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Items: 1 to 50 of 154

1.

Predicting motor, cognitive & functional impairment in Parkinson's.

Lo C, Arora S, Baig F, Lawton MA, El Mouden C, Barber TR, Ruffmann C, Klein JC, Brown P, Ben-Shlomo Y, de Vos M, Hu MT.

Ann Clin Transl Neurol. 2019 Aug;6(8):1498-1509. doi: 10.1002/acn3.50853. Epub 2019 Jul 26.

2.

Impulse control disorders in Parkinson disease and RBD: A longitudinal study of severity.

Baig F, Kelly MJ, Lawton MA, Ruffmann C, Rolinski M, Klein JC, Barber T, Lo C, Ben-Shlomo Y, Okai D, Hu MT.

Neurology. 2019 Aug 13;93(7):e675-e687. doi: 10.1212/WNL.0000000000007942. Epub 2019 Jul 16.

PMID:
31311842
3.

Predictors of motor complications in early Parkinson's disease: A prospective cohort study.

Kelly MJ, Lawton MA, Baig F, Ruffmann C, Barber TR, Lo C, Klein JC, Ben-Shlomo Y, Hu MT.

Mov Disord. 2019 Aug;34(8):1174-1183. doi: 10.1002/mds.27783. Epub 2019 Jul 8.

PMID:
31283854
4.

Functional testing of thousands of osteoarthritis-associated variants for regulatory activity.

Klein JC, Keith A, Rice SJ, Shepherd C, Agarwal V, Loughlin J, Shendure J.

Nat Commun. 2019 Jun 4;10(1):2434. doi: 10.1038/s41467-019-10439-y.

5.

Signal variance-based collateral index in DSC perfusion: A novel method to assess leptomeningeal collateralization in acute ischaemic stroke.

Seiler A, Lauer A, Deichmann R, Nöth U, Herrmann E, Berkefeld J, Singer OC, Pfeilschifter W, Klein JC, Wagner M.

J Cereb Blood Flow Metab. 2019 Feb 13:271678X19831024. doi: 10.1177/0271678X19831024. [Epub ahead of print]

PMID:
30755069
6.

Developing and validating Parkinson's disease subtypes and their motor and cognitive progression.

Lawton M, Ben-Shlomo Y, May MT, Baig F, Barber TR, Klein JC, Swallow DMA, Malek N, Grosset KA, Bajaj N, Barker RA, Williams N, Burn DJ, Foltynie T, Morris HR, Wood NW, Grosset DG, Hu MTM.

J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):1279-1287. doi: 10.1136/jnnp-2018-318337. Epub 2018 Jul 25.

7.

Unique methionine-aromatic interactions govern the calmodulin redox sensor.

Walgenbach DG, Gregory AJ, Klein JC.

Biochem Biophys Res Commun. 2018 Oct 20;505(1):236-241. doi: 10.1016/j.bbrc.2018.09.052. Epub 2018 Sep 20.

PMID:
30243720
8.

Smartphone motor testing to distinguish idiopathic REM sleep behavior disorder, controls, and PD.

Arora S, Baig F, Lo C, Barber TR, Lawton MA, Zhan A, Rolinski M, Ruffmann C, Klein JC, Rumbold J, Louvel A, Zaiwalla Z, Lennox G, Quinnell T, Dennis G, Wade-Martins R, Ben-Shlomo Y, Little MA, Hu MT.

Neurology. 2018 Oct 16;91(16):e1528-e1538. doi: 10.1212/WNL.0000000000006366. Epub 2018 Sep 19.

9.

Apathy in rapid eye movement sleep behaviour disorder is associated with serotonin depletion in the dorsal raphe nucleus.

Barber TR, Griffanti L, Muhammed K, Drew DS, Bradley KM, McGowan DR, Crabbe M, Lo C, Mackay CE, Husain M, Hu MT, Klein JC.

Brain. 2018 Oct 1;141(10):2848-2854. doi: 10.1093/brain/awy240.

10.

Functional characterization of enhancer evolution in the primate lineage.

Klein JC, Keith A, Agarwal V, Durham T, Shendure J.

Genome Biol. 2018 Jul 25;19(1):99. doi: 10.1186/s13059-018-1473-6.

11.

Abnormal rheological properties of red blood cells as a potential marker of Gulf War Illness: A preliminary study.

Falvo MJ, Chen Y, Klein JC, Ndirangu D, Condon MR.

Clin Hemorheol Microcirc. 2018;68(4):361-370. doi: 10.3233/CH-170262.

PMID:
29660926
12.

Exploring variability in basal ganglia connectivity with functional MRI in healthy aging.

Griffanti L, Stratmann P, Rolinski M, Filippini N, Zsoldos E, Mahmood A, Zamboni G, Douaud G, Klein JC, Kivimäki M, Singh-Manoux A, Hu MT, Ebmeier KP, Mackay CE.

Brain Imaging Behav. 2018 Dec;12(6):1822-1827. doi: 10.1007/s11682-018-9824-1.

13.

Cortical structural involvement and cognitive dysfunction in early Parkinson's disease.

Klein JC, Rolinski M, Griffanti L, Szewczyk-Krolikowski K, Baig F, Ruffmann C, Groves AR, Menke RAL, Hu MT, Mackay C.

NMR Biomed. 2018 Apr;31(4):e3900. doi: 10.1002/nbm.3900. Epub 2018 Feb 13.

PMID:
29436039
14.

Identifying Novel Enhancer Elements with CRISPR-Based Screens.

Klein JC, Chen W, Gasperini M, Shendure J.

ACS Chem Biol. 2018 Feb 16;13(2):326-332. doi: 10.1021/acschembio.7b00778. Epub 2018 Jan 10. Review.

15.

Correction: Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness.

Chen Y, Meyer JN, Hill HZ, Lange G, Condon MR, Klein JC, Ndirangu D, Falvo MJ.

PLoS One. 2017 Oct 16;12(10):e0186711. doi: 10.1371/journal.pone.0186711. eCollection 2017.

16.

The relationship between blood flow impairment and oxygen depletion in acute ischemic stroke imaged with magnetic resonance imaging.

Seiler A, Blockley NP, Deichmann R, Nöth U, Singer OC, Chappell MA, Klein JC, Wagner M.

J Cereb Blood Flow Metab. 2019 Mar;39(3):454-465. doi: 10.1177/0271678X17732448. Epub 2017 Sep 20.

PMID:
28929836
17.

Role of mitochondrial DNA damage and dysfunction in veterans with Gulf War Illness.

Chen Y, Meyer JN, Hill HZ, Lange G, Condon MR, Klein JC, Ndirangu D, Falvo MJ.

PLoS One. 2017 Sep 14;12(9):e0184832. doi: 10.1371/journal.pone.0184832. eCollection 2017. Erratum in: PLoS One. 2017 Oct 16;12 (10 ):e0186711.

18.

Neuroimaging in pre-motor Parkinson's disease.

Barber TR, Klein JC, Mackay CE, Hu MTM.

Neuroimage Clin. 2017 Apr 21;15:215-227. doi: 10.1016/j.nicl.2017.04.011. eCollection 2017. Review.

19.

Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder.

Barber TR, Lawton M, Rolinski M, Evetts S, Baig F, Ruffmann C, Gornall A, Klein JC, Lo C, Dennis G, Bandmann O, Quinnell T, Zaiwalla Z, Ben-Shlomo Y, Hu MTM.

Sleep. 2017 Aug 1;40(8). doi: 10.1093/sleep/zsx071.

20.

Oxygenation-Sensitive Magnetic Resonance Imaging in Acute Ischemic Stroke Using T2'/R2' Mapping: Influence of Relative Cerebral Blood Volume.

Seiler A, Deichmann R, Nöth U, Pfeilschifter W, Berkefeld J, Singer OC, Klein JC, Wagner M.

Stroke. 2017 Jun;48(6):1671-1674. doi: 10.1161/STROKEAHA.117.017086. Epub 2017 Apr 28.

PMID:
28455319
21.

Teaching NeuroImages: HIV-associated cerebral vasculopathy with multiple nodular aneurysms.

Seiler A, You SJ, Wagner M, Klein JC.

Neurology. 2017 Apr 4;88(14):e143-e144. doi: 10.1212/WNL.0000000000003793. No abstract available.

PMID:
28373376
22.

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth.

Klein JC, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, Helfrich I, Dittmer U, Kirschning CJ, Brandau S.

Nat Commun. 2017 Mar 16;8:14600. doi: 10.1038/ncomms14600.

23.

Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Droby A, Wahl M, Steinmetz H, Groppa S, Deichmann R, Klein JC.

J Magn Reson Imaging. 2017 Nov;46(5):1485-1490. doi: 10.1002/jmri.25685. Epub 2017 Feb 27.

PMID:
28240801
24.

Personality and addictive behaviours in early Parkinson's disease and REM sleep behaviour disorder.

Baig F, Lawton MA, Rolinski M, Ruffmann C, Klein JC, Nithi K, Okai D, Ben-Shlomo Y, Hu MT.

Parkinsonism Relat Disord. 2017 Apr;37:72-78. doi: 10.1016/j.parkreldis.2017.01.017. Epub 2017 Feb 1.

25.

Longitudinal changes of cortical microstructure in Parkinson's disease assessed with T1 relaxometry.

Nürnberger L, Gracien RM, Hok P, Hof SM, Rüb U, Steinmetz H, Hilker R, Klein JC, Deichmann R, Baudrexel S.

Neuroimage Clin. 2016 Dec 21;13:405-414. doi: 10.1016/j.nicl.2016.12.025. eCollection 2017.

26.

Genome sequencing in a case of Niemann-Pick type C.

Dougherty M, Lazar J, Klein JC, Diaz K, Gobillot T, Grunblatt E, Hasle N, Lawrence D, Maurano M, Nelson M, Olson G, Srivatsan S, Shendure J, Keene CD, Bird T, Horwitz MS, Marshall DA.

Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001222.

27.

Isolated diffusing capacity reduction is a common clinical presentation in deployed Iraq and Afghanistan veterans with deployment-related environmental exposures.

Falvo MJ, Helmer DA, Klein JC, Osinubi OY, Ndirangu D, Patrick-DeLuca LA, Sotolongo AM.

Clin Respir J. 2018 Feb;12(2):795-798. doi: 10.1111/crj.12552. Epub 2016 Sep 27.

PMID:
27614096
28.

Comparison of two quantitative proton density mapping methods in multiple sclerosis.

Gracien RM, Reitz SC, Wagner M, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Klein JC, Deichmann R.

MAGMA. 2017 Feb;30(1):75-83. doi: 10.1007/s10334-016-0585-9. Epub 2016 Aug 20.

PMID:
27544270
29.

The Relationship between Gray Matter Quantitative MRI and Disability in Secondary Progressive Multiple Sclerosis.

Gracien RM, Jurcoane A, Wagner M, Reitz SC, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Zipp F, Hattingen E, Deichmann R, Klein JC.

PLoS One. 2016 Aug 11;11(8):e0161036. doi: 10.1371/journal.pone.0161036. eCollection 2016.

30.

Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years.

Gracien RM, Nürnberger L, Hok P, Hof SM, Reitz SC, Rüb U, Steinmetz H, Hilker-Roggendorf R, Klein JC, Deichmann R, Baudrexel S.

Eur Radiol. 2017 Apr;27(4):1568-1576. doi: 10.1007/s00330-016-4485-1. Epub 2016 Jul 5.

PMID:
27379992
31.

Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease.

Rolinski M, Griffanti L, Piccini P, Roussakis AA, Szewczyk-Krolikowski K, Menke RA, Quinnell T, Zaiwalla Z, Klein JC, Mackay CE, Hu MT.

Brain. 2016 Aug;139(Pt 8):2224-34. doi: 10.1093/brain/aww124. Epub 2016 Jun 12.

32.

The Effect of Handcycle Ergometer Exercise on Glucose Tolerance in Ambulatory and Non-Ambulatory Adolescents.

Short KR, Teague AM, Klein JC, Malm-Buatsi E, Frimberger D.

Pediatr Exerc Sci. 2017 Feb;29(1):63-72. doi: 10.1123/pes.2016-0047. Epub 2016 Aug 19.

PMID:
27176627
33.

Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis.

Gracien RM, Jurcoane A, Wagner M, Reitz SC, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Deichmann R, Klein JC.

J Magn Reson Imaging. 2016 Dec;44(6):1600-1607. doi: 10.1002/jmri.25297. Epub 2016 May 6.

PMID:
27153293
34.

Multi-parametric quantitative MRI of normal appearing white matter in multiple sclerosis, and the effect of disease activity on T2.

Reitz SC, Hof SM, Fleischer V, Brodski A, Gröger A, Gracien RM, Droby A, Steinmetz H, Ziemann U, Zipp F, Deichmann R, Klein JC.

Brain Imaging Behav. 2017 Jun;11(3):744-753. doi: 10.1007/s11682-016-9550-5.

PMID:
27138529
35.

Bronchodilator Responsiveness and Airflow Limitation Are Associated With Deployment Length in Iraq and Afghanistan Veterans.

Falvo MJ, Abraham JH, Osinubi OY, Klein JC, Sotolongo AM, Ndirangu D, Patrick-DeLuca LA, Helmer DA.

J Occup Environ Med. 2016 Apr;58(4):325-8. doi: 10.1097/JOM.0000000000000675.

PMID:
27058470
36.

Differential immunomodulatory activity of tumor cell death induced by cancer therapeutic toll-like receptor ligands.

Klein JC, Wild CA, Lang S, Brandau S.

Cancer Immunol Immunother. 2016 Jun;65(6):689-700. doi: 10.1007/s00262-016-1828-3. Epub 2016 Mar 31.

PMID:
27034235
37.

Uniting C1-Ammonium Enolates and Transition Metal Electrophiles via Cooperative Catalysis: The Direct Asymmetric α-Allylation of Aryl Acetic Acid Esters.

Schwarz KJ, Amos JL, Klein JC, Do DT, Snaddon TN.

J Am Chem Soc. 2016 Apr 27;138(16):5214-7. doi: 10.1021/jacs.6b01694. Epub 2016 Apr 18.

PMID:
27028057
38.

Assessment of cortical damage in early multiple sclerosis with quantitative T2 relaxometry.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Zimmermann H, Droby A, Steinmetz H, Zipp F, Deichmann R, Klein JC.

NMR Biomed. 2016 Apr;29(4):444-50. doi: 10.1002/nbm.3486. Epub 2016 Jan 28.

PMID:
26820580
39.

Survival of residual neutrophils and accelerated myelopoiesis limit the efficacy of antibody-mediated depletion of Ly-6G+ cells in tumor-bearing mice.

Moses K, Klein JC, Männ L, Klingberg A, Gunzer M, Brandau S.

J Leukoc Biol. 2016 Jun;99(6):811-23. doi: 10.1189/jlb.1HI0715-289R. Epub 2016 Jan 27.

PMID:
26819319
40.

Studies toward Australifungin. A Synthesis Dilemma of Regioselective Keto-Enol Tautomerization.

Williams DR, Klein JC, Kopel LC, Nguyen N, Tantillo DJ.

Org Lett. 2016 Feb 5;18(3):424-7. doi: 10.1021/acs.orglett.5b03464. Epub 2016 Jan 19.

PMID:
26782295
41.

Intramolecular Diels-Alder (IMDA) Studies toward the Synthesis of Australifungin. Stereocontrol in the Acetate Aldol Reaction of β,β'-Branched Aldehydes.

Williams DR, Klein JC.

Org Lett. 2016 Feb 5;18(3):420-3. doi: 10.1021/acs.orglett.5b03463. Epub 2016 Jan 19.

PMID:
26782107
42.

Quantitative T1 and proton density mapping with direct calculation of radiofrequency coil transmit and receive profiles from two-point variable flip angle data.

Baudrexel S, Reitz SC, Hof S, Gracien RM, Fleischer V, Zimmermann H, Droby A, Klein JC, Deichmann R.

NMR Biomed. 2016 Mar;29(3):349-60. doi: 10.1002/nbm.3460. Epub 2016 Jan 12.

PMID:
26756673
43.

Multiplex pairwise assembly of array-derived DNA oligonucleotides.

Klein JC, Lajoie MJ, Schwartz JJ, Strauch EM, Nelson J, Baker D, Shendure J.

Nucleic Acids Res. 2016 Mar 18;44(5):e43. doi: 10.1093/nar/gkv1177. Epub 2015 Nov 8.

44.

Changes and variability of proton density and T1 relaxation times in early multiple sclerosis: MRI markers of neuronal damage in the cerebral cortex.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Zimmermann H, Droby A, Steinmetz H, Zipp F, Deichmann R, Klein JC.

Eur Radiol. 2016 Aug;26(8):2578-86. doi: 10.1007/s00330-015-4072-x. Epub 2015 Oct 22.

PMID:
26494641
45.

Impact of methionine oxidation on calmodulin structural dynamics.

McCarthy MR, Thompson AR, Nitu F, Moen RJ, Olenek MJ, Klein JC, Thomas DD.

Biochem Biophys Res Commun. 2015 Jan 9;456(2):567-72. doi: 10.1016/j.bbrc.2014.11.091. Epub 2014 Dec 2.

46.

Twenty-four hour in-hospital congenital cardiac surgical coverage improves perioperative ECMO support outcomes.

Peer SM, Costello JP, Klein JC, Engle AM, Zurakowski D, Berger JT, Jonas RA, Nath DS.

Ann Thorac Surg. 2014 Dec;98(6):2152-7; discussion 2157-8. doi: 10.1016/j.athoracsur.2014.07.042. Epub 2014 Oct 29.

PMID:
25443020
47.

Upper gastrointestinal bleeding: patient presentation, risk stratification, and early management.

Meltzer AC, Klein JC.

Gastroenterol Clin North Am. 2014 Dec;43(4):665-75. doi: 10.1016/j.gtc.2014.08.002. Epub 2014 Oct 24. Review.

PMID:
25440918
48.

Redox-sensitive residue in the actin-binding interface of myosin.

Moen RJ, Cornea S, Oseid DE, Binder BP, Klein JC, Thomas DD.

Biochem Biophys Res Commun. 2014 Oct 24;453(3):345-9. doi: 10.1016/j.bbrc.2014.09.072. Epub 2014 Sep 26.

49.

Saturation editing of genomic regions by multiplex homology-directed repair.

Findlay GM, Boyle EA, Hause RJ, Klein JC, Shendure J.

Nature. 2014 Sep 4;513(7516):120-3. doi: 10.1038/nature13695.

50.

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides.

Kandasamy J, Schuhmacher F, Hahm HS, Klein JC, Seeberger PH.

Chem Commun (Camb). 2014 Feb 21;50(15):1875-7. doi: 10.1039/c3cc48860h. Epub 2014 Jan 9.

PMID:
24402061

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