 2017 Feb;19(2):249-255. doi: 10.1038/gim.2016.190. Epub 2016 Nov 17. Erratum in: Genet Med. 2017 Apr;19(4):484.

PMID:
27854360
50.

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.

Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R.

Transl Psychiatry. 2016 Nov 1;6(11):e937. doi: 10.1038/tp.2016.187. No abstract available.

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