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Items: 1 to 50 of 156

1.

Tools and Approaches for Dissecting Protein Bacteriocin Import in Gram-Negative Bacteria.

Atanaskovic I, Kleanthous C.

Front Microbiol. 2019 Mar 28;10:646. doi: 10.3389/fmicb.2019.00646. eCollection 2019. Review.

2.

Ultrahigh specificity in a network of computationally designed protein-interaction pairs.

Netzer R, Listov D, Lipsh R, Dym O, Albeck S, Knop O, Kleanthous C, Fleishman SJ.

Nat Commun. 2018 Dec 11;9(1):5286. doi: 10.1038/s41467-018-07722-9.

3.

O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.

Sharp C, Boinett C, Cain A, Housden NG, Kumar S, Turner K, Parkhill J, Kleanthous C.

J Bacteriol. 2019 Jan 28;201(4). pii: e00545-18. doi: 10.1128/JB.00545-18. Print 2019 Feb 15.

4.

Compartmentalizing acid stress in bacteria.

Kleanthous C.

Nat Chem Biol. 2018 Nov;14(11):993-994. doi: 10.1038/s41589-018-0148-7. No abstract available.

PMID:
30323216
5.

The CcmC-CcmE interaction during cytochrome c maturation by System I is driven by protein-protein and not protein-heme contacts.

Shevket SH, Gonzalez D, Cartwright JL, Kleanthous C, Ferguson SJ, Redfield C, Mavridou DAI.

J Biol Chem. 2018 Oct 26;293(43):16778-16790. doi: 10.1074/jbc.RA118.005024. Epub 2018 Sep 11.

6.

Correction to "Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm".

Housden NG, Rassam P, Lee S, Samsudin F, Kaminska R, Sharp C, Goult JD, Francis ML, Khalid S, Bayley H, Kleanthous C.

Biochemistry. 2018 Sep 4;57(35):5270. doi: 10.1021/acs.biochem.8b00864. Epub 2018 Aug 23. No abstract available.

7.

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins.

Chavent M, Duncan AL, Rassam P, Birkholz O, Hélie J, Reddy T, Beliaev D, Hambly B, Piehler J, Kleanthous C, Sansom MSP.

Nat Commun. 2018 Jul 20;9(1):2846. doi: 10.1038/s41467-018-05255-9.

8.

Directional Porin Binding of Intrinsically Disordered Protein Sequences Promotes Colicin Epitope Display in the Bacterial Periplasm.

Housden NG, Rassam P, Lee S, Samsudin F, Kaminska R, Sharp C, Goult JD, Francis ML, Khalid S, Bayley H, Kleanthous C.

Biochemistry. 2018 Jul 24;57(29):4374-4381. doi: 10.1021/acs.biochem.8b00621. Epub 2018 Jul 6. Erratum in: Biochemistry. 2018 Sep 4;57(35):5270.

9.

Lipid binding attenuates channel closure of the outer membrane protein OmpF.

Liko I, Degiacomi MT, Lee S, Newport TD, Gault J, Reading E, Hopper JTS, Housden NG, White P, Colledge M, Sula A, Wallace BA, Kleanthous C, Stansfeld PJ, Bayley H, Benesch JLP, Allison TM, Robinson CV.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6691-6696. doi: 10.1073/pnas.1721152115. Epub 2018 Jun 11.

10.

Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.

Jackson VA, Meijer DH, Carrasquero M, van Bezouwen LS, Lowe ED, Kleanthous C, Janssen BJC, Seiradake E.

Nat Commun. 2018 Mar 14;9(1):1079. doi: 10.1038/s41467-018-03460-0.

11.

Intermembrane crosstalk drives inner-membrane protein organization in Escherichia coli.

Rassam P, Long KR, Kaminska R, Williams DJ, Papadakos G, Baumann CG, Kleanthous C.

Nat Commun. 2018 Mar 14;9(1):1082. doi: 10.1038/s41467-018-03521-4.

12.

Exploitation of an iron transporter for bacterial protein antibiotic import.

White P, Joshi A, Rassam P, Housden NG, Kaminska R, Goult JD, Redfield C, McCaughey LC, Walker D, Mohammed S, Kleanthous C.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12051-12056. doi: 10.1073/pnas.1713741114. Epub 2017 Oct 25.

13.

Carbene Footprinting Reveals Binding Interfaces of a Multimeric Membrane-Spanning Protein.

Manzi L, Barrow AS, Hopper JTS, Kaminska R, Kleanthous C, Robinson CV, Moses JE, Oldham NJ.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14873-14877. doi: 10.1002/anie.201708254. Epub 2017 Oct 20.

PMID:
28960650
14.

Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces.

Ambrose S, Housden NG, Gupta K, Fan J, White P, Yen HY, Marcoux J, Kleanthous C, Hopper JTS, Robinson CV.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14463-14468. doi: 10.1002/anie.201704849. Epub 2017 Sep 18.

15.

Diversity and distribution of nuclease bacteriocins in bacterial genomes revealed using Hidden Markov Models.

Sharp C, Bray J, Housden NG, Maiden MCJ, Kleanthous C.

PLoS Comput Biol. 2017 Jul 17;13(7):e1005652. doi: 10.1371/journal.pcbi.1005652. eCollection 2017 Jul.

16.

Orientation of the OmpF Porin in Planar Lipid Bilayers.

Ionescu SA, Lee S, Housden NG, Kaminska R, Kleanthous C, Bayley H.

Chembiochem. 2017 Mar 16;18(6):554-562. doi: 10.1002/cbic.201600644. Epub 2017 Feb 28.

PMID:
28094462
17.

The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core.

Rajasekar KV, Zdanowski K, Yan J, Hopper JT, Francis ML, Seepersad C, Sharp C, Pecqueur L, Werner JM, Robinson CV, Mohammed S, Potts JR, Kleanthous C.

Nat Commun. 2016 Jul 19;7:12194. doi: 10.1038/ncomms12194.

18.

Structural and biophysical analysis of nuclease protein antibiotics.

Klein A, Wojdyla JA, Joshi A, Josts I, McCaughey LC, Housden NG, Kaminska R, Byron O, Walker D, Kleanthous C.

Biochem J. 2016 Sep 15;473(18):2799-812. doi: 10.1042/BCJ20160544. Epub 2016 Jul 8.

19.

Discovery, characterization and in vivo activity of pyocin SD2, a protein antibiotic from Pseudomonas aeruginosa.

McCaughey LC, Josts I, Grinter R, White P, Byron O, Tucker NP, Matthews JM, Kleanthous C, Whitchurch CB, Walker D.

Biochem J. 2016 Aug 1;473(15):2345-58. doi: 10.1042/BCJ20160470. Epub 2016 Jun 1.

20.

High-resolution mass spectrometry of small molecules bound to membrane proteins.

Gault J, Donlan JA, Liko I, Hopper JT, Gupta K, Housden NG, Struwe WB, Marty MT, Mize T, Bechara C, Zhu Y, Wu B, Kleanthous C, Belov M, Damoc E, Makarov A, Robinson CV.

Nat Methods. 2016 Apr;13(4):333-6. doi: 10.1038/nmeth.3771. Epub 2016 Feb 22.

21.

Protein-protein interactions and the spatiotemporal dynamics of bacterial outer membrane proteins.

Kleanthous C, Rassam P, Baumann CG.

Curr Opin Struct Biol. 2015 Dec;35:109-15. doi: 10.1016/j.sbi.2015.10.007. Epub 2015 Nov 26. Review.

22.

The bacterial cell envelope.

Kleanthous C, Armitage JP.

Philos Trans R Soc Lond B Biol Sci. 2015 Oct 5;370(1679). pii: 20150019. doi: 10.1098/rstb.2015.0019. No abstract available.

23.

Structure and function of the Escherichia coli Tol-Pal stator protein TolR.

Wojdyla JA, Cutts E, Kaminska R, Papadakos G, Hopper JT, Stansfeld PJ, Staunton D, Robinson CV, Kleanthous C.

J Biol Chem. 2015 Oct 30;290(44):26675-87. doi: 10.1074/jbc.M115.671586. Epub 2015 Sep 9.

24.

Structures of the Ultra-High-Affinity Protein-Protein Complexes of Pyocins S2 and AP41 and Their Cognate Immunity Proteins from Pseudomonas aeruginosa.

Joshi A, Grinter R, Josts I, Chen S, Wojdyla JA, Lowe ED, Kaminska R, Sharp C, McCaughey L, Roszak AW, Cogdell RJ, Byron O, Walker D, Kleanthous C.

J Mol Biol. 2015 Aug 28;427(17):2852-66. doi: 10.1016/j.jmb.2015.07.014. Epub 2015 Jul 26.

25.

Supramolecular assemblies underpin turnover of outer membrane proteins in bacteria.

Rassam P, Copeland NA, Birkholz O, Tóth C, Chavent M, Duncan AL, Cross SJ, Housden NG, Kaminska R, Seger U, Quinn DM, Garrod TJ, Sansom MS, Piehler J, Baumann CG, Kleanthous C.

Nature. 2015 Jul 16;523(7560):333-6. doi: 10.1038/nature14461. Epub 2015 Jun 10.

26.

Consequences of inducing intrinsic disorder in a high-affinity protein-protein interaction.

Papadakos G, Sharma A, Lancaster LE, Bowen R, Kaminska R, Leech AP, Walker D, Redfield C, Kleanthous C.

J Am Chem Soc. 2015 Apr 29;137(16):5252-5. doi: 10.1021/ja512607r. Epub 2015 Apr 17.

PMID:
25856265
27.

Blind prediction of interfacial water positions in CAPRI.

Lensink MF, Moal IH, Bates PA, Kastritis PL, Melquiond AS, Karaca E, Schmitz C, van Dijk M, Bonvin AM, Eisenstein M, Jiménez-García B, Grosdidier S, Solernou A, Pérez-Cano L, Pallara C, Fernández-Recio J, Xu J, Muthu P, Praneeth Kilambi K, Gray JJ, Grudinin S, Derevyanko G, Mitchell JC, Wieting J, Kanamori E, Tsuchiya Y, Murakami Y, Sarmiento J, Standley DM, Shirota M, Kinoshita K, Nakamura H, Chavent M, Ritchie DW, Park H, Ko J, Lee H, Seok C, Shen Y, Kozakov D, Vajda S, Kundrotas PJ, Vakser IA, Pierce BG, Hwang H, Vreven T, Weng Z, Buch I, Farkash E, Wolfson HJ, Zacharias M, Qin S, Zhou HX, Huang SY, Zou X, Wojdyla JA, Kleanthous C, Wodak SJ.

Proteins. 2014 Apr;82(4):620-32. doi: 10.1002/prot.24439. Epub 2013 Nov 23.

28.

Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement.

Vankemmelbeke M, Housden NG, James R, Kleanthous C, Penfold CN.

Microbiologyopen. 2013 Oct;2(5):853-61. doi: 10.1002/mbo3.122. Epub 2013 Aug 28.

29.

Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF.

Housden NG, Hopper JT, Lukoyanova N, Rodriguez-Larrea D, Wojdyla JA, Klein A, Kaminska R, Bayley H, Saibil HR, Robinson CV, Kleanthous C.

Science. 2013 Jun 28;340(6140):1570-4. doi: 10.1126/science.1237864.

30.

A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.

Farrance OE, Hann E, Kaminska R, Housden NG, Derrington SR, Kleanthous C, Radford SE, Brockwell DJ.

PLoS Biol. 2013;11(2):e1001489. doi: 10.1371/journal.pbio.1001489. Epub 2013 Feb 19.

31.

Colicin translocation across the Escherichia coli outer membrane.

Housden NG, Kleanthous C.

Biochem Soc Trans. 2012 Dec 1;40(6):1475-9. doi: 10.1042/BST20120255. Review.

PMID:
23176501
32.

How bugs kill bugs: progress and challenges in bacteriocin research.

Penfold CN, Walker D, Kleanthous C.

Biochem Soc Trans. 2012 Dec 1;40(6):1433-7. doi: 10.1042/BST20120253.

PMID:
23176494
33.

Kinetic basis for the competitive recruitment of TolB by the intrinsically disordered translocation domain of colicin E9.

Papadakos G, Housden NG, Lilly KJ, Kaminska R, Kleanthous C.

J Mol Biol. 2012 May 18;418(5):269-80. doi: 10.1016/j.jmb.2012.01.039. Epub 2012 Jan 30.

34.

Structure of the ultra-high-affinity colicin E2 DNase--Im2 complex.

Wojdyla JA, Fleishman SJ, Baker D, Kleanthous C.

J Mol Biol. 2012 Mar 16;417(1-2):79-94. doi: 10.1016/j.jmb.2012.01.019. Epub 2012 Jan 27.

PMID:
22306467
35.

Conformational properties of the unfolded state of Im7 in nondenaturing conditions.

Pashley CL, Morgan GJ, Kalverda AP, Thompson GS, Kleanthous C, Radford SE.

J Mol Biol. 2012 Feb 17;416(2):300-18. doi: 10.1016/j.jmb.2011.12.041. Epub 2011 Dec 28.

36.

Nuclease colicins and their immunity proteins.

Papadakos G, Wojdyla JA, Kleanthous C.

Q Rev Biophys. 2012 Feb;45(1):57-103. doi: 10.1017/S0033583511000114. Epub 2011 Nov 16. Review.

PMID:
22085441
37.

Thermodynamic dissection of colicin interactions.

Housden NG, Kleanthous C.

Methods Enzymol. 2011;488:123-45. doi: 10.1016/B978-0-12-381268-1.00006-9. Review.

PMID:
21195227
38.

Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF.

Housden NG, Wojdyla JA, Korczynska J, Grishkovskaya I, Kirkpatrick N, Brzozowski AM, Kleanthous C.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21412-7. doi: 10.1073/pnas.1010780107. Epub 2010 Nov 22.

39.

Swimming against the tide: progress and challenges in our understanding of colicin translocation.

Kleanthous C.

Nat Rev Microbiol. 2010 Dec;8(12):843-8. doi: 10.1038/nrmicro2454. Epub 2010 Nov 9. Review.

PMID:
21060316
40.

Structural basis for 16S ribosomal RNA cleavage by the cytotoxic domain of colicin E3.

Ng CL, Lang K, Meenan NA, Sharma A, Kelley AC, Kleanthous C, Ramakrishnan V.

Nat Struct Mol Biol. 2010 Oct;17(10):1241-1246. doi: 10.1038/nsmb.1896. Epub 2010 Sep 19.

41.

TolA modulates the oligomeric status of YbgF in the bacterial periplasm.

Krachler AM, Sharma A, Cauldwell A, Papadakos G, Kleanthous C.

J Mol Biol. 2010 Oct 22;403(2):270-85. doi: 10.1016/j.jmb.2010.08.050. Epub 2010 Sep 15.

PMID:
20816983
42.

The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction.

Meenan NA, Sharma A, Fleishman SJ, Macdonald CJ, Morel B, Boetzel R, Moore GR, Baker D, Kleanthous C.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10080-5. doi: 10.1073/pnas.0910756107. Epub 2010 May 17.

43.

Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomer.

Krachler AM, Sharma A, Kleanthous C.

Proteins. 2010 Jul;78(9):2131-43. doi: 10.1002/prot.22726.

PMID:
20455268
44.

Translocator hunt comes full Cir-Col.

Kleanthous C.

Mol Microbiol. 2010 Feb;75(3):529-33. doi: 10.1111/j.1365-2958.2009.06967.x. Epub 2009 Dec 23.

45.

Following evolutionary paths to protein-protein interactions with high affinity and selectivity.

Levin KB, Dym O, Albeck S, Magdassi S, Keeble AH, Kleanthous C, Tawfik DS.

Nat Struct Mol Biol. 2009 Oct;16(10):1049-55. doi: 10.1038/nsmb.1670. Epub 2009 Sep 13.

PMID:
19749752
46.

Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.

Bonsor DA, Hecht O, Vankemmelbeke M, Sharma A, Krachler AM, Housden NG, Lilly KJ, James R, Moore GR, Kleanthous C.

EMBO J. 2009 Sep 16;28(18):2846-57. doi: 10.1038/emboj.2009.224. Epub 2009 Aug 20. Erratum in: EMBO J. 2009 Sep 16;28(18):2858.

47.

Energy-dependent immunity protein release during tol-dependent nuclease colicin translocation.

Vankemmelbeke M, Zhang Y, Moore GR, Kleanthous C, Penfold CN, James R.

J Biol Chem. 2009 Jul 10;284(28):18932-41. doi: 10.1074/jbc.M806149200. Epub 2009 May 19.

48.

Colicins exploit native disorder to gain cell entry: a hitchhiker's guide to translocation.

Bonsor DA, Meenan NA, Kleanthous C.

Biochem Soc Trans. 2008 Dec;36(Pt 6):1409-13. doi: 10.1042/BST0361409. Review.

PMID:
19021565
49.

Colicin E3 cleavage of 16S rRNA impairs decoding and accelerates tRNA translocation on Escherichia coli ribosomes.

Lancaster LE, Savelsbergh A, Kleanthous C, Wintermeyer W, Rodnina MV.

Mol Microbiol. 2008 Jul;69(2):390-401. doi: 10.1111/j.1365-2958.2008.06283.x.

50.

Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.

Keeble AH, Joachimiak LA, Maté MJ, Meenan N, Kirkpatrick N, Baker D, Kleanthous C.

J Mol Biol. 2008 Jun 13;379(4):745-59. doi: 10.1016/j.jmb.2008.03.055. Epub 2008 Apr 3.

PMID:
18471830

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