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Items: 31

1.

Self-immolative bioluminogenic quinone luciferins for NAD(P)H assays and reducing capacity-based cell viability assays.

Zhou W, Leippe D, Duellman S, Sobol M, Vidugiriene J, O'Brien M, Shultz JW, Kimball JJ, DiBernardo C, Moothart L, Bernad L, Cali J, Klaubert DH, Meisenheimer P.

Chembiochem. 2014 Mar 21;15(5):670-5. doi: 10.1002/cbic.201300744. Epub 2014 Mar 3.

PMID:
24591148
2.

Development of a dehalogenase-based protein fusion tag capable of rapid, selective and covalent attachment to customizable ligands.

Encell LP, Friedman Ohana R, Zimmerman K, Otto P, Vidugiris G, Wood MG, Los GV, McDougall MG, Zimprich C, Karassina N, Learish RD, Hurst R, Hartnett J, Wheeler S, Stecha P, English J, Zhao K, Mendez J, Benink HA, Murphy N, Daniels DL, Slater MR, Urh M, Darzins A, Klaubert DH, Bulleit RF, Wood KV.

Curr Chem Genomics. 2012;6:55-71. doi: 10.2174/1875397301206010055. Epub 2012 Oct 5.

3.

Novel heterocyclic analogues of firefly luciferin.

Woodroofe CC, Meisenheimer PL, Klaubert DH, Kovic Y, Rosenberg JC, Behney CE, Southworth TL, Branchini BR.

Biochemistry. 2012 Dec 11;51(49):9807-13. doi: 10.1021/bi301411d. Epub 2012 Nov 29.

PMID:
23164087
4.

Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate.

Hall MP, Unch J, Binkowski BF, Valley MP, Butler BL, Wood MG, Otto P, Zimmerman K, Vidugiris G, Machleidt T, Robers MB, Benink HA, Eggers CT, Slater MR, Meisenheimer PL, Klaubert DH, Fan F, Encell LP, Wood KV.

ACS Chem Biol. 2012 Nov 16;7(11):1848-57. doi: 10.1021/cb3002478. Epub 2012 Aug 30.

5.

Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates.

Cali JJ, Ma D, Wood MG, Meisenheimer PL, Klaubert DH.

Expert Opin Drug Metab Toxicol. 2012 Sep;8(9):1115-30. doi: 10.1517/17425255.2012.695345. Epub 2012 Jun 11. Review.

PMID:
22686499
6.

Molecular imaging of cytochrome P450 activity in mice.

Roncoroni C, Rizzi N, Brunialti E, Cali JJ, Klaubert DH, Maggi A, Ciana P.

Pharmacol Res. 2012 May;65(5):531-6. doi: 10.1016/j.phrs.2012.02.006. Epub 2012 Feb 25.

PMID:
22391453
7.

HaloTag: a novel reporter gene for positron emission tomography.

Hong H, Benink HA, Zhang Y, Yang Y, Uyeda HT, Engle JW, Severin GW, McDougall MG, Barnhart TE, Klaubert DH, Nickles RJ, Fan F, Cai W.

Am J Transl Res. 2011 Aug 15;3(4):392-403. Epub 2011 Jul 28.

8.

Proluciferin acetals as bioluminogenic substrates for cytochrome P450 activity and probes for CYP3A inhibition.

Meisenheimer PL, Uyeda HT, Ma D, Sobol M, McDougall MG, Corona C, Simpson D, Klaubert DH, Cali JJ.

Drug Metab Dispos. 2011 Dec;39(12):2403-10. doi: 10.1124/dmd.111.041541. Epub 2011 Sep 2.

PMID:
21890735
9.

A bioluminescent assay for the sensitive detection of proteases.

Leippe DM, Nguyen D, Zhou M, Good T, Kirkland TA, Scurria M, Bernad L, Ugo T, Vidugiriene J, Cali JJ, Klaubert DH, O'Brien MA.

Biotechniques. 2011 Aug;51(2):105-10. doi: 10.2144/000113716.

10.

Chromophore-assisted light inactivation of HaloTag fusion proteins labeled with eosin in living cells.

Takemoto K, Matsuda T, McDougall M, Klaubert DH, Hasegawa A, Los GV, Wood KV, Miyawaki A, Nagai T.

ACS Chem Biol. 2011 May 20;6(5):401-6. doi: 10.1021/cb100431e. Epub 2011 Jan 20.

PMID:
21226520
11.

Methods for detection of protein-protein and protein-DNA interactions using HaloTag.

Urh M, Hartzell D, Mendez J, Klaubert DH, Wood K.

Methods Mol Biol. 2008;421:191-209.

PMID:
18826056
12.

N-Alkylated 6'-aminoluciferins are bioluminescent substrates for Ultra-Glo and QuantiLum luciferase: new potential scaffolds for bioluminescent assays.

Woodroofe CC, Shultz JW, Wood MG, Osterman J, Cali JJ, Daily WJ, Meisenheimer PL, Klaubert DH.

Biochemistry. 2008 Sep 30;47(39):10383-93. doi: 10.1021/bi800505u. Epub 2008 Sep 5.

PMID:
18771284
13.

HaloTag: a novel protein labeling technology for cell imaging and protein analysis.

Los GV, Encell LP, McDougall MG, Hartzell DD, Karassina N, Zimprich C, Wood MG, Learish R, Ohana RF, Urh M, Simpson D, Mendez J, Zimmerman K, Otto P, Vidugiris G, Zhu J, Darzins A, Klaubert DH, Bulleit RF, Wood KV.

ACS Chem Biol. 2008 Jun 20;3(6):373-82. doi: 10.1021/cb800025k.

PMID:
18533659
14.

Spatial separation and bidirectional trafficking of proteins using a multi-functional reporter.

Svendsen S, Zimprich C, McDougall MG, Klaubert DH, Los GV.

BMC Cell Biol. 2008 Apr 2;9:17. doi: 10.1186/1471-2121-9-17.

15.

Self-cleavable bioluminogenic luciferin phosphates as alkaline phosphatase reporters.

Zhou W, Andrews C, Liu J, Shultz JW, Valley MP, Cali JJ, Hawkins EM, Klaubert DH, Bulleit RF, Wood KV.

Chembiochem. 2008 Mar 25;9(5):714-8. doi: 10.1002/cbic.200700644. No abstract available.

PMID:
18247448
16.

A bioluminescent assay for monoamine oxidase activity.

Valley MP, Zhou W, Hawkins EM, Shultz J, Cali JJ, Worzella T, Bernad L, Good T, Good D, Riss TL, Klaubert DH, Wood KV.

Anal Biochem. 2006 Dec 15;359(2):238-46. Epub 2006 Oct 18.

PMID:
17084801
17.

Electrophilic aromatic substituted luciferins as bioluminescent probes for glutathione S-transferase assays.

Zhou W, Shultz JW, Murphy N, Hawkins EM, Bernad L, Good T, Moothart L, Frackman S, Klaubert DH, Bulleit RF, Wood KV.

Chem Commun (Camb). 2006 Nov 28;(44):4620-2. Epub 2006 Sep 26.

PMID:
17082862
18.

New bioluminogenic substrates for monoamine oxidase assays.

Zhou W, Valley MP, Shultz J, Hawkins EM, Bernad L, Good T, Good D, Riss TL, Klaubert DH, Wood KV.

J Am Chem Soc. 2006 Mar 15;128(10):3122-3.

PMID:
16522074
19.

Homogeneous, bioluminescent protease assays: caspase-3 as a model.

O'Brien MA, Daily WJ, Hesselberth PE, Moravec RA, Scurria MA, Klaubert DH, Bulleit RF, Wood KV.

J Biomol Screen. 2005 Mar;10(2):137-48.

PMID:
15799957
20.

Fluorescent molecular probes V: a sensitive caspase-3 substrate for fluorometric assays.

Liu J, Bhalgat M, Zhang C, Diwu Z, Hoyland B, Klaubert DH.

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3231-6.

PMID:
10576694
21.

Fluorogenic substrates based on fluorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases.

Gee KR, Sun WC, Bhalgat MK, Upson RH, Klaubert DH, Latham KA, Haugland RP.

Anal Biochem. 1999 Aug 15;273(1):41-8.

PMID:
10452797
22.

A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells.

Diwu Z, Chen CS, Zhang C, Klaubert DH, Haugland RP.

Chem Biol. 1999 Jul;6(7):411-8.

PMID:
10381401
23.

5-(Pentafluorobenzoylamino)fluorescein: A selective substrate for the determination of glutathione concentration and glutathione S-transferase activity.

Arttamangkul S, Bhalgat MK, Haugland RP, Diwu Z, Liu J, Klaubert DH, Haugland RP.

Anal Biochem. 1999 May 1;269(2):410-7.

PMID:
10222018
24.

Antibacterial agents that inhibit two-component signal transduction systems.

Barrett JF, Goldschmidt RM, Lawrence LE, Foleno B, Chen R, Demers JP, Johnson S, Kanojia R, Fernandez J, Bernstein J, Licata L, Donetz A, Huang S, Hlasta DJ, Macielag MJ, Ohemeng K, Frechette R, Frosco MB, Klaubert DH, Whiteley JM, Wang L, Hoch JA.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22.

25.

Small-molecule immunostimulants. Synthesis and activity of 7,8-disubstituted guanosines and structurally related compounds.

Reitz AB, Goodman MG, Pope BL, Argentieri DC, Bell SC, Burr LE, Chourmouzis E, Come J, Goodman JH, Klaubert DH, et al.

J Med Chem. 1994 Oct 14;37(21):3561-78.

PMID:
7932584
26.

Design, synthesis and bronchodilatory activity of a series of quinazoline-3-oxides.

Combs DW, Rampulla MS, Russell RK, Rampulla RA, Klaubert DH, Ritchie D, Meeks AS, Kirchner T.

Drug Des Deliv. 1990 Oct;6(4):241-54.

PMID:
2083028
27.

6-Benzoxazinylpyridazin-3-ones: potent, long-acting positive inotrope and peripheral vasodilator agents.

Combs DW, Rampulla MS, Bell SC, Klaubert DH, Tobia AJ, Falotico R, Haertlein B, Lakas-Weiss C, Moore JB.

J Med Chem. 1990 Jan;33(1):380-6.

PMID:
2153210
28.

Novel 1,3-bis(aryloxy)propanes as leukotriene D4 antagonists.

Kreft AF, Klaubert DH, Bell SC, Pattison TW, Yardley JP, Carlson RP, Hand JM, Chang JY, Lewis AJ.

J Med Chem. 1986 Jul;29(7):1134-8.

PMID:
3806566
29.

5-Tetrazolecarboxamides and their salts: new orally active antiallergy agents.

Klaubert DH, Sellstedt JH, Guinosso CJ, Bell SC, Capetola RJ.

J Med Chem. 1981 Jun;24(6):748-52. No abstract available.

PMID:
7252984
30.

N-(aminophenyl)oxamic acids and esters as potent, orally active antiallergy agents.

Klaubert DH, Sellstedt JH, Guinosso CJ, Capetola RJ, Bell SC.

J Med Chem. 1981 Jun;24(6):742-8. No abstract available.

PMID:
7252983
31.

Structure and synthesis of kotanin and desmethylkotanin, metabolites of Aspergillus glaucus.

B├╝chi G, Klaubert DH, Shank RC, Weinreb SM, Wogan GN.

J Org Chem. 1971 Apr 23;36(8):1143-7. No abstract available.

PMID:
5551701

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