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Items: 1 to 50 of 149

1.

Effects of sublethal Cd, Zn, and mixture exposures on antioxidant defense and oxidative stress parameters in early life stages of the purple sea urchin Strongylocentrotus purpuratus.

Klein RD, Nogueira LS, Domingos-Moreira FXV, Gomes Costa P, Bianchini A, Wood CM.

Aquat Toxicol. 2019 Oct 30;217:105338. doi: 10.1016/j.aquatox.2019.105338. [Epub ahead of print]

PMID:
31711008
2.

Current Policy Challenges in Genomic Medicine.

Klein RD.

Clin Chem. 2019 Nov 7. pii: clinchem.2019.308775. doi: 10.1373/clinchem.2019.308775. [Epub ahead of print]

PMID:
31699701
3.

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.

Klein RD, Shu Q, Cusumano ZT, Nagamatsu K, Gualberto NC, Lynch AJL, Wu C, Wang W, Jain N, Pinkner JS, Amarasinghe GK, Hultgren SJ, Frieden C, Chapman MR.

MBio. 2018 Jul 17;9(4). pii: e01349-18. doi: 10.1128/mBio.01349-18.

4.

Testing biomarker feasibility: a case study of Laeonereis culveri (Nereididae, Annelida) exposed to sewage contamination in a subtropical estuary.

Barros TL, Klein RD, Sandrini-Neto L, Bianchini A, Martins CC, Lana P.

Environ Sci Pollut Res Int. 2018 Aug;25(24):24181-24191. doi: 10.1007/s11356-018-2470-8. Epub 2018 Jun 12.

PMID:
29948697
5.

Effects of life-time exposure to waterborne copper on the somatotropic axis of the viviparous fish Poecilia vivipara.

Zebral YD, Anni ISA, Afonso SB, Abril SIM, Klein RD, Bianchini A.

Chemosphere. 2018 Jul;203:410-417. doi: 10.1016/j.chemosphere.2018.03.202. Epub 2018 Apr 2.

PMID:
29631113
6.

Precision antimicrobial therapeutics: the path of least resistance?

Spaulding CN, Klein RD, Schreiber HL 4th, Janetka JW, Hultgren SJ.

NPJ Biofilms Microbiomes. 2018 Feb 27;4:4. doi: 10.1038/s41522-018-0048-3. eCollection 2018. Review.

7.

Phylogenetic and environmental components of inter-specific variability in the antioxidant defense system in freshwater anomurans Aegla (Crustacea, Decapoda).

Faria SC, Klein RD, Costa PG, Crivellaro MS, Santos S, Bueno SLS, Bianchini A.

Sci Rep. 2018 Feb 12;8(1):2850. doi: 10.1038/s41598-018-21188-1.

8.

Core Clinical Data Elements for Cancer Genomic Repositories: A Multi-stakeholder Consensus.

Conley RB, Dickson D, Zenklusen JC, Al Naber J, Messner DA, Atasoy A, Chaihorsky L, Collyar D, Compton C, Ferguson M, Khozin S, Klein RD, Kotte S, Kurzrock R, Lin CJ, Liu F, Marino I, McDonough R, McNeal A, Miller V, Schilsky RL, Wang LI.

Cell. 2017 Nov 16;171(5):982-986. doi: 10.1016/j.cell.2017.10.032.

9.
10.

Antioxidant defense system and oxidative status in Antarctic fishes: The sluggish rockcod Notothenia coriiceps versus the active marbled notothen Notothenia rossii.

Klein RD, Rosa CE, Colares EP, Robaldo RB, Martinez PE, Bianchini A.

J Therm Biol. 2017 Aug;68(Pt A):119-127. doi: 10.1016/j.jtherbio.2017.02.013. Epub 2017 Feb 27.

PMID:
28689713
11.

Effects of increasing temperature on antioxidant defense system and oxidative stress parameters in the Antarctic fish Notothenia coriiceps and Notothenia rossii.

Klein RD, Borges VD, Rosa CE, Colares EP, Robaldo RB, Martinez PE, Bianchini A.

J Therm Biol. 2017 Aug;68(Pt A):110-118. doi: 10.1016/j.jtherbio.2017.02.016. Epub 2017 Feb 27.

PMID:
28689712
12.

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.

Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.

13.

Effects of Roundup formulations on biochemical biomarkers and male sperm quality of the livebearing Jenynsia multidentata.

Sánchez JA, Varela AS Junior, Corcini CD, da Silva JC, Primel EG, Caldas S, Klein RD, Martins CM.

Chemosphere. 2017 Jun;177:200-210. doi: 10.1016/j.chemosphere.2017.02.147. Epub 2017 Mar 1.

14.

Next-generation sequencing of liquid-based cytology non-small cell lung cancer samples.

Reynolds JP, Zhou Y, Jakubowski MA, Wang Z, Brainard JA, Klein RD, Farver CF, Almeida FA, Cheng YW.

Cancer Cytopathol. 2017 Mar;125(3):178-187. doi: 10.1002/cncy.21812. Epub 2017 Jan 13.

15.

Clinical and Psychosocial Outcomes of Vascularized Lymph Node Transfer for the Treatment of Upper Extremity Lymphedema After Breast Cancer Therapy.

Gratzon A, Schultz J, Secrest K, Lee K, Feiner J, Klein RD.

Ann Surg Oncol. 2017 Jun;24(6):1475-1481. doi: 10.1245/s10434-016-5614-4. Epub 2016 Oct 12.

PMID:
27734176
16.

The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer: A Report of the Association for Molecular Pathology.

Joseph L, Cankovic M, Caughron S, Chandra P, Emmadi R, Hagenkord J, Hallam S, Jewell KE, Klein RD, Pratt VM, Rothberg PG, Temple-Smolkin RL, Lyon E.

J Mol Diagn. 2016 Sep;18(5):605-619. doi: 10.1016/j.jmoldx.2016.05.007. Epub 2016 Aug 16. Review.

17.

Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections.

Cusumano ZT, Klein RD, Hultgren SJ.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0023-2015. Review.

PMID:
27227305
18.

Metal contamination as a possible etiology of fibropapillomatosis in juvenile female green sea turtles Chelonia mydas from the southern Atlantic Ocean.

da Silva CC, Klein RD, Barcarolli IF, Bianchini A.

Aquat Toxicol. 2016 Jan;170:42-51. doi: 10.1016/j.aquatox.2015.11.007. Epub 2015 Nov 14.

PMID:
26615366
19.

Bacterial amyloid formation: structural insights into curli biogensis.

Van Gerven N, Klein RD, Hultgren SJ, Remaut H.

Trends Microbiol. 2015 Nov;23(11):693-706. doi: 10.1016/j.tim.2015.07.010. Epub 2015 Oct 1. Review.

20.

Chaos controlled: discovery of a powerful amyloid inhibitor.

Klein RD, Hultgren SJ.

Mol Cell. 2015 Feb 5;57(3):391-3. doi: 10.1016/j.molcel.2015.01.031.

21.

Reimbursement in molecular pathology: bringing genomic medicine to patients.

Klein RD.

Clin Chem. 2015 Jan;61(1):136-8. doi: 10.1373/clinchem.2014.223032. Epub 2014 Nov 24. No abstract available.

22.

Evidence synthesis and guideline development in genomic medicine: current status and future prospects.

Schully SD, Lam TK, Dotson WD, Chang CQ, Aronson N, Birkeland ML, Brewster SJ, Boccia S, Buchanan AH, Calonge N, Calzone K, Djulbegovic B, Goddard KA, Klein RD, Klein TE, Lau J, Long R, Lyman GH, Morgan RL, Palmer CG, Relling MV, Rubinstein WS, Swen JJ, Terry SF, Williams MS, Khoury MJ.

Genet Med. 2015 Jan;17(1):63-7. doi: 10.1038/gim.2014.69. Epub 2014 Jun 19.

23.

Oxidative stress and DNA damage responses to phenanthrene exposure in the estuarine guppy Poecilia vivipara.

Machado AA, Hoff ML, Klein RD, Cordeiro GJ, Lencina Avila JM, Costa PG, Bianchini A.

Mar Environ Res. 2014 Jul;98:96-105. doi: 10.1016/j.marenvres.2014.03.013. Epub 2014 Mar 25.

PMID:
24722053
24.

Chaperone function of two small heat shock proteins from maize.

Klein RD, Chidawanyika T, Tims HS, Meulia T, Bouchard RA, Pett VB.

Plant Sci. 2014 May;221-222:48-58. doi: 10.1016/j.plantsci.2014.01.012. Epub 2014 Feb 6.

PMID:
24656335
25.

Intellectual property and regulation of molecular pathology tests.

Klein RD.

Cancer J. 2014 Jan-Feb;20(1):85-90. doi: 10.1097/PPO.0000000000000012. Review.

PMID:
24445770
26.

Revisiting oversight and regulation of molecular-based laboratory-developed tests: a position statement of the Association for Molecular Pathology.

Ferreira-Gonzalez A, Emmadi R, Day SP, Klees RF, Leib JR, Lyon E, Nowak JA, Pratt VM, Williams MS, Klein RD.

J Mol Diagn. 2014 Jan;16(1):3-6. doi: 10.1016/j.jmoldx.2013.10.003.

27.

AMP v Myriad: the Supreme Court gives a win to personalized medicine.

Klein RD.

J Mol Diagn. 2013 Nov;15(6):731-2. doi: 10.1016/j.jmoldx.2013.09.002.

28.

Molecular diagnostics: Molecular Med Tri-Con 2013.

Klein RD.

Expert Rev Mol Diagn. 2013 Jul;13(6):527-8. doi: 10.1586/14737159.2013.811900.

PMID:
23895123
29.

Biomarkers of waterborne copper exposure in the guppy Poecilia vivipara acclimated to salt water.

Machado AA, Hoff ML, Klein RD, Cardozo JG, Giacomin MM, Pinho GL, Bianchini A.

Aquat Toxicol. 2013 Aug 15;138-139:60-9. doi: 10.1016/j.aquatox.2013.04.009. Epub 2013 Apr 29.

PMID:
23721848
30.

Toxic effects of the ingestion of water-soluble elements found in soil under the atmospheric influence of an industrial complex.

da Silva Júnior FM, Silva PF, Garcia EM, Klein RD, Peraza-Cardoso G, Baisch PR, Vargas VM, Muccillo-Baisch AL.

Environ Geochem Health. 2013 Jun;35(3):317-31. doi: 10.1007/s10653-012-9496-5. Epub 2012 Oct 25.

PMID:
23096081
31.

Opportunities and challenges associated with clinical diagnostic genome sequencing: a report of the Association for Molecular Pathology.

Schrijver I, Aziz N, Farkas DH, Furtado M, Gonzalez AF, Greiner TC, Grody WW, Hambuch T, Kalman L, Kant JA, Klein RD, Leonard DG, Lubin IM, Mao R, Nagan N, Pratt VM, Sobel ME, Voelkerding KV, Gibson JS.

J Mol Diagn. 2012 Nov;14(6):525-40. doi: 10.1016/j.jmoldx.2012.04.006. Epub 2012 Aug 20.

32.

Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme maleamate amidohydrolase from Bordetella bronchiseptica RB50.

Kincaid VA, Sullivan ED, Klein RD, Noel JW, Rowlett RS, Snider MJ.

Biochemistry. 2012 Jan 10;51(1):545-54. doi: 10.1021/bi201347n. Epub 2011 Dec 23.

PMID:
22214383
33.

Gene patents and personalized medicine.

Klein RD.

Am Soc Clin Oncol Educ Book. 2012:81-3. doi: 10.14694/EdBook_AM.2012.32.81.

PMID:
24451713
34.

Legal developments and practical implications of gene patenting on targeted drug discovery and development.

Klein RD.

Clin Pharmacol Ther. 2010 Jun;87(6):633-5. doi: 10.1038/clpt.2010.47.

PMID:
20485317
35.

Dr Roger Klein speaks to Tarryn Greenberg, Commissioning Editor. Interview.

Klein RD.

Pharmacogenomics. 2009 Jan;10(1):9-12. doi: 10.2217/14622416.10.1.9. No abstract available.

PMID:
19102709
36.

Analysis: Secretary's Advisory Committee on Genetics, Health, and Society Report falls short.

Klein RD.

Hum Pathol. 2009 Feb;40(2):147-55. doi: 10.1016/j.humpath.2008.09.007. Epub 2008 Dec 11.

PMID:
19084265
37.

Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression.

Colby JK, Klein RD, McArthur MJ, Conti CJ, Kiguchi K, Kawamoto T, Riggs PK, Pavone AI, Sawicki J, Fischer SM.

Neoplasia. 2008 Aug;10(8):782-96.

38.

Genetic testing and primary care.

Klein RD.

JAMA. 2008 May 21;299(19):2275; author reply 2275-6. doi: 10.1001/jama.299.19.2275-a. No abstract available.

PMID:
18492967
39.

OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model.

Sargeant AM, Rengel RC, Kulp SK, Klein RD, Clinton SK, Wang YC, Chen CS.

Cancer Res. 2008 May 15;68(10):3999-4009. doi: 10.1158/0008-5472.CAN-08-0203.

40.

Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immune- and cell proliferation-related genes.

Wang X, Colby JK, Rengel RC, Fischer SM, Clinton SK, Klein RD.

Mol Carcinog. 2009 Jan;48(1):1-13. doi: 10.1002/mc.20449.

PMID:
18444251
41.

Germline SDHB mutations are common in patients with apparently sporadic sympathetic paragangliomas.

Klein RD, Jin L, Rumilla K, Young WF Jr, Lloyd RV.

Diagn Mol Pathol. 2008 Jun;17(2):94-100. doi: 10.1097/PDM.0b013e318150d67c.

PMID:
18382370
42.

LabCorp v. Metabolite Laboratories: The Supreme Court listens, but declines to speak.

Klein RD, Mahoney MJ.

J Law Med Ethics. 2008 Spring;36(1):141-9, 4. doi: 10.1111/j.1748-720X.2008.00243.x.

PMID:
18315767
43.

The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue.

Wang X, Colby JK, Yang P, Fischer SM, Newman RA, Klein RD.

Carcinogenesis. 2008 Jan;29(1):120-8. Epub 2007 Oct 17.

PMID:
17942462
44.

Gene patents and genetic testing in the United States.

Klein RD.

Nat Biotechnol. 2007 Sep;25(9):989-90. No abstract available.

PMID:
17846625
45.

Gene patents and personalized medicine.

Klein RD.

Per Med. 2007 Aug;4(3):237-241. doi: 10.2217/17410541.4.3.237. No abstract available.

46.

Medical legal issues in prenatal diagnosis.

Klein RD, Mahoney MJ.

Clin Perinatol. 2007 Jun;34(2):287-97, vi. Review.

PMID:
17572235
47.

Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer.

Sargeant AM, Klein RD, Rengel RC, Clinton SK, Kulp SK, Kashida Y, Yamaguchi M, Wang X, Chen CS.

Toxicol Pathol. 2007 Jun;35(4):549-61.

PMID:
17562488
48.

The pain protective haplotype: introducing the modern genetic test.

Klein RD.

Clin Chem. 2007 Jun;53(6):1007-9. No abstract available.

50.

Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat.

Bella AJ, Fandel TM, Tantiwongse K, Brant WO, Klein RD, Garcia CA, Lue TF.

J Brachial Plex Peripher Nerve Inj. 2007 Mar 6;2:5. doi: 10.1186/1749-7221-2-5.

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