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Items: 1 to 50 of 280

1.

Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection.

Aravanis AM, Lee M, Klausner RD.

Cell. 2017 Feb 9;168(4):571-574. doi: 10.1016/j.cell.2017.01.030.

2.

Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma.

Riss J, Khanna C, Koo S, Chandramouli GV, Yang HH, Hu Y, Kleiner DE, Rosenwald A, Schaefer CF, Ben-Sasson SA, Yang L, Powell J, Kane DW, Star RA, Aprelikova O, Bauer K, Vasselli JR, Maranchie JK, Kohn KW, Buetow KH, Linehan WM, Weinstein JN, Lee MP, Klausner RD, Barrett JC.

Cancer Res. 2006 Jul 15;66(14):7216-24.

3.

An audience with... Richard D. Klausner.

Klausner RD.

Nat Rev Drug Discov. 2004 Jun;3(6):470. No abstract available.

PMID:
15214330
4.

Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location.

Maranchie JK, Afonso A, Albert PS, Kalyandrug S, Phillips JL, Zhou S, Peterson J, Ghadimi BM, Hurley K, Riss J, Vasselli JR, Ried T, Zbar B, Choyke P, Walther MM, Klausner RD, Linehan WM.

Hum Mutat. 2004 Jan;23(1):40-6.

PMID:
14695531
5.

Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma.

Rosenwald A, Wright G, Leroy K, Yu X, Gaulard P, Gascoyne RD, Chan WC, Zhao T, Haioun C, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Campo E, Montserrat E, Lopez-Guillermo A, Ott G, Muller-Hermelink HK, Connors JM, Braziel R, Grogan TM, Fisher RI, Miller TP, LeBlanc M, Chiorazzi M, Zhao H, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Staudt LM.

J Exp Med. 2003 Sep 15;198(6):851-62.

6.

Medicine. The need for a global HIV vaccine enterprise.

Klausner RD, Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, Kazatchkine MD, McMichael AJ, Makgoba MW, Pantaleo G, Piot P, Shao Y, Tramont E, Varmus H, Wasserheit JN.

Science. 2003 Jun 27;300(5628):2036-9.

PMID:
12829768
7.

Predicting survival in patients with metastatic kidney cancer by gene-expression profiling in the primary tumor.

Vasselli JR, Shih JH, Iyengar SR, Maranchie J, Riss J, Worrell R, Torres-Cabala C, Tabios R, Mariotti A, Stearman R, Merino M, Walther MM, Simon R, Klausner RD, Linehan WM.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6958-63. Epub 2003 May 30.

8.

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma.

Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J, Staudt LM.

Cancer Cell. 2003 Feb;3(2):185-97.

9.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA; Mammalian Gene Collection Program Team.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

10.

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.

Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29.

11.

The fabric of cancer cell biology-Weaving together the strands.

Klausner RD.

Cancer Cell. 2002 Feb;1(1):3-10. Review. No abstract available.

12.

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.

Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD.

Cancer Cell. 2002 Apr;1(3):247-55.

13.

Cancer Molecular Analysis Project: weaving a rich cancer research tapestry.

Buetow KH, Klausner RD, Fine H, Kaplan R, Singer DS, Strausberg RL.

Cancer Cell. 2002 May;1(4):315-8. Review.

14.

The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.

Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM; Lymphoma/Leukemia Molecular Profiling Project.

N Engl J Med. 2002 Jun 20;346(25):1937-47.

15.

VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.

Bindra RS, Vasselli JR, Stearman R, Linehan WM, Klausner RD.

Cancer Res. 2002 Jun 1;62(11):3014-9.

16.

Reductive iron uptake by Candida albicans: role of copper, iron and the TUP1 regulator.

Knight SA, Lesuisse E, Stearman R, Klausner RD, Dancis A.

Microbiology. 2002 Jan;148(Pt 1):29-40.

PMID:
11782496
17.

Biomedicine. The NASA-NCI collaboration on biomolecular sensors.

Goldin DS, Dahl CA, Olsen KL, Ostrach LH, Klausner RD.

Science. 2001 Apr 20;292(5516):443-4. No abstract available.

PMID:
11330296
18.

Molecular cytogenetic characterization of early and late renal cell carcinomas in von Hippel-Lindau disease.

Phillips JL, Ghadimi BM, Wangsa D, Padilla-Nash H, Worrell R, Hewitt S, Walther M, Linehan WM, Klausner RD, Ried T.

Genes Chromosomes Cancer. 2001 May;31(1):1-9.

PMID:
11284029
19.

Molecular profiling of clinical tissues specimens: feasibility and applications.

Emmert-Buck MR, Strausberg RL, Krizman DB, Bonaldo MF, Bonner RF, Bostwick DG, Brown MR, Buetow KH, Chuaqui RF, Cole KA, Duray PH, Englert CR, Gillespie JW, Greenhut S, Grouse L, Hillier LW, Katz KS, Klausner RD, Kuznetzov V, Lash AE, Lennon G, Linehan WM, Liotta LA, Marra MA, Munson PJ, Ornstein DK, Prabhu VV, Prang C, Schuler GD, Soares MB, Tolstoshev CM, Vocke CD, Waterston RH.

J Mol Diagn. 2000 May;2(2):60-6. Review. No abstract available.

20.

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.

de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S.

Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1387-92. Epub 2001 Feb 6.

21.

Foreword

Klausner RD.

J Natl Cancer Inst Monogr. 1999;(25):1. No abstract available.

PMID:
10854445
22.

Molecular profiling of clinical tissue specimens: feasibility and applications.

Emmert-Buck MR, Strausberg RL, Krizman DB, Bonaldo MF, Bonner RF, Bostwick DG, Brown MR, Buetow KH, Chuaqui RF, Cole KA, Duray PH, Englert CR, Gillespie JW, Greenhut S, Grouse L, Hillier LW, Katz KS, Klausner RD, Kuznetzov V, Lash AE, Lennon G, Linehan WM, Liotta LA, Marra MA, Munson PJ, Ornstein DK, Prabhu VV, Prange C, Schuler GD, Soares MB, Tolstoshev CM, Vocke CD, Waterston RH.

Am J Pathol. 2000 Apr;156(4):1109-15. Review. No abstract available.

23.

A systematic, high-resolution linkage of the cytogenetic and physical maps of the human genome.

Kirsch IR, Green ED, Yonescu R, Strausberg R, Carter N, Bentley D, Leversha MA, Dunham I, Braden VV, Hilgenfeld E, Schuler G, Lash AE, Shen GL, Martelli M, Kuehl WM, Klausner RD, Ried T.

Nat Genet. 2000 Apr;24(4):339-40. No abstract available.

PMID:
10742091
24.

The cancer genome anatomy project: building an annotated gene index.

Strausberg RL, Buetow KH, Emmert-Buck MR, Klausner RD.

Trends Genet. 2000 Mar;16(3):103-6. No abstract available.

PMID:
10689348
25.

Constitutional von Hippel-Lindau (VHL) gene deletions detected in VHL families by fluorescence in situ hybridization.

Pack SD, Zbar B, Pak E, Ault DO, Humphrey JS, Pham T, Hurley K, Weil RJ, Park WS, Kuzmin I, Stolle C, Glenn G, Liotta LA, Lerman MI, Klausner RD, Linehan WM, Zhuang Z.

Cancer Res. 1999 Nov 1;59(21):5560-4.

26.

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.

Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12436-41.

27.

The mammalian gene collection.

Strausberg RL, Feingold EA, Klausner RD, Collins FS.

Science. 1999 Oct 15;286(5439):455-7.

PMID:
10521335
28.

Studying cancer in the mouse.

Klausner RD.

Oncogene. 1999 Sep 20;18(38):5249-52. Review. No abstract available.

29.

The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells.

Koochekpour S, Jeffers M, Wang PH, Gong C, Taylor GA, Roessler LM, Stearman R, Vasselli JR, Stetler-Stevenson WG, Kaelin WG Jr, Linehan WM, Klausner RD, Gnarra JR, Vande Woude GF.

Mol Cell Biol. 1999 Sep;19(9):5902-12.

30.

Cancer, genomics, and the National Cancer Institute.

Klausner RD.

J Clin Invest. 1999;104 Suppl:S15-7. No abstract available.

PMID:
10453252
32.

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.

Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis GN, Klausner RD.

Mol Cell Biol. 1999 Feb;19(2):1486-97.

33.

'Breast cancer prevention trial'.

Klausner RD.

Jpn J Clin Oncol. 1998 Jul;28(7):459-60. No abstract available.

PMID:
9739790
34.

Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast.

Philpott CC, Rashford J, Yamaguchi-Iwai Y, Rouault TA, Dancis A, Klausner RD.

EMBO J. 1998 Sep 1;17(17):5026-36.

35.

Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast.

Hochstenbach F, Klis FM, van den Ende H, van Donselaar E, Peters PJ, Klausner RD.

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9161-6.

36.

Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.

Iwai K, Drake SK, Wehr NB, Weissman AM, LaVaute T, Minato N, Klausner RD, Levine RL, Rouault TA.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):4924-8.

37.

YIpDCE1 - an integrating plasmid for dual constitutive expression in yeast.

Stearman R, Dancis A, Klausner RD.

Gene. 1998 Jun 8;212(2):197-202.

PMID:
9611262
38.

The yeast CLC chloride channel functions in cation homeostasis.

Gaxiola RA, Yuan DS, Klausner RD, Fink GR.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4046-50.

39.

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal.

Pause A, Lee S, Lonergan KM, Klausner RD.

Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):993-8.

40.

Structure and dynamics of the iron responsive element RNA: implications for binding of the RNA by iron regulatory binding proteins.

Addess KJ, Basilion JP, Klausner RD, Rouault TA, Pardi A.

J Mol Biol. 1997 Nov 21;274(1):72-83.

PMID:
9398517
41.
42.

Grappling with cancer--defeatism versus the reality of progress.

Kramer BS, Klausner RD.

N Engl J Med. 1997 Sep 25;337(13):931-4; discussion 937-8. No abstract available.

PMID:
9302311
43.

Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae.

Hung IH, Suzuki M, Yamaguchi Y, Yuan DS, Klausner RD, Gitlin JD.

J Biol Chem. 1997 Aug 22;272(34):21461-6.

44.

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.

Gnarra JR, Ward JM, Porter FD, Wagner JR, Devor DE, Grinberg A, Emmert-Buck MR, Westphal H, Klausner RD, Linehan WM.

Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9102-7.

45.

Homeostatic regulation of copper uptake in yeast via direct binding of MAC1 protein to upstream regulatory sequences of FRE1 and CTR1.

Yamaguchi-Iwai Y, Serpe M, Haile D, Yang W, Kosman DJ, Klausner RD, Dancis A.

J Biol Chem. 1997 Jul 11;272(28):17711-8.

46.

Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.

Humphrey JS, Salim A, Erdos MR, Collins FS, Brody LC, Klausner RD.

Proc Natl Acad Sci U S A. 1997 May 27;94(11):5820-5.

47.

Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis.

Klomp LW, Lin SJ, Yuan DS, Klausner RD, Culotta VC, Gitlin JD.

J Biol Chem. 1997 Apr 4;272(14):9221-6.

48.

New opportunities for uncovering the molecular basis of cancer.

Strausberg RL, Dahl CA, Klausner RD.

Nat Genet. 1997 Apr;15 Spec No:415-6. No abstract available.

PMID:
9140408
49.

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.

Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD.

Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2156-61.

50.

Intramembrane bis-heme motif for transmembrane electron transport conserved in a yeast iron reductase and the human NADPH oxidase.

Finegold AA, Shatwell KP, Segal AW, Klausner RD, Dancis A.

J Biol Chem. 1996 Dec 6;271(49):31021-4.

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