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Items: 23


Using In Vitro Ubiquitylation Assays to Estimate the Affinities of Ubiquitin-Conjugating Enzymes for Their Ubiquitin Ligase Partners.

Hill S, Hill C, Kleiger G.

Methods Mol Biol. 2018;1844:39-58. doi: 10.1007/978-1-4939-8706-1_4.


Self-regulating ubiquitin ligases.

Hill S, Kleiger G.

EMBO J. 2017 Feb 15;36(4):392-393. doi: 10.15252/embj.201696154. Epub 2017 Jan 13. No abstract available.


Tag Team Ubiquitin Ligases.

Kleiger G, Deshaies R.

Cell. 2016 Aug 25;166(5):1080-1081. doi: 10.1016/j.cell.2016.08.014.


The San1 Ubiquitin Ligase Functions Preferentially with Ubiquitin-conjugating Enzyme Ubc1 during Protein Quality Control.

Ibarra R, Sandoval D, Fredrickson EK, Gardner RG, Kleiger G.

J Biol Chem. 2016 Sep 2;291(36):18778-90. doi: 10.1074/jbc.M116.737619. Epub 2016 Jul 12.


Mechanism of Lysine 48 Selectivity during Polyubiquitin Chain Formation by the Ube2R1/2 Ubiquitin-Conjugating Enzyme.

Hill S, Harrison JS, Lewis SM, Kuhlman B, Kleiger G.

Mol Cell Biol. 2016 May 16;36(11):1720-32. doi: 10.1128/MCB.00097-16. Print 2016 Jun 1.


Ubiquitin-conjugating enzyme Cdc34 and ubiquitin ligase Skp1-cullin-F-box ligase (SCF) interact through multiple conformations.

Sandoval D, Hill S, Ziemba A, Lewis S, Kuhlman B, Kleiger G.

J Biol Chem. 2015 Jan 9;290(2):1106-18. doi: 10.1074/jbc.M114.615559. Epub 2014 Nov 25.


Perilous journey: a tour of the ubiquitin-proteasome system.

Kleiger G, Mayor T.

Trends Cell Biol. 2014 Jun;24(6):352-9. doi: 10.1016/j.tcb.2013.12.003. Epub 2014 Jan 20. Review.


E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F.

Nat Chem Biol. 2014 Feb;10(2):156-163. doi: 10.1038/nchembio.1412. Epub 2013 Dec 15.


Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails.

Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G.

J Biol Chem. 2013 Nov 29;288(48):34882-96. doi: 10.1074/jbc.M113.509190. Epub 2013 Oct 15.


NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

den Besten W, Verma R, Kleiger G, Oania RS, Deshaies RJ.

Nat Struct Mol Biol. 2012 Apr 1;19(5):511-6, S1. doi: 10.1038/nsmb.2269.


Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate.

Saha A, Lewis S, Kleiger G, Kuhlman B, Deshaies RJ.

Mol Cell. 2011 Apr 8;42(1):75-83. doi: 10.1016/j.molcel.2011.03.016.


Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins.

Tyrrell A, Flick K, Kleiger G, Zhang H, Deshaies RJ, Kaiser P.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19796-801. doi: 10.1073/pnas.1010648107. Epub 2010 Nov 1.


Detection of sequential polyubiquitylation on a millisecond timescale.

Pierce NW, Kleiger G, Shan SO, Deshaies RJ.

Nature. 2009 Dec 3;462(7273):615-9. doi: 10.1038/nature08595.


Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates.

Kleiger G, Saha A, Lewis S, Kuhlman B, Deshaies RJ.

Cell. 2009 Nov 25;139(5):957-68. doi: 10.1016/j.cell.2009.10.030.


The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4.

Kleiger G, Hao B, Mohl DA, Deshaies RJ.

J Biol Chem. 2009 Dec 25;284(52):36012-23. doi: 10.1074/jbc.M109.058529. Epub 2009 Oct 29.


PFIT and PFRIT: bioinformatic algorithms for detecting glycosidase function from structure and sequence.

Kleiger G, Panina EM, Mallick P, Eisenberg D.

Protein Sci. 2004 Jan;13(1):221-9.


Selective dimerization of a C2H2 zinc finger subfamily.

McCarty AS, Kleiger G, Eisenberg D, Smale ST.

Mol Cell. 2003 Feb;11(2):459-70.


GXXXG and AXXXA: common alpha-helical interaction motifs in proteins, particularly in extremophiles.

Kleiger G, Grothe R, Mallick P, Eisenberg D.

Biochemistry. 2002 May 14;41(19):5990-7.


Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding.

Cobb BS, Morales-Alcelay S, Kleiger G, Brown KE, Fisher AG, Smale ST.

Genes Dev. 2000 Sep 1;14(17):2146-60.


The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold.

Kleiger G, Beamer LJ, Grothe R, Mallick P, Eisenberg D.

J Mol Biol. 2000 Jun 16;299(4):1019-34.


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