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Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus.

Merkhofer RM Jr, O'Neill MB, Xiong D, Hernandez-Santos N, Dobson H, Fites JS, Shockey AC, Wuethrich M, Pepperell CS, Klein BS.

MBio. 2019 Jun 18;10(3). pii: e01224-19. doi: 10.1128/mBio.01224-19.


Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection.

Hernández-Santos N, Wiesner DL, Fites JS, McDermott AJ, Warner T, Wüthrich M, Klein BS.

Cell Host Microbe. 2019 Apr 10;25(4):630. doi: 10.1016/j.chom.2019.03.013. No abstract available.


Phenylpyrrole fungicides act on triosephosphate isomerase to induce methylglyoxal stress and alter hybrid histidine kinase activity.

Brandhorst TT, Kean IRL, Lawry SM, Wiesner DL, Klein BS.

Sci Rep. 2019 Mar 25;9(1):5047. doi: 10.1038/s41598-019-41564-9.


Uncertainty surrounding the mechanism and safety of the post-harvest fungicide fludioxonil.

Brandhorst TT, Klein BS.

Food Chem Toxicol. 2019 Jan;123:561-565. doi: 10.1016/j.fct.2018.11.037. Epub 2018 Nov 17. Review.


LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes.

Sharma A, Lawry SM, Klein BS, Wang X, Sherer NM, Zumwalde NA, Gumperz JE.

J Immunol. 2018 Oct 15;201(8):2452-2461. doi: 10.4049/jimmunol.1800537. Epub 2018 Aug 31.


CBLB Constrains Inactivated Vaccine-Induced CD8+ T Cell Responses and Immunity against Lethal Fungal Pneumonia.

Nanjappa SG, Mudalagiriyappa S, Fites JS, Suresh M, Klein BS.

J Immunol. 2018 Sep 15;201(6):1717-1726. doi: 10.4049/jimmunol.1701241. Epub 2018 Jul 27.


An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

Fites JS, Gui M, Kernien JF, Negoro P, Dagher Z, Sykes DB, Nett JE, Mansour MK, Klein BS.

PLoS Pathog. 2018 May 21;14(5):e1007073. doi: 10.1371/journal.ppat.1007073. eCollection 2018 May.


Helper T-cell responses and pulmonary fungal infections.

McDermott AJ, Klein BS.

Immunology. 2018 Oct;155(2):155-163. doi: 10.1111/imm.12953. Epub 2018 Jun 14. Review.


CRISPR/Cas9-Mediated Gene Disruption Reveals the Importance of Zinc Metabolism for Fitness of the Dimorphic Fungal Pathogen Blastomyces dermatitidis.

Kujoth GC, Sullivan TD, Merkhofer R, Lee TJ, Wang H, Brandhorst T, Wüthrich M, Klein BS.

MBio. 2018 Apr 3;9(2). pii: e00412-18. doi: 10.1128/mBio.00412-18.


Pulmonary neuroendocrine cells amplify allergic asthma responses.

Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X.

Science. 2018 Jun 8;360(6393). pii: eaan8546. doi: 10.1126/science.aan8546. Epub 2018 Mar 29.


Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection.

Hernández-Santos N, Wiesner DL, Fites JS, McDermott AJ, Warner T, Wüthrich M, Klein BS.

Cell Host Microbe. 2018 Apr 11;23(4):511-522.e5. doi: 10.1016/j.chom.2018.02.011. Epub 2018 Mar 22. Erratum in: Cell Host Microbe. 2019 Apr 10;25(4):630.


Turning on virulence: Mechanisms that underpin the morphologic transition and pathogenicity of Blastomyces.

McBride JA, Gauthier GM, Klein BS.

Virulence. 2018 Aug 1:1-9. doi: 10.1080/21505594.2018.1449506. [Epub ahead of print]


O-Mannosylation of Proteins Enables Histoplasma Yeast Survival at Mammalian Body Temperatures.

Garfoot AL, Goughenour KD, Wüthrich M, Rajaram MVS, Schlesinger LS, Klein BS, Rappleye CA.

MBio. 2018 Jan 2;9(1). pii: e02121-17. doi: 10.1128/mBio.02121-17.


Through the Scope Darkly: The Gut Mycobiome Comes into Focus.

Hernández-Santos N, Klein BS.

Cell Host Microbe. 2017 Dec 13;22(6):728-729. doi: 10.1016/j.chom.2017.11.013.


Lung epithelium: barrier immunity to inhaled fungi and driver of fungal-associated allergic asthma.

Wiesner DL, Klein BS.

Curr Opin Microbiol. 2017 Dec;40:8-13. doi: 10.1016/j.mib.2017.10.007. Epub 2017 Oct 27. Review.


Inhaled Cryptococcus neoformans elicits allergic airway inflammation independent of Nuclear Factor Kappa B signalling in lung epithelial cells.

McDermott AJ, Tumey TA, Huang M, Hull CM, Klein BS.

Immunology. 2018 Apr;153(4):513-522. doi: 10.1111/imm.12853. Epub 2017 Nov 16.


The balance between immunity and inflammation.

Wiesner DL, Klein BS.

Science. 2017 Sep 8;357(6355):973-974. doi: 10.1126/science.aao3086. No abstract available.


Clinical Manifestations and Treatment of Blastomycosis.

McBride JA, Gauthier GM, Klein BS.

Clin Chest Med. 2017 Sep;38(3):435-449. doi: 10.1016/j.ccm.2017.04.006. Epub 2017 Jun 12. Review.


Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 Jun 6;19(10):2174-2176. doi: 10.1016/j.celrep.2017.05.075. No abstract available.


Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells.

Nanjappa SG, McDermott AJ, Fites JS, Galles K, Wüthrich M, Deepe GS Jr, Klein BS.

PLoS Pathog. 2017 May 22;13(5):e1006356. doi: 10.1371/journal.ppat.1006356. eCollection 2017 May.


Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 May 2;19(5):1008-1021. doi: 10.1016/j.celrep.2017.04.019. Erratum in: Cell Rep. 2017 Jun 6;19(10 ):2174-2176.


Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR+ CXC chemokines altering their effects on neutrophils.

Lorenzini J, Scott Fites J, Nett J, Klein BS.

Cell Microbiol. 2017 Sep;19(9). doi: 10.1111/cmi.12741. Epub 2017 May 30.


Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1.

Lawry SM, Tebbets B, Kean I, Stewart D, Hetelle J, Klein BS.

Antimicrob Agents Chemother. 2017 Jan 24;61(2). pii: e01414-16. doi: 10.1128/AAC.01414-16. Print 2017 Feb.


Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs.

Xu X, Pocock GM, Sharma A, Peery SL, Fites JS, Felley L, Zarnowski R, Stewart D, Berthier E, Klein BS, Sherer NM, Gumperz JE.

Cell Rep. 2016 Sep 20;16(12):3273-3285. doi: 10.1016/j.celrep.2016.08.061.


MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase.

Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M.

PLoS Pathog. 2016 Aug 19;12(8):e1005787. doi: 10.1371/journal.ppat.1005787. eCollection 2016 Aug.


Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis.

Xiong Y, Lingrel JB, Wüthrich M, Klein BS, Vasudevan NT, Jain MK, George M, Deepe GS Jr.

MBio. 2016 Jun 14;7(3). pii: e00436-16. doi: 10.1128/mBio.00436-16.


The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure.

Garfoot AL, Shen Q, Wüthrich M, Klein BS, Rappleye CA.

MBio. 2016 Apr 19;7(2):e01388-15. doi: 10.1128/mBio.01388-15.


Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.

Sterkel AK, Lorenzini JL, Fites JS, Subramanian Vignesh K, Sullivan TD, Wuthrich M, Brandhorst T, Hernandez-Santos N, Deepe GS Jr, Klein BS.

Cell Host Microbe. 2016 Mar 9;19(3):361-74. doi: 10.1016/j.chom.2016.02.001. Epub 2016 Feb 25.


The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia.

Muñoz JF, Gauthier GM, Desjardins CA, Gallo JE, Holder J, Sullivan TD, Marty AJ, Carmen JC, Chen Z, Ding L, Gujja S, Magrini V, Misas E, Mitreva M, Priest M, Saif S, Whiston EA, Young S, Zeng Q, Goldman WE, Mardis ER, Taylor JW, McEwen JG, Clay OK, Klein BS, Cuomo CA.

PLoS Genet. 2015 Oct 6;11(10):e1005493. doi: 10.1371/journal.pgen.1005493. eCollection 2015 Oct.


Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase.

Beaussart A, Brandhorst T, Dufrêne YF, Klein BS.

MBio. 2015 Sep 22;6(5):e01403-15. doi: 10.1128/mBio.01403-15.


Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia.

Nanjappa SG, Hernández-Santos N, Galles K, Wüthrich M, Suresh M, Klein BS.

PLoS Pathog. 2015 Sep 14;11(9):e1005161. doi: 10.1371/journal.ppat.1005161. eCollection 2015 Sep.


T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.

Nelson RW, Beisang D, Tubo NJ, Dileepan T, Wiesner DL, Nielsen K, Wüthrich M, Klein BS, Kotov DI, Spanier JA, Fife BT, Moon JJ, Jenkins MK.

Immunity. 2015 Jan 20;42(1):95-107. Erratum in: Immunity. 2015 Jun 16;42(6):1212-3.


The unappreciated intracellular lifestyle of Blastomyces dermatitidis.

Sterkel AK, Mettelman R, Wüthrich M, Klein BS.

J Immunol. 2015 Feb 15;194(4):1796-805. doi: 10.4049/jimmunol.1303089. Epub 2015 Jan 14.


Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection.

Hung CY, Jiménez-Alzate Mdel P, Gonzalez A, Wüthrich M, Klein BS, Cole GT.

Infect Immun. 2014 May;82(5):2106-14. doi: 10.1128/IAI.01579-13. Epub 2014 Mar 10.


Vaccine immunity against fungal infections.

Nanjappa SG, Klein BS.

Curr Opin Immunol. 2014 Jun;28:27-33. doi: 10.1016/j.coi.2014.01.014. Epub 2014 Mar 3. Review. No abstract available.


C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America.

Wang H, LeBert V, Hung CY, Galles K, Saijo S, Lin X, Cole GT, Klein BS, Wüthrich M.

J Immunol. 2014 Feb 1;192(3):1107-1119. doi: 10.4049/jimmunol.1302314. Epub 2014 Jan 3.


Novel strategies to enhance vaccine immunity against coccidioidomycosis.

Cole GT, Hung CY, Sanderson SD, Hurtgen BJ, Wüthrich M, Klein BS, Deepe GS, Ostroff GR, Levitz SM.

PLoS Pathog. 2013;9(12):e1003768. doi: 10.1371/journal.ppat.1003768. Epub 2013 Dec 19. No abstract available.


Development of a highly sensitive and specific blastomycosis antibody enzyme immunoassay using Blastomyces dermatitidis surface protein BAD-1.

Richer SM, Smedema ML, Durkin MM, Brandhorst TT, Hage CA, Connolly PA, Leland DS, Davis TE, Klein BS, Wheat LJ.

Clin Vaccine Immunol. 2014 Feb;21(2):143-6. doi: 10.1128/CVI.00597-13. Epub 2013 Nov 27.


Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection.

Wüthrich M, LeBert V, Galles K, Hu-Li J, Ben-Sasson SZ, Paul WE, Klein BS.

J Infect Dis. 2013 Oct 1;208(7):1175-82. doi: 10.1093/infdis/jit283. Epub 2013 Jun 20.


A large community outbreak of blastomycosis in Wisconsin with geographic and ethnic clustering.

Roy M, Benedict K, Deak E, Kirby MA, McNiel JT, Sickler CJ, Eckardt E, Marx RK, Heffernan RT, Meece JK, Klein BS, Archer JR, Theurer J, Davis JP, Park BJ.

Clin Infect Dis. 2013 Sep;57(5):655-62. doi: 10.1093/cid/cit366. Epub 2013 Jun 3.


Fungal glycan interactions with epithelial cells in allergic airway disease.

Roy RM, Klein BS.

Curr Opin Microbiol. 2013 Aug;16(4):404-8. doi: 10.1016/j.mib.2013.03.004. Epub 2013 Apr 17. Review.


Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation.

Roy RM, Paes HC, Nanjappa SG, Sorkness R, Gasper D, Sterkel A, Wüthrich M, Klein BS.

MBio. 2013 Apr 2;4(2). pii: e00162-13. doi: 10.1128/mBio.00162-13.


Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling.

Marty AJ, Wüthrich M, Carmen JC, Sullivan TD, Klein BS, Cuomo CA, Gauthier GM.

Fungal Genet Biol. 2013 Jul;56:1-8. doi: 10.1016/j.fgb.2013.03.001. Epub 2013 Mar 14.


Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis.

Li W, Sullivan TD, Walton E, Averette AF, Sakthikumar S, Cuomo CA, Klein BS, Heitman J.

Eukaryot Cell. 2013 Jan;12(1):109-17. doi: 10.1128/EC.00249-12. Epub 2012 Nov 9.


Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung.

Roy RM, Wüthrich M, Klein BS.

J Immunol. 2012 Sep 1;189(5):2545-52. doi: 10.4049/jimmunol.1200689. Epub 2012 Jul 30.


Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells.

Nanjappa SG, Heninger E, Wüthrich M, Gasper DJ, Klein BS.

PLoS Pathog. 2012;8(7):e1002771. doi: 10.1371/journal.ppat.1002771. Epub 2012 Jul 19. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004148.


Dendritic cells in antifungal immunity and vaccine design.

Roy RM, Klein BS.

Cell Host Microbe. 2012 May 17;11(5):436-46. doi: 10.1016/j.chom.2012.04.005. Review.


Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay.

Tebbets B, Stewart D, Lawry S, Nett J, Nantel A, Andes D, Klein BS.

PLoS One. 2012;7(5):e36021. doi: 10.1371/journal.pone.0036021. Epub 2012 May 4.


Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes.

Wüthrich M, Ersland K, Sullivan T, Galles K, Klein BS.

Immunity. 2012 Apr 20;36(4):680-92. doi: 10.1016/j.immuni.2012.02.015. Epub 2012 Apr 5.


ARFI-based tissue elasticity quantification and kidney graft dysfunction: first clinical experiences.

Stock KF, Klein BS, Cong MT, Regenbogen C, Kemmner S, Büttner M, Wagenpfeil S, Matevossian E, Renders L, Heemann U, Küchle C.

Clin Hemorheol Microcirc. 2011;49(1-4):527-35. doi: 10.3233/CH-2011-1503.


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