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Items: 1 to 50 of 213


Crossover Interference, Crossover Maturation, and Human Aneuploidy.

Wang S, Liu Y, Shang Y, Zhai B, Yang X, Kleckner N, Zhang L.

Bioessays. 2019 Oct;41(10):e1800221. doi: 10.1002/bies.201800221. Epub 2019 Aug 19. Review.


Building bridges to move recombination complexes.

Dubois E, De Muyt A, Soyer JL, Budin K, Legras M, Piolot T, Debuchy R, Kleckner N, Zickler D, Espagne E.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12400-12409. doi: 10.1073/pnas.1901237116. Epub 2019 May 30.


Per-Nucleus Crossover Covariation and Implications for Evolution.

Wang S, Veller C, Sun F, Ruiz-Herrera A, Shang Y, Liu H, Zickler D, Chen Z, Kleckner N, Zhang L.

Cell. 2019 Apr 4;177(2):326-338.e16. doi: 10.1016/j.cell.2019.02.021. Epub 2019 Mar 14.


A rigorous measure of genome-wide genetic shuffling that takes into account crossover positions and Mendel's second law.

Veller C, Kleckner N, Nowak MA.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1659-1668. doi: 10.1073/pnas.1817482116. Epub 2019 Jan 11.


Coordination of Growth, Chromosome Replication/Segregation, and Cell Division in E. coli.

Kleckner NE, Chatzi K, White MA, Fisher JK, Stouf M.

Front Microbiol. 2018 Jul 9;9:1469. doi: 10.3389/fmicb.2018.01469. eCollection 2018.


Asy2/Mer2: an evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction.

Tessé S, Bourbon HM, Debuchy R, Budin K, Dubois E, Liangran Z, Antoine R, Piolot T, Kleckner N, Zickler D, Espagne E.

Genes Dev. 2017 Sep 15;31(18):1880-1893. doi: 10.1101/gad.304543.117. Epub 2017 Oct 11.


Crossover maturation inefficiency and aneuploidy in human female meiosis.

Wang S, Kleckner N, Zhang L.

Cell Cycle. 2017 Jun 3;16(11):1017-1019. doi: 10.1080/15384101.2017.1319689. Epub 2017 May 4. No abstract available.


DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora.

Gladyshev E, Kleckner N.

Nat Genet. 2017 Jun;49(6):887-894. doi: 10.1038/ng.3857. Epub 2017 May 1.


Quantitative Modeling and Automated Analysis of Meiotic Recombination.

White MA, Wang S, Zhang L, Kleckner N.

Methods Mol Biol. 2017;1471:305-323. doi: 10.1007/978-1-4939-6340-9_18.


Inefficient Crossover Maturation Underlies Elevated Aneuploidy in Human Female Meiosis.

Wang S, Hassold T, Hunt P, White MA, Zickler D, Kleckner N, Zhang L.

Cell. 2017 Mar 9;168(6):977-989.e17. doi: 10.1016/j.cell.2017.02.002. Epub 2017 Mar 2.


Interrogating the Escherichia coli cell cycle by cell dimension perturbations.

Zheng H, Ho PY, Jiang M, Tang B, Liu W, Li D, Yu X, Kleckner NE, Amir A, Liu C.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15000-15005. doi: 10.1073/pnas.1617932114. Epub 2016 Dec 12.


Questions and Assays.

Kleckner N.

Genetics. 2016 Dec;204(4):1343-1349.


Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure.

Yoon SW, Lee MS, Xaver M, Zhang L, Hong SG, Kong YJ, Cho HR, Kleckner N, Kim KP.

Nucleic Acids Res. 2016 Nov 2;44(19):9296-9314. Epub 2016 Aug 2.


Recombination-independent recognition of DNA homology for repeat-induced point mutation.

Gladyshev E, Kleckner N.

Curr Genet. 2017 Jun;63(3):389-400. doi: 10.1007/s00294-016-0649-4. Epub 2016 Sep 14. Review.


Single molecule identification of homology-dependent interactions between long ssRNA and dsDNA.

Liu C, Danilowicz C, Kleckner N, Prentiss M.

Nucleic Acids Res. 2017 Jan 25;45(2):894-901. doi: 10.1093/nar/gkw758. Epub 2016 Aug 31.


Recombination-Independent Recognition of DNA Homology for Repeat-Induced Point Mutation (RIP) Is Modulated by the Underlying Nucleotide Sequence.

Gladyshev E, Kleckner N.

PLoS Genet. 2016 May 5;12(5):e1006015. doi: 10.1371/journal.pgen.1006015. eCollection 2016 May.


A few of our favorite things: Pairing, the bouquet, crossover interference and evolution of meiosis.

Zickler D, Kleckner N.

Semin Cell Dev Biol. 2016 Jun;54:135-48. doi: 10.1016/j.semcdb.2016.02.024. Epub 2016 Feb 27. Review.


The challenge of evolving stable polyploidy: could an increase in "crossover interference distance" play a central role?

Bomblies K, Jones G, Franklin C, Zickler D, Kleckner N.

Chromosoma. 2016 Jun;125(2):287-300. doi: 10.1007/s00412-015-0571-4. Epub 2016 Jan 12. Review.


Chromosomes Progress to Metaphase in Multiple Discrete Steps via Global Compaction/Expansion Cycles.

Liang Z, Zickler D, Prentiss M, Chang FS, Witz G, Maeshima K, Kleckner N.

Cell. 2015 May 21;161(5):1124-1137. doi: 10.1016/j.cell.2015.04.030.


Recombination, Pairing, and Synapsis of Homologs during Meiosis.

Zickler D, Kleckner N.

Cold Spring Harb Perspect Biol. 2015 May 18;7(6). pii: a016626. doi: 10.1101/cshperspect.a016626. Review.


Meiotic crossover patterns: obligatory crossover, interference and homeostasis in a single process.

Wang S, Zickler D, Kleckner N, Zhang L.

Cell Cycle. 2015;14(3):305-14. doi: 10.4161/15384101.2014.991185. Review.


The bacterial nucleoid: nature, dynamics and sister segregation.

Kleckner N, Fisher JK, Stouf M, White MA, Bates D, Witz G.

Curr Opin Microbiol. 2014 Dec;22:127-37. doi: 10.1016/j.mib.2014.10.001. Review. Erratum in: Curr Opin Microbiol. 2015 Jun;25:146.


Interference-mediated synaptonemal complex formation with embedded crossover designation.

Zhang L, Espagne E, de Muyt A, Zickler D, Kleckner NE.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5059-68. doi: 10.1073/pnas.1416411111. Epub 2014 Nov 7.


Absence of SUN-domain protein Slp1 blocks karyogamy and switches meiotic recombination and synapsis from homologs to sister chromatids.

Vasnier C, de Muyt A, Zhang L, Tessé S, Kleckner NE, Zickler D, Espagne E.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4015-23. doi: 10.1073/pnas.1415758111. Epub 2014 Sep 10.


Topoisomerase II mediates meiotic crossover interference.

Zhang L, Wang S, Yin S, Hong S, Kim KP, Kleckner N.

Nature. 2014 Jul 31;511(7511):551-6. doi: 10.1038/nature13442. Epub 2014 Jul 13.


E3 ligase Hei10: a multifaceted structure-based signaling molecule with roles within and beyond meiosis.

De Muyt A, Zhang L, Piolot T, Kleckner N, Espagne E, Zickler D.

Genes Dev. 2014 May 15;28(10):1111-23. doi: 10.1101/gad.240408.114.


Direct recognition of homology between double helices of DNA in Neurospora crassa.

Gladyshev E, Kleckner N.

Nat Commun. 2014 Apr 3;5:3509. doi: 10.1038/ncomms4509.


Crossover patterning by the beam-film model: analysis and implications.

Zhang L, Liang Z, Hutchinson J, Kleckner N.

PLoS Genet. 2014 Jan 30;10(1):e1004042. doi: 10.1371/journal.pgen.1004042. eCollection 2014 Jan.


Molecular biology. Chromosome capture brings it all together.

Kleckner N, Zickler D, Witz G.

Science. 2013 Nov 22;342(6161):940-1. doi: 10.1126/science.1247514. No abstract available.


Protein-mediated chromosome pairing of repetitive arrays.

Mirkin EV, Chang FS, Kleckner N.

J Mol Biol. 2014 Feb 6;426(3):550-7. doi: 10.1016/j.jmb.2013.11.001. Epub 2013 Nov 8.


Dynamic trans interactions in yeast chromosomes.

Mirkin EV, Chang FS, Kleckner N.

PLoS One. 2013 Sep 30;8(9):e75895. doi: 10.1371/journal.pone.0075895. eCollection 2013.


The differential extension in dsDNA bound to Rad51 filaments may play important roles in homology recognition and strand exchange.

Danilowicz C, Peacock-Villada A, Vlassakis J, Facon A, Feinstein E, Kleckner N, Prentiss M.

Nucleic Acids Res. 2014 Jan;42(1):526-33. doi: 10.1093/nar/gkt867. Epub 2013 Sep 30.


The logic and mechanism of homologous recombination partner choice.

Hong S, Sung Y, Yu M, Lee M, Kleckner N, Kim KP.

Mol Cell. 2013 Aug 22;51(4):440-53. doi: 10.1016/j.molcel.2013.08.008.


Four-dimensional imaging of E. coli nucleoid organization and dynamics in living cells.

Fisher JK, Bourniquel A, Witz G, Weiner B, Prentiss M, Kleckner N.

Cell. 2013 May 9;153(4):882-95. doi: 10.1016/j.cell.2013.04.006. Epub 2013 Apr 25.


Meiotic double-strand breaks occur once per pair of (sister) chromatids and, via Mec1/ATR and Tel1/ATM, once per quartet of chromatids.

Zhang L, Kim KP, Kleckner NE, Storlazzi A.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20036-41. doi: 10.1073/pnas.1117937108. Epub 2011 Nov 28. Erratum in: Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1353.


Changes in the tension in dsDNA alter the conformation of RecA bound to dsDNA-RecA filaments.

Conover AJ, Danilowicz C, Gunaratne R, Coljee VW, Kleckner N, Prentiss M.

Nucleic Acids Res. 2011 Nov 1;39(20):8833-43. doi: 10.1093/nar/gkr561. Epub 2011 Jul 18.


Sme4 coiled-coil protein mediates synaptonemal complex assembly, recombinosome relocalization, and spindle pole body morphogenesis.

Espagne E, Vasnier C, Storlazzi A, Kleckner NE, Silar P, Zickler D, Malagnac F.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10614-9. doi: 10.1073/pnas.1107272108. Epub 2011 Jun 10.


Escherichia coli sister chromosome separation includes an abrupt global transition with concomitant release of late-splitting intersister snaps.

Joshi MC, Bourniquel A, Fisher J, Ho BT, Magnan D, Kleckner N, Bates D.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2765-70. doi: 10.1073/pnas.1019593108. Epub 2011 Jan 31.


Single-molecule studies of the stringency factors and rates governing the polymerization of RecA on double-stranded DNA.

Feinstein E, Danilowicz C, Conover A, Gunaratne R, Kleckner N, Prentiss M.

Nucleic Acids Res. 2011 May;39(9):3781-91. doi: 10.1093/nar/gkr013. Epub 2011 Jan 18.


Sister cohesion and structural axis components mediate homolog bias of meiotic recombination.

Kim KP, Weiner BM, Zhang L, Jordan A, Dekker J, Kleckner N.

Cell. 2010 Dec 10;143(6):924-37. doi: 10.1016/j.cell.2010.11.015.


Mesoscale spatial patterning in the Escherichia coli Min system: reaction-diffusion versus mechanical communication.

Kleckner N.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8053-4. doi: 10.1073/pnas.1002477107. Epub 2010 Apr 26. No abstract available.


Recombination proteins mediate meiotic spatial chromosome organization and pairing.

Storlazzi A, Gargano S, Ruprich-Robert G, Falque M, David M, Kleckner N, Zickler D.

Cell. 2010 Apr 2;141(1):94-106. doi: 10.1016/j.cell.2010.02.041.


Double Holliday junctions are intermediates of DNA break repair.

Bzymek M, Thayer NH, Oh SD, Kleckner N, Hunter N.

Nature. 2010 Apr 8;464(7290):937-41. doi: 10.1038/nature08868. Epub 2010 Mar 28.


PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis.

Grinthal A, Adamovic I, Weiner B, Karplus M, Kleckner N.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2467-72. doi: 10.1073/pnas.0914073107. Epub 2010 Jan 25.


Single molecule detection of direct, homologous, DNA/DNA pairing.

Danilowicz C, Lee CH, Kim K, Hatch K, Coljee VW, Kleckner N, Prentiss M.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19824-9. doi: 10.1073/pnas.0911214106. Epub 2009 Nov 10.


Dynamic chromosome movements during meiosis: a way to eliminate unwanted connections?

Koszul R, Kleckner N.

Trends Cell Biol. 2009 Dec;19(12):716-24. doi: 10.1016/j.tcb.2009.09.007. Epub 2009 Oct 23. Review. Erratum in: Trends Cell Biol. 2010 Feb;20(2):63.


Assaying chromosome pairing by FISH analysis of spread Saccharomyces cerevisiae nuclei.

Weiner BM, Kleckner N.

Methods Mol Biol. 2009;558:37-51. doi: 10.1007/978-1-60761-103-5_3. Review.


The structure of DNA overstretched from the 5'5' ends differs from the structure of DNA overstretched from the 3'3' ends.

Danilowicz C, Limouse C, Hatch K, Conover A, Coljee VW, Kleckner N, Prentiss M.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13196-201. doi: 10.1073/pnas.0904729106. Epub 2009 Jul 28.


Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.

Wanat JJ, Kim KP, Koszul R, Zanders S, Weiner B, Kleckner N, Alani E.

PLoS Genet. 2008 Sep 26;4(9):e1000188. doi: 10.1371/journal.pgen.1000188.

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