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Items: 1 to 50 of 170

1.

Mitochondrial biology in airway pathogenesis and the role of NRF2.

Cho HY, Kleeberger SR.

Arch Pharm Res. 2019 Sep 4. doi: 10.1007/s12272-019-01182-5. [Epub ahead of print] Review.

PMID:
31486024
2.

Multi-walled carbon nanotubes upregulate mitochondrial gene expression and trigger mitochondrial dysfunction in primary human bronchial epithelial cells.

Snyder RJ, Verhein KC, Vellers HL, Burkholder AB, Garantziotis S, Kleeberger SR.

Nanotoxicology. 2019 Sep 3:1-18. doi: 10.1080/17435390.2019.1655107. [Epub ahead of print]

PMID:
31478767
3.

p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.

Menendez D, Snipe J, Marzec J, Innes CL, Polack FP, Caballero MT, Schurman SH, Kleeberger SR, Resnick MA.

J Clin Invest. 2019 Oct 7. pii: 128626. doi: 10.1172/JCI128626. [Epub ahead of print]

4.

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response.

Antunes KH, Fachi JL, de Paula R, da Silva EF, Pral LP, Dos Santos AÁ, Dias GBM, Vargas JE, Puga R, Mayer FQ, Maito F, Zárate-Bladés CR, Ajami NJ, Sant'Ana MR, Candreva T, Rodrigues HG, Schmiele M, Silva Clerici MTP, Proença-Modena JL, Vieira AT, Mackay CR, Mansur D, Caballero MT, Marzec J, Li J, Wang X, Bell D, Polack FP, Kleeberger SR, Stein RT, Vinolo MAR, de Souza APD.

Nat Commun. 2019 Jul 22;10(1):3273. doi: 10.1038/s41467-019-11152-6.

5.

The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants.

Ofman G, Caballero MT, Alvarez Paggi D, Marzec J, Nowogrodzki F, Cho HY, Sorgetti M, Colantonio G, Bianchi A, Prudent LM, Vain N, Mariani G, Digregorio J, Turconi EL, Osio C, Galletti F, Quiros M, Brum A, Lopez Garcia S, Garcia S, Bell D, Jones MH, Tipple TE, Kleeberger SR, Polack FP.

BMC Pediatr. 2019 Jul 6;19(1):227. doi: 10.1186/s12887-019-1610-8.

6.

Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice.

Cho HY, Miller-DeGraff L, Blankenship-Paris T, Wang X, Bell DA, Lih F, Deterding L, Panduri V, Morgan DL, Yamamoto M, Reddy AJ, Talalay P, Kleeberger SR.

Toxicol Appl Pharmacol. 2019 Feb 1;364:29-44. doi: 10.1016/j.taap.2018.12.004. Epub 2018 Dec 5.

7.

Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes.

Rusyn I, Kleeberger SR, McAllister KA, French JE, Svenson KL.

Mamm Genome. 2018 Feb;29(1-2):1-4. doi: 10.1007/s00335-018-9740-0. No abstract available.

8.

Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype.

Vellers HL, Kleeberger SR, Lightfoot JT.

Mamm Genome. 2018 Feb;29(1-2):48-62. doi: 10.1007/s00335-017-9732-5. Epub 2018 Jan 22. Review.

9.

Inter-individual variation in health and disease associated with pulmonary infectious agents.

Verhein KC, Vellers HL, Kleeberger SR.

Mamm Genome. 2018 Feb;29(1-2):38-47. doi: 10.1007/s00335-018-9733-z.

10.

Potential therapeutic targets in Nrf2-dependent protection against neonatal respiratory distress disease predicted by cDNA microarray analysis and bioinformatics tools.

Cho HY, Wang X, Li J, Bell DA, Kleeberger SR.

Curr Opin Toxicol. 2016 Dec;1:125-133. doi: 10.1016/j.cotox.2016.10.006. Epub 2016 Oct 29.

11.

Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.

Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ.

FASEB J. 2017 Oct;31(10):4600-4611. doi: 10.1096/fj.201700187R. Epub 2017 Jul 17.

12.

Correction: Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice.

Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP.

J Immunol. 2017 May 1;198(9):3755. doi: 10.4049/jimmunol.1700291. No abstract available.

13.

Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

High M, Cho HY, Marzec J, Wiltshire T, Verhein KC, Caballero MT, Acosta PL, Ciencewicki J, McCaw ZR, Kobzik L, Miller-DeGraff L, Gladwell W, Peden DB, Serra ME, Shi M, Weinberg C, Suzuki O, Wang X, Bell DA, Polack FP, Kleeberger SR.

EBioMedicine. 2016 Sep;11:73-84. doi: 10.1016/j.ebiom.2016.08.011. Epub 2016 Aug 6.

14.

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders.

Wang X, Campbell MR, Lacher SE, Cho HY, Wan M, Crowl CL, Chorley BN, Bond GL, Kleeberger SR, Slattery M, Bell DA.

Cell Rep. 2016 Apr 26;15(4):830-842. doi: 10.1016/j.celrep.2016.03.068. Epub 2016 Apr 14.

15.

Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone.

Ciencewicki JM, Verhein KC, Gerrish K, McCaw ZR, Li J, Bushel PR, Kleeberger SR.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L280-91. doi: 10.1152/ajplung.00205.2015. Epub 2016 Apr 22.

16.

Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models.

Cho HY, Kleeberger SR.

Arch Toxicol. 2015 Nov;89(11):1931-57. doi: 10.1007/s00204-015-1557-y. Epub 2015 Jul 21. Review.

17.

Functional polymorphisms in Nrf2: implications for human disease.

Cho HY, Marzec J, Kleeberger SR.

Free Radic Biol Med. 2015 Nov;88(Pt B):362-372. doi: 10.1016/j.freeradbiomed.2015.06.012. Epub 2015 Jun 25. Review.

18.

Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.

Krishnaswamy JK, Singh A, Gowthaman U, Wu R, Gorrepati P, Sales Nascimento M, Gallman A, Liu D, Rhebergen AM, Calabro S, Xu L, Ranney P, Srivastava A, Ranson M, Gorham JD, McCaw Z, Kleeberger SR, Heinz LX, Müller AC, Bennett KL, Superti-Furga G, Henao-Mejia J, Sutterwala FS, Williams A, Flavell RA, Eisenbarth SC.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61. doi: 10.1073/pnas.1501554112. Epub 2015 Feb 23.

19.

Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.

Verhein KC, McCaw Z, Gladwell W, Trivedi S, Bushel PR, Kleeberger SR.

Environ Health Perspect. 2015 Aug;123(8):799-805. doi: 10.1289/ehp.1408852. Epub 2015 Feb 6.

20.

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.

Caballero MT, Serra ME, Acosta PL, Marzec J, Gibbons L, Salim M, Rodriguez A, Reynaldi A, Garcia A, Bado D, Buchholz UJ, Hijano DR, Coviello S, Newcomb D, Bellabarba M, Ferolla FM, Libster R, Berenstein A, Siniawaski S, Blumetti V, Echavarria M, Pinto L, Lawrence A, Ossorio MF, Grosman A, Mateu CG, Bayle C, Dericco A, Pellegrini M, Igarza I, Repetto HA, Grimaldi LA, Gudapati P, Polack NR, Althabe F, Shi M, Ferrero F, Bergel E, Stein RT, Peebles RS, Boothby M, Kleeberger SR, Polack FP.

J Clin Invest. 2015 Feb;125(2):571-82. doi: 10.1172/JCI75183. Epub 2015 Jan 2.

21.

Association of Nrf2 polymorphism haplotypes with acute lung injury phenotypes in inbred strains of mice.

Cho HY, Jedlicka AE, Gladwell W, Marzec J, McCaw ZR, Bienstock RJ, Kleeberger SR.

Antioxid Redox Signal. 2015 Feb 1;22(4):325-38. doi: 10.1089/ars.2014.5942. Epub 2014 Nov 12.

22.

Noblesse oblige: NRF2 functions in the airways.

Cho HY, Kleeberger SR.

Am J Respir Cell Mol Biol. 2014 May;50(5):844-7. doi: 10.1165/rcmb.2014-0116PS.

23.

Genome-wide association mapping of acute lung injury in neonatal inbred mice.

Nichols JL, Gladwell W, Verhein KC, Cho HY, Wess J, Suzuki O, Wiltshire T, Kleeberger SR.

FASEB J. 2014 Jun;28(6):2538-50. doi: 10.1096/fj.13-247221. Epub 2014 Feb 26.

24.

A genetic model of differential susceptibility to human respiratory syncytial virus (RSV) infection.

Ciencewicki JM, Wang X, Marzec J, Serra ME, Bell DA, Polack FP, Kleeberger SR.

FASEB J. 2014 Apr;28(4):1947-56. doi: 10.1096/fj.13-239855. Epub 2014 Jan 13.

25.

Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V2O5).

Walters DM, White KM, Patel U, Davis MJ, Veluci-Marlow RM, Bhupanapadu Sunkesula SR, Bonner JC, Martin JR, Gladwell W, Kleeberger SR.

FASEB J. 2014 Mar;28(3):1098-112. doi: 10.1096/fj.13-235044. Epub 2013 Nov 27.

26.

Exacerbated airway toxicity of environmental oxidant ozone in mice deficient in Nrf2.

Cho HY, Gladwell W, Yamamoto M, Kleeberger SR.

Oxid Med Cell Longev. 2013;2013:254069. doi: 10.1155/2013/254069. Epub 2013 May 9.

27.

The influence of Nrf2 on cardiac responses to environmental stressors.

Howden R, Gougian E, Lawrence M, Cividanes S, Gladwell W, Miller-DeGraff L, Myers PH, Rouse DC, Devlin RB, Cho HY, Kleeberger SR.

Oxid Med Cell Longev. 2013;2013:901239. doi: 10.1155/2013/901239. Epub 2013 Apr 22.

28.

Genetic and environmental influences on gas exchange.

Howden R, Kleeberger SR.

Compr Physiol. 2012 Oct;2(4):2595-614. doi: 10.1002/cphy.c110060. Review.

PMID:
23720259
29.

N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner.

Messier EM, Day BJ, Bahmed K, Kleeberger SR, Tuder RM, Bowler RP, Chu HW, Mason RJ, Kosmider B.

Am J Respir Cell Mol Biol. 2013 May;48(5):559-67. doi: 10.1165/rcmb.2012-0295OC. Erratum in: Am J Respir Cell Mol Biol. 2013 Jul;49(1):165. Bahmed, Karim [added].

30.

Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans.

Marczak ED, Marzec J, Zeldin DC, Kleeberger SR, Brown NJ, Pretorius M, Lee CR.

Pharmacogenet Genomics. 2012 Aug;22(8):620-8. doi: 10.1097/FPC.0b013e32835516e5.

31.

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR, Bell DA.

Nucleic Acids Res. 2012 Aug;40(15):7416-29. doi: 10.1093/nar/gks409. Epub 2012 May 11.

32.

Targeted deletion of nrf2 impairs lung development and oxidant injury in neonatal mice.

Cho HY, van Houten B, Wang X, Miller-DeGraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, Kleeberger SR.

Antioxid Redox Signal. 2012 Oct 15;17(8):1066-82. doi: 10.1089/ars.2011.4288. Epub 2012 Apr 18.

33.

Human rhinoviruses in severe respiratory disease in very low birth weight infants.

Miller EK, Bugna J, Libster R, Shepherd BE, Scalzo PM, Acosta PL, Hijano D, Reynoso N, Batalle JP, Coviello S, Klein MI, Bauer G, Benitez A, Kleeberger SR, Polack FP.

Pediatrics. 2012 Jan;129(1):e60-7. doi: 10.1542/peds.2011-0583. Epub 2011 Dec 26.

34.

Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice.

Howden R, Cho HY, Miller-DeGraff L, Walker C, Clark JA, Myers PH, Rouse DC, Kleeberger SR.

Am J Respir Cell Mol Biol. 2012 Apr;46(4):470-8. doi: 10.1165/rcmb.2011-0204OC. Epub 2011 Nov 3.

35.

Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice.

Bauer AK, Cho HY, Miller-Degraff L, Walker C, Helms K, Fostel J, Yamamoto M, Kleeberger SR.

PLoS One. 2011;6(10):e26590. doi: 10.1371/journal.pone.0026590. Epub 2011 Oct 21.

36.

Identification of candidate genes downstream of TLR4 signaling after ozone exposure in mice: a role for heat-shock protein 70.

Bauer AK, Rondini EA, Hummel KA, Degraff LM, Walker C, Jedlicka AE, Kleeberger SR.

Environ Health Perspect. 2011 Aug;119(8):1091-7. doi: 10.1289/ehp.1003326. Epub 2011 May 4.

37.

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter.

Pendyala S, Moitra J, Kalari S, Kleeberger SR, Zhao Y, Reddy SP, Garcia JG, Natarajan V.

Free Radic Biol Med. 2011 Jun 15;50(12):1749-59. doi: 10.1016/j.freeradbiomed.2011.03.022. Epub 2011 Mar 26.

38.

The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers.

Anwar-Mohamed A, Degenhardt OS, El Gendy MA, Seubert JM, Kleeberger SR, El-Kadi AO.

Toxicol In Vitro. 2011 Jun;25(4):785-95. doi: 10.1016/j.tiv.2011.01.014. Epub 2011 Jan 31.

PMID:
21281708
39.

Impact of ABCB1 allelic variants on QTc interval prolongation.

Sissung TM, Gardner ER, Piekarz RL, Howden R, Chen X, Woo S, Franke R, Clark JA, Miller-DeGraff L, Steinberg SM, Venzon D, Liewehr D, Kleeberger SR, Bates SE, Price DK, Rosing DR, Cabell C, Sparreboom A, Figg WD.

Clin Cancer Res. 2011 Feb 15;17(4):937-46. doi: 10.1158/1078-0432.CCR-10-0925. Epub 2010 Nov 24.

40.

Protective role of interleukin-10 in ozone-induced pulmonary inflammation.

Backus GS, Howden R, Fostel J, Bauer AK, Cho HY, Marzec J, Peden DB, Kleeberger SR.

Environ Health Perspect. 2010 Dec;118(12):1721-7. doi: 10.1289/ehp.1002182. Epub 2010 Sep 8.

41.

Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone.

Hernandez ML, Lay JC, Harris B, Esther CR Jr, Brickey WJ, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Alexis NE, Peden DB.

J Allergy Clin Immunol. 2010 Sep;126(3):537-44.e1. doi: 10.1016/j.jaci.2010.06.043.

42.

Genetic mechanisms of susceptibility to ozone-induced lung disease.

Bauer AK, Kleeberger SR.

Ann N Y Acad Sci. 2010 Aug;1203:113-9. doi: 10.1111/j.1749-6632.2010.05606.x. Review.

PMID:
20716292
43.

Toxicogenetics: population-based testing of drug and chemical safety in mouse models.

Rusyn I, Gatti DM, Wiltshire T, Kleeberger SR, Threadgill DW.

Pharmacogenomics. 2010 Aug;11(8):1127-36. doi: 10.2217/pgs.10.100. Review. Erratum in: Pharmacogenomics. 2010 Sep;11(9):1344. Wilshire, Timothy [corrected to Wiltshire, Timothy].

44.

Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.

Wang X, Chorley BN, Pittman GS, Kleeberger SR, Brothers J 2nd, Liu G, Spira A, Bell DA.

PLoS One. 2010 Aug 3;5(8):e11934. doi: 10.1371/journal.pone.0011934.

45.

Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge.

Hernandez ML, Harris B, Lay JC, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Alexis NE, Peden DB.

Inhal Toxicol. 2010 Jul;22(8):648-56. doi: 10.3109/08958371003610966.

46.

Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice.

Cho HY, Gladwell W, Wang X, Chorley B, Bell D, Reddy SP, Kleeberger SR.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):170-82. doi: 10.1164/rccm.200907-1047OC. Epub 2010 Mar 11.

47.

Identification of novel susceptibility genes in ozone-induced inflammation in mice.

Bauer AK, Travis EL, Malhotra SS, Rondini EA, Walker C, Cho HY, Trivedi S, Gladwell W, Reddy S, Kleeberger SR.

Eur Respir J. 2010 Aug;36(2):428-37. doi: 10.1183/09031936.00145309. Epub 2009 Dec 23.

48.

Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis.

Bauer AK, Fostel J, Degraff LM, Rondini EA, Walker C, Grissom SF, Foley J, Kleeberger SR.

Mol Cancer. 2009 Nov 19;8:107. doi: 10.1186/1476-4598-8-107.

49.

The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects.

Alexis NE, Zhou H, Lay JC, Harris B, Hernandez ML, Lu TS, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Peden DB.

J Allergy Clin Immunol. 2009 Dec;124(6):1222-1228.e5. doi: 10.1016/j.jaci.2009.07.036.

50.

Genetic polymorphisms associated with acute lung injury.

Reddy AJ, Kleeberger SR.

Pharmacogenomics. 2009 Sep;10(9):1527-39. doi: 10.2217/pgs.09.89. Review.

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