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Cleavage of the leptin receptor by matrix metalloproteinase-2 promotes leptin resistance and obesity in mice.

Mazor R, Friedmann-Morvinski D, Alsaigh T, Kleifeld O, Kistler EB, Rousso-Noori L, Huang C, Li JB, Verma IM, Schmid-Schönbein GW.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaah6324. doi: 10.1126/scitranslmed.aah6324.


Biodosimetric transcriptional and proteomic changes are conserved in irradiated human tissue.

Keam SP, Gulati T, Gamell C, Caramia F, Arnau GM, Huang C, Schittenhelm RB, Kleifeld O, Neeson PJ, Williams SG, Haupt Y.

Radiat Environ Biophys. 2018 Aug;57(3):241-249. doi: 10.1007/s00411-018-0746-5. Epub 2018 May 30.


Identification of Novel Acinetobacter baumannii Type VI Secretion System Antibacterial Effector and Immunity Pairs.

Fitzsimons TC, Lewis JM, Wright A, Kleifeld O, Schittenhelm RB, Powell D, Harper M, Boyce JD.

Infect Immun. 2018 Jul 23;86(8). pii: e00297-18. doi: 10.1128/IAI.00297-18. Print 2018 Aug.


Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.

Deo P, Chow SH, Hay ID, Kleifeld O, Costin A, Elgass KD, Jiang JH, Ramm G, Gabriel K, Dougan G, Lithgow T, Heinz E, Naderer T.

PLoS Pathog. 2018 Mar 30;14(3):e1006945. doi: 10.1371/journal.ppat.1006945. eCollection 2018 Mar.


Activity-Based Probes Developed by Applying a Sequential Dehydroalanine Formation Strategy to Expressed Proteins Reveal a Potential α-Globin-Modulating Deubiquitinase.

Meledin R, Mali SM, Kleifeld O, Brik A.

Angew Chem Int Ed Engl. 2018 May 14;57(20):5645-5649. doi: 10.1002/anie.201800032. Epub 2018 Apr 14.


Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry.

Keam SP, Gulati T, Gamell C, Caramia F, Huang C, Schittenhelm RB, Kleifeld O, Neeson PJ, Haupt Y, Williams SG.

Prostate. 2018 Jun;78(8):563-575. doi: 10.1002/pros.23500. Epub 2018 Mar 9.


Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

Huang C, Lewis C, Borg NA, Canals M, Diep H, Drummond GR, Goode RJ, Schittenhelm RB, Vinh A, Zhu M, Kemp-Harper B, Kleifeld O, Stone MJ.

J Proteome Res. 2018 Apr 6;17(4):1485-1499. doi: 10.1021/acs.jproteome.7b00828. Epub 2018 Mar 13.


Proteotranscriptomic Measurements of E6-Associated Protein (E6AP) Targets in DU145 Prostate Cancer Cells.

Gulati T, Huang C, Caramia F, Raghu D, Paul PJ, Goode RJA, Keam SP, Williams SG, Haupt S, Kleifeld O, Schittenhelm RB, Gamell C, Haupt Y.

Mol Cell Proteomics. 2018 Jun;17(6):1170-1183. doi: 10.1074/mcp.RA117.000504. Epub 2018 Feb 20.


Determination of the small RNA GcvB regulon in the Gram-negative bacterial pathogen Pasteurella multocida and identification of the GcvB seed binding region.

Gulliver EL, Wright A, Lucas DD, Mégroz M, Kleifeld O, Schittenhelm RB, Powell DR, Seemann T, Bulitta JB, Harper M, Boyce JD.

RNA. 2018 May;24(5):704-720. doi: 10.1261/rna.063248.117. Epub 2018 Feb 12.


N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection.

Jagdeo JM, Dufour A, Klein T, Solis N, Kleifeld O, Kizhakkedathu J, Luo H, Overall CM, Jan E.

J Virol. 2018 Mar 28;92(8). pii: e02211-17. doi: 10.1128/JVI.02211-17. Print 2018 Apr 15.


Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.

Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T.

J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29.


Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.

Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ.

Blood. 2017 Feb 23;129(8):981-990. doi: 10.1182/blood-2016-06-721191. Epub 2017 Jan 9.


Synthetic Uncleavable Ubiquitinated Proteins Dissect Proteasome Deubiquitination and Degradation, and Highlight Distinctive Fate of Tetraubiquitin.

Singh SK, Sahu I, Mali SM, Hemantha HP, Kleifeld O, Glickman MH, Brik A.

J Am Chem Soc. 2016 Dec 14;138(49):16004-16015. Epub 2016 Dec 6.


Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.

Silva A, Johnston C, Kuruppu S, Kneisz D, Maduwage K, Kleifeld O, Smith AI, Siribaddana S, Buckley NA, Hodgson WC, Isbister GK.

PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005172. doi: 10.1371/journal.pntd.0005172. eCollection 2016 Dec.


Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

Samson AL, Ho B, Au AE, Schoenwaelder SM, Smyth MJ, Bottomley SP, Kleifeld O, Medcalf RL.

Open Biol. 2016 Nov;6(11). pii: 160098.


Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism.

Keren-Kaplan T, Zeev Peters L, Levin-Kravets O, Attali I, Kleifeld O, Shohat N, Artzi S, Zucker O, Pilzer I, Reis N, Glickman MH, Ben-Aroya S, Prag G.

Nat Commun. 2016 Oct 4;7:12960. doi: 10.1038/ncomms12960.


Studying Protein Ubiquitylation in Yeast.

Hovsepian J, Becuwe M, Kleifeld O, Glickman MH, Léon S.

Methods Mol Biol. 2016;1449:117-42. doi: 10.1007/978-1-4939-3756-1_5.


Corrigendum: N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Apr 22;6:24333. doi: 10.1038/srep24333. No abstract available.


N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin.

Smith AI, Rajapakse NW, Kleifeld O, Lomonte B, Sikanyika NL, Spicer AJ, Hodgson WC, Conroy PJ, Small DH, Kaye DM, Parkington HC, Whisstock JC, Kuruppu S.

Sci Rep. 2016 Mar 2;6:22413. doi: 10.1038/srep22413. Erratum in: Sci Rep. 2016 Apr 22;6:24333.


The RNA-Binding Chaperone Hfq Is an Important Global Regulator of Gene Expression in Pasteurella multocida and Plays a Crucial Role in Production of a Number of Virulence Factors, Including Hyaluronic Acid Capsule.

Mégroz M, Kleifeld O, Wright A, Powell D, Harrison P, Adler B, Harper M, Boyce JD.

Infect Immun. 2016 Apr 22;84(5):1361-1370. doi: 10.1128/IAI.00122-16. Print 2016 May.


Changes in protein abundance are observed in bacterial isolates from a natural host.

Rees MA, Stinear TP, Goode RJ, Coppel RL, Smith AI, Kleifeld O.

Front Cell Infect Microbiol. 2015 Oct 14;5:71. doi: 10.3389/fcimb.2015.00071. eCollection 2015.


Base-CP proteasome can serve as a platform for stepwise lid formation.

Yu Z, Livnat-Levanon N, Kleifeld O, Mansour W, Nakasone MA, Castaneda CA, Dixon EK, Fushman D, Reis N, Pick E, Glickman MH.

Biosci Rep. 2015 Jan 27;35(3). pii: e00194. doi: 10.1042/BSR20140173.


Heterogeneous Nuclear Ribonucleoprotein M Facilitates Enterovirus Infection.

Jagdeo JM, Dufour A, Fung G, Luo H, Kleifeld O, Overall CM, Jan E.

J Virol. 2015 Jul;89(14):7064-78.


Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.


Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling.

Prakash MD, Munoz MA, Jain R, Tong PL, Koskinen A, Regner M, Kleifeld O, Ho B, Olson M, Turner SJ, Mrass P, Weninger W, Bird PI.

Immunity. 2014 Dec 18;41(6):960-72. doi: 10.1016/j.immuni.2014.11.012. Epub 2014 Nov 28.


LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.

Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM.

Nat Methods. 2015 Jan;12(1):55-8. doi: 10.1038/nmeth.3177. Epub 2014 Nov 24.


Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.

Mansour W, Nakasone MA, von Delbrück M, Yu Z, Krutauz D, Reis N, Kleifeld O, Sommer T, Fushman D, Glickman MH.

J Biol Chem. 2015 Feb 20;290(8):4688-704. doi: 10.1074/jbc.M114.568295. Epub 2014 Nov 11.


Proteomic characterization of a natural host-pathogen interaction: repertoire of in vivo expressed bacterial and host surface-associated proteins.

Rees MA, Kleifeld O, Crellin PK, Ho B, Stinear TP, Smith AI, Coppel RL.

J Proteome Res. 2015 Jan 2;14(1):120-32. doi: 10.1021/pr5010086. Epub 2014 Oct 30.


Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase.

Au AE, Sashindranath M, Borg RJ, Kleifeld O, Andrews RK, Gardiner EE, Medcalf RL, Samson AL.

Cell Death Dis. 2014 Sep 11;5:e1410. doi: 10.1038/cddis.2014.373.


Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

Samson AL, Knaupp AS, Kass I, Kleifeld O, Marijanovic EM, Hughes VA, Lupton CJ, Buckle AM, Bottomley SP, Medcalf RL.

J Biol Chem. 2014 Sep 26;289(39):26922-36. doi: 10.1074/jbc.M114.570275. Epub 2014 Aug 1.


Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.

Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9.


Reversible 26S proteasome disassembly upon mitochondrial stress.

Livnat-Levanon N, Kevei É, Kleifeld O, Krutauz D, Segref A, Rinaldi T, Erpapazoglou Z, Cohen M, Reis N, Hoppe T, Glickman MH.

Cell Rep. 2014 Jun 12;7(5):1371-1380. doi: 10.1016/j.celrep.2014.04.030. Epub 2014 May 22.


Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB.

Alonso H, Kleifeld O, Yeheskel A, Ong PC, Liu YC, Stok JE, De Voss JJ, Roujeinikova A.

Biochem J. 2014 Jun 1;460(2):283-93. doi: 10.1042/BJ20131648.


Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system.

Singh RK, Zerath S, Kleifeld O, Scheffner M, Glickman MH, Fushman D.

Mol Cell Proteomics. 2012 Dec;11(12):1595-611. doi: 10.1074/mcp.M112.022467. Epub 2012 Oct 26.


Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria.

Keren-Kaplan T, Attali I, Motamedchaboki K, Davis BA, Tanner N, Reshef Y, Laudon E, Kolot M, Levin-Kravets O, Kleifeld O, Glickman M, Horazdovsky BF, Wolf DA, Prag G.

EMBO J. 2012 Jan 18;31(2):378-90. doi: 10.1038/emboj.2011.397. Epub 2011 Nov 11.


Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates.

Kleifeld O, Doucet A, Prudova A, auf dem Keller U, Gioia M, Kizhakkedathu JN, Overall CM.

Nat Protoc. 2011 Sep 22;6(10):1578-611. doi: 10.1038/nprot.2011.382.


Identification of proteolytic products and natural protein N-termini by Terminal Amine Isotopic Labeling of Substrates (TAILS).

Doucet A, Kleifeld O, Kizhakkedathu JN, Overall CM.

Methods Mol Biol. 2011;753:273-87. doi: 10.1007/978-1-61779-148-2_18.


A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.

Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O.

Mol Cell Proteomics. 2011 May;10(5):M111.009753. doi: 10.1074/mcp.M111.009753. Epub 2011 Mar 22.


Nuclear import of an intact preassembled proteasome particle.

Savulescu AF, Shorer H, Kleifeld O, Cohen I, Gruber R, Glickman MH, Harel A.

Mol Biol Cell. 2011 Mar 15;22(6):880-91. doi: 10.1091/mbc.E10-07-0595. Epub 2011 Feb 2.


Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.

Yu Z, Kleifeld O, Lande-Atir A, Bsoul M, Kleiman M, Krutauz D, Book A, Vierstra RD, Hofmann K, Reis N, Glickman MH, Pick E.

Mol Biol Cell. 2011 Apr;22(7):911-20. doi: 10.1091/mbc.E10-08-0655. Epub 2011 Feb 2.


Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products.

Kleifeld O, Doucet A, auf dem Keller U, Prudova A, Schilling O, Kainthan RK, Starr AE, Foster LJ, Kizhakkedathu JN, Overall CM.

Nat Biotechnol. 2010 Mar;28(3):281-8. doi: 10.1038/nbt.1611. Epub 2010 Mar 7.


The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.

Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA.

Mol Cell. 2009 Oct 9;36(1):141-52. doi: 10.1016/j.molcel.2009.09.026.


Nonconformity in ubiquitin compliance.

Ziv I, Kleifeld O, Glickman M.

EMBO J. 2009 Jul 8;28(13):1825-7. doi: 10.1038/emboj.2009.132. No abstract available.


Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome.

Matiuhin Y, Kirkpatrick DS, Ziv I, Kim W, Dakshinamurthy A, Kleifeld O, Gygi SP, Reis N, Glickman MH.

Mol Cell. 2008 Nov 7;32(3):415-25. doi: 10.1016/j.molcel.2008.10.011.


Biological Control of the Root-Knot Nematode Meloidogyne javanica by Trichoderma harzianum.

Sharon E, Bar-Eyal M, Chet I, Herrera-Estrella A, Kleifeld O, Spiegel Y.

Phytopathology. 2001 Jul;91(7):687-93. doi: 10.1094/PHYTO.2001.91.7.687.


Towards third generation matrix metalloproteinase inhibitors for cancer therapy.

Overall CM, Kleifeld O.

Br J Cancer. 2006 Apr 10;94(7):941-6. Review.


Higher metal-ligand coordination in the catalytic site of cobalt-substituted Thermoanaerobacter brockii alcohol dehydrogenase lowers the barrier for enzyme catalysis.

Kleifeld O, Rulísek L, Bogin O, Frenkel A, Havlas Z, Burstein Y, Sagi I.

Biochemistry. 2004 Jun 8;43(22):7151-61.


Structural basis for potent slow binding inhibition of human matrix metalloproteinase-2 (MMP-2).

Rosenblum G, Meroueh SO, Kleifeld O, Brown S, Singson SP, Fridman R, Mobashery S, Sagi I.

J Biol Chem. 2003 Jul 18;278(29):27009-15. Epub 2003 Apr 4.


The conserved Glu-60 residue in Thermoanaerobacter brockii alcohol dehydrogenase is not essential for catalysis.

Kleifeld O, Shi SP, Zarivach R, Eisenstein M, Sagi I.

Protein Sci. 2003 Mar;12(3):468-79.

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