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Mechanisms of Pathogen Invasion into the Central Nervous System.

Cain MD, Salimi H, Diamond MS, Klein RS.

Neuron. 2019 Sep 4;103(5):771-783. doi: 10.1016/j.neuron.2019.07.015. Review.


Differential In Vitro Infection of Neural Cells by Astroviruses.

Janowski AB, Klein RS, Wang D.

MBio. 2019 Jul 9;10(4). pii: e01455-19. doi: 10.1128/mBio.01455-19.


Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor.

Luo Z, Liu H, Klein RS, Tu Z.

Bioorg Med Chem. 2019 Aug 15;27(16):3619-3631. doi: 10.1016/j.bmc.2019.06.047. Epub 2019 Jun 29.


T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses.

Garber C, Soung A, Vollmer LL, Kanmogne M, Last A, Brown J, Klein RS.

Nat Neurosci. 2019 Aug;22(8):1276-1288. doi: 10.1038/s41593-019-0427-y. Epub 2019 Jun 24.


Neuroinflammation During RNA Viral Infections.

Klein RS, Garber C, Funk KE, Salimi H, Soung A, Kanmogne M, Manivasagam S, Agner S, Cain M.

Annu Rev Immunol. 2019 Apr 26;37:73-95. doi: 10.1146/annurev-immunol-042718-041417.


An In Vitro Brain Endothelial Model for Studies of Cryptococcal Transmigration into the Central Nervous System.

Santiago-Tirado FH, Klein RS, Doering TL.

Curr Protoc Microbiol. 2019 Jun;53(1):e78. doi: 10.1002/cpmc.78. Epub 2019 Feb 18.


CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis.

Funk KE, Klein RS.

J Neuroinflammation. 2019 Jan 31;16(1):22. doi: 10.1186/s12974-019-1397-4.


Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA.

Nat Microbiol. 2018 Nov;3(11):1327. doi: 10.1038/s41564-018-0281-9.


Viral Encephalitis and Neurologic Diseases: Focus on Astrocytes.

Soung A, Klein RS.

Trends Mol Med. 2018 Nov;24(11):950-962. doi: 10.1016/j.molmed.2018.09.001. Epub 2018 Oct 9. Review.


Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection.

Luo H, Winkelmann ER, Zhu S, Ru W, Mays E, Silvas JA, Vollmer LL, Gao J, Peng BH, Bopp NE, Cromer C, Shan C, Xie G, Li G, Tesh R, Popov VL, Shi PY, Sun SC, Wu P, Klein RS, Tang SJ, Zhang W, Aguilar PV, Wang T.

J Clin Invest. 2018 Nov 1;128(11):4980-4991. doi: 10.1172/JCI99902. Epub 2018 Sep 24.


Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA.

Nat Microbiol. 2018 Oct;3(10):1099-1108. doi: 10.1038/s41564-018-0245-0. Epub 2018 Sep 17. Erratum in: Nat Microbiol. 2018 Nov;3(11):1327.


MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis.

Hoye ML, Archambault AS, Gordon TM, Oetjen LK, Cain MD, Klein RS, Crosby SD, Kim BS, Miller TM, Wu GF.

Immunology. 2018 Sep;155(1):112-122. doi: 10.1111/imm.12934. Epub 2018 May 10.


Viruses have multiple paths to central nervous system pathology.

Agner SC, Klein RS.

Curr Opin Neurol. 2018 Jun;31(3):313-317. doi: 10.1097/WCO.0000000000000556. Review.


Astrocytes decrease adult neurogenesis during virus-induced memory dysfunction via IL-1.

Garber C, Vasek MJ, Vollmer LL, Sun T, Jiang X, Klein RS.

Nat Immunol. 2018 Feb;19(2):151-161. doi: 10.1038/s41590-017-0021-y. Epub 2018 Jan 1.


Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.

Luo Z, Yue X, Yang H, Liu H, Klein RS, Tu Z.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):488-496. doi: 10.1016/j.bmcl.2017.12.010. Epub 2017 Dec 6.


Dual Blades: The Role of Musashi 1 in Zika Replication and Microcephaly.

Klein RS.

Cell Host Microbe. 2017 Jul 12;22(1):9-11. doi: 10.1016/j.chom.2017.06.015.


Protective and Pathological Immunity during Central Nervous System Infections.

Klein RS, Hunter CA.

Immunity. 2017 Jun 20;46(6):891-909. doi: 10.1016/j.immuni.2017.06.012. Review.


Virus entry and replication in the brain precedes blood-brain barrier disruption during intranasal alphavirus infection.

Cain MD, Salimi H, Gong Y, Yang L, Hamilton SL, Heffernan JR, Hou J, Miller MJ, Klein RS.

J Neuroimmunol. 2017 Jul 15;308:118-130. doi: 10.1016/j.jneuroim.2017.04.008. Epub 2017 May 1.


Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice.

Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE.

PLoS One. 2017 May 5;12(5):e0177142. doi: 10.1371/journal.pone.0177142. eCollection 2017.


Cytokine/chemokine expression associated with Human Pegivirus (HPgV) infection in women with HIV.

Blackard JT, Ma G, Welge JA, Taylor LE, Mayer KH, Klein RS, Celentano DD, Sobel JD, Jamieson DJ, King CC.

J Med Virol. 2017 Nov;89(11):1904-1911. doi: 10.1002/jmv.24836. Epub 2017 Aug 28.


Speaking out about gender imbalance in invited speakers improves diversity.

Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH.

Nat Immunol. 2017 Apr 18;18(5):475-478. doi: 10.1038/ni.3707. No abstract available.


Sex Drives Dimorphic Immune Responses to Viral Infections.

Ghosh S, Klein RS.

J Immunol. 2017 Mar 1;198(5):1782-1790. doi: 10.4049/jimmunol.1601166. Review.


Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen.

Santiago-Tirado FH, Onken MD, Cooper JA, Klein RS, Doering TL.

MBio. 2017 Jan 31;8(1). pii: e02183-16. doi: 10.1128/mBio.02183-16.


Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection.

Daniels BP, Jujjavarapu H, Durrant DM, Williams JL, Green RR, White JP, Lazear HM, Gale M Jr, Diamond MS, Klein RS.

J Clin Invest. 2017 Mar 1;127(3):843-856. doi: 10.1172/JCI88720. Epub 2017 Jan 30.


Infectious immunity in the central nervous system and brain function.

Klein RS, Garber C, Howard N.

Nat Immunol. 2017 Feb;18(2):132-141. doi: 10.1038/ni.3656. Epub 2017 Jan 16. Review.


Sporotrichoid fluctuant nodules.

Peart JM, Klein RS, Xu X, Stewart C, Rosenbach M.

Cutis. 2016 Aug;98(2):82;96. No abstract available.


A complement-microglial axis drives synapse loss during virus-induced memory impairment.

Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS.

Nature. 2016 Jun 23;534(7608):538-43. doi: 10.1038/nature18283.


Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis.

Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE.

MBio. 2016 Jun 7;7(3). pii: e00617-16. doi: 10.1128/mBio.00617-16.


Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.

Salimi H, Cain MD, Klein RS.

Neurotherapeutics. 2016 Jul;13(3):514-34. doi: 10.1007/s13311-016-0443-5. Review.


Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise.

Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS.

Cell. 2016 May 19;165(5):1081-1091. doi: 10.1016/j.cell.2016.05.008. Epub 2016 May 11.


Viral interactions with the blood-brain barrier: old dog, new tricks.

Hou J, Baker LA, Zhou L, Klein RS.

Tissue Barriers. 2016 Jan 28;4(1):e1142492. doi: 10.1080/21688370.2016.1142492. eCollection 2016 Jan-Mar. Review.


The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.

Durrant DM, Ghosh S, Klein RS.

ACS Chem Neurosci. 2016 Apr 20;7(4):464-9. doi: 10.1021/acschemneuro.6b00043. Epub 2016 Apr 8. Review.


Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice.

Selvaraj UM, Ortega SB, Hu R, Gilchrist R, Kong X, Partin A, Plautz EJ, Klein RS, Gidday JM, Stowe AM.

J Cereb Blood Flow Metab. 2017 Mar;37(3):801-813. doi: 10.1177/0271678X16639327. Epub 2016 Jul 21.


Physician-initiated daily verbal reminders decrease the duration of indwelling urinary catheter use compared with nurse-initiated reminders.

Felix L, Smith BA, Santos E, Gabasan A, Dzenkevych O, Kourouni I, Klein RS.

Am J Infect Control. 2016 Mar 1;44(3):346-8. doi: 10.1016/j.ajic.2015.10.019. Epub 2015 Dec 21.


CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system.

Durrant DM, Daniels BP, Pasieka T, Dorsey D, Klein RS.

J Neuroinflammation. 2015 Dec 15;12:233. doi: 10.1186/s12974-015-0447-9.


The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.

Miner JJ, Daniels BP, Shrestha B, Proenca-Modena JL, Lew ED, Lazear HM, Gorman MJ, Lemke G, Klein RS, Diamond MS.

Nat Med. 2015 Dec;21(12):1464-72. doi: 10.1038/nm.3974. Epub 2015 Nov 2.


Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System.

Daniels BP, Klein RS.

PLoS Pathog. 2015 Sep 17;11(9):e1005096. doi: 10.1371/journal.ppat.1005096. eCollection 2015 Sep. Review. No abstract available.


Parental leave in dermatology residency: ethical considerations.

Peart JM, Klein RS, Pappas-Taffer L, Lipoff JB.

J Am Acad Dermatol. 2015 Oct;73(4):707-9. doi: 10.1016/j.jaad.2015.05.016. Review. No abstract available.


A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

Yue X, Jin H, Liu H, Rosenberg AJ, Klein RS, Tu Z.

Org Biomol Chem. 2015 Aug 7;13(29):7928-39. doi: 10.1039/c5ob00951k. Epub 2015 Jun 25.


Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier.

Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M Jr, Klein RS, Diamond MS.

Sci Transl Med. 2015 Apr 22;7(284):284ra59. doi: 10.1126/scitranslmed.aaa4304. Erratum in: Sci Transl Med. 2015 May 27;7(289):289er5.


Viral sensing at the blood-brain barrier: new roles for innate immunity at the CNS vasculature.

Daniels BP, Klein RS.

Clin Pharmacol Ther. 2015 Apr;97(4):372-9. doi: 10.1002/cpt.75. Epub 2015 Feb 26. Review.


TREM2 regulates microglial cell activation in response to demyelination in vivo.

Cantoni C, Bollman B, Licastro D, Xie M, Mikesell R, Schmidt R, Yuede CM, Galimberti D, Olivecrona G, Klein RS, Cross AH, Otero K, Piccio L.

Acta Neuropathol. 2015 Mar;129(3):429-47. doi: 10.1007/s00401-015-1388-1. Epub 2015 Jan 29.


GB Virus C (GBV-C) Infection in Hepatitis C Virus (HCV) Seropositive Women with or at Risk for HIV Infection.

Blackard JT, Ma G, Welge JA, King CC, Taylor LE, Mayer KH, Klein RS, Celentano DD, Sobel JD, Jamieson DJ, Gardner L.

PLoS One. 2014 Dec 10;9(12):e114467. doi: 10.1371/journal.pone.0114467. eCollection 2014.


IL-1R1 signaling regulates CXCL12-mediated T cell localization and fate within the central nervous system during West Nile Virus encephalitis.

Durrant DM, Daniels BP, Klein RS.

J Immunol. 2014 Oct 15;193(8):4095-106. doi: 10.4049/jimmunol.1401192. Epub 2014 Sep 8.


Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals.

Daniels BP, Holman DW, Cruz-Orengo L, Jujjavarapu H, Durrant DM, Klein RS.

MBio. 2014 Aug 26;5(5):e01476-14. doi: 10.1128/mBio.01476-14.


Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers.

Williams JL, Holman DW, Klein RS.

Front Cell Neurosci. 2014 May 28;8:154. doi: 10.3389/fncel.2014.00154. eCollection 2014. Review.


Dense genotyping of immune-related loci identifies variants associated with clearance of HPV among HIV-positive women in the HIV epidemiology research study (HERS).

Sudenga SL, Wiener HW, King CC, Rompalo AM, Cu-Uvin S, Klein RS, Shah KV, Sobel JD, Jamieson DJ, Shrestha S.

PLoS One. 2014 Jun 11;9(6):e99109. doi: 10.1371/journal.pone.0099109. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e102728.


Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.

Cruz-Orengo L, Daniels BP, Dorsey D, Basak SA, Grajales-Reyes JG, McCandless EE, Piccio L, Schmidt RE, Cross AH, Crosby SD, Klein RS.

J Clin Invest. 2014 Jun;124(6):2571-84. doi: 10.1172/JCI73408. Epub 2014 May 8.


Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system.

Williams JL, Patel JR, Daniels BP, Klein RS.

J Exp Med. 2014 May 5;211(5):791-9. doi: 10.1084/jem.20131224. Epub 2014 Apr 14.

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