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Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis.

de Araujo LS, Pessler K, Sühs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F.

J Transl Med. 2020 Jan 7;18(1):9. doi: 10.1186/s12967-019-02179-w.


Common pre-diagnostic features in individuals with different rare diseases represent a key for diagnostic support with computerized pattern recognition?

Grigull L, Mehmecke S, Rother AK, Blöß S, Klemann C, Schumacher U, Mücke U, Kortum X, Lechner W, Klawonn F.

PLoS One. 2019 Oct 10;14(10):e0222637. doi: 10.1371/journal.pone.0222637. eCollection 2019.


Bacterial load and pathogenic species on healthcare personnel attire: implications of alcohol hand-rub use, profession, and time of duty.

Ambrosch A, Wahrburg K, Klawonn F.

J Hosp Infect. 2019 Apr;101(4):414-421. doi: 10.1016/j.jhin.2018.10.017. Epub 2018 Oct 26.


Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.

Döring M, Blees H, Koller N, Tischer-Zimmermann S, Müsken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampé R, Kalinke U.

Blood Adv. 2019 Mar 26;3(6):839-850. doi: 10.1182/bloodadvances.2018027268.


xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery.

Franke R, Hinkelmann B, Fetz V, Stradal T, Sasse F, Klawonn F, Brönstrup M.

SLAS Discov. 2019 Mar;24(3):213-223. doi: 10.1177/2472555218819459. Epub 2019 Jan 25.


Künstliche Intelligenz zur diagnostischen Unterstützung ausgewählter seltener lysosomaler Speichererkrankungen: Ergebnisse einer Pilotstudie.

Sieg AL, Martin Das A, Maria Muschol N, Köhn A, Lampe C, Kortum X, Mehmecke S, Blöß S, Lechner W, Klawonn F, Grigull L.

Klin Padiatr. 2019 Mar;231(2):60-66. doi: 10.1055/a-0816-5681. Epub 2019 Jan 10. German.


Bacterial community structure and effects of picornavirus infection on the anterior nares microbiome in early childhood.

Caputo M, Zoch-Lesniak B, Karch A, Vital M, Meyer F, Klawonn F, Baillot A, Pieper DH, Mikolajczyk RT.

BMC Microbiol. 2019 Jan 7;19(1):1. doi: 10.1186/s12866-018-1372-8.


Induced B Cell Development in Adult Mice.

Brennecke AM, Düber S, Roy B, Thomsen I, Garbe AI, Klawonn F, Pabst O, Kretschmer K, Weiss S.

Front Immunol. 2018 Oct 31;9:2483. doi: 10.3389/fimmu.2018.02483. eCollection 2018.


Clostridioides difficile Activates Human Mucosal-Associated Invariant T Cells.

Bernal I, Hofmann JD, Bulitta B, Klawonn F, Michel AM, Jahn D, Neumann-Schaal M, Bruder D, Jänsch L.

Front Microbiol. 2018 Oct 25;9:2532. doi: 10.3389/fmicb.2018.02532. eCollection 2018.


Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition.

Lang D, Schott BH, van Ham M, Morton L, Kulikovskaja L, Herrera-Molina R, Pielot R, Klawonn F, Montag D, Jänsch L, Gundelfinger ED, Smalla KH, Dunay IR.

J Neuroinflammation. 2018 Aug 1;15(1):216. doi: 10.1186/s12974-018-1242-1.


Proteome analysis of human CD56neg NK cells reveals a homogeneous phenotype surprisingly similar to CD56dim NK cells.

Voigt J, Malone DFG, Dias J, Leeansyah E, Björkström NK, Ljunggren HG, Gröbe L, Klawonn F, Heyner M, Sandberg JK, Jänsch L.

Eur J Immunol. 2018 Sep;48(9):1456-1469. doi: 10.1002/eji.201747450. Epub 2018 Aug 1.


Proteomic definition of human mucosal-associated invariant T cells determines their unique molecular effector phenotype.

Bulitta B, Zuschratter W, Bernal I, Bruder D, Klawonn F, von Bergen M, Garritsen HSP, Jänsch L.

Eur J Immunol. 2018 Aug;48(8):1336-1349. doi: 10.1002/eji.201747398. Epub 2018 May 30.


External quality assessment schemes for glucose measurements in Germany: factors for successful participation, analytical performance and medical impact.

Bietenbeck A, Geilenkeuser WJ, Klawonn F, Spannagl M, Nauck M, Petersmann A, Thaler MA, Winter C, Luppa PB.

Clin Chem Lab Med. 2018 Jul 26;56(8):1238-1250. doi: 10.1515/cclm-2017-1142.


[Clinical Characteristics and Course of Infections by Influenza A- and Respiratory Syncytial Virus (RSV) in Hospitalized Adults].

Ambrosch A, Klinger A, Luber D, Arp C, Lepiorz M, Schroll S, Klawonn F.

Dtsch Med Wochenschr. 2018 May;143(9):e68-e75. doi: 10.1055/s-0044-102004. Epub 2018 Mar 6. German.


Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.

Kuhn M, Sühs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F.

J Neuroinflammation. 2018 Jan 17;15(1):20. doi: 10.1186/s12974-017-1041-0.


Sweep Dynamics (SD) plots: Computational identification of selective sweeps to monitor the adaptation of influenza A viruses.

Klingen TR, Reimering S, Loers J, Mooren K, Klawonn F, Krey T, Gabriel G, McHardy AC.

Sci Rep. 2018 Jan 10;8(1):373. doi: 10.1038/s41598-017-18791-z.


Effects of pathogen dependency in a multi-pathogen infectious disease system including population level heterogeneity - a simulation study.

Bakuli A, Klawonn F, Karch A, Mikolajczyk R.

Theor Biol Med Model. 2017 Dec 13;14(1):26. doi: 10.1186/s12976-017-0072-7.


TCR signalling network organization at the immunological synapses of murine regulatory T cells.

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.

Eur J Immunol. 2017 Dec;47(12):2043-2058. doi: 10.1002/eji.201747041. Epub 2017 Sep 12.


CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation.

Lingel H, Wissing J, Arra A, Schanze D, Lienenklaus S, Klawonn F, Pierau M, Zenker M, Jänsch L, Brunner-Weinzierl MC.

Cell Death Differ. 2017 Oct;24(10):1739-1749. doi: 10.1038/cdd.2017.102. Epub 2017 Jun 23.


Stronger Together: Aggregated Z-values of Traditional Quality Control Measurements and Patient Medians Improve Detection of Biases.

Bietenbeck A, Thaler MA, Luppa PB, Klawonn F.

Clin Chem. 2017 Aug;63(8):1377-1387. doi: 10.1373/clinchem.2016.269845. Epub 2017 Jun 14.


Patient's Experience in Pediatric Primary Immunodeficiency Disorders: Computerized Classification of Questionnaires.

Mücke U, Klemann C, Baumann U, Meyer-Bahlburg A, Kortum X, Klawonn F, Lechner WM, Grigull L.

Front Immunol. 2017 Apr 5;8:384. doi: 10.3389/fimmu.2017.00384. eCollection 2017.


[On the fast track to diagnosis : Recommendations for patients without a diagnosis].

Stieber C, Mücke M, Windheuser IC, Grigull L, Klawonn F, Tunc S, Münchau A, Klockgether T.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017 May;60(5):517-522. doi: 10.1007/s00103-017-2535-8. German.


Diagnostic needs for rare diseases and shared prediagnostic phenomena: Results of a German-wide expert Delphi survey.

Blöß S, Klemann C, Rother AK, Mehmecke S, Schumacher U, Mücke U, Mücke M, Stieber C, Klawonn F, Kortum X, Lechner W, Grigull L.

PLoS One. 2017 Feb 24;12(2):e0172532. doi: 10.1371/journal.pone.0172532. eCollection 2017.


Analysis of Practical Identifiability of a Viral Infection Model.

Nguyen VK, Klawonn F, Mikolajczyk R, Hernandez-Vargas EA.

PLoS One. 2016 Dec 30;11(12):e0167568. doi: 10.1371/journal.pone.0167568. eCollection 2016.


Alignment of time-resolved data from high throughput experiments.

Abidi N, Franke R, Findeisen P, Klawonn F.

J Bioinform Comput Biol. 2016 Dec;14(6):1650030. doi: 10.1142/S021972001650030X. Epub 2016 Aug 3.


Transcriptome-Wide High-Density Microarray Analysis Reveals Differential Gene Transcription in Periprosthetic Tissue From Hips With Chronic Periprosthetic Joint Infection vs Aseptic Loosening.

Omar M, Klawonn F, Brand S, Stiesch M, Krettek C, Eberhard J.

J Arthroplasty. 2017 Jan;32(1):234-240. doi: 10.1016/j.arth.2016.06.036. Epub 2016 Jun 29.


Listeriosis downregulates hepatic cytochrome P450 enzymes in sublethal murine infection.

Kummer A, Nishanth G, Koschel J, Klawonn F, Schlüter D, Jänsch L.

Proteomics Clin Appl. 2016 Oct;10(9-10):1025-1035. doi: 10.1002/prca.201600030. Epub 2016 Jun 27.


Transcriptome Profiling of Antimicrobial Resistance in Pseudomonas aeruginosa.

Khaledi A, Schniederjans M, Pohl S, Rainer R, Bodenhofer U, Xia B, Klawonn F, Bruchmann S, Preusse M, Eckweiler D, Dötsch A, Häussler S.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4722-33. doi: 10.1128/AAC.00075-16. Print 2016 Aug.


Diagnostic support for selected neuromuscular diseases using answer-pattern recognition and data mining techniques: a proof of concept multicenter prospective trial.

Grigull L, Lechner W, Petri S, Kollewe K, Dengler R, Mehmecke S, Schumacher U, Lücke T, Schneider-Gold C, Köhler C, Güttsches AK, Kortum X, Klawonn F.

BMC Med Inform Decis Mak. 2016 Mar 8;16:31. doi: 10.1186/s12911-016-0268-5.


Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor α and β.

Seeger B, Klawonn F, Nguema Bekale B, Steinberg P.

PLoS One. 2016 Jan 26;11(1):e0147490. doi: 10.1371/journal.pone.0147490. eCollection 2016.


Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells.

Vogel S, Grabski E, Buschjäger D, Klawonn F, Döring M, Wang J, Fletcher E, Bechmann I, Witte T, Durisin M, Schraven B, Mangsbo SM, Schönfeld K, Czeloth N, Kalinke U.

Sci Rep. 2015 Dec 16;5:18308. doi: 10.1038/srep18308.


The ability of the YAS and AR CALUX assays to detect the additive effects of anti-androgenic fungicide mixtures.

Seeger B, Klawonn F, Bekale BN, Steinberg P.

Toxicol Lett. 2016 Jan 22;241:193-9. doi: 10.1016/j.toxlet.2015.11.015. Epub 2015 Nov 19.


The LasB Elastase of Pseudomonas aeruginosa Acts in Concert with Alkaline Protease AprA To Prevent Flagellin-Mediated Immune Recognition.

Casilag F, Lorenz A, Krueger J, Klawonn F, Weiss S, Häussler S.

Infect Immun. 2015 Oct 26;84(1):162-71. doi: 10.1128/IAI.00939-15. Print 2016 Jan.


Diagnostic Support for Selected Paediatric Pulmonary Diseases Using Answer-Pattern Recognition in Questionnaires Based on Combined Data Mining Applications--A Monocentric Observational Pilot Study.

Rother AK, Schwerk N, Brinkmann F, Klawonn F, Lechner W, Grigull L.

PLoS One. 2015 Aug 12;10(8):e0135180. doi: 10.1371/journal.pone.0135180. eCollection 2015.


Linear Discriminant Analysis Identifies Mitochondrially Localized Proteins in Neurospora crassa.

Wirsing L, Klawonn F, Sassen WA, Lünsdorf H, Probst C, Hust M, Mendel RR, Kruse T, Jänsch L.

J Proteome Res. 2015 Sep 4;14(9):3900-11. doi: 10.1021/acs.jproteome.5b00329. Epub 2015 Aug 10.


Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains.

Preusse M, Schughart K, Wilk E, Klawonn F, Pessler F.

BMC Res Notes. 2015 Jun 6;8:225. doi: 10.1186/s13104-015-1195-8.


Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure.

Pfaender S, Walter S, Todt D, Behrendt P, Doerrbecker J, Wölk B, Engelmann M, Gravemann U, Seltsam A, Steinmann J, Burbelo PD, Klawonn F, Feige K, Pietschmann T, Cavalleri JM, Steinmann E.

J Gen Virol. 2015 Sep;96(9):2636-42. doi: 10.1099/vir.0.000208. Epub 2015 Jun 3.


Optimized leaf ordering with class labels for hierarchical clustering.

Novoselova N, Wang J, Klawonn F.

J Bioinform Comput Biol. 2015 Aug;13(4):1550012. doi: 10.1142/S0219720015500122. Epub 2015 Mar 2.


Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection.

Worthmann H, Tryc AB, Dirks M, Schuppner R, Brand K, Klawonn F, Lichtinghagen R, Weissenborn K.

J Neuroinflammation. 2015 Jan 23;12:13. doi: 10.1186/s12974-014-0231-2.


The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung.

Wu CF, Andzinski L, Kasnitz N, Kröger A, Klawonn F, Lienenklaus S, Weiss S, Jablonska J.

Int J Cancer. 2015 Aug 15;137(4):837-47. doi: 10.1002/ijc.29444. Epub 2015 Feb 5.


Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters.

Rand U, Riedel J, Hillebrand U, Shin D, Willenberg S, Behme S, Klawonn F, Köster M, Hauser H, Wirth D.

Biotechnol J. 2015 Feb;10(2):323-31. doi: 10.1002/biot.201400076. Epub 2015 Feb 6.


High-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis.

Szafranski SP, Wos-Oxley ML, Vilchez-Vargas R, Jáuregui R, Plumeier I, Klawonn F, Tomasch J, Meisinger C, Kühnisch J, Sztajer H, Pieper DH, Wagner-Döbler I.

Appl Environ Microbiol. 2015 Feb;81(3):1047-58. doi: 10.1128/AEM.03534-14. Epub 2014 Dec 1.


Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.

Milanez-Almeida P, Klawonn F, Meyer-Hermann M, Huehn J.

Eur J Microbiol Immunol (Bp). 2014 Sep;4(3):147-55. doi: 10.1556/EUJMI-D-14-00022. Epub 2014 Sep 11.


HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies.

Shevchuk O, Abidi N, Klawonn F, Wissing J, Nimtz M, Kugler C, Steinert M, Goldmann T, Jänsch L.

J Proteome Res. 2014 Nov 7;13(11):5230-9. doi: 10.1021/pr500096a. Epub 2014 Apr 28.


HUM calculator and HUM package for R: easy-to-use software tools for multicategory receiver operating characteristic analysis.

Novoselova N, Della Beffa C, Wang J, Li J, Pessler F, Klawonn F.

Bioinformatics. 2014 Jun 1;30(11):1635-6. doi: 10.1093/bioinformatics/btu086. Epub 2014 Feb 10.


Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice.

Preusse M, Tantawy MA, Klawonn F, Schughart K, Pessler F.

BMC Microbiol. 2013 Dec 17;13:293. doi: 10.1186/1471-2180-13-293.


The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification.

Della Beffa C, Slansky E, Pommerenke C, Klawonn F, Li J, Dai L, Schumacher HR Jr, Pessler F.

PLoS One. 2013 Aug 8;8(8):e72494. doi: 10.1371/journal.pone.0072494. eCollection 2013.


A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.

Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L.

Cell. 2013 Apr 11;153(2):389-401. doi: 10.1016/j.cell.2013.03.026.


Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions.

Scheiter M, Bulitta B, van Ham M, Klawonn F, König S, Jänsch L.

Front Immunol. 2013 Mar 18;4:66. doi: 10.3389/fimmu.2013.00066. eCollection 2013.


Proteome analysis of distinct developmental stages of human natural killer (NK) cells.

Scheiter M, Lau U, van Ham M, Bulitta B, Gröbe L, Garritsen H, Klawonn F, König S, Jänsch L.

Mol Cell Proteomics. 2013 May;12(5):1099-114. doi: 10.1074/mcp.M112.024596. Epub 2013 Jan 13.

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