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Items: 1 to 50 of 69

1.

New Human Organotypic Corneal Tissue Model for Ophthalmic Drug Delivery Studies.

Kaluzhny Y, Kinuthia MW, Truong T, Lapointe AM, Hayden P, Klausner M.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2880-2898. doi: 10.1167/iovs.18-23944.

PMID:
30025134
2.

Prevalidation of an Acute Inhalation Toxicity Test Using the EpiAirway In Vitro Human Airway Model.

Jackson GR Jr, Maione AG, Klausner M, Hayden PJ.

Appl In Vitro Toxicol. 2018 Jun 1;4(2):149-158. doi: 10.1089/aivt.2018.0004.

3.

Human Primary Cell-Based Organotypic Microtissues for Modeling Small Intestinal Drug Absorption.

Ayehunie S, Landry T, Stevens Z, Armento A, Hayden P, Klausner M.

Pharm Res. 2018 Feb 23;35(4):72. doi: 10.1007/s11095-018-2362-0.

4.

Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.

Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D.

J Virol. 2018 Mar 14;92(7). pii: e01318-17. doi: 10.1128/JVI.01318-17. Print 2018 Apr 1.

5.

Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia.

Ruppe MD, Zhang X, Imel EA, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO.

Bone Rep. 2016 May 13;5:158-162. doi: 10.1016/j.bonr.2016.05.004. eCollection 2016 Dec.

6.

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model.

Kaluzhny Y, Kandárová H, d'Argembeau-Thornton L, Kearney P, Klausner M.

J Vis Exp. 2015 Aug 23;(102):e52979. doi: 10.3791/52979.

7.

Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia.

Zhang X, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey J, Glorieux FH, Portale AA, Insogna K, Carpenter TO, Peacock M.

J Clin Pharmacol. 2016 Feb;56(2):176-85. doi: 10.1002/jcph.570. Epub 2015 Aug 11.

8.

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Kaluzhny Y, Kandárová H, Handa Y, DeLuca J, Truong T, Hunter A, Kearney P, d'Argembeau-Thornton L, Klausner M.

Altern Lab Anim. 2015 May;43(2):101-27.

PMID:
25995013
9.

Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.

Imel EA, Zhang X, Ruppe MD, Weber TJ, Klausner MA, Ito T, Vergeire M, Humphrey JS, Glorieux FH, Portale AA, Insogna K, Peacock M, Carpenter TO.

J Clin Endocrinol Metab. 2015 Jul;100(7):2565-73. doi: 10.1210/jc.2015-1551. Epub 2015 Apr 28. Erratum in: J Clin Endocrinol Metab. 2017 Jan 1;102(1):336.

10.

Characterization of a Hormone-Responsive Organotypic Human Vaginal Tissue Model: Morphologic and Immunologic Effects.

Ayehunie S, Islam A, Cannon C, Landry T, Pudney J, Klausner M, Anderson DJ.

Reprod Sci. 2015 Aug;22(8):980-90. doi: 10.1177/1933719115570906. Epub 2015 Feb 11.

11.

Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia.

Carpenter TO, Imel EA, Ruppe MD, Weber TJ, Klausner MA, Wooddell MM, Kawakami T, Ito T, Zhang X, Humphrey J, Insogna KL, Peacock M.

J Clin Invest. 2014 Apr;124(4):1587-97. doi: 10.1172/JCI72829. Epub 2014 Feb 24.

12.

Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma.

Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB.

Mol Cancer Ther. 2013 Apr;12(4):361-72. doi: 10.1158/1535-7163.MCT-12-0965. Epub 2013 Mar 29.

13.
14.

Development of an in vitro alternative assay method for vaginal irritation.

Ayehunie S, Cannon C, Larosa K, Pudney J, Anderson DJ, Klausner M.

Toxicology. 2011 Jan 11;279(1-3):130-8. doi: 10.1016/j.tox.2010.10.001. Epub 2010 Oct 17.

15.

In vitro skin irritation testing: Improving the sensitivity of the EpiDerm skin irritation test protocol.

Kandárová H, Hayden P, Klausner M, Kubilus J, Kearney P, Sheasgreen J.

Altern Lab Anim. 2009 Dec;37(6):671-89.

PMID:
20105002
16.

The MatTek story - how the three Rs principles led to 3-D tissue success!

Sheasgreen J, Klausner M, Kandárová H, Ingalls D.

Altern Lab Anim. 2009 Dec;37(6):611-22.

PMID:
20104997
17.

HIV type 1 fails to trigger innate immune factor synthesis in differentiated oral epithelium.

Nittayananta W, Hladik F, Klausner M, Harb S, Dale BA, Coombs RW.

AIDS Res Hum Retroviruses. 2009 Oct;25(10):1013-21. doi: 10.1089/aid.2009.0032.

18.

Evaluation of EpiDerm full thickness-300 (EFT-300) as an in vitro model for skin irritation: studies on aliphatic hydrocarbons.

Mallampati R, Patlolla RR, Agarwal S, Babu RJ, Hayden P, Klausner M, Singh MS.

Toxicol In Vitro. 2010 Mar;24(2):669-76. doi: 10.1016/j.tiv.2009.08.019. Epub 2009 Aug 29.

19.

A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals.

Ayehunie S, Snell M, Child M, Klausner M.

Toxicology. 2009 Oct 1;264(1-2):1-9. doi: 10.1016/j.tox.2009.07.021. Epub 2009 Aug 7.

20.

Microvesicating effects of sulfur mustard on an in vitro human skin model.

Hayden PJ, Petrali JP, Stolper G, Hamilton TA, Jackson GR Jr, Wertz PW, Ito S, Smith WJ, Klausner M.

Toxicol In Vitro. 2009 Oct;23(7):1396-405. doi: 10.1016/j.tiv.2009.07.021. Epub 2009 Jul 18.

PMID:
19619636
21.

An in vitro skin irritation test (SIT) using the EpiDerm reconstructed human epidermal (RHE) model.

Kandárová H, Hayden P, Klausner M, Kubilus J, Sheasgreen J.

J Vis Exp. 2009 Jul 13;(29). pii: 1366. doi: 10.3791/1366.

22.

Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay.

Mun GC, Aardema MJ, Hu T, Barnett B, Kaluzhny Y, Klausner M, Karetsky V, Dahl EL, Curren RD.

Mutat Res. 2009 Mar 17;673(2):92-9. doi: 10.1016/j.mrgentox.2008.12.004. Epub 2009 Jan 9.

PMID:
19167515
23.

Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay.

Hu T, Kaluzhny Y, Mun GC, Barnett B, Karetsky V, Wilt N, Klausner M, Curren RD, Aardema MJ.

Mutat Res. 2009 Mar 17;673(2):100-8. doi: 10.1016/j.mrgentox.2008.12.003. Epub 2009 Jan 9.

PMID:
19167513
24.

A device for in vivo measurements of quantitative ultrasound variables at the human proximal femur.

Barkmann R, Laugier P, Moser U, Dencks S, Klausner M, Padilla F, Haïat G, Glüer CC.

IEEE Trans Ultrason Ferroelectr Freq Control. 2008;55(6):1197-204. doi: 10.1109/TUFFC.2008.783.

PMID:
18599408
25.

In vivo measurements of ultrasound transmission through the human proximal femur.

Barkmann R, Laugier P, Moser U, Dencks S, Klausner M, Padilla F, Haiat G, Heller M, Glüer CC.

Ultrasound Med Biol. 2008 Jul;34(7):1186-90. doi: 10.1016/j.ultrasmedbio.2007.12.008. Epub 2008 Feb 21.

PMID:
18294756
26.

Efficacy and safety of epoetin alfa in critically ill patients.

Corwin HL, Gettinger A, Fabian TC, May A, Pearl RG, Heard S, An R, Bowers PJ, Burton P, Klausner MA, Corwin MJ; EPO Critical Care Trials Group.

N Engl J Med. 2007 Sep 6;357(10):965-76.

27.

Activated CD34-derived Langerhans cells mediate transinfection with human immunodeficiency virus.

Fahrbach KM, Barry SM, Ayehunie S, Lamore S, Klausner M, Hope TJ.

J Virol. 2007 Jul;81(13):6858-68. Epub 2007 Apr 18.

28.

Organotypic human oral tissue models for toxicological studies.

Klausner M, Ayehunie S, Breyfogle BA, Wertz PW, Bacca L, Kubilus J.

Toxicol In Vitro. 2007 Aug;21(5):938-49. Epub 2007 Feb 8.

PMID:
17383851
29.

Permeation of WIN 55,212-2, a potent cannabinoid receptor agonist, across human tracheo-bronchial tissue in vitro and rat nasal epithelium in vivo.

Agu RU, Valiveti S, Paudel KS, Klausner M, Hayden PJ, Stinchcomb AL.

J Pharm Pharmacol. 2006 Nov;58(11):1459-65.

PMID:
17132208
30.

In vitro and in vivo comparison of dermal irritancy of jet fuel exposure using EpiDerm (EPI-200) cultured human skin and hairless rats.

Chatterjee A, Babu RJ, Klausner M, Singh M.

Toxicol Lett. 2006 Dec 1;167(2):85-94. Epub 2006 Sep 10.

PMID:
17049765
31.

Antimicrobial barrier of an in vitro oral epithelial model.

Kimball JR, Nittayananta W, Klausner M, Chung WO, Dale BA.

Arch Oral Biol. 2006 Sep;51(9):775-83. Epub 2006 Jul 3.

32.

Ensuring quality of in vitro alternative test methods: Current practice.

Rispin A, Stitzel K, Harbell J, Klausner M.

Regul Toxicol Pharmacol. 2006 Jul;45(2):97-103. Epub 2006 Apr 27. Review.

PMID:
16644076
33.

Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue.

Walle T, Walle UK, Sedmera D, Klausner M.

Drug Metab Dispos. 2006 Mar;34(3):346-50. Epub 2005 Dec 28.

PMID:
16381670
34.

Organotypic human vaginal-ectocervical tissue model for irritation studies of spermicides, microbicides, and feminine-care products.

Ayehunie S, Cannon C, Lamore S, Kubilus J, Anderson DJ, Pudney J, Klausner M.

Toxicol In Vitro. 2006 Aug;20(5):689-98. Epub 2005 Nov 23.

PMID:
16309879
35.

Renal function, erythropoietin, and anemia of older persons: the InCHIANTI study.

Ble A, Fink JC, Woodman RC, Klausner MA, Windham BG, Guralnik JM, Ferrucci L.

Arch Intern Med. 2005 Oct 24;165(19):2222-7.

PMID:
16246987
36.
37.

Extended epoetin alfa dosing in chronic kidney disease patients: a retrospective review.

Germain M, Ram CV, Bhaduri S, Tang KL, Klausner M, Curzi M.

Nephrol Dial Transplant. 2005 Oct;20(10):2146-52. Epub 2005 Jun 28.

PMID:
15985516
38.

Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent.

Hammell DC, Stolarczyk EI, Klausner M, Hamad MO, Crooks PA, Stinchcomb AL.

J Pharm Sci. 2005 Apr;94(4):828-36.

PMID:
15736197
39.

Intranasal delivery of recombinant human parathyroid hormone [hPTH (1-34)], teriparatide in rats.

Agu RU, Valiveti S, Earles DC, Klausner M, Hayden PJ, Wermeling DP, Stinchcomb AL.

Endocr Res. 2004 Aug;30(3):455-67.

PMID:
15554361
40.

Quality assurance for in vitro alternative test methods: quality control issues in test kit production.

Rispin A, Harbell JW, Klausner M, Jordan FT, Coecke S, Gupta K, Stitzel K.

Altern Lab Anim. 2004 Jun;32 Suppl 1B:725-9.

PMID:
23581166
41.

Full Thickness EpiDerm: a dermal-epidermal skin model to study epithelial-mesenchymal interactions.

Kubilus J, Hayden PJ, Ayehunie S, Lamore SD, Servattalab C, Bellavance KL, Sheasgreen JE, Klausner M.

Altern Lab Anim. 2004 Jun;32 Suppl 1A:75-82.

PMID:
23577437
42.

Gene expression profile of tissue engineered skin subjected to acute barrier disruption.

Koria P, Brazeau D, Kirkwood K, Hayden P, Klausner M, Andreadis ST.

J Invest Dermatol. 2003 Aug;121(2):368-82.

43.

Contraindicated medications dispensed with cisapride: temporal trends in relation to the sending of 'Dear Doctor' letters.

Weatherby LB, Walker AM, Fife D, Vervaet P, Klausner MA.

Pharmacoepidemiol Drug Saf. 2001 May;10(3):211-8.

PMID:
11501334
44.

Metastases to the retroperitoneum in patients with extremity soft tissue sarcoma: an unusual metastatic pattern.

Lev-Chelouche D, Nakache R, Soffer D, Merimsky O, Klausner MJ, Gutman M.

Cancer. 2000 Jan 15;88(2):364-8.

PMID:
10640969
45.

Astemizole use with erythromycin.

Klausner MA.

Ann Allergy Asthma Immunol. 1999 Nov;83(5):422. No abstract available.

PMID:
10582723
46.

Treatment of fluconazole-refractory oropharyngeal candidiasis with itraconazole oral solution in HIV-positive patients.

Saag MS, Fessel WJ, Kaufman CA, Merrill KW, Ward DJ, Moskovitz BL, Thomas C, Oleka N, Guarnieri JA, Lee J, Brenner-Gati L, Klausner M.

AIDS Res Hum Retroviruses. 1999 Nov 1;15(16):1413-7.

PMID:
10555103
47.

Reproducible fentanyl doses delivered intermittently at different time intervals from an electrotransport system.

Gupta SK, Sathyan G, Phipps B, Klausner M, Southam M.

J Pharm Sci. 1999 Aug;88(8):835-41.

PMID:
10430551
48.

Ketoconazole 2% shampoo in the treatment of tinea versicolor: a multicenter, randomized, double-blind, placebo-controlled trial.

Lange DS, Richards HM, Guarnieri J, Humeniuk JM, Savin RC, Reyes BA, Hickman J, Pariser DM, Pariser RJ, Sherertz EF, Grossman RM, Gisoldi EM, Klausner MA.

J Am Acad Dermatol. 1998 Dec;39(6):944-50.

PMID:
9843006
49.
50.

Evaluation of the EpiOcular((TM)) Tissue Model as an Alternative to the Draize Eye Irritation Test.

Stern M, Klausner M, Alvarado R, Renskers K, Dickens M.

Toxicol In Vitro. 1998 Aug;12(4):455-61.

PMID:
20654428

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