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Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space.

Rizvi NF, Santa Maria JP Jr, Nahvi A, Klappenbach J, Klein DJ, Curran PJ, Richards MP, Chamberlin C, Saradjian P, Burchard J, Aguilar R, Lee JT, Dandliker PJ, Smith GF, Kutchukian P, Nickbarg EB.

SLAS Discov. 2019 Nov 8:2472555219885373. doi: 10.1177/2472555219885373. [Epub ahead of print]


Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies.

Selnick HG, Hess JF, Tang C, Liu K, Schachter JB, Ballard JE, Marcus J, Klein DJ, Wang X, Pearson M, Savage MJ, Kaul R, Li TS, Vocadlo DJ, Zhou Y, Zhu Y, Mu C, Wang Y, Wei Z, Bai C, Duffy JL, McEachern EJ.

J Med Chem. 2019 Nov 27;62(22):10062-10097. doi: 10.1021/acs.jmedchem.9b01090. Epub 2019 Sep 29.


An online alcohol and risky sex prevention program for college students studying abroad: study protocol for a randomized controlled trial.

Pedersen ER, D'Amico EJ, LaBrie JW, Farris C, Klein DJ, Griffin BA.

Addict Sci Clin Pract. 2019 Aug 20;14(1):32. doi: 10.1186/s13722-019-0162-4.


The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS.

Iba T, Klein DJ.

J Intensive Care. 2019 May 16;7:31. doi: 10.1186/s40560-019-0386-0. eCollection 2019.


Age matters: differences in correlates of self-reported HIV antiretroviral treatment adherence between older and younger Black men who have sex with men living with HIV.

Mutchler MG, Bogart LM, Klein DJ, Wagner GJ, Klinger IA, Tyagi K, McDavitt B.

AIDS Care. 2019 Aug;31(8):965-972. doi: 10.1080/09540121.2019.1612020. Epub 2019 May 9.


Cortical-Basal Ganglia-Cerebellar Networks in Unilateral Vocal Fold Paralysis: A Pilot Study.

Perez PL, Cueva KL, Rosen CA, Young VN, Naunheim ML, Yung KC, Schneider SL, Mizuiri D, Klein DJ, Houde JF, Hinkley LB, Nagarajan SS, Cheung SW.

Laryngoscope. 2020 Feb;130(2):460-464. doi: 10.1002/lary.28004. Epub 2019 May 9.


A multicenter, randomized, double-blind study of ulimorelin and metoclopramide in the treatment of critically ill patients with enteral feeding intolerance: PROMOTE trial.

Heyland DK, van Zanten ARH, Grau-Carmona T, Evans D, Beishuizen A, Schouten J, Hoiting O, Bordejé ML, Krell K, Klein DJ, Gonzalez J, Perez A, Brown R, James J, Harris MS; Investigators of the PROMOTE LP101-CL-201 Trial.

Intensive Care Med. 2019 May;45(5):647-656. doi: 10.1007/s00134-019-05593-2. Epub 2019 May 6.


The influence of mobility among high-risk populations on HIV transmission in Western Kenya.

Bershteyn A, Mutai KK, Akullian AN, Klein DJ, Jewell BL, Mwalili SM.

Infect Dis Model. 2018 Apr 23;3:97-106. doi: 10.1016/j.idm.2018.04.001. eCollection 2018.


Overt Perceived Discrimination and Racial Microaggressions and their Association with Health Risk Behaviors among a Sample of Urban American Indian/Alaska Native Adolescents.

Dickerson DL, Brown RA, Klein DJ, Agniel D, Johnson C, D'Amico EJ.

J Racial Ethn Health Disparities. 2019 Aug;6(4):733-742. doi: 10.1007/s40615-019-00572-1. Epub 2019 Feb 20.


Activity Tracker to Prescribe Various Exercise Intensities in Breast Cancer Survivors.

McNeil J, Brenner DR, Stone CR, O'Reilly R, Ruan Y, Vallance JK, Courneya KS, Thorpe KE, Klein DJ, Friedenreich CM.

Med Sci Sports Exerc. 2019 May;51(5):930-940. doi: 10.1249/MSS.0000000000001890.


Unveiling an 'invisible population': health, substance use, sexual behavior, culture, and discrimination among urban American Indian/Alaska Native adolescents in California.

D'Amico EJ, Dickerson DL, Brown RA, Klein DJ, Agniel D, Johnson C.

Ethn Health. 2019 Jan 9:1-18. doi: 10.1080/13557858.2018.1562054. [Epub ahead of print]


Cortical networks for speech motor control in unilateral vocal fold paralysis.

Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Hinkley LB, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW.

Laryngoscope. 2019 Sep;129(9):2125-2130. doi: 10.1002/lary.27730. Epub 2018 Dec 20.


Vocal motor control and central auditory impairments in unilateral vocal fold paralysis.

Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW.

Laryngoscope. 2019 Sep;129(9):2112-2117. doi: 10.1002/lary.27680. Epub 2018 Nov 28.


Polymyxin B hemoperfusion in endotoxemic septic shock patients without extreme endotoxemia: a post hoc analysis of the EUPHRATES trial.

Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M.

Intensive Care Med. 2018 Dec;44(12):2205-2212. doi: 10.1007/s00134-018-5463-7. Epub 2018 Nov 23.


Using predicted Spanish preference to target bilingual mailings in a mail survey with telephone follow-up.

Elliott MN, Klein DJ, Kallaur P, Brown JA, Hays RD, Orr N, Zaslavsky AM, Beckett MK, Gaillot S, Edwards CA, Haviland AM.

Health Serv Res. 2019 Feb;54(1):5-12. doi: 10.1111/1475-6773.13088. Epub 2018 Nov 22.


A Comparison of Methods for Classifying and Modeling Respondents Who Endorse Multiple Racial/Ethnic Categories: A Health Care Experience Application.

Klein DJ, Elliott MN, Haviland AM, Morrison PA, Orr N, Gaillot S, Weech-Maldonado R.

Med Care. 2019 Jun;57(6):e34-e41. doi: 10.1097/MLR.0000000000001012.


Antiretroviral Adherence Trajectories Among Black Americans Living with HIV.

Storholm ED, Bogart LM, Mutchler MG, Klein DJ, Ghosh-Dastidar B, McDavitt B, Wagner GJ.

AIDS Behav. 2019 Aug;23(8):1985-1997. doi: 10.1007/s10461-018-2303-2.


Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial.

Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, Palevsky PM, Weisberg LS, Schorr CA, Trzeciak S, Walker PM; EUPHRATES Trial Investigators.

JAMA. 2018 Oct 9;320(14):1455-1463. doi: 10.1001/jama.2018.14618.


Racial And Ethnic Differences In The Attainment Of Behavioral Health Quality Measures In Medicare Advantage Plans.

Breslau J, Elliott MN, Haviland AM, Klein DJ, Dembosky JW, Adams JL, Gaillot SJ, Horvitz-Lennon M, Schneider EC.

Health Aff (Millwood). 2018 Oct;37(10):1685-1692. doi: 10.1377/hlthaff.2018.0655.


Typhoid fever in Santiago, Chile: Insights from a mathematical model utilizing venerable archived data from a successful disease control program.

Gauld JS, Hu H, Klein DJ, Levine MM.

PLoS Negl Trop Dis. 2018 Sep 6;12(9):e0006759. doi: 10.1371/journal.pntd.0006759. eCollection 2018 Sep.


How Do Gender Differences in Quality of Care Vary Across Medicare Advantage Plans?

Bird CE, Elliott MN, Adams JL, Schneider EC, Klein DJ, Dembosky JW, Gaillot S, Fremont AM, Haviland AM.

J Gen Intern Med. 2018 Oct;33(10):1752-1759. doi: 10.1007/s11606-018-4605-5. Epub 2018 Aug 10.


Improving Response Rates and Representation of Hard-to-Reach Groups in Family Experience Surveys.

Toomey SL, Elliott MN, Zaslavsky AM, Quinn J, Klein DJ, Wagner S, Thomson C, Wu M, Onorato S, Schuster MA.

Acad Pediatr. 2019 May - Jun;19(4):446-453. doi: 10.1016/j.acap.2018.07.007. Epub 2018 Jul 26.


The emerging health impact of voluntary medical male circumcision in Zimbabwe: An evaluation using three epidemiological models.

McGillen JB, Stover J, Klein DJ, Xaba S, Ncube G, Mhangara M, Chipendo GN, Taramusi I, Beacroft L, Hallett TB, Odawo P, Manzou R, Korenromp EL.

PLoS One. 2018 Jul 18;13(7):e0199453. doi: 10.1371/journal.pone.0199453. eCollection 2018.


Implementation and applications of EMOD, an individual-based multi-disease modeling platform.

Bershteyn A, Gerardin J, Bridenbecker D, Lorton CW, Bloedow J, Baker RS, Chabot-Couture G, Chen Y, Fischle T, Frey K, Gauld JS, Hu H, Izzo AS, Klein DJ, Lukacevic D, McCarthy KA, Miller JC, Ouedraogo AL, Perkins TA, Steinkraus J, Ten Bosch QA, Ting HF, Titova S, Wagner BG, Welkhoff PA, Wenger EA, Wiswell CN; Institute for Disease Modeling.

Pathog Dis. 2018 Jul 1;76(5). pii: fty059. doi: 10.1093/femspd/fty059.


Racial disparities in fifth-grade sun protection: Evidence from the Healthy Passages study.

Correnti CM, Klein DJ, Elliott MN, Veledar E, Saraiya M, Chien AT, Schwebel DC, Mrug S, Tortolero SR, Cuccaro PM, Schuster MA, Chen SC.

Pediatr Dermatol. 2018 Sep;35(5):588-596. doi: 10.1111/pde.13550. Epub 2018 Jul 2.


Pilot intervention for discrimination-related coping among HIV-positive Black sexual minority men.

Bogart LM, Dale SK, Daffin GK, Patel KN, Klein DJ, Mayer KH, Pantalone DW.

Cultur Divers Ethnic Minor Psychol. 2018 Oct;24(4):541-551. doi: 10.1037/cdp0000205. Epub 2018 Jun 14.


Perceived Need and Receipt of Behavioral Health Services at Drop-In Centers among Homeless Youth.

Pedersen ER, Tucker JS, Klein DJ, Parast L.

Health Serv Res. 2018 Dec;53(6):4609-4628. doi: 10.1111/1475-6773.12990. Epub 2018 Jun 3.


Healthcare provider counseling to quit smoking and patient desire to quit: The role of negative smoking outcome expectancies.

Tucker JS, Stucky BD, Edelen MO, Shadel WG, Klein DJ.

Addict Behav. 2018 Oct;85:8-13. doi: 10.1016/j.addbeh.2018.05.008. Epub 2018 May 22.


Patient-reported denials, appeals, and complaints: associations with overall plan ratings.

Quigley DD, Haviland AM, Dembosky JW, Klein DJ, Elliott MN.

Am J Manag Care. 2018 Mar 1;24(3):e86-e92.


Effects of ovariectomy and exercise training intensity on energy substrate and hepatic lipid metabolism, and spontaneous physical activity in mice.

Tuazon MA, Campbell SC, Klein DJ, Shapses SA, Anacker KR, Anthony TG, Uzumcu M, Henderson GC.

Metabolism. 2018 Jun;83:234-244. doi: 10.1016/j.metabol.2018.02.011. Epub 2018 Mar 6.


Neighborhood Crime and Sexual Transmission Risk Behavior among Black Men Living with HIV.

Ojikutu BO, Bogart LM, Klein DJ, Galvan FH, Wagner GJ.

J Health Care Poor Underserved. 2018;29(1):383-399. doi: 10.1353/hpu.2018.0026.


A Social Network Analysis of HIV Treatment Partners and Patient Viral Suppression in Botswana.

Bogart LM, Mosepele M, Phaladze N, Lekoko B, Klein DJ, MacCarthy S, Green HD Jr.

J Acquir Immune Defic Syndr. 2018 Jun 1;78(2):183-192. doi: 10.1097/QAI.0000000000001661.


Evaluation of the dissemination of SNaX, a middle school-based obesity prevention intervention, within a large US school district.

Bogart LM, Fu CM, Eyraud J, Cowgill BO, Hawes-Dawson J, Uyeda K, Klein DJ, Elliott MN, Schuster MA.

Transl Behav Med. 2018 Sep 8;8(5):724-732. doi: 10.1093/tbm/ibx055.


Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.

Rizvi NF, Howe JA, Nahvi A, Klein DJ, Fischmann TO, Kim HY, McCoy MA, Walker SS, Hruza A, Richards MP, Chamberlin C, Saradjian P, Butko MT, Mercado G, Burchard J, Strickland C, Dandliker PJ, Smith GF, Nickbarg EB.

ACS Chem Biol. 2018 Mar 16;13(3):820-831. doi: 10.1021/acschembio.7b01013. Epub 2018 Feb 14.


Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.

Burlein C, Wang C, Xu M, Bhatt T, Stahlhut M, Ou Y, Adam GC, Heath J, Klein DJ, Sanders J, Narayan K, Abeywickrema P, Heo MR, Carroll SS, Grobler JA, Sharma S, Diamond TL, Converso A, Krosky DJ.

ACS Chem Biol. 2017 Nov 17;12(11):2858-2865. doi: 10.1021/acschembio.7b00550. Epub 2017 Oct 19.


Novel Insights into the Direct Removal of Endotoxin by Polymyxin B Hemoperfusion.

Romaschin AD, Obiezu-Forster CV, Shoji H, Klein DJ.

Blood Purif. 2017;44(3):193-197. doi: 10.1159/000475982. Epub 2017 Jun 10. Erratum in: Blood Purif. 2018;45(1-3):311.


A Randomized Controlled Trial of Rise, a Community-Based Culturally Congruent Adherence Intervention for Black Americans Living with HIV.

Bogart LM, Mutchler MG, McDavitt B, Klein DJ, Cunningham WE, Goggin KJ, Ghosh-Dastidar B, Rachal N, Nogg KA, Wagner GJ.

Ann Behav Med. 2017 Dec;51(6):868-878. doi: 10.1007/s12160-017-9910-4.


Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

Elsen NL, Patel SB, Ford RE, Hall DL, Hess F, Kandula H, Kornienko M, Reid J, Selnick H, Shipman JM, Sharma S, Lumb KJ, Soisson SM, Klein DJ.

Nat Chem Biol. 2017 Jun;13(6):613-615. doi: 10.1038/nchembio.2357. Epub 2017 Mar 27.


Medical mistrust as a key mediator in the association between perceived discrimination and adherence to antiretroviral therapy among HIV-positive Latino men.

Galvan FH, Bogart LM, Klein DJ, Wagner GJ, Chen YT.

J Behav Med. 2017 Oct;40(5):784-793. doi: 10.1007/s10865-017-9843-1. Epub 2017 Mar 23.


Variation in Family Experience of Pediatric Inpatient Care As Measured by Child HCAHPS.

Toomey SL, Elliott MN, Zaslavsky AM, Klein DJ, Ndon S, Hardy S, Wu M, Schuster MA.

Pediatrics. 2017 Apr;139(4). pii: e20163372. doi: 10.1542/peds.2016-3372. Epub 2017 Mar 22.


Home Sweet Home: Parent and Home Environmental Factors in Adolescent Consumption of Sugar-Sweetened Beverages.

Bogart LM, Elliott MN, Ober AJ, Klein DJ, Hawes-Dawson J, Cowgill BO, Uyeda K, Schuster MA.

Acad Pediatr. 2017 Jul;17(5):529-536. doi: 10.1016/j.acap.2017.01.015. Epub 2017 Jan 29.


A Comparison of Home-Based Versus Outreach Event-Based Community HIV Testing in Ugandan Fisherfolk Communities.

Bogart LM, Wagner GJ, Musoke W, Naigino R, Linnemayr S, Maistrellis E, Klein DJ, Jumamil RB, Mukasa B, Bassett IV, Giordano TP, Wanyenze RK.

AIDS Behav. 2017 Feb;21(2):547-560. doi: 10.1007/s10461-016-1629-x.


Toward Molecular Magnets of Organic Origin via Anion-π Interaction Involving m-Aminyl Diradical: A Theoretical Study.

Bhattacharya D, Shil S, Misra A, Bytautas L, Klein DJ.

J Phys Chem A. 2016 Nov 17;120(45):9117-9130. Epub 2016 Nov 3.


Investing Wisely in Health Care Capital.

Klein DJ, Brown AD, Detsky AS.

JAMA. 2016 Oct 18;316(15):1543-1544. doi: 10.1001/jama.2016.10605. No abstract available.


Two-Year BMI Outcomes From a School-Based Intervention for Nutrition and Exercise: A Randomized Trial.

Bogart LM, Elliott MN, Cowgill BO, Klein DJ, Hawes-Dawson J, Uyeda K, Schuster MA.

Pediatrics. 2016 May;137(5). pii: e20152493. doi: 10.1542/peds.2015-2493.


PharmGKB summary: isoniazid pathway, pharmacokinetics.

Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE.

Pharmacogenet Genomics. 2016 Sep;26(9):436-44. doi: 10.1097/FPC.0000000000000232. No abstract available.


Medical mistrust among social network members may contribute to antiretroviral treatment nonadherence in African Americans living with HIV.

Bogart LM, Wagner GJ, Green HD Jr, Mutchler MG, Klein DJ, McDavitt B, Lawrence SJ, Hilliard CL.

Soc Sci Med. 2016 Sep;164:133-140. doi: 10.1016/j.socscimed.2016.03.028. Epub 2016 Mar 19.


Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.

Stachel SJ, Zerbinatti C, Rudd MT, Cosden M, Suon S, Nanda KK, Wessner K, DiMuzio J, Maxwell J, Wu Z, Uslaner JM, Michener MS, Szczerba P, Brnardic E, Rada V, Kim Y, Meissner R, Wuelfing P, Yuan Y, Ballard J, Holahan M, Klein DJ, Lu J, Fradera X, Parthasarathy G, Uebele VN, Chen Z, Li Y, Li J, Cooke AJ, Bennett DJ, Bilodeau MT, Renger J.

J Med Chem. 2016 Apr 14;59(7):3489-98. doi: 10.1021/acs.jmedchem.6b00176. Epub 2016 Apr 1.


Association of Internalized and Social Network Level HIV Stigma With High-Risk Condomless Sex Among HIV-Positive African American Men.

Wagner GJ, Bogart LM, Klein DJ, Green HD Jr, Mutchler MG, McDavitt B, Hilliard C.

Arch Sex Behav. 2016 Aug;45(6):1347-55. doi: 10.1007/s10508-015-0641-y. Epub 2015 Dec 30.

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