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Items: 11


Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.

Parzych K, Chinn TM, Chen Z, Loaiza S, Porsch F, Valbuena GN, Kleijnen MF, Karadimitris A, Gentleman E, Keun HC, Auner HW.

Cell Death Dis. 2015 Dec 31;6:e2031. doi: 10.1038/cddis.2015.373.


Bortezomib Amplifies Effect on Intracellular Proteasomes by Changing Proteasome Structure.

Pitcher DS, de Mattos-Shipley K, Tzortzis K, Auner HW, Karadimitris A, Kleijnen MF.

EBioMedicine. 2015 May 28;2(7):642-8. doi: 10.1016/j.ebiom.2015.05.016. eCollection 2015 Jul.


Nuclear proteasomes carry a constitutive posttranslational modification which derails SDS-PAGE (but not CTAB-PAGE).

Pitcher DS, de Mattos-Shipley K, Wang Z, Tzortzis K, Goudevenou K, Flynn H, Bohn G, Rahemtulla A, Roberts I, Snijders AP, Karadimitris A, Kleijnen MF.

Biochim Biophys Acta. 2014 Dec;1844(12):2222-8. doi: 10.1016/j.bbapap.2014.08.013. Epub 2014 Sep 2.


Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.

Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D.

Nat Struct Mol Biol. 2007 Dec;14(12):1180-8. Epub 2007 Nov 18.


The ubiquitin-proteasome system regulates membrane fusion of yeast vacuoles.

Kleijnen MF, Kirkpatrick DS, Gygi SP.

EMBO J. 2007 Jan 24;26(2):275-87. Epub 2006 Dec 21.


The ubiquitin-associated domain of hPLIC-2 interacts with the proteasome.

Kleijnen MF, Alarcon RM, Howley PM.

Mol Biol Cell. 2003 Sep;14(9):3868-75. Epub 2003 May 29.


Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.

Walters KJ, Kleijnen MF, Goh AM, Wagner G, Howley PM.

Biochemistry. 2002 Feb 12;41(6):1767-77.


The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.

Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM.

Mol Cell. 2000 Aug;6(2):409-19.


A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface.

Kleijnen MF, Huppa JB, Lucin P, Mukherjee S, Farrell H, Campbell AE, Koszinowski UH, Hill AB, Ploegh HL.

EMBO J. 1997 Feb 17;16(4):685-94.


Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation.

Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G.

Mol Cell Biol. 1996 Dec;16(12):7098-108.


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