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Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model.

Tian X, Richard A, El-Saadi MW, Bhandari A, Latimer B, Van Savage I, Holmes K, Klein RL, Dwyer D, Goeders NE, Yang XW, Lu XH.

Mol Psychiatry. 2019 Aug 23. doi: 10.1038/s41380-019-0492-3. [Epub ahead of print]


Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort.

Hunt KJ, Jenkins AJ, Fu D, Stevens D, Ma JX, Klein RL, Azar M, Zhang SX, Lopes-Virella MF, Lyons TJ; VADT Investigators.

J Diabetes Complications. 2019 Oct;33(10):107410. doi: 10.1016/j.jdiacomp.2019.107410. Epub 2019 Jul 26.


Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D.

Basu A, Bebu I, Jenkins AJ, Stoner JA, Zhang Y, Klein RL, Lopes-Virella MF, Garvey WT, Budoff MJ, Alaupovic P, Lyons TJ; Diabetes Control Complications Trial/Epidemiology of Diabetes Interventions Complications Research Group.

J Lipid Res. 2019 Aug;60(8):1432-1439. doi: 10.1194/jlr.P090647. Epub 2019 Jun 15.


Glycosylated sphingolipids and progression to kidney dysfunction in type 1 diabetes.

Lopes-Virella MF, Baker NL, Hunt KJ, Hammad SM, Arthur J, Virella G, Klein RL; DCCT/EDIC Research Group.

J Clin Lipidol. 2019 May - Jun;13(3):481-491.e1. doi: 10.1016/j.jacl.2019.03.005. Epub 2019 Apr 3.


Relevance of electroencephalogram assessment in amyloid and tau pathology in rat.

Maleysson V, Page G, Janet T, Klein RL, Haida O, Maurin A, Richard S, Champeroux P, Fauconneau B.

Behav Brain Res. 2019 Feb 1;359:127-134. doi: 10.1016/j.bbr.2018.10.026. Epub 2018 Oct 24.


AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice.

Vozenilek AE, Blackburn CMR, Schilke RM, Chandran S, Castore R, Klein RL, Woolard MD.

Atherosclerosis. 2018 Nov;278:66-72. doi: 10.1016/j.atherosclerosis.2018.09.005. Epub 2018 Sep 8.


Gene Transfer Induced Hypercholesterolemia in Amyloid Mice.

Grames MS, Dayton RD, Lu X, Schilke RM, Alexander JS, Orr AW, Barmada SJ, Woolard MD, Klein RL.

J Alzheimers Dis. 2018;65(4):1079-1086. doi: 10.3233/JAD-180494.


More expansive gene transfer to the rat CNS: AAV PHP.EB vector dose-response and comparison to AAV PHP.B.

Dayton RD, Grames MS, Klein RL.

Gene Ther. 2018 Aug;25(5):392-400. doi: 10.1038/s41434-018-0028-5. Epub 2018 Jul 16.


Aberrant Cortical Event-Related Potentials During Associative Learning in Rat Models for Presymptomatic Stages of Alzheimer's Disease.

Nouriziabari B, Sarkar S, Tanninen SE, Dayton RD, Klein RL, Takehara-Nishiuchi K.

J Alzheimers Dis. 2018;63(2):725-740. doi: 10.3233/JAD-171033.


Apolipoprotein-defined lipoprotein subclasses, serum apolipoproteins, and carotid intima-media thickness in T1D.

Basu A, Jenkins AJ, Stoner JA, Zhang Y, Klein RL, Lopes-Virella MF, Garvey WT, Schade DS, Wood J, Alaupovic P, Lyons TJ; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group.

J Lipid Res. 2018 May;59(5):872-883. doi: 10.1194/jlr.P080143. Epub 2018 Mar 25.


TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.

Archbold HC, Jackson KL, Arora A, Weskamp K, Tank EM, Li X, Miguez R, Dayton RD, Tamir S, Klein RL, Barmada SJ.

Sci Rep. 2018 Mar 15;8(1):4606. doi: 10.1038/s41598-018-22858-w.


Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra.

Grames MS, Dayton RD, Jackson KL, Richard AD, Lu X, Klein RL.

FASEB J. 2018 Aug;32(8):4420-4427. doi: 10.1096/fj.201701529RR. Epub 2018 Mar 7.


Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.

Vozenilek AE, Vetkoetter M, Green JM, Shen X, Traylor JG, Klein RL, Orr AW, Woolard MD, Krzywanski DM.

J Vasc Res. 2018;55(2):98-110. doi: 10.1159/000486337. Epub 2018 Feb 16.


Behavioral interventions for reducing head motion during MRI scans in children.

Greene DJ, Koller JM, Hampton JM, Wesevich V, Van AN, Nguyen AL, Hoyt CR, McIntyre L, Earl EA, Klein RL, Shimony JS, Petersen SE, Schlaggar BL, Fair DA, Dosenbach NUF.

Neuroimage. 2018 May 1;171:234-245. doi: 10.1016/j.neuroimage.2018.01.023. Epub 2018 Jan 12.


Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.

Vozenilek AE, Navratil AR, Green JM, Coleman DT, Blackburn CMR, Finney AC, Pearson BH, Chrast R, Finck BN, Klein RL, Orr AW, Woolard MD.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):324-334. doi: 10.1161/ATVBAHA.117.310455. Epub 2017 Dec 7. Erratum in: Arterioscler Thromb Vasc Biol. 2018 May;38(5):e89.


Association Between Inflammatory Markers and Progression to Kidney Dysfunction: Examining Different Assessment Windows in Patients With Type 1 Diabetes.

Baker NL, Hunt KJ, Stevens DR, Jarai G, Rosen GD, Klein RL, Virella G, Lopes-Virella MF; DCCT/EDIC Research Group.

Diabetes Care. 2018 Jan;41(1):128-135. doi: 10.2337/dc17-0867. Epub 2017 Nov 8.


Methods and Tips for Intravenous Administration of Adeno-associated Virus to Rats and Evaluation of Central Nervous System Transduction.

Grames MS, Jackson KL, Dayton RD, Stanford JA, Klein RL.

J Vis Exp. 2017 Aug 25;(126). doi: 10.3791/55994.


Real-time motion analytics during brain MRI improve data quality and reduce costs.

Dosenbach NUF, Koller JM, Earl EA, Miranda-Dominguez O, Klein RL, Van AN, Snyder AZ, Nagel BJ, Nigg JT, Nguyen AL, Wesevich V, Greene DJ, Fair DA.

Neuroimage. 2017 Nov 1;161:80-93. doi: 10.1016/j.neuroimage.2017.08.025. Epub 2017 Aug 10.


Entorhinal tau pathology disrupts hippocampal-prefrontal oscillatory coupling during associative learning.

Tanninen SE, Nouriziabari B, Morrissey MD, Bakir R, Dayton RD, Klein RL, Takehara-Nishiuchi K.

Neurobiol Aging. 2017 Oct;58:151-162. doi: 10.1016/j.neurobiolaging.2017.06.024. Epub 2017 Jul 6.


p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration.

Jackson KL, Lin WL, Miriyala S, Dayton RD, Panchatcharam M, McCarthy KJ, Castanedes-Casey M, Dickson DW, Klein RL.

PLoS One. 2017 Jan 11;12(1):e0169291. doi: 10.1371/journal.pone.0169291. eCollection 2017.


Corrigendum: Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B.

Jackson KL, Dayton RD, Deverman BE, Klein RL.

Front Mol Neurosci. 2016 Dec 22;9:154. doi: 10.3389/fnmol.2016.00154. eCollection 2016.


S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization.

Lee MH, Appleton KM, El-Shewy HM, Sorci-Thomas MG, Thomas MJ, Lopes-Virella MF, Luttrell LM, Hammad SM, Klein RL.

J Lipid Res. 2017 Feb;58(2):325-338. doi: 10.1194/jlr.M070706. Epub 2016 Nov 23.


Better Targeting, Better Efficiency for Wide-Scale Neuronal Transduction with the Synapsin Promoter and AAV-PHP.B.

Jackson KL, Dayton RD, Deverman BE, Klein RL.

Front Mol Neurosci. 2016 Nov 4;9:116. eCollection 2016. Erratum in: Front Mol Neurosci. 2016 Dec 22;9:154.


Severe respiratory changes at end stage in a FUS-induced disease state in adult rats.

Jackson KL, Dhaibar HA, Dayton RD, Cananzi SG, Mayhan WG, Glasscock E, Klein RL.

BMC Neurosci. 2016 Oct 28;17(1):69.


Gene vector 'magic bullet': targeted expression in the central nervous system after peripheral delivery using the synapsin promoter.

Jackson KL, Dayton RD, Klein RL.

Expert Opin Ther Targets. 2016 Oct;20(10):1153-4. doi: 10.1080/14728222.2016.1212016. Epub 2016 Jul 25. No abstract available.


Increased Plasma Levels of Select Deoxy-ceramide and Ceramide Species are Associated with Increased Odds of Diabetic Neuropathy in Type 1 Diabetes: A Pilot Study.

Hammad SM, Baker NL, El Abiad JM, Spassieva SD, Pierce JS, Rembiesa B, Bielawski J, Lopes-Virella MF, Klein RL; DCCT/EDIC Group of Investigators.

Neuromolecular Med. 2017 Mar;19(1):46-56. doi: 10.1007/s12017-016-8423-9. Epub 2016 Jul 7.


Financial Benefits of a Hepatopancreaticobiliary Program.

Rosemurgy AS, Ryan CE, Klein RL, Wood TW, Co F, Ross SB.

Am Surg. 2016 May;82(5):380-5.


Sequential Adeno-Associated Viral Vector Serotype 9-Green Fluorescent Protein Gene Transfer Causes Massive Inflammation and Intense Immune Response in Rat Striatum.

Yang C, Hao F, He J, Lu T, Klein RL, Zhao LR, Duan WM.

Hum Gene Ther. 2016 Jul;27(7):528-43. doi: 10.1089/hum.2015.083. Epub 2016 Mar 16.


Data on carotid intima-media thickness and lipoprotein subclasses in type 1 diabetes from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC).

Basu A, Jenkins AJ, Zhang Y, Stoner JA, Klein RL, Lopes-Virella MF, Timothy Garvey W, Lyons TJ; DCCT/EDIC Research Group.

Data Brief. 2015 Nov 22;6:33-8. doi: 10.1016/j.dib.2015.11.036. eCollection 2016 Mar.


Associations between intensive diabetes therapy and NMR-determined lipoprotein subclass profiles in type 1 diabetes.

Zhang Y, Jenkins AJ, Basu A, Stoner JA, Lopes-Virella MF, Klein RL; DCCT/EDIC Research Group, Lyons TJ.

J Lipid Res. 2016 Feb;57(2):310-7. doi: 10.1194/jlr.P060657. Epub 2015 Dec 9.


Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes.

Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA; DCCT/EDIC Research Group.

Diabetes. 2016 Feb;65(2):498-502. doi: 10.2337/db15-0930. Epub 2015 Nov 24.


Nuclear magnetic resonance-determined lipoprotein subclasses and carotid intima-media thickness in type 1 diabetes.

Basu A, Jenkins AJ, Zhang Y, Stoner JA, Klein RL, Lopes-Virella MF, Garvey WT, Lyons TJ; DCCT/EDIC Research Group.

Atherosclerosis. 2016 Jan;244:93-100. doi: 10.1016/j.atherosclerosis.2015.10.106. Epub 2015 Oct 31.


AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats.

Jackson KL, Dayton RD, Klein RL.

Mol Ther Methods Clin Dev. 2015 Sep 30;2:15036. doi: 10.1038/mtm.2015.36. eCollection 2015.


Microsomal Triglyceride Transfer Protein Transfers and Determines Plasma Concentrations of Ceramide and Sphingomyelin but Not Glycosylceramide.

Iqbal J, Walsh MT, Hammad SM, Cuchel M, Tarugi P, Hegele RA, Davidson NO, Rader DJ, Klein RL, Hussain MM.

J Biol Chem. 2015 Oct 23;290(43):25863-75. doi: 10.1074/jbc.M115.659110. Epub 2015 Sep 8.


Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.

Jackson KL, Dayton RD, Fisher-Perkins JM, Didier PJ, Baker KC, Weimer M, Gutierrez A, Cain CD, Mathis JM, Gitcho MA, Bunnell BA, Klein RL.

J Med Primatol. 2015 Apr;44(2):66-75. doi: 10.1111/jmp.12162. Epub 2015 Jan 29.


Influence of acute hyperlipidemia to adipocyte-derived hormones in lean normotensive and subjects with metabolic syndrome.

Lopes HF, Klein RL, Garvey WT, Goodfriend T, Egan BM.

Diabetol Metab Syndr. 2014 Dec 2;6(1):132. doi: 10.1186/1758-5996-6-132. eCollection 2014.


Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.

Jackson KL, Dayton RD, Orchard EA, Ju S, Ringe D, Petsko GA, Maquat LE, Klein RL.

Gene Ther. 2015 Jan;22(1):20-8. doi: 10.1038/gt.2014.101. Epub 2014 Nov 6.


Decreased plasma levels of select very long chain ceramide species are associated with the development of nephropathy in type 1 diabetes.

Klein RL, Hammad SM, Baker NL, Hunt KJ, Al Gadban MM, Cleary PA, Virella G, Lopes-Virella MF; DCCT/EDIC Research Group.

Metabolism. 2014 Oct;63(10):1287-95. doi: 10.1016/j.metabol.2014.07.001. Epub 2014 Jul 9.


Plasma total homocysteine and carotid intima-media thickness in type 1 diabetes: a prospective study.

Basu A, Jenkins AJ, Stoner JA, Thorpe SR, Klein RL, Lopes-Virella MF, Garvey WT, Lyons TJ; DCCT/EDIC Research Group.

Atherosclerosis. 2014 Sep;236(1):188-195. doi: 10.1016/j.atherosclerosis.2014.07.001. Epub 2014 Jul 15.


Skewing of immune cell cytokine production by mediators from adipocytes and endothelial cells.

Vielma SA, Klein RL, Levingston CA, Young MR.

Adipocyte. 2014 Apr 1;3(2):126-31. doi: 10.4161/adip.28287. Epub 2014 Feb 25.


Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients.

Jenkins AJ, Fu D, Azar M, Stoner JA, Kaufman DG, Zhang S, Klein RL, Lopes-Virella MF, Ma JX, Lyons TJ; VADT investigators.

J Diabetes Complications. 2014 May-Jun;28(3):353-9. doi: 10.1016/j.jdiacomp.2014.01.008. Epub 2014 Jan 17.


Apolipoprotein-defined and NMR lipoprotein subclasses in the veterans affairs diabetes trial.

Azar M, Lyons TJ, Alaupovic P, Stoner JA, Quiroga C, Kaufman DG, Lopes-Virella M, Klein RL, Jenkins AJ; VADT Study Group.

J Diabetes Complications. 2013 Nov-Dec;27(6):627-32. doi: 10.1016/j.jdiacomp.2013.05.005. Epub 2013 Aug 1.


Apolipoprotein-defined lipoproteins and apolipoproteins: associations with abnormal albuminuria in type 1 diabetes in the diabetes control and complications trial/epidemiology of diabetes interventions and complications cohort.

Jenkins AJ, Yu J, Alaupovic P, Basu A, Klein RL, Lopes-Virella M, Baker NL, Hunt KJ, Lackland DT, Garvey WT, Lyons TJ; DCCT/EDIC Research Group.

J Diabetes Complications. 2013 Sep-Oct;27(5):447-53. doi: 10.1016/j.jdiacomp.2013.06.002. Epub 2013 Jul 11.


Selective forelimb impairment in rats expressing a pathological TDP-43 25‚ÄČkDa C-terminal fragment to mimic amyotrophic lateral sclerosis.

Dayton RD, Gitcho MA, Orchard EA, Wilson JD, Wang DB, Cain CD, Johnson JA, Zhang YJ, Petrucelli L, Mathis JM, Klein RL.

Mol Ther. 2013 Jul;21(7):1324-34. doi: 10.1038/mt.2013.88. Epub 2013 May 21.


Pre-immunization with an intramuscular injection of AAV9-human erythropoietin vectors reduces the vector-mediated transduction following re-administration in rat brain.

Yang C, Yang WH, Chen SS, Ma BF, Li B, Lu T, Qu TY, Klein RL, Zhao LR, Duan WM.

PLoS One. 2013 May 8;8(5):e63876. doi: 10.1371/journal.pone.0063876. Print 2013.


Premalignant lesions skew spleen cell responses to immune modulation by adipocytes.

Vielma SA, Klein RL, Levingston CA, Young MR.

Anticancer Res. 2013 May;33(5):1809-18.


Recombinant AAV9-TLK1B administration ameliorates fractionated radiation-induced xerostomia.

Timiri Shanmugam PS, Dayton RD, Palaniyandi S, Abreo F, Caldito G, Klein RL, Sunavala-Dossabhoy G.

Hum Gene Ther. 2013 Jun;24(6):604-12. doi: 10.1089/hum.2012.235.


Adipocytes as immune regulatory cells.

Vielma SA, Klein RL, Levingston CA, Young MR.

Int Immunopharmacol. 2013 Jun;16(2):224-31. doi: 10.1016/j.intimp.2013.04.002. Epub 2013 Apr 13.


Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages.

Luo N, Chung BH, Wang X, Klein RL, Tang CK, Garvey WT, Fu Y.

Atherosclerosis. 2013 May;228(1):124-35. doi: 10.1016/j.atherosclerosis.2013.02.026. Epub 2013 Mar 4.


Imaging the response of the retina to electrical stimulation with genetically encoded calcium indicators.

Weitz AC, Behrend MR, Lee NS, Klein RL, Chiodo VA, Hauswirth WW, Humayun MS, Weiland JD, Chow RH.

J Neurophysiol. 2013 Apr;109(7):1979-88. doi: 10.1152/jn.00852.2012. Epub 2013 Jan 23.

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